Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer's disease

Journal of Psychiatric Research

Volumn 33, Issue 5, 1999, Pages 397-405

  Maes, Michael ^a,b,c   Devos, Nathalie ^a   Wauters, Annick ^d   Demedts, Paul ^d   Maurits, Vandewoude ^e   Neels, Hugo ^d   Bosmans, Eugene ^f   Altamura, Carlo ^c   Lin, Aihua ^a   Song, Cai ^a,g   Vandenbroucke, Michel ^e   Scharpe, Simon ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b VANDERBILT UNIVERSITY   (United States)

^c IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^d Laboratory of Clinical Biology   (Belgium)

^e Brussels Saint Elisabeth Clinic   (Belgium)

^f Eurogenetics   (Belgium)

^g CARLETON UNIVERSITY   (Canada)

Author keywords

Acute phase proteins; Aging; Alzheimer's disease; Cytokines; Interleukin 6; Zinc

Indexed keywords

ALBUMIN; ALPHA 2 GLOBULIN; GLOBULIN; INTERLEUKIN 6; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; ZINC;

ADULT; AGED; AGING; ALBUMIN BLOOD LEVEL; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ZINC BLOOD LEVEL;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BIOLOGICAL MARKERS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; REFERENCE VALUES; SERUM ALBUMIN; TUMOR NECROSIS FACTOR-ALPHA; ZINC;

EID: 0032774318     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3956(99)00016-3     Document Type: Article

References (74)

1. Aisen P.S. Inflammation and Alzheimer disease. Molecular and Chemical Neuropathology. 28:1996;83-88.
2. Aisen P.S., Davis K.L. Inflammatory mechanisms of Alzheimer' s disease: implications for therapy. American Journal of Psychiatry. 151:1994;1105-1113.
3. Alvarez X.A., Franco A., Fernandez Novoa L., Cacabelos R. Blood levels of histamine, IL-1, and TNF-alpha in patients with mild to moderate Alzheimer disease. Molecular and Chemical Neuropathology. 29:1996;237-252.
4. Diagnostic and statistical manual of mental disorders. 4th ed. 1994;American Psychiatric Association, Washington, DC.
5. Angelis P., Scharf S., Mander A., Vajda F., Christophidis N. Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease. Neuroscience Letters. 244:1998;106-108.
6. Atukorala T.M., Herath C.A., Ramachandran S. Zinc and vitamin A status of alcoholics in a medical unit in Sri Lanka. Alcohol and Alcoholism. 21:1986;269-275.
7. Baumgartner R.N., Koehler K.M., Romero L., Garry P.J. Serum is associated with skeletal muscle in elderly men and women. American Journal of Clinical Nutrition. 64:1996;552-558.
8. Bibby D.C., Grimble R.F. Dietary fat modifies some metabolic actions of human recombinant tumour necrosis factor alpha in rats. British Journal of Nutrition. 63:1990;653-668.
9. Blasko I., Schmitt T.L., Steiner E., Trieb K., Grubeck-Loebenstein B. Tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells. Neuroscience Letters. 238:1997;17-20.
10. Born J., Uthgenannt D., Dodt C., Nunninghoff D., Ringvolt E., Wagner T., Fehm H.L. Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mechanisms of Ageing and Development. 84:1995;113-126.
11. Cals M.J., Bories P.N., Blonde Cynober F., Coudry Lucas C., Desveaux N., Devanlay M., Duche J.C., Luciani L., Meneguzzer E., Ponteziere C., Succari M., Tortrat D. Reference intervals and biological profile in a group of healthy elderly population in the Paris region. Annales de Biologie Cliniques de Paris. 54:1996;307-315.
12. Caruso C., Candore G., Cigna D., di Lorenzo G., Sireci G., Dieli F., Salerno A. Cytokine production pathway in the elderly. Immunology Research. 15:1996;84-90.
13. Constantinidis J. Alzheimer's disease and the zinc theory. Encephale. 16:1990;231-239.
14. Cousins R.J., Leinart A.S. Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin-1. FASEB Journal. 2:1988;2884-2890.
15. De Groote D., Zangerle P.F., Gevaert Y., Fassotte M.F., Beguin Y., Noizat-Pirenne F., Pirenne J., Gathy R., Lopez M., Dehart I., Igot D., Baudrihaye M., Delacroix D., Franchimont P. Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation. Cytokine. 4:1992;239-248.
16. De Groote D., Gevaert Y., Lopez M., Gathy R., Fauchet F., Dehart I., Jadoul M., Radoux D., Franchimont P. Novel method for the measurement of cytokine production by one-stage procedure. J Immunol Methods. 9:1993;259-267.
17. Ershler W.B. Interleukin-6: a cytokine for gerontologists. Journal of the American Geriatric Society. 41:1993;176-181.
18. Ershler W.B., Sun W.H., Binkley N., Gravenstein S., Volk M.J., Kamoske G., Klopp R.G., Roecker E.B., Daynes R.A., Weinruch R. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine and Cytokine Research. 12:1993;225-230.
19. Fagiolo U., Cossarizza A., Scala E., Fanales Belasio E., Ortolani C., Cozzi E., Monti D., Francescji C., Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. European Journal of Immunology. 23:1993;2375-2378.
20. Fillit H., Ding W., Buee L., Kalman J., Altstiel L., Larlow B., Wolf-Klein G. Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neuroscience Letters. 129:1991;318-320.
21. Giometto B., Argentiero V., Sanson F., Ongaro G., Tavolato B. Acute-phase proteins in Alzheimer's disease. European Neurology. 28:1988;30-33.
22. Giroux E., Schechter P.J., Schoun J., Sjoerdsma A. Reduced binding of added zinc in serum of patients with decompensated hepatic cirrhosis. European Journal of Clinical Investigation. 7:1977;71-73.
23. Goodman M.N. Tumor necrosis factor induces skeletal muscle protein breakdown in rats. American Journal of Physiology. 260:1991;E727-730.
24. Gronek I., Kolomaznik M. Serum zinc levels in various mental disorders. Zhurnal Nevropatologii I Psikhiatrii Imeni I P Pavlova. 89:1989;126-127.
25. Hager K., Machein U., Krieger S., Platt D., Seefried G., Bauer J. Interleukin-6 and selected plasma proteins in healthy persons of different ages. Neurobiology of Aging. 15:1994;771-772.
26. Hampel H., Kotter H.U., Moller H.J. Blood-cerebrospinal fluid barrier dysfunction for high molecular weight proteins in Alzheimer disease and major depression: indication for disease subsets. Alzheimer Disease and Associated Disorders. 11:1997;78-87.
27. Hauss Wegrzyniak B., Dobrzanski P., Stoehr J.D., Wenk G.L. Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer' s disease. Brain Research. 780:1998;294-303.
28. Hirose N., Arai Y., Kawamura M., Homma S., Hasegawa H., Ishida H., Shimizu K., Osono Y., Takeda S., Noji H., Homma A., Nakamura Y. Tokyo Centenarian Study. 5. Nutritional status of Japanese centenarians. Japanese Journal of Geriatrics. 34:1997;324-330.
29. Hsu S.H., Chan C.Y., Tam T.N., Lin S.H., Tang K.C., Lee S.D. The liver biochemical tests and serological markers of hepatitis B virus in the very old-aged population in Taiwan. Chung Hua I Hsueh Tsa Chih Taipei - Chinese Medical Journal. 57:1996;16-21.
30. Huberman M., Shalit F., Roth Deri I., Gutman B., Brodie C., Kott E., Sredni B. Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage. Journal of Neuroimmunology. 52:1994;147-152.
31. Hull M., Strauss S., Berger M., Volk B., Bauer J. The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease. Behavioral Brain Research. 78:1996;37-41.
32. Hull M., Strauss S., Berger M., Volk B., Bauer J. Inflammatory mechanisms in Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 246:1996;124-128.
33. Jeandel C., Nicolas M.B., Dubois F., Nabet Belleville F., Penin F., Cuny G. Lipid peroxidation and free radical scavengers in Alzheimer' s disease. Gerontology. 35:1989;275-282.
34. Jobst K.A., Barnetson L.P., Shepstone B.J. Corrected and republished article originally printed in Int Psychogeriatry 1997;9 Suppl 1:191-222; discussion 247-52. Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and Apo E4 in medial temporal lobe dementias. Oxford Project to Investigate Memory and Aging. Int Psychogeriatr. 10:1998;271-302.
35. Kalman J., Juhasz A., Laird G., Dickens P., Jardanhazy T., Rimanoczy A., Boncz I., Parry-Jones W.L., Janka Z. Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease. Acta Neurologica Scandinavica. 96:1997;236-240.
36. Klonoff Cohen H., Barrett Connor E.L., Edelstein S.L. Albumin levels as a predictor of mortality in the healthy elderly. Journal of Clinical Epidemiology. 45:1992;207-212.
37. Kushner I. The acute phase response: An overview. Methods Enzymol. 163:1988;373-383.
38. Licastro F., Savorani G., Sarti G., Salsi A., Cavazzuti F., Zanichelli L., Tucci G., Mocchegiani E., Fabris N. Zinc and thymic hormone-dependent immunity in normal ageing and in patients with senile dementia of the Alzheimer type. Journal of Neuroimmunology. 27:1990;201-208.
39. Licastro F., Morini M.C., Chiricolo M., Conte R., Belletti D., Mancini R., Beltrandi E., Casadei Maldini M., Carpene E. Plasmic levels of trace elements and immune functions in the healthy elderly. Journal of Trace Elements and Electrolytes in Health and Disease. 7:1993;234-236.
40. Licastro F., Chiricolo M., Morini M.C., Capri I., Davis L.J., Conte R., Mancini R., Melotti C., Parente R., Serra R. Influence of age and health on immune functions and trace elements. Gerontology. 41:1995;235-241.
41. Licastro F., Davis L.J., Mocchegiani E., Fabris N. Impaired peripheral zinc metabolism in patients with senile dementia of probable Alzheimer' s type as shown by low plasma concentrations of thymulin. Biological Trace Element Research. 51:1996;55-62.
42. Lieb K., Fiebich B.L., Schaller H., Berger M., Bauer J. Interleukin-1 beta and tumor necrosis factor-alpha induce expression of alpha 1-antichymotrypsin in human astrocytoma cells by activation of nuclear factor-kappa B. Journal of Neurochemistry. 67:1996;2039-2044.
43. Madaric A., Ginter E., Kadrabova J. Serum copper, zinc and copper/zinc ratio in males: influence of aging. Physiological Research. 43:1994;107-111.
44. Maes M., Song C., Lin A., Gabriels L., DeJongh R., Van Gastel A., Kenis G., Bosmans E., DeMeester I., Benoyt I., Neels H., Demedts P., Janca A., Scharpe S., Smith R.S. The effects of psychological stress on humans: increased production of proinflammatory cytokines and a Th-1-like response in stress-induced anxiety. Cytokine. 10:1998;313-318.
45. McGeer P.L., McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Research Reviews. 21:1995;195-218.
46. McRae A., Dahlstrom A. Immune responses in brains of Alzheimer's and Parkinson's disease patients: hypothesis and reality. Reviews in the Neurosciences. 3:1992;79-97.
47. Mocchegiani E., Santarelli L., Muzzioli M., Fabris N. Reversibility of the thymic involution and of age-related peripheral immune dysfunction's by zinc supplementation in old mice. International Journal of Immunopharmacology. 17:1995;703-718.
48. Monget A.L., Galan P., Preziosi P., Keller H., Bourgeois C., Arnaud J., Favier A., Hercberg S. Micronutrient status in elderly people. International Journal of Vitamin and Nutrition Research. 66:1996;71-76.
49. Morimoto A., Murakami N., Nakamori T., Sakata Y., Watanabe T. Brain regions involved in the development of acute phase responses accompanying fever in rabbits. Journal of Physiology. 416:1989;645-657.
50. Morimoto A., Sakata Y., Watanabe T., Murakami N. Characteristics of fever and acute-phase responses induced in rabbits by IL-1 and TNF. American Journal of Physiology. 156:1989;35-41.
51. Mussalo-Rauhamaa H., Konttinen Y.T., Lehto J., Honkanen V. Predictive clinical and laboratory parameters for serum zinc and copper in rheumatoid arthritis. Annals of Rheumatic Disease. 47:1988;816-819.
52. Mysliwska J., Bryl E., Zorena K., Balon J., Foerster J., Mysliwska A. Overactivity of tumor necrosis factor-alpha but not interleukin-6 is associated with low natural killer cytotoxic activity in the elderly. Gerontology. 43:1997;158-167.
53. Powers J.S., Folk M.C., Burger C., Wilson P., Stocking B.J., Collins J. Assessment of nutritional status in noninstitutionalized elderly. Southern Medical Journal. 82:1989;990-994.
54. Prasad A.S., Fitzgerald J.T., Hess J.W., Kaplan J., Pelen F., Dardenne M. Zinc deficiency in elderly patients. Nutrition. 9:1993;218-224.
55. Riancho J.A., Zarrabeitia M.T., Amado J.A., Olmos J.M., Gonzales Macias J. Age-related differences in cytokine secretion. Gerontology. 40:1994;8-12.
56. Rink L., Seyfarth M. Characteristics of immunologic test values in the elderly. Zeitschrift fur Gerontologie und Geriatrie. 30:1997;220-225.
57. Roubenoff R., Harris T.B., Abad L.W., Wilson P.W., Dallal G.E., Dinarello C.A. Monocyte cytokine production in an elderly population: effect of age and inflammation. Journals of Gerontology Series A - Biological Sciences and Medical Sciences. 53:1998;M20-26.
58. Salive M.E., Cornoni Huntley J., Phillips C.L., Guralnik J.M., Cohen H.J., Ostfeld A.M., Wallace R.B. Serum albumin in older persons: relationship with age and health status. Journal of Clinical Epidemiology. 45:1992;213-221.
59. Shalit F., Sredni B., Stern L., Kott E., Huberman M. Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients. Neuroscience Letters. 174:1994;130-132.
60. Sheng J.G., Ito K., Skinner R.D., Mrak R.E., Rovnaghi C.R., van Eldik L.J., Griffin W.S.T. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiology of Aging. 17:1996;761-766.
61. Shore D., Henkin R.I., Nelson N.R., Agarwal R.P., Wyatt R.J. Hair and serum copper, zinc, calcium and magnesium concentrations in Alzheimer- type dementia. Journal of the American Geriatric Society. 32:1984;892-895.
62. Singh V.K., Guthikonda P. Circulating cytokines in Alzheimer' s disease. Journal of Psychiatric Research. 31:1997;657-660.
63. Solomons N.W. Zinc and copper. Shils M.E., Young V.R. Modern nutrition in health and disease. 1988;238-262 Lea & Febiger, Philadelphia.
64. Srinivas U., Braconier J.H., Jeppsson B., Abdulla M., Akesson B., Ockerman P.A. Trace element alterations in infectious diseases. Scandinavian Journal of Clinical Laboratory Investigation. 48:1988;495-500.
65. Spaulding C.C., Walford R.L., Effros R.B. Calorie restriction inhibits the age-related dysregulation of the cytokines TNF- alpha and IL-6 in C3B10RF1 mice. Mechanisms of Ageing and Development. 93:1997;87-94.
66. Swanson C.A., Mansourion R., Dirren H., Rapin C.H. Zinc status of healthy elderly adults: response to supplementation. American Journal of Clinical Nutrition. 48:1988;343-349.
67. Taubeneck M.W., Daston G.P., Rogers J.M., Gershwin M.E., Ansari A., Keen C.L. Tumor necrosis factor-alpha alters maternal and embryonic zinc metabolism and is developmentally toxic in mice. Journal of Nutrition. 125:1995;908-919.
68. Tietz N.W., Shuey D.F., Wekstein D.R. Laboratory values in fit aging individuals - sexagenarians through centenarians. Clinical Chemistry. 38:1992;1167-1185.
69. Tully C.L., Snowdon D.A., Markesbery W.R. Serum zinc, senile plaques, and neurofibrillary tangles: findings from the Nun Study. Neuroreport. 6:1995;2105-2108.
70. van Duijn C.M., Hofman A., Nagelkerken L. Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease. Neuroscience Letters. 108:1990;350-354.
71. Van Miert A.S., Van Duin C.T., Wensing T. Fever and changes in plasma zinc and iron concentrations in the goat. The effects of interferon inducers and recombinant IFN-alpha 2a. Journal of Comparative Pathology. 103:1990;289-300.
72. Woodward W.D., Filteau S.M., Allen O.B. Decline in serum zinc level throughout adult life in the laboratory mouse. Journal of Gerontology. 39:1984;521-524.
73. Yoshimine N. Nutrition in the elderly. Japanese Journal of Geriatrics. 27:1990;7-11.
74. Zangerle P.F., De Groote D., Lopez M., Meuleman R.J., Vrindts Y., Fauchet F., Dehart I., Jadoul M., Radoux D., Franchimont P. Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood: II. Application to rheumatoid arthritis and osteoarthritis. Cytokine. 4:1992;568-575.