Ionic and cofactor requirements for the activity of the apoptotic endonuclease DFF40/CAD

Molecular and Cellular Biochemistry

Volumn 218, Issue 1-2, 2001, Pages 125-130

  Widlak, P ^a   Garrard, W T ^b  

^a INSTITUTE OF ONCOLOGY   (Poland)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Apoptosis; CAD; Chromatin; Co factor requirements; DFF; Nuclease

Indexed keywords

CALCIUM ION; CASPASE ACTIVATED DEOXYRIBONUCLEASE; COPPER ION; DNA FRAGMENT; DNA FRAGMENTATION FACTOR; ENDONUCLEASE; MAGNESIUM ION; MANGANESE; OLIGOMER; POTASSIUM ION; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; ZINC ION;

APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOPLASM; DNA CLEAVAGE; ENZYME ACTIVITY; HAMSTER; HUMAN; IONIC STRENGTH; NICK END LABELING; NONHUMAN; PH; POTASSIUM CELL LEVEL; REGULATORY MECHANISM; TEMPERATURE; THERMOSTABILITY;

ANIMALS; APOPTOSIS; CALCIUM; CASPASES; CHROMATIN; COPPER; CRICETINAE; DEOXYRIBONUCLEASES; ENZYME ACTIVATION; ENZYME STABILITY; HEAT; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IONS; MAGNESIUM; MANGANESE; OSMOLAR CONCENTRATION; POTASSIUM; RECOMBINANT PROTEINS; ZINC;

CRICETINAE;

EID: 0035074074     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007231822086     Document Type: Article

References (23)

1. Cell death: The significance of apoptosis
2. Nuclear changes in apoptosis
3. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
4. Apoptosis. The role of the endonuclease
5. Role of nucleases in apoptosis
6. Cellular catabolism in apoptosis: DNA degradation and endonuclease activation
7. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
8. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
9. DFF40 induces DNA fragmentation and chromatin condensation during apoptosis
10. CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45
11. Activation of the apoptotic endonuclease DFF40 (caspase-activated Dnase or nuclease). Oligomerization and direct interactions with histone H1
12. Cleavage preferences of the apoptotic endonuclease DFF40 (Caspase-activated DNase or Nuclease) on naked DNA and chromatin substrates
13. + suppresses the activation of apoptosis in lymphocytes
14. Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo
15. Role of intracellular pH in proliferation, transformation and apoptosis
16. Identification of deoxyribonuclease II as endonuclease involved in apoptosis
17. 2+ concentration and DNA fragmentation
18. 2+
19. Apoptosis and necrosis: Intracellular ATP level as a determinant for cell death modes
20. In vitro chromatin assembly of the HIV-1 promoter: ATP-dependent polar repositioning of nucleosomes by Sp1 and NFκB
21. Chromatin condensation during apoptosis requires ATP
22. Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin
23. DNA fragmentation during apoptosis is caused by frequent single-strand cuts