Glutamatergic neurotransmission in aging: A critical perspective

Mechanisms of Ageing and Development

Volumn 122, Issue 1, 2001, Pages 1-29

  Segovia, G ^a   Porras, A ^a   Del Arco, A ^a   Mora, F ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Brain aging; Glutamate; Neurotransmitters interaction

Indexed keywords

4 AMINOBUTYRIC ACID; DOPAMINE; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

AGING; AMINO ACID BRAIN LEVEL; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; BRAIN CORTEX; BRAIN REGION; COGNITION; EMOTION; HIPPOCAMPUS; HUMAN; LOCOMOTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; REVIEW; SYNAPTIC TRANSMISSION;

EID: 0035054493     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00225-6     Document Type: Article

References (141)

1. Importance of forebrain cholinergic and GABAergic systems to the age-related deficits in water maze performance of rats
2. Tripartite synapses: Glia, the unacknowledged partner
3. Extrasynaptic glutamate spillover in the hippocampus: Dependence on temperature and the role of active glutameate uptake
4. Nonvesicular release of neurotransmitter
5. Changes with aging in the levels of amino acids in rat CNS structural elements. 1. Glutamate and related amino acids
6. The pathogenesis of Parkinson's disease: A new hypothesis
7. Region-specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1
8. The cholinergic hypothesis of geriatric memory dysfunctions
9. NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex
10. Brain microdialysis
11. Age-related toxicity to lactate, glutamate, and beta-amyloid in cultured adult neurons
12. Age pigments, cell loss and hippocampal function
13. Age pigments and cell loss in the mammalian nervous system: Functional implications
14. Interaction between glutamatergic and monoaminergic systems within the basal ganglia - Implications for schizophrenia and Parkinson's disease
15. Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: Prevention by acetyl-L-carnitine
16. Altered responsiveness of caudate neurons to amino acids and dopamine in aged cats
17. Aging reduces neostriatal responsiveness to N-methyl-D-aspartate and dopamine: An in vitro electrophysiological study
18. Glutamate neurotoxicity and disease of the nervous system
19. [3H]-CGP 39653 mapping of glutamatergic N-methyl-D-aspartate receptors in the brain of aged rats
20. Transmitter timecourse in the synaptic cleft: Its role in central synaptic function
21. Acidic amino acids and self-stimulation of the prefrontal cortex in the rat
22. Release of amino acid neurotransmitters in different cortical areas of conscious adult and aged rats
23. Aging, prefrontal cortex, and amino acid neurotransmitters: Differential effects produced by electrical stimulation
24. Age-related alterations of NMDA-receptor properties in the mouse forebrain: Partial restoration by chronic phophatidylserine treatment
25. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
26. NMDA receptors - Their role in long term potentiation
27. In vivo amino acid release from the striatum of aging rats: Adenosine modulation
28. +-evoked glutamate release in vivo in young and aged rats
29. Anatomical organization of excitatory amino acid receptors and their pathways
30. Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity
31. Selective loss of phorbol-12,13-dibutyrate-facilitated L-glutamate transport in forebrain neurons of aged rats
32. Glial reaction in the hippocampal formation is highly correlated with aging in human brain
33. Neurochemistry of the developing and aging mammalian brain
34. Kainic acid-induced seizures in aged rats: Neurochemical correlates
35. Endogenous glutamate release from frontal cortex of adult and aged rats
36. Effects of endogenous glutamate on extracellular concentrations of GABA, dopamine and dopamine metabolites in the prefrontal cortex of the freely moving rat: Involvement of NMDA and AMPA/kainate receptors
37. Amphetamine releases GABA in striatum of the freely moving rat: Involvement of calcium and high affinity transporter mechanisms
38. Amphetamine increases extracellular concentrations of glutamate in striatum of the awake rat: Involvement of high affinity transporter mechanisms
39. Aging, emotional states, and memory
40. Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions
41. Alterations in neurotransmitter amino acid content in the aging rat striatum are subregion dependent
42. Extracellular glutamate levels increase with age in the lateral striatum-potential involvement of presynaptic D-2 receptors
43. Effects of apomorphine and L-methionine sulfoximine on the release of excitatory amino acid neurotransmitters and glutamine in the neostriatum of the conscious rat
44. The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageing
45. Amino acid neurotransmitters and their pathways in the mammalian central nervous system
46. Neuropeptide changes in aging and Alzheimer's disease
47. Glutamate: A neurotransmitter in mammalian brain
48. Regulation of the synthesis of the transmitter glutamate pool
49. Endogenous levels of amino acid neurotransmitters in different regions of frontal and temporal cortex of the rat during the normal process of aging
50. Selective alteration of mouse brain neurotransmitter release with age
51. Cellular distribution and kinetic properties of high-affinity glutamate transporters
52. Aging and stress-induced changes in choline and glutamate uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors
53. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices
54. N-methyl-D-aspartate mediated responses decrease with age in Fischer 344 rat brain
55. The central dopaminergic system: Susceptibility to risk factors for accelerated aging
56. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
57. Glutamate-dopamine interactions in the basal ganglia: Relationship to Parkinson's disease
58. Excitatory amino acids and Alzheimer's disease
59. Effect of aging on concentrations of D2-receptor containing neurons in rat striatum
60. Neuronal death in the development and aging of the cerebral cortex of the mouse
61. Cloned glutamate receptors
62. Age related decrease in the density of dopamine D1 and D2 receptors in corpus striatum of rats
63. Analysis of age-related impairments in learning and memory in rodent models
64. Cognitive, emotional and behavioral dysfunctions in aging and dementia
65. Is the activation of the metabotropic glutamate receptors impaired in the hippocampal CA1 area of the aged rat
66. Age-related regional loss of caudate-putamen dopamine receptors revealed by quantitative autoradiography
67. Effects of aging and chronic arterial hypertension on the cell populations in the neocortex and archicortex of the rat
68. Extrasynaptic glutamate spillover in the hippocampus: Evidence and implications
69. Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections
70. Glutamate-dopamine balance in the striatum: Pre- and post-synaptic interactions
71. Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis
72. Age-dependent effects of glutamate toxicity in the hippocampus
73. Age-related impairment in long-term potentiation in hippocampus: A role for the cytokine, interleukin-1 beta?
74. The effects of age and dietary restriction on metabotropic glutamate receptors in C57B1 mice
75. Aging of glutamate receptors: Correlations between binding and spatial memory performance in mice
76. Effects of aging on NMDA and MK-801 binding sites in mice
77. Age-related changes in excitatory amino acid receptors in two mouse strains
78. Glutamate uptake impairment and neuronal damage in young and aged rats in vivo
79. Excitatory amino acid neurotoxicity and neurodegenerative
80. [3H]D-aspartic acid release in brain slices of adult and aged Fischer 344 rats
81. Age-related changes in [3H]MK-801 binding in the Fischer 344 rat brain
82. Age-related changes of strychnine-insensitive glycine receptors in rat brain as studied by in vitro autoradiography
83. Interaction of neurotransmitters and cerebral aging
84. The neurobiological basis of prefrontal cortex self-stimulation: A review and an integrative hypothesis
85. Are there plastic and compensatory mechanisms in EAA neurotransmission during aging of the cerebral cortex?
86. Interaction of dopamine, excitatory amino acids, and inhibitory amino acids in the basal ganglia of the conscious rat
87. Endogenous glutamate-dopamine-GABA interactions in specific circuits of the brain of the awake animal
88. Endogenous interaction of glutamate and dopamine in the basal ganglia of the awake rat during aging
89. Quantitative autoradiographical analysis of the age-related modulation of central dopamine D1 and D2 receptors
90. Dopamine and serotonine systems in human and rodent brain: Effects of age and neurodegenerative diseases
91. Behavioral and morphological aspect of aging: An analysis of rat frontal cortex
92. Age-related changes in the regulation of behaviour by D1:D2 dopamine receptor interactions
93. Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged rats
94. Age-related alteration in excitatory amino acid neurotransmission in rat brain
95. The glutamatergic nerve terminal
96. In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: Relationship to spatial learning
97. Fine structural localization of glutamine synthetase in astrocytes of rat brain
98. Altered glutamatergic transmission in neurological disorders: From high extracellular glutamate to excessive synaptic efficacy
99. The chemical nature of the main central excitatory transmitter: A critical appraisal based upon release studies and synaptic vesicle localization
100. Glutamate receptors in the mammalian central nervous system
101. The release and uptake of excitatory amino acids in rat brain: Effect of aging and oxidative stress
102. Regulation of extracellular adenosine levels in the striatum of aging rats
103. Glutamic acid as a putative transmitter of the interhemispheric corticocortical connections in the rat
104. The effect of increased longevity, produced by dietary restriction, on the neuronal population of area 17 in rat cerebral cortex
105. Strain-dependent decrease in glutamate binding to the N-methyl-D-aspartic acid receptor during aging
106. [3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging
107. Metabotropic glutamate receptor agonist (1S,3R-ACPD) increased frontal cortex dopamine in aged but not in young rats
108. Dopamine-glutamate-GABA interactions and aging: Studies in striatum of the conscious rat
109. Dopamine-glutamate interactions in the prefrontal cortex of the conscious rat: Studies on aging
110. Age-related changes in glutamate concentration and synaptosomal glutamate uptake in adult rat striatum
111. Effects of age on L-glutamate-induced depolarization in three hippocampal subfields
112. The striatal-dopaminergic system as a model for modulation of altered neurotransmitter action during aging: Effects of dietary and neuroendocime manipulations
113. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
114. Unchanged exocytotic release of glutamic acid in cortex and neostriatum of the rat during aging
115. M1 acetylcholine receptor stimulation increases the extracellular concentrations of glutamate and GABA in the medial prefrontal cortex of the rat
116. Age-related changes in the uptake and release of glutamate and aspartate in the mouse brain
117. Behavioural pharmacology of glutamate in the basal ganglia
118. Excitatory amino acid transporters: A family in flux
119. Role of nitric oxide in modulating the release of dopamine, glutamate and GABA in striatum of the freely moving rat
120. Endogenous glutamate increases extracellular concentrations of dopamine, GABA, and taurine through NMDA and AMPA/kainate receptors in striatum of the freely moving rat: A microdialysis study
121. Effects of aging on the interaction between glutamate, dopamine and GABA in striatum and nucleus accumbens of the awake rat
122. Role of glutamate receptors and glutamate transporters in the regulation of the glutamate-glutamine cycle in the awake rat
123. NMDA receptor functions is enhanced in the hippocampus of aged rats
124. The unique properties of glutamate receptor channels
125. High-affinity uptake of neurotransmitters in rat neostriatum: Effects of aging
126. The effects of aging on MAO activity and amino acid levels in rat brain
127. Effects of aging on the content in sulfur-containing amino acids in rat brain
128. Age-related decreases of the N-methyl-D-aspartate receptor complex in the rat cerebral cortex and hippocampus
129. Interrelations among the lesions of normal and abnormal aging of the brain
130. Brain microdialysis of GABA and glutamate: What does it signify?
131. Aging is associated with a decrease in synaptosomal glutamate uptake and an increase in the susceptibility of synaptosomal vitamin E to oxidative stress
132. Increase of astrocyte population in the medial prefrontal cortex of the rat during aging
133. Effect of age and monosodium-L-glutamate (MSG) treatment on neurotransmitter content in brain regions from male Fischer-344 rats
134. Ammonia regulation of phosphate-activated glutaminase displays regional variation and impairment in the brain of aged rat
135. Regional differences in glutaminase activation by phosphate and calcium in rat brain: Impairment in aged rats and implications for regional glutaminase isozymes
136. Age-related changes in glutamate receptors: An autoradiographic analysis
137. Time course of the aging of the high affinity L-glutamate transporter in rat cortical synaptosomes
138. Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys
139. Microcialysis compared with other in vivo release models
140. Extracellular glutamate: On-line monitoring using microdialysis coupled to enzyme-amperometric analysis