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Volumn 10, Issue 2, 1996, Pages 239-263

Neurodegenerative disorders: Clues from glutamate and energy metabolism

Author keywords

Aging; Excitotoxicity; Huntington's disease; Ischemia; Mitochondrial toxins; Neurodegeneration; Parkinson's disease; Trauma

Indexed keywords

GANGLIOSIDE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0030478699     PISSN: 08920915     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevneurobiol.v10.i2.50     Document Type: Review
Times cited : (74)

References (301)
  • 1
    • 76349094638 scopus 로고
    • A physiological study of epileptic seizures following cortical stimulation in animals and its application to human clinics
    • Hayashi, T., A physiological study of epileptic seizures following cortical stimulation in animals and its application to human clinics, Jpn. J. Pharmacol., 3. 46, 1952.
    • (1952) Jpn. J. Pharmacol. , vol.3 , pp. 46
    • Hayashi, T.1
  • 2
    • 0005139360 scopus 로고
    • Inhibition and excitation due to γ-aminobutyric acid in the central nervous system
    • Hayashi, T., Inhibition and excitation due to γ-aminobutyric acid in the central nervous system, Nature, 182, 1076, 1958.
    • (1958) Nature , vol.182 , pp. 1076
    • Hayashi, T.1
  • 3
    • 84948011844 scopus 로고
    • The toxic effect of sodium L-glutamate on the inner layers of the retina
    • Lucas, D. R. and Newhouse, J. P., The toxic effect of sodium L-glutamate on the inner layers of the retina, Arch. Ophthalmol., 58, 193, 1957.
    • (1957) Arch. Ophthalmol. , vol.58 , pp. 193
    • Lucas, D.R.1    Newhouse, J.P.2
  • 4
    • 0014668762 scopus 로고
    • Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate
    • Olney, J. W., Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate, Science, 164, 719, 1969.
    • (1969) Science , vol.164 , pp. 719
    • Olney, J.W.1
  • 5
    • 0014682523 scopus 로고
    • Brain lesions in infant rhesus monkey treated with monosodium glutamate
    • Olney, J. W. and Sharpe, L. G., Brain lesions in infant rhesus monkey treated with monosodium glutamate, Science, 166, 386, 1969.
    • (1969) Science , vol.166 , pp. 386
    • Olney, J.W.1    Sharpe, L.G.2
  • 6
    • 0020585505 scopus 로고
    • Synaptic activity mediates death of hypoxic neurons
    • Rothman, S. M., Synaptic activity mediates death of hypoxic neurons, Science, 220, 536, 1983.
    • (1983) Science , vol.220 , pp. 536
    • Rothman, S.M.1
  • 7
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity in cortical cell culture
    • Choi, D. W., Ionic dependence of glutamate neurotoxicity in cortical cell culture, J. Neurosci., 7, 369, 1987.
    • (1987) J. Neurosci. , vol.7 , pp. 369
    • Choi, D.W.1
  • 8
    • 2642652575 scopus 로고
    • Thirty years of excitatory amino acid research
    • Cavalheiro, E. A., Lehmann, J., and Turski, L., Eds., Liss, New York
    • Watkins, J. C., Thirty years of excitatory amino acid research, in Frontiers in Excitatory Amino Acid Research, Cavalheiro, E. A., Lehmann, J., and Turski, L., Eds., Liss, New York, 1988, 3.
    • (1988) Frontiers in Excitatory Amino Acid Research , pp. 3
    • Watkins, J.C.1
  • 9
    • 0019952387 scopus 로고
    • Anticonvulsant action of excitatory amino acid antagonists
    • Croucher, M. J., Collins, J. F., and Meldrum, B. S., Anticonvulsant action of excitatory amino acid antagonists, Science, 216, 899, 1992.
    • (1992) Science , vol.216 , pp. 899
    • Croucher, M.J.1    Collins, J.F.2    Meldrum, B.S.3
  • 12
    • 0021743001 scopus 로고
    • Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain
    • Simon, R. P., Swan, J. H., Griffith, T., and Meldrum, B. S., Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain, Science, 226, 850, 1984.
    • (1984) Science , vol.226 , pp. 850
    • Simon, R.P.1    Swan, J.H.2    Griffith, T.3    Meldrum, B.S.4
  • 13
    • 8044255040 scopus 로고
    • Medical treatment of acute ischemic stroke
    • Sandercock, P. and Willems, H., Medical treatment of acute ischemic stroke, Lancet, 339, 1540, 1992.
    • (1992) Lancet , vol.339 , pp. 1540
    • Sandercock, P.1    Willems, H.2
  • 14
    • 0026597324 scopus 로고
    • Investigation of patients with stroke and transient ischaemic attacks
    • Donnan, G. A., Investigation of patients with stroke and transient ischaemic attacks, Lancet, 339, 473, 1992.
    • (1992) Lancet , vol.339 , pp. 473
    • Donnan, G.A.1
  • 15
    • 0002655565 scopus 로고
    • Head injury
    • Adams, J. H. and Duchen, L. W., Eds., Arnold, London
    • Adams, J. H., Head injury, in Greenfield's Neuropathology, Adams, J. H. and Duchen, L. W., Eds., Arnold, London, 1992, 106.
    • (1992) Greenfield's Neuropathology , pp. 106
    • Adams, J.H.1
  • 16
    • 0026501717 scopus 로고
    • Pathophysiology of acute ischaemic stroke
    • Pulsinelli, W., Pathophysiology of acute ischaemic stroke, Lancet, 339, 533, 1992.
    • (1992) Lancet , vol.339 , pp. 533
    • Pulsinelli, W.1
  • 17
    • 0027186008 scopus 로고
    • Molecular mechanisms of trauma-induced neuronal degeneration
    • Lipton, S. A., Molecular mechanisms of trauma-induced neuronal degeneration, Curr. Opinion Neurol. Neurosurg., 6, 588, 1993.
    • (1993) Curr. Opinion Neurol. Neurosurg. , vol.6 , pp. 588
    • Lipton, S.A.1
  • 18
    • 0021707433 scopus 로고
    • Elevation of extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • Benveniste, H., Drejer, J., Schousboe, A., and Diemer, N. H., Elevation of extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem., 43, 1369, 1984.
    • (1984) J. Neurochem. , vol.43 , pp. 1369
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 19
    • 0023723433 scopus 로고
    • Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and γ-aminobutyric acid studied by intracerebral microdialysis
    • Globus, M. Y.-T., Busto, R., Dietrich, W. D., Martinez, E., Valdes, I., and Ginsberg, M. D., Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and γ-aminobutyric acid studied by intracerebral microdialysis, J. Neurochem., 51, 1455, 1988.
    • (1988) J. Neurochem. , vol.51 , pp. 1455
    • Globus, M.Y.-T.1    Busto, R.2    Dietrich, W.D.3    Martinez, E.4    Valdes, I.5    Ginsberg, M.D.6
  • 21
    • 0027953005 scopus 로고
    • Changes in the extracellular concentrations of amino acids in the rat striatum during transient focal cerebral ischemia
    • Uchiyama-Tsuyuki, Y., Araki, H., Yae, T., and Otomo, S., Changes in the extracellular concentrations of amino acids in the rat striatum during transient focal cerebral ischemia, J. Neurochem., 62,1074, 1994.
    • (1994) J. Neurochem. , vol.62 , pp. 1074
    • Uchiyama-Tsuyuki, Y.1    Araki, H.2    Yae, T.3    Otomo, S.4
  • 22
    • 0024365739 scopus 로고
    • The role of excitatory amino acids and NMDA receptors in traumatic brain injury
    • Faden, A. I., Demediuk, P., Panter, S. S., and Vink, R., The role of excitatory amino acids and NMDA receptors in traumatic brain injury, Science, 244, 798, 1989.
    • (1989) Science , vol.244 , pp. 798
    • Faden, A.I.1    Demediuk, P.2    Panter, S.S.3    Vink, R.4
  • 23
    • 0025907224 scopus 로고
    • Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord
    • Liu, D., Thangnipon, W., and McAdoo, D. J., Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord, Brain Res., 547, 344, 1991.
    • (1991) Brain Res. , vol.547 , pp. 344
    • Liu, D.1    Thangnipon, W.2    McAdoo, D.J.3
  • 25
    • 8044261243 scopus 로고
    • Glutamate neurotransmission during and after ischemia: Histochemical studies
    • Ottersen, O. P., Torp, R., and Meldrum, B. S., Glutamate neurotransmission during and after ischemia: histochemical studies, Neuropsychopharmacology, 10, S209, 1994.
    • (1994) Neuropsychopharmacology , vol.10
    • Ottersen, O.P.1    Torp, R.2    Meldrum, B.S.3
  • 26
    • 0026531063 scopus 로고
    • Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis
    • Person, L. and Hillered, L., Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis, J. Neurosurg., 76, 72, 1992.
    • (1992) J. Neurosurg. , vol.76 , pp. 72
    • Person, L.1    Hillered, L.2
  • 27
    • 0019427434 scopus 로고
    • Plasma and cerebrospinal fluid free amino acid concentration in post-traumatic cerebral oedema in patients with shock
    • Bondoli, A., Barbi, S., Camaioni, D., Della Morte, F., and Magalini, S. J., Plasma and cerebrospinal fluid free amino acid concentration in post-traumatic cerebral oedema in patients with shock, Resuscitation, 9, 119, 1981.
    • (1981) Resuscitation , vol.9 , pp. 119
    • Bondoli, A.1    Barbi, S.2    Camaioni, D.3    Della Morte, F.4    Magalini, S.J.5
  • 28
    • 0027295901 scopus 로고
    • Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans
    • Baker, A. J., Moulton, R. J., MacMillan, V. H., and Shedden, P. M., Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans, J. Neurosurg., 79, 369, 1993.
    • (1993) J. Neurosurg. , vol.79 , pp. 369
    • Baker, A.J.1    Moulton, R.J.2    MacMillan, V.H.3    Shedden, P.M.4
  • 29
    • 0027152254 scopus 로고
    • Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia
    • Pulsinelli, W., Sarokin, A., and Buchan, A., Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia, Prog. Brain Res., 96, 125, 1993.
    • (1993) Prog. Brain Res. , vol.96 , pp. 125
    • Pulsinelli, W.1    Sarokin, A.2    Buchan, A.3
  • 30
    • 0027207494 scopus 로고
    • Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions
    • Wahlstedt, C., Golanov, E., Yamamoto, S., Yee, F., Ericson, H., Yoo, H., Inturrisi, C. E., and Reis, D. J., Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions, Nature, 363, 260, 1993.
    • (1993) Nature , vol.363 , pp. 260
    • Wahlstedt, C.1    Golanov, E.2    Yamamoto, S.3    Yee, F.4    Ericson, H.5    Yoo, H.6    Inturrisi, C.E.7    Reis, D.J.8
  • 31
    • 0025396451 scopus 로고
    • Do NMDA antagonists protect against cerebral ischemia: Are clinical trials warranted?
    • Buchan, A., Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? Cerebrovasc. Brain Metab. Rev., 2, 1, 1990.
    • (1990) Cerebrovasc. Brain Metab. Rev. , vol.2 , pp. 1
    • Buchan, A.1
  • 32
    • 0025390880 scopus 로고
    • Protection against ischemic neuronal damage by drugs acting on excitatory neurotransmission
    • Meldrum, B. S., Protection against ischemic neuronal damage by drugs acting on excitatory neurotransmission, Cerebrovasc. Brain Metab. Rev., 2, 27, 1990.
    • (1990) Cerebrovasc. Brain Metab. Rev. , vol.2 , pp. 27
    • Meldrum, B.S.1
  • 33
    • 0028337577 scopus 로고
    • The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke
    • Hasegawa, Y., Fisher, M., Baron, B. M., and Metcalf, G., The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke, Stroke, 25, 1241, 1994.
    • (1994) Stroke , vol.25 , pp. 1241
    • Hasegawa, Y.1    Fisher, M.2    Baron, B.M.3    Metcalf, G.4
  • 34
    • 8044246357 scopus 로고
    • Non-competitive NMDA receptor antagonists and ischemia-induced neuronal degeneration
    • Cavalheiro, E. A., Lehmann, J., and Turski, L., Eds., Liss, New York
    • Foster, A. C., Gill, R., Woodruff, G. N., and Iversen, L. L., Non-competitive NMDA receptor antagonists and ischemia-induced neuronal degeneration, in Frontiers in Excitatory Amino Acid Research, Cavalheiro, E. A., Lehmann, J., and Turski, L., Eds., Liss, New York, 1988, 707.
    • (1988) Frontiers in Excitatory Amino Acid Research , pp. 707
    • Foster, A.C.1    Gill, R.2    Woodruff, G.N.3    Iversen, L.L.4
  • 35
    • 0023896462 scopus 로고
    • Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia
    • Steinberg, G. K., Saleh, J., and Kunis, D., Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia, Neurosci. Lett., 89, 193, 1988.
    • (1988) Neurosci. Lett. , vol.89 , pp. 193
    • Steinberg, G.K.1    Saleh, J.2    Kunis, D.3
  • 39
    • 0028032883 scopus 로고
    • Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats
    • Nishikawa, T., Kirsch, J. R., Koehler, R. C., Miyabe, M., and Traystman, R. J., Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats, Stroke, 25, 2258, 1994.
    • (1994) Stroke , vol.25 , pp. 2258
    • Nishikawa, T.1    Kirsch, J.R.2    Koehler, R.C.3    Miyabe, M.4    Traystman, R.J.5
  • 40
    • 8044231100 scopus 로고
    • Memantine is protective after stroke, has fewer behavioral side effects than MK-801, and does not block long-term potentiation
    • Jensen, F. E., Edgecomb, P., Sondheimer, N., Lipton, S., and Stieg, P., Memantine is protective after stroke, has fewer behavioral side effects than MK-801, and does not block long-term potentiation, Ann. Neurol., 36, 304, 1994.
    • (1994) Ann. Neurol. , vol.36 , pp. 304
    • Jensen, F.E.1    Edgecomb, P.2    Sondheimer, N.3    Lipton, S.4    Stieg, P.5
  • 41
    • 0028834171 scopus 로고
    • In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antagonists
    • Warner, D. S., Martin, H., Ludwig, P., McAllister, A., Keana, J. F. W., and Weber, E., In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists, J. Cereb. Blood Flow Metab., 15, 188, 1995.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 188
    • Warner, D.S.1    Martin, H.2    Ludwig, P.3    McAllister, A.4    Keana, J.F.W.5    Weber, E.6
  • 42
    • 0028852625 scopus 로고
    • The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687-414) in a rat model of focal ischemia
    • Gill, R., Hargreaves, R. J., and Kemp, J. A., The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687-414) in a rat model of focal ischemia, J. Cereb. Blood Flow Metab., 15, 197, 1995.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 197
    • Gill, R.1    Hargreaves, R.J.2    Kemp, J.A.3
  • 44
    • 0024991826 scopus 로고
    • The pharmacology of focal cortical ischaemia in the mouse
    • Gotti, B., Benavides, J., MacKenzie, E. T., and Scatton, B., The pharmacology of focal cortical ischaemia in the mouse, Brain Res., 522, 290, 1990.
    • (1990) Brain Res. , vol.522 , pp. 290
    • Gotti, B.1    Benavides, J.2    MacKenzie, E.T.3    Scatton, B.4
  • 48
    • 0026750123 scopus 로고
    • Protection against ischemic hippocampal CA1 damage in the rat with a new non-NMDA antagonist, NBQX
    • Diemer, N. H., Jorgensen, M. B., Johansen, F. F., Sheardown, M., and Honore, T., Protection against ischemic hippocampal CA1 damage in the rat with a new non-NMDA antagonist, NBQX, Acta Neurol. Scand., 86, 45, 1993.
    • (1993) Acta Neurol. Scand. , vol.86 , pp. 45
    • Diemer, N.H.1    Jorgensen, M.B.2    Johansen, F.F.3    Sheardown, M.4    Honore, T.5
  • 49
    • 0027186008 scopus 로고
    • Molecular mechanisms of trauma-induced neuronal degeneration
    • Lipton, S. A., Molecular mechanisms of trauma-induced neuronal degeneration, Curr. Opinion Neurol. Neurosurg., 6, 588, 1993.
    • (1993) Curr. Opinion Neurol. Neurosurg. , vol.6 , pp. 588
    • Lipton, S.A.1
  • 50
    • 0023946078 scopus 로고
    • A potential role for excitotoxins in the pathophysiology of spinal cord injury
    • Faden, A. I. and Simon, R. P., A potential role for excitotoxins in the pathophysiology of spinal cord injury, Ann. Neurol., 23, 623, 1988.
    • (1988) Ann. Neurol. , vol.23 , pp. 623
    • Faden, A.I.1    Simon, R.P.2
  • 51
    • 0026794490 scopus 로고
    • Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist
    • Inglis, F., Kuroda, Y., and Bullock, R., Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist, J. Neurotrauma, 9, 75, 1992.
    • (1992) J. Neurotrauma , vol.9 , pp. 75
    • Inglis, F.1    Kuroda, Y.2    Bullock, R.3
  • 52
    • 0000655261 scopus 로고
    • The NMDA receptor antagonist MK-801 prevents edema and restores magnesium homeostasis after traumatic brain injury in rats
    • Cavalheiro, E. A., Lehmann, J., and Turski, L., Eds., Liss, New York
    • McIntosh, T., Soares, H., Hayes, R., and Simon, R., The NMDA receptor antagonist MK-801 prevents edema and restores magnesium homeostasis after traumatic brain injury in rats, in Frontiers in Excitatory Amino Acid Research, Cavalheiro, E. A., Lehmann, J., and Turski, L., Eds., Liss, New York, 1988, 653
    • (1988) Frontiers in Excitatory Amino Acid Research , pp. 653
    • McIntosh, T.1    Soares, H.2    Hayes, R.3    Simon, R.4
  • 53
    • 0027980388 scopus 로고
    • Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury
    • Shapira, Y., Lam, A. M., Eng, C. C., Laohaprasit, V., and Michel, M., Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury, Stroke, 25, 1637, 1994.
    • (1994) Stroke , vol.25 , pp. 1637
    • Shapira, Y.1    Lam, A.M.2    Eng, C.C.3    Laohaprasit, V.4    Michel, M.5
  • 54
    • 0027132491 scopus 로고
    • Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury
    • Smith, D. H., Okiyama, K., Thomas, M. J., and McIntosh, T. K., Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury, J. Neurosci., 13, 5383, 1993.
    • (1993) J. Neurosci. , vol.13 , pp. 5383
    • Smith, D.H.1    Okiyama, K.2    Thomas, M.J.3    McIntosh, T.K.4
  • 55
    • 0028105981 scopus 로고
    • Kynurenate is neuroprotective following experimental brain injury in the rat
    • Hicks, R. R., Smith, D. H., Gennarelli, T. A., and Mclntosh, T., Kynurenate is neuroprotective following experimental brain injury in the rat, Brain Res., 655, 91, 1994.
    • (1994) Brain Res. , vol.655 , pp. 91
    • Hicks, R.R.1    Smith, D.H.2    Gennarelli, T.A.3    Mclntosh, T.4
  • 56
    • 0027313217 scopus 로고
    • Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window
    • Toulmond, S., Serrano, A., Benavides, J., and Scatton, B., Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window, Brain Res., 620, 32, 1993.
    • (1993) Brain Res. , vol.620 , pp. 32
    • Toulmond, S.1    Serrano, A.2    Benavides, J.3    Scatton, B.4
  • 58
    • 0024338054 scopus 로고
    • Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney, J. W., Labruyere, J., and Price, M. T., Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs, Science, 244, 1360, 1989.
    • (1989) Science , vol.244 , pp. 1360
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 60
    • 0028074425 scopus 로고
    • Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/ retrosplenial cerebral cortex: A review
    • Fix, A. S., Long, G. G., Wozniak, D. F., and Olney, J. W., Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/ retrosplenial cerebral cortex: a review, Drug Dev. Res., 32,147, 1994.
    • (1994) Drug Dev. Res. , vol.32 , pp. 147
    • Fix, A.S.1    Long, G.G.2    Wozniak, D.F.3    Olney, J.W.4
  • 61
    • 0027294037 scopus 로고
    • Lack of effect of L-687,414 ((+)-cis-4-methyl-HA-966), an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology
    • Hargreaves, R. J., Rigby, M., Smith, D., and Hill, R. G., Lack of effect of L-687,414 ((+)-cis-4-methyl-HA-966), an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology, Br. J. Pharmacol., 110, 36, 1993.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 36
    • Hargreaves, R.J.1    Rigby, M.2    Smith, D.3    Hill, R.G.4
  • 62
    • 0028222785 scopus 로고
    • Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex
    • Berger, P., Farrel, K., Sharp, F., and Skolnick, P., Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex, Neurosci. Lett., 168, 147, 1994.
    • (1994) Neurosci. Lett. , vol.168 , pp. 147
    • Berger, P.1    Farrel, K.2    Sharp, F.3    Skolnick, P.4
  • 63
    • 0026537754 scopus 로고
    • SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons
    • Duval, D., Roome, N., Gauffeny, C., Nowicki, J. P., and Scatton, B., SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons, Neurosci. Lett., 137, 193, 1992.
    • (1992) Neurosci. Lett. , vol.137 , pp. 193
    • Duval, D.1    Roome, N.2    Gauffeny, C.3    Nowicki, J.P.4    Scatton, B.5
  • 64
    • 0023886994 scopus 로고
    • N-methyl-D-aspartate (NMDA) receptors control respiratory off-switch in cat
    • Foutz, A. S., Champagnat, J., and Denavit-Saubrie, M., N-methyl-D-aspartate (NMDA) receptors control respiratory off-switch in cat, Neurosci. Lett, 87, 221, 1988.
    • (1988) Neurosci. Lett , vol.87 , pp. 221
    • Foutz, A.S.1    Champagnat, J.2    Denavit-Saubrie, M.3
  • 65
    • 0025132940 scopus 로고
    • Pneumotaxic mechanisms in the nonhuman primate: Effect of the N-methyl-D-aspartate (NMDA) antagonist ketamine
    • Pierrefiche, O., Foutz, A. S., and Denavit-Saubrie, M., Pneumotaxic mechanisms in the nonhuman primate: effect of the N-methyl-D-aspartate (NMDA) antagonist ketamine, Neurosci. Lett., 119, 90, 1990.
    • (1990) Neurosci. Lett. , vol.119 , pp. 90
    • Pierrefiche, O.1    Foutz, A.S.2    Denavit-Saubrie, M.3
  • 66
    • 0024400096 scopus 로고
    • The noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits
    • Scheller, M. S., Zornow, M. H., Fleischer, J. E., Sherman, G. T., and Gerber, T. F., The noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits, Neuropharmacology, 28, 677, 1989.
    • (1989) Neuropharmacology , vol.28 , pp. 677
    • Scheller, M.S.1    Zornow, M.H.2    Fleischer, J.E.3    Sherman, G.T.4    Gerber, T.F.5
  • 67
    • 0026322360 scopus 로고
    • Effect of CGS 19755, a competitive N-methyl-D-aspartate antagonist, on general anesthetic potency
    • Daniell, L.C., Effect of CGS 19755, a competitive N-methyl-D-aspartate antagonist, on general anesthetic potency, Pharmacol. Biochem. Behav., 40, 767, 1991.
    • (1991) Pharmacol. Biochem. Behav. , vol.40 , pp. 767
    • Daniell, L.C.1
  • 68
    • 0025117917 scopus 로고
    • The influence of ketamine anesthesia given to patients with critical trauma at the prehospital stage upon the course of outcome of shock
    • Danilevich, E. J., Galtseva, I. V., Kuznetsowa, O. J., Lapshin, V. N., and Michailovich, V. A., The influence of ketamine anesthesia given to patients with critical trauma at the prehospital stage upon the course of outcome of shock, Vest. Khir., 145, 104, 1990.
    • (1990) Vest. Khir. , vol.145 , pp. 104
    • Danilevich, E.J.1    Galtseva, I.V.2    Kuznetsowa, O.J.3    Lapshin, V.N.4    Michailovich, V.A.5
  • 70
    • 0000576804 scopus 로고
    • Safety and tolerability of the glutamate antagonist CGS19755 in acute stroke patients
    • Grotta, J., Safety and tolerability of the glutamate antagonist CGS19755 in acute stroke patients, Stroke, 25, 255, 1994.
    • (1994) Stroke , vol.25 , pp. 255
    • Grotta, J.1
  • 71
    • 0002343056 scopus 로고
    • Randomized trial of CGS19755, a glutamate antagonist, in acute ischemic stroke treatment
    • Clark, W. M. and Coull, B. M., Randomized trial of CGS19755, a glutamate antagonist, in acute ischemic stroke treatment, Neurology, 44, A270, 1994.
    • (1994) Neurology , vol.44
    • Clark, W.M.1    Coull, B.M.2
  • 72
    • 0000942415 scopus 로고
    • D-CPPene (SDZ EAA 494), a competitive NMDA antagonist: Results from animal models and first results in humans
    • Herrling, P. L., D-CPPene (SDZ EAA 494), a competitive NMDA antagonist: results from animal models and first results in humans, Neuropsychopharmacology, 10, S591, 1994.
    • (1994) Neuropsychopharmacology , vol.10
    • Herrling, P.L.1
  • 73
    • 0000105003 scopus 로고
    • Cerestat™ (CNS 1102), a noncompetitive NMDA antagonist, in ischemic stroke patients: Dose-escalating safety study
    • Fisher, M., Cerestat™ (CNS 1102), a noncompetitive NMDA antagonist, in ischemic stroke patients: dose-escalating safety study, Cardiovasc. Dis., 4, 245, 1994.
    • (1994) Cardiovasc. Dis. , vol.4 , pp. 245
    • Fisher, M.1
  • 74
    • 8044248189 scopus 로고
    • Cerestat™ (CNS1102) - Preliminary results in stroke and TBI patients
    • Gamzu, E. R. and McBurney, R., Cerestat™ (CNS1102) - preliminary results in stroke and TBI patients, Neuropsychopharmacology, 10, S592, 1994.
    • (1994) Neuropsychopharmacology , vol.10
    • Gamzu, E.R.1    McBurney, R.2
  • 75
    • 0028870990 scopus 로고
    • Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke
    • Albers, G. W., Atkinson, R., Kelley, R., and Rosenbaum, D. M., Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke, Stroke, 26, 254, 1995.
    • (1995) Stroke , vol.26 , pp. 254
    • Albers, G.W.1    Atkinson, R.2    Kelley, R.3    Rosenbaum, D.M.4
  • 77
    • 0025779342 scopus 로고
    • Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia
    • Buchan, A. M., Xue, D., Huang, Z. G., Smith, K. H., and Lesiuk, H., Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia, Neuroreport, 2, 473, 1991.
    • (1991) Neuroreport , vol.2 , pp. 473
    • Buchan, A.M.1    Xue, D.2    Huang, Z.G.3    Smith, K.H.4    Lesiuk, H.5
  • 78
    • 0026710232 scopus 로고
    • The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischemia model
    • Gill, R., Nordholm, L., and Lodge, D., The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischemia model, Brain Res., 580, 35, 1992.
    • (1992) Brain Res. , vol.580 , pp. 35
    • Gill, R.1    Nordholm, L.2    Lodge, D.3
  • 79
    • 0026623418 scopus 로고
    • Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat
    • Smith, S. and Meldrum, B. S., Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat, Stroke, 23, 861, 1992.
    • (1992) Stroke , vol.23 , pp. 861
    • Smith, S.1    Meldrum, B.S.2
  • 81
    • 0028279015 scopus 로고
    • Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat
    • Bullock, R., Graham, D. I., Swanson, S., and McCulloch, J., Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat, J. Cereb. Blood Flow Metab., 14, 466, 1994.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 466
    • Bullock, R.1    Graham, D.I.2    Swanson, S.3    McCulloch, J.4
  • 83
    • 0028587095 scopus 로고
    • The neuroprotective effects of the decahydroisoquinoline, LY215490; novel AMPA antagonist in focal ischaemia
    • Gill, R. and Lodge, D., The neuroprotective effects of the decahydroisoquinoline, LY215490; novel AMPA antagonist in focal ischaemia, Neuropharmacology, 33, 1529, 1994.
    • (1994) Neuropharmacology , vol.33 , pp. 1529
    • Gill, R.1    Lodge, D.2
  • 84
    • 0027382986 scopus 로고
    • Enhancing the efficacy of thrombolysis by AMPA receptor blockade with NBQX in a rat embolic stroke model
    • Meden, P., Overgaard, K., Sereghy, T., and Boysen, G., Enhancing the efficacy of thrombolysis by AMPA receptor blockade with NBQX in a rat embolic stroke model, J. Neurol Sci., 119, 209, 1993.
    • (1993) J. Neurol Sci. , vol.119 , pp. 209
    • Meden, P.1    Overgaard, K.2    Sereghy, T.3    Boysen, G.4
  • 85
    • 0027360045 scopus 로고
    • Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke
    • Overgaard, K., Sereghy, T., Pedersen, H., and Boysen, G., Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke, Neurol. Res., 15, 344, 1993.
    • (1993) Neurol. Res. , vol.15 , pp. 344
    • Overgaard, K.1    Sereghy, T.2    Pedersen, H.3    Boysen, G.4
  • 86
    • 0025117827 scopus 로고
    • 2,3-Dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline: A neuroprotectant for cerebral ischemia
    • Sheardown, M. J., Nielsen, E. O., Hansen, A. J., Jacobsen, P., and Honore, T., 2,3-Dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline: a neuroprotectant for cerebral ischemia, Science, 247, 571, 1990.
    • (1990) Science , vol.247 , pp. 571
    • Sheardown, M.J.1    Nielsen, E.O.2    Hansen, A.J.3    Jacobsen, P.4    Honore, T.5
  • 87
    • 0025943535 scopus 로고
    • Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats
    • Buchan, A. M., Li, H., Cho, S., and Pulsinelli, W. A., Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats, Neurosci. Lett., 132, 255, 1991.
    • (1991) Neurosci. Lett. , vol.132 , pp. 255
    • Buchan, A.M.1    Li, H.2    Cho, S.3    Pulsinelli, W.A.4
  • 88
    • 0026702565 scopus 로고
    • NBQX protects against delayed cell death following complete forebrain ischemia in the rat
    • Kaiser, F., Hansen, A. J., Laursen, H., and Sheardown, M. J., NBQX protects against delayed cell death following complete forebrain ischemia in the rat, Mol. Neuropharmacol., 2, 219, 1992.
    • (1992) Mol. Neuropharmacol. , vol.2 , pp. 219
    • Kaiser, F.1    Hansen, A.J.2    Laursen, H.3    Sheardown, M.J.4
  • 89
    • 0026505401 scopus 로고
    • Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia
    • Nellgard, B. and Wieloch, T., Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia, J. Cereb. Blood Flow Metab., 12, 2, 1992.
    • (1992) J. Cereb. Blood Flow Metab. , vol.12 , pp. 2
    • Nellgard, B.1    Wieloch, T.2
  • 90
    • 0026537712 scopus 로고
    • The non-NMDA antagonists, NBQX and GYKI52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat
    • LePeillet, E., Arvin, B., Moncada, C., and Meldrum, B., The non-NMDA antagonists, NBQX and GYKI52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat, Brain Res., 511, 115, 1992.
    • (1992) Brain Res. , vol.511 , pp. 115
    • LePeillet, E.1    Arvin, B.2    Moncada, C.3    Meldrum, B.4
  • 91
    • 0000708928 scopus 로고
    • Effects of a novel AMPA antagonist YM900 and other excitatory amino acid antagonists on the delayed neuronal death in the gerbil hippocampus
    • Yatsugi, S., Kawasaki, S., Katoh, M., Takahashi, M., Koshiya, K., and Shimazu-Sasamata, M., Effects of a novel AMPA antagonist YM900 and other excitatory amino acid antagonists on the delayed neuronal death in the gerbil hippocampus, J. Cereb. Blood Flow Metab., 13, S635, 1993.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13
    • Yatsugi, S.1    Kawasaki, S.2    Katoh, M.3    Takahashi, M.4    Koshiya, K.5    Shimazu-Sasamata, M.6
  • 92
    • 0027336469 scopus 로고
    • AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischemia, even when delayed 24 h
    • Sheardown, M. J., Suzdak, P. D., and Nordholm, L., AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischemia, even when delayed 24 h, Eur. J. Pharmacol., 236, 347, 1993.
    • (1993) Eur. J. Pharmacol. , vol.236 , pp. 347
    • Sheardown, M.J.1    Suzdak, P.D.2    Nordholm, L.3
  • 93
    • 0027445864 scopus 로고
    • Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury
    • Li, H. and Buchan, A.M., Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury, J. Cereb. Blood Flow Metab., 13, 933, 1993.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 933
    • Li, H.1    Buchan, A.M.2
  • 94
    • 0028218676 scopus 로고
    • Over-additive protective effect of dizocilpine and NBQX against neuronal damage
    • Lippert, K., Welsch, M., and Krieglstein, J., Over-additive protective effect of dizocilpine and NBQX against neuronal damage, Eur. J. Pharmacol., 253, 207, 1994.
    • (1994) Eur. J. Pharmacol. , vol.253 , pp. 207
    • Lippert, K.1    Welsch, M.2    Krieglstein, J.3
  • 96
    • 0026649325 scopus 로고
    • Evidence that local non-NMDA receptors contribute to functional deficits in contusive spinal cord injury
    • Wrathall, J. R., Teng, Y. D., Choiniere, D., and Mundt, D. J., Evidence that local non-NMDA receptors contribute to functional deficits in contusive spinal cord injury, Brain Res., 586, 140, 1992.
    • (1992) Brain Res. , vol.586 , pp. 140
    • Wrathall, J.R.1    Teng, Y.D.2    Choiniere, D.3    Mundt, D.J.4
  • 97
    • 0028084386 scopus 로고
    • NMDA and non-NMDA receptors may play distinct roles in timing mechanisms and transmission in the feline respiratory network
    • Pierrefiche, O., Foutz, A. S., Champagnat, J., and Denavit-Saubrie, M., NMDA and non-NMDA receptors may play distinct roles in timing mechanisms and transmission in the feline respiratory network, J. Physiol., 474, 509, 1994.
    • (1994) J. Physiol. , vol.474 , pp. 509
    • Pierrefiche, O.1    Foutz, A.S.2    Champagnat, J.3    Denavit-Saubrie, M.4
  • 98
    • 0028047148 scopus 로고
    • Intravenous NBQX inhibits spontaneously occurring sympathetic nerve activity and reduces blood pressure in cats
    • Chen, K., Hernandez, Y. M., Dretchen, K. L., and Gillis, R. A., Intravenous NBQX inhibits spontaneously occurring sympathetic nerve activity and reduces blood pressure in cats, Eur. J. Pharmacol., 252, 155, 1994.
    • (1994) Eur. J. Pharmacol. , vol.252 , pp. 155
    • Chen, K.1    Hernandez, Y.M.2    Dretchen, K.L.3    Gillis, R.A.4
  • 99
    • 0027495382 scopus 로고
    • AMPA antagonists: Do they hold more promise for clinical stroke trials than NMDA antagonists?
    • Buchan, A. M., Lesiuk, H., Barnes, K. A., Li, H., Huang, Z.-G., Smith, K. E., and Xue, D., AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists? Stroke, 24, 1148, 1993.
    • (1993) Stroke , vol.24 , pp. 1148
    • Buchan, A.M.1    Lesiuk, H.2    Barnes, K.A.3    Li, H.4    Huang, Z.-G.5    Smith, K.E.6    Xue, D.7
  • 100
    • 0028158921 scopus 로고
    • Potentiation of MK-801-induced breathing impairment by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline
    • McMaingle, J. E., Taveira DaSilva, A. M., Dretchen, K. L., and Gillis, R. A., Potentiation of MK-801-induced breathing impairment by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline, Eur. J. Pharmacol., 252, 11, 1994.
    • (1994) Eur. J. Pharmacol. , vol.252 , pp. 11
    • McMaingle, J.E.1    Taveira DaSilva, A.M.2    Dretchen, K.L.3    Gillis, R.A.4
  • 101
    • 0026716860 scopus 로고
    • AMPA receptor competitive antagonism reduces halothane MAC in rats
    • McFarlane, C., Warner, D. S., Todd, M. M., and Nordhohn, L., AMPA receptor competitive antagonism reduces halothane MAC in rats, Anesthesiology, 77, 1165, 1992.
    • (1992) Anesthesiology , vol.77 , pp. 1165
    • McFarlane, C.1    Warner, D.S.2    Todd, M.M.3    Nordhohn, L.4
  • 102
    • 0027517058 scopus 로고
    • Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital
    • Dall, V., Orntoft, U., Schmidt, A., and Nordholm, L., Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital, Pharmacol. Biochem. Behav., 46, 7376, 1993.
    • (1993) Pharmacol. Biochem. Behav. , vol.46 , pp. 7376
    • Dall, V.1    Orntoft, U.2    Schmidt, A.3    Nordholm, L.4
  • 103
    • 0028297544 scopus 로고
    • AMPA receptor antagonists and local cerebral glucose utilization in the rat
    • Browne, S. E. and McCulloch, J., AMPA receptor antagonists and local cerebral glucose utilization in the rat, Brain Res., 641, 10, 1994.
    • (1994) Brain Res. , vol.641 , pp. 10
    • Browne, S.E.1    McCulloch, J.2
  • 104
    • 0026076110 scopus 로고
    • Autoradiographic assessment of the effects of N-methyl-D-aspartate receptor antagonists in vivo
    • McCulloch, J. and Iversen, L. L., Autoradiographic assessment of the effects of N-methyl-D-aspartate receptor antagonists in vivo, Neurochem. Res., 16, 951, 1991.
    • (1991) Neurochem. Res. , vol.16 , pp. 951
    • McCulloch, J.1    Iversen, L.L.2
  • 105
    • 8044241353 scopus 로고
    • Discriminative effects of NBQX (2,3-dihydroxy-6-mtro-7-sulfamoyl-benzo(f)quinoxaline)
    • Swedberg, M. D. B., Jacobsen, P., and Honore, T., Discriminative effects of NBQX (2,3-dihydroxy-6-mtro-7-sulfamoyl-benzo(f)quinoxaline), Soc. Neurosci. Abstr., 17, 260, 1991.
    • (1991) Soc. Neurosci. Abstr. , vol.17 , pp. 260
    • Swedberg, M.D.B.1    Jacobsen, P.2    Honore, T.3
  • 106
    • 0028324812 scopus 로고
    • Prophylactic neuroprotection for cerebral ischemia
    • Fisher, M., Jones, S., and Sacco, R. L., Prophylactic neuroprotection for cerebral ischemia, Stroke, 25, 1075, 1994.
    • (1994) Stroke , vol.25 , pp. 1075
    • Fisher, M.1    Jones, S.2    Sacco, R.L.3
  • 108
    • 0027287896 scopus 로고
    • BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage
    • Leach, M. J., Swan, J. H., Eisenthal, D., Dopson, M., and Nobbs, M., BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage, Stroke, 24, 1063, 1993.
    • (1993) Stroke , vol.24 , pp. 1063
    • Leach, M.J.1    Swan, J.H.2    Eisenthal, D.3    Dopson, M.4    Nobbs, M.5
  • 109
    • 0028959228 scopus 로고
    • Cerebroprotective effect of lamotrigine after focal ischemia in rats
    • Smith, S. E. and Meldrum, B. S., Cerebroprotective effect of lamotrigine after focal ischemia in rats, Stroke, 26, 117, 1995.
    • (1995) Stroke , vol.26 , pp. 117
    • Smith, S.E.1    Meldrum, B.S.2
  • 110
    • 0024307317 scopus 로고
    • Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils
    • Malgorius, C., Bardot, F., Daniel, M., Pellis, F., Rataud, J., Uzan, J.-C., and Laduron, P. M., Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils, J. Neurosci., 9, 3720, 1989.
    • (1989) J. Neurosci. , vol.9 , pp. 3720
    • Malgorius, C.1    Bardot, F.2    Daniel, M.3    Pellis, F.4    Rataud, J.5    Uzan, J.-C.6    Laduron, P.M.7
  • 112
    • 0028762647 scopus 로고
    • Excitatory amino acids as a common pathway for neurologic disorders
    • Lipton, S.A. and Rosenberg, P. A., Excitatory amino acids as a common pathway for neurologic disorders, N. Engl. J. Med., 330, 613, 1994.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 613
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 113
    • 0025036657 scopus 로고
    • Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat
    • Boxer, P. A., Cordon, J. J., Mann, M. E., Rodolosi, L. C., Vartanian, M. G., Rock, D. M., Taylor, C. P., and Marcoux, F. W., Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat, Stroke, 21, III47, 1990.
    • (1990) Stroke , vol.21
    • Boxer, P.A.1    Cordon, J.J.2    Mann, M.E.3    Rodolosi, L.C.4    Vartanian, M.G.5    Rock, D.M.6    Taylor, C.P.7    Marcoux, F.W.8
  • 114
    • 0025171430 scopus 로고
    • Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia
    • Kinouchi, H., Imaizumi, S., Yoshimoto, T., and Motomiya, M., Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia, Stroke, 21, 1326, 1990.
    • (1990) Stroke , vol.21 , pp. 1326
    • Kinouchi, H.1    Imaizumi, S.2    Yoshimoto, T.3    Motomiya, M.4
  • 115
    • 18244427236 scopus 로고
    • Protective action of phenytoin on cerebral ischemia in rats
    • Qi, L. and Dong, W., Protective action of phenytoin on cerebral ischemia in rats, Chung-Hua i Hsueh Tsa Chih., 72, 420, 1992.
    • (1992) Chung-Hua I Hsueh Tsa Chih. , vol.72 , pp. 420
    • Qi, L.1    Dong, W.2
  • 116
    • 0028153725 scopus 로고
    • Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats
    • Hayakawa, T., Hamada, Y., Maihara, T., Hattori, H., and Mikawa, H., Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats, Life Sci., 54, 387, 1994.
    • (1994) Life Sci. , vol.54 , pp. 387
    • Hayakawa, T.1    Hamada, Y.2    Maihara, T.3    Hattori, H.4    Mikawa, H.5
  • 117
    • 0028246507 scopus 로고
    • Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents
    • Rataud, J., Debarnot, F., Mary, V., Pratt, J., and Stutzmann, J.-M., Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents, Neurosci. Lett., 172, 19, 1994.
    • (1994) Neurosci. Lett. , vol.172 , pp. 19
    • Rataud, J.1    Debarnot, F.2    Mary, V.3    Pratt, J.4    Stutzmann, J.-M.5
  • 118
    • 0026443154 scopus 로고
    • Neuroprotective role of adenosine in cerebral ischemia
    • Rudolphi, K. A., Schubert, P., Parkinson, F. E., and Fredholm, B. B., Neuroprotective role of adenosine in cerebral ischemia, TIPS, 13, 439, 1992.
    • (1992) TIPS , vol.13 , pp. 439
    • Rudolphi, K.A.1    Schubert, P.2    Parkinson, F.E.3    Fredholm, B.B.4
  • 119
    • 0026264722 scopus 로고
    • Calcium channel antagonists in the prevention of neurotoxicity
    • Lipton, S. A., Calcium channel antagonists in the prevention of neurotoxicity, Adv. Pharmacol., 22, 271, 1991.
    • (1991) Adv. Pharmacol. , vol.22 , pp. 271
    • Lipton, S.A.1
  • 120
    • 0028277909 scopus 로고
    • Calcium antagonists in cerebral ischemia: Experimental basis and clinical experience
    • Akopov, S. E., Calcium antagonists in cerebral ischemia: experimental basis and clinical experience, Drugs of Today, 30, 171, 1994.
    • (1994) Drugs of Today , vol.30 , pp. 171
    • Akopov, S.E.1
  • 121
    • 0028328642 scopus 로고
    • Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischemia
    • Barone, F. C., Price, W. J., Jacobsen, P., Sheardown, M. J., and Feuerstein, G., Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischemia, Pharmacol. Bioch. Behav., 48, 77, 1994.
    • (1994) Pharmacol. Bioch. Behav. , vol.48 , pp. 77
    • Barone, F.C.1    Price, W.J.2    Jacobsen, P.3    Sheardown, M.J.4    Feuerstein, G.5
  • 122
    • 0020702374 scopus 로고
    • Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat striatum
    • Schwarcz, R., Whetsell, W. O., and Mangano, R. M., Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat striatum, Science, 219, 316, 1983.
    • (1983) Science , vol.219 , pp. 316
    • Schwarcz, R.1    Whetsell, W.O.2    Mangano, R.M.3
  • 123
    • 0022534519 scopus 로고
    • In vitro release and electrophysiological effects in situ of homocysteic acid, an endogenous N-methyl-(D)-aspartic acid agonist, in the mammalian striatum
    • Do, K. Q., Herrling, P. L., Streit, P., Turski, W. A., and Cuenod, M., In vitro release and electrophysiological effects in situ of homocysteic acid, an endogenous N-methyl-(D)-aspartic acid agonist, in the mammalian striatum, J. Neurosci., 6, 2226, 1986.
    • (1986) J. Neurosci. , vol.6 , pp. 2226
    • Do, K.Q.1    Herrling, P.L.2    Streit, P.3    Turski, W.A.4    Cuenod, M.5
  • 124
    • 0005841846 scopus 로고
    • Kynurenines, glia and the pathogenesis of neurodegenerative disorders
    • Calne, D. B., Comi, G., Crippa, D., Horowski, R., and Trabucchi, M., Eds., Raven, New York
    • Schwarcz, R., Speciale, C., and Turski, W. A., Kynurenines, glia and the pathogenesis of neurodegenerative disorders, in Parkinsonism and Ageing, Calne, D. B., Comi, G., Crippa, D., Horowski, R., and Trabucchi, M., Eds., Raven, New York, 1990, 97.
    • (1990) Parkinsonism and Ageing , pp. 97
    • Schwarcz, R.1    Speciale, C.2    Turski, W.A.3
  • 125
    • 0027085867 scopus 로고
    • Mechanisms of excitotoxicity in neurologic diseases
    • Beal, M. F., Mechanisms of excitotoxicity in neurologic diseases, FASEB J., 6, 3338, 1992.
    • (1992) FASEB J. , vol.6 , pp. 3338
    • Beal, M.F.1
  • 126
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
    • Novelli, A., Reilly, J. A., Lysko, P. G., and Henneberry, R. C., Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced, Brain Res., 451, 205, 1988.
    • (1988) Brain Res. , vol.451 , pp. 205
    • Novelli, A.1    Reilly, J.A.2    Lysko, P.G.3    Henneberry, R.C.4
  • 127
    • 0025290130 scopus 로고
    • Chemically induced hypoglycemia and anoxia: Relationship to glutamate receptor-mediated toxicity in retina
    • Zeevalk, G. D. and Nicklas, W. J., Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina, J. Pharmacol. Exp. Ther., 253, 1285, 1990.
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 1285
    • Zeevalk, G.D.1    Nicklas, W.J.2
  • 128
    • 0025768972 scopus 로고
    • Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition
    • Zeevalk, G. D. and Nicklas, W. J., Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition, J. Pharmacol. Exp. Ther., 257, 870, 1991.
    • (1991) J. Pharmacol. Exp. Ther. , vol.257 , pp. 870
    • Zeevalk, G.D.1    Nicklas, W.J.2
  • 130
    • 0025949127 scopus 로고
    • Aminooxyacetic acid produces excitotoxic lesions in the rat striatum
    • Urbańska, E., Ikonomidou, C., Sieklucka, M., and Turski, W. A., Aminooxyacetic acid produces excitotoxic lesions in the rat striatum, Synapse, 9, 129, 1991.
    • (1991) Synapse , vol.9 , pp. 129
    • Urbańska, E.1    Ikonomidou, C.2    Sieklucka, M.3    Turski, W.A.4
  • 131
    • 8044222549 scopus 로고
    • Quinolinate-like neurotoxicity produced by aminooxyacetic acid in rat striatum
    • Turski, W. A., Urbanska, E., Sieklucka, M., and Ikonomidou, C., Quinolinate-like neurotoxicity produced by aminooxyacetic acid in rat striatum, Amino Acids, 2, 245, 1992.
    • (1992) Amino Acids , vol.2 , pp. 245
    • Turski, W.A.1    Urbanska, E.2    Sieklucka, M.3    Ikonomidou, C.4
  • 132
    • 0027477946 scopus 로고
    • Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
    • Beal, M. F., Hyman, B. T., and Koroshetz, W., Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci., 16, 125, 1993.
    • (1993) Trends Neurosci. , vol.16 , pp. 125
    • Beal, M.F.1    Hyman, B.T.2    Koroshetz, W.3
  • 133
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases
    • Wallace, D. C., Mitochondrial genetics: a paradigm for aging and degenerative diseases, Science, 256, 628, 1992.
    • (1992) Science , vol.256 , pp. 628
    • Wallace, D.C.1
  • 136
    • 0026347825 scopus 로고
    • Aminooxyacetic acid results in excitotoxic lesions by a novel indirect mechanisms
    • Beal, M. F., Swartz, K. J., Hyman, B. T., Storey, E., Finn, S. F., and Koroshetz, W., Aminooxyacetic acid results in excitotoxic lesions by a novel indirect mechanisms, J. Neurochem., 57, 1068, 1991.
    • (1991) J. Neurochem. , vol.57 , pp. 1068
    • Beal, M.F.1    Swartz, K.J.2    Hyman, B.T.3    Storey, E.4    Finn, S.F.5    Koroshetz, W.6
  • 137
    • 0025808038 scopus 로고
    • Focal injection of aminooxyacetic acid produces seizures and lesions in rat hippocampus: Evidence for mediation by NMDA receptors
    • McMaster, O. G., Du, F., French, E. D., and Schwarcz, R., Focal injection of aminooxyacetic acid produces seizures and lesions in rat hippocampus: evidence for mediation by NMDA receptors, Exp. Neurol, 113, 378, 1991.
    • (1991) Exp. Neurol , vol.113 , pp. 378
    • McMaster, O.G.1    Du, F.2    French, E.D.3    Schwarcz, R.4
  • 138
    • 0026719208 scopus 로고
    • 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism
    • Storey, E., Hyman, B. T., Jenkins, B., Brouillet, E., Miller, J. M., Rosen, B. R., and Beal, M. F., 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism, J. Neurochem., 58, 1975, 1992.
    • (1992) J. Neurochem. , vol.58 , pp. 1975
    • Storey, E.1    Hyman, B.T.2    Jenkins, B.3    Brouillet, E.4    Miller, J.M.5    Rosen, B.R.6    Beal, M.F.7
  • 139
    • 0027177628 scopus 로고
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment: A stereological estimate of neuronal loss
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss, Neurobiol. Aging, 14, 295, 1993.
    • (1993) Neurobiol. Aging , vol.14 , pp. 295
    • Srivastava, R.1    Brouillet, E.2    Beal, M.F.3    Storey, E.4    Hyman, B.T.5
  • 140
    • 0343158930 scopus 로고
    • Aminooxyacetic acid produces excitotoxic lesions in the rat substantia nigra
    • Turski, W. A., Aminooxyacetic acid produces excitotoxic lesions in the rat substantia nigra, Naunyn-Schmiedeberg's Arch. Pharmacol., 344, R67, 1991.
    • (1991) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.344
    • Turski, W.A.1
  • 144
    • 0011085219 scopus 로고
    • 3-Nitropropionic acid (3-NPA)-induced axonal degeneration: A silver impregnation study
    • Allen, C. N., Marino, J. L., and Meshul, C. K., 3-Nitropropionic acid (3-NPA)-induced axonal degeneration: a silver impregnation study, Neurodegeneration, 3, 225, 1994.
    • (1994) Neurodegeneration , vol.3 , pp. 225
    • Allen, C.N.1    Marino, J.L.2    Meshul, C.K.3
  • 145
    • 0027204154 scopus 로고
    • Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate
    • Beal, M. F., Brouillet, E., Jenkins, B., Henshaw, R., Rosen, B., and Hyman, B. T., Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate, J. Neurochem., 61, 1147, 1993.
    • (1993) J. Neurochem. , vol.61 , pp. 1147
    • Beal, M.F.1    Brouillet, E.2    Jenkins, B.3    Henshaw, R.4    Rosen, B.5    Hyman, B.T.6
  • 146
    • 0027198567 scopus 로고
    • Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum
    • Greene, J. G., Porter, R. H. P., Eller, R. V., and Greenamyre, J. T., Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum, J. Neurochem., 61, 1151, 1993.
    • (1993) J. Neurochem. , vol.61 , pp. 1151
    • Greene, J.G.1    Porter, R.H.P.2    Eller, R.V.3    Greenamyre, J.T.4
  • 148
    • 0028104170 scopus 로고
    • 3-Acetylpyridine produces age-dependent neuronal lesions by an excitotoxic and free radical mediated mechanism
    • Schulz, J. B., Henshaw, D. R., Jenkins, B. G., Ferrante, R. J., Kowall, N. W., and Beal, M. F., 3-Acetylpyridine produces age-dependent neuronal lesions by an excitotoxic and free radical mediated mechanism, J. Cereb. Blood Flow Metab., 14, 1024, 1994.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 1024
    • Schulz, J.B.1    Henshaw, D.R.2    Jenkins, B.G.3    Ferrante, R.J.4    Kowall, N.W.5    Beal, M.F.6
  • 150
    • 0023219060 scopus 로고
    • Excitotoxicity and the NMDA receptor
    • Rothman, S. M. and Olney, J. W., Excitotoxicity and the NMDA receptor, Trends Neurosci., 10, 299, 1987.
    • (1987) Trends Neurosci. , vol.10 , pp. 299
    • Rothman, S.M.1    Olney, J.W.2
  • 151
    • 0027842804 scopus 로고
    • Effect of ischemia and reperfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW1003C87
    • Torp, R., Arvin, B., LePeillet, E., Chapman, A. G., Ottersen, O. P., and Meldrum, B. S., Effect of ischemia and reperfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW1003C87, Exp. Brain Res., 96, 365, 1993.
    • (1993) Exp. Brain Res. , vol.96 , pp. 365
    • Torp, R.1    Arvin, B.2    LePeillet, E.3    Chapman, A.G.4    Ottersen, O.P.5    Meldrum, B.S.6
  • 152
    • 0007400414 scopus 로고
    • Glutamate, energy metabolism and neuropathology: Relevance to neurodegenerative disorders
    • Martignoni, E. and Nappi, G., Eds., Smith-Gordon, London
    • Turski, L. and Ikonomidou, C., Glutamate, energy metabolism and neuropathology: relevance to neurodegenerative disorders, in Parkinson's Disease and Extrapyramidal Disorders, Martignoni, E. and Nappi, G., Eds., Smith-Gordon, London, 1994, 15.
    • (1994) Parkinson's Disease and Extrapyramidal Disorders , pp. 15
    • Turski, L.1    Ikonomidou, C.2
  • 153
    • 0001799405 scopus 로고
    • (+)MK 801 prevents dopaminergic perikarya damage in MPTP and acetaldehydetreated mice
    • Corsini, G. U., Vaglini, F., Fornai, F., Saginario, A., and Zuddas, A., (+)MK 801 prevents dopaminergic perikarya damage in MPTP and acetaldehydetreated mice, Posters Neurosci., 1, 33, 1991.
    • (1991) Posters Neurosci. , vol.1 , pp. 33
    • Corsini, G.U.1    Vaglini, F.2    Fornai, F.3    Saginario, A.4    Zuddas, A.5
  • 155
    • 0027008312 scopus 로고
    • Neurotoxicity and neuroprotection in Parkinson's disease
    • Lange, K. W., Youdim, M. B. H., and Riederer, P., Neurotoxicity and neuroprotection in Parkinson's disease, J. Neurol. Transm., S38, 27, 1992.
    • (1992) J. Neurol. Transm. , vol.S38 , pp. 27
    • Lange, K.W.1    Youdim, M.B.H.2    Riederer, P.3
  • 156
    • 0023878506 scopus 로고
    • Intracerebroventricular administration of 1-methyl-4-phenylpyridinium ion in mice: Effects of simultaneously administered nomifensine, deprenyl, and 1-t-butyl-4,4-diphenylpiperidine
    • Mihatsch, W., Russ, H., and Przuntek, H., Intracerebroventricular administration of 1-methyl-4-phenylpyridinium ion in mice: effects of simultaneously administered nomifensine, deprenyl, and 1-t-butyl-4,4-diphenylpiperidine, J. Neurol. Transm., 71, 177, 1988.
    • (1988) J. Neurol. Transm. , vol.71 , pp. 177
    • Mihatsch, W.1    Russ, H.2    Przuntek, H.3
  • 157
    • 0026704416 scopus 로고
    • Partial effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice
    • Tabatabaei, A., Perry, T. L., Hansen, S., and Krieger, C., Partial effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice, Neurosci. Lett., 141, 192, 1992.
    • (1992) Neurosci. Lett. , vol.141 , pp. 192
    • Tabatabaei, A.1    Perry, T.L.2    Hansen, S.3    Krieger, C.4
  • 158
    • 8044260050 scopus 로고
    • Excitatory amino acid antagonists and Parkinson's disease
    • Rinne, U. K., Nagatsu, T., and Horowski, R., Eds., Medicom, Bussum
    • Turski, L., Excitatory amino acid antagonists and Parkinson's disease, in Parkinson's Disease - from Basic Research and Early Diagnosis to Long-Term Treatment, Rinne, U. K., Nagatsu, T., and Horowski, R., Eds., Medicom, Bussum, 1991, 97.
    • (1991) Parkinson's Disease - From Basic Research and Early Diagnosis to Long-Term Treatment , pp. 97
    • Turski, L.1
  • 159
    • 8044252588 scopus 로고
    • Is there a role for excitatory amino acid antagonists?
    • Marsden, C. D. and Oertel, W. H., Eds., Medicom, Bussum
    • Turski, L. and Melamed, E., Is there a role for excitatory amino acid antagonists? in Parkinson's Disease - Controversial Issues in Therapy, Marsden, C. D. and Oertel, W. H., Eds., Medicom, Bussum, 1993, 44.
    • (1993) Parkinson's Disease - Controversial Issues in Therapy , pp. 44
    • Turski, L.1    Melamed, E.2
  • 162
    • 0022403289 scopus 로고
    • Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity
    • Heikkila, R. E., Nicklas, W. J., Vyas, I., and Duvoisin, R. C., Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity, Neurosci. Lett., 62, 389, 1985.
    • (1985) Neurosci. Lett. , vol.62 , pp. 389
    • Heikkila, R.E.1    Nicklas, W.J.2    Vyas, I.3    Duvoisin, R.C.4
  • 165
    • 0027289605 scopus 로고
    • Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum
    • Simpson, J. R. and Isacson, O., Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum, Exp. Neurol., 121, 57, 1993.
    • (1993) Exp. Neurol. , vol.121 , pp. 57
    • Simpson, J.R.1    Isacson, O.2
  • 166
    • 0028228363 scopus 로고
    • Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutamate and aspartate in the mouse brain
    • Chan, P., Di Monte, D., and Langston, J. W., Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutamate and aspartate in the mouse brain, Brain Res., 647, 249, 1994.
    • (1994) Brain Res. , vol.647 , pp. 249
    • Chan, P.1    Di Monte, D.2    Langston, J.W.3
  • 167
    • 8044237502 scopus 로고
    • Selective decrease in glutamate levels in the nigrostriatal system of monkeys with parkinsonism
    • Chan, P., Irwin, I., Di Monte, D., DeLanney, L. E., Sandy, M. S., and Langston, J. W., Selective decrease in glutamate levels in the nigrostriatal system of monkeys with parkinsonism, Ann. Neurol., 36, 314, 1994.
    • (1994) Ann. Neurol. , vol.36 , pp. 314
    • Chan, P.1    Irwin, I.2    Di Monte, D.3    DeLanney, L.E.4    Sandy, M.S.5    Langston, J.W.6
  • 169
    • 0025440265 scopus 로고
    • Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice
    • Otto, D. and Unsicker, K., Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice, J. Neurosci., 10, 1912, 1990.
    • (1990) J. Neurosci. , vol.10 , pp. 1912
    • Otto, D.1    Unsicker, K.2
  • 170
  • 171
    • 0026602688 scopus 로고
    • Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity
    • Freese, A., Finklestein, S. P., and DiFiglia, M., Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity, Brain Res., 575, 351, 1993.
    • (1993) Brain Res. , vol.575 , pp. 351
    • Freese, A.1    Finklestein, S.P.2    DiFiglia, M.3
  • 172
    • 0027407036 scopus 로고
    • Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats
    • Nozaki, K., Finklestein, S. P., and Beal, M. F., Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats, J. Cereb. Blood Flow Metab., 13, 221, 1993.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 221
    • Nozaki, K.1    Finklestein, S.P.2    Beal, M.F.3
  • 173
    • 0027480337 scopus 로고
    • Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil
    • Nakata, N., Kato, H., and Kogure, K., Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil, Brain Res., 605, 354, 1993.
    • (1993) Brain Res. , vol.605 , pp. 354
    • Nakata, N.1    Kato, H.2    Kogure, K.3
  • 174
    • 0027319561 scopus 로고
    • Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose
    • Mattson, M. P., Zhang, Y., and Bose, S., Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose, Exp. Neurol., 121, 1, 1993.
    • (1993) Exp. Neurol. , vol.121 , pp. 1
    • Mattson, M.P.1    Zhang, Y.2    Bose, S.3
  • 178
    • 0026744455 scopus 로고
    • Ganglioside derivative LIGA 20 reduces NMDA neurotoxicity in neonatal rat brain
    • Lipartiti, M., Lazzaro, A., and Manev, H., Ganglioside derivative LIGA 20 reduces NMDA neurotoxicity in neonatal rat brain, Neuroreport, 3, 919 , 1992.
    • (1992) Neuroreport , vol.3 , pp. 919
    • Lipartiti, M.1    Lazzaro, A.2    Manev, H.3
  • 179
    • 0027197190 scopus 로고
    • Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion
    • Kharlamov, A., Guidotti, A., Costa, E., Hayes, R., and Armstrong, D., Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion, J. Neurosci., 13, 2483, 1993.
    • (1993) J. Neurosci. , vol.13 , pp. 2483
    • Kharlamov, A.1    Guidotti, A.2    Costa, E.3    Hayes, R.4    Armstrong, D.5
  • 182
    • 0027359141 scopus 로고
    • Protection by gangliosides against glutamate excitotoxicity
    • Manev, H., Guidotti, A., and Costa, E., Protection by gangliosides against glutamate excitotoxicity, Adv. Lipid Res.,25, 269, 1993.
    • (1993) Adv. Lipid Res. , vol.25 , pp. 269
    • Manev, H.1    Guidotti, A.2    Costa, E.3
  • 183
    • 0025137923 scopus 로고
    • Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: Protection by synthetic derivatives of endogenous sphingolipids
    • Manev, H., Favron, M., Vicini, S., Guidotti, A., and Costa, E., Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids, J. Pharmacol. Exp. Ther., 252, 419, 1990.
    • (1990) J. Pharmacol. Exp. Ther. , vol.252 , pp. 419
    • Manev, H.1    Favron, M.2    Vicini, S.3    Guidotti, A.4    Costa, E.5
  • 185
    • 0026646195 scopus 로고
    • Mechanism for ganglioside-mediated modulation of a calmodulin-dependent enzyme
    • Higashi, H. and Yamagata, T., Mechanism for ganglioside-mediated modulation of a calmodulin-dependent enzyme, J. Biol. Chem., 267, 9839, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 9839
    • Higashi, H.1    Yamagata, T.2
  • 186
    • 0027159165 scopus 로고
    • The N-methyl-D-aspartate antagonist MK-801 fails to protect dopaminergic neurons from 1-methyl-4-phenylpyridinium toxicity in vitro
    • Finiels-Marlier, F., Marini, A. M., Williams, P., and Paul, S. M., The N-methyl-D-aspartate antagonist MK-801 fails to protect dopaminergic neurons from 1-methyl-4-phenylpyridinium toxicity in vitro, J. Neurochem., 60, 1968, 1993.
    • (1993) J. Neurochem. , vol.60 , pp. 1968
    • Finiels-Marlier, F.1    Marini, A.M.2    Williams, P.3    Paul, S.M.4
  • 187
    • 0026743442 scopus 로고
    • +) in rat dissociated mesencephalic cultures
    • +) in rat dissociated mesencephalic cultures, Brain Res., 597, 233, 1992.
    • (1992) Brain Res. , vol.597 , pp. 233
    • Michel, P.P.1    Agid, Y.2
  • 188
    • 8044244616 scopus 로고
    • Methylphenylpyridinium ion enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon
    • Sawada, H., Shimohama, S., Kimura, J., Kawamura, T., Akaike, A., and Tamura, Y., Methylphenylpyridinium ion enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon, Neurosci. Res., 20, S63, 1994.
    • (1994) Neurosci. Res. , vol.20
    • Sawada, H.1    Shimohama, S.2    Kimura, J.3    Kawamura, T.4    Akaike, A.5    Tamura, Y.6
  • 189
    • 0000298671 scopus 로고
    • 3-Nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants
    • Ludolph, A. C.., Seelig, M.O., Ludolph, A., Novitt, P., Allen, C. N., Spencer, P. S., and Sabri, M. I., 3-Nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants, Neurode generation, 1, 21, 1992.
    • (1992) Neurode Generation , vol.1 , pp. 21
    • Ludolph, A.C.1    Seelig, M.O.2    Ludolph, A.3    Novitt, P.4    Allen, C.N.5    Spencer, P.S.6    Sabri, M.I.7
  • 190
    • 0026689954 scopus 로고
    • Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: Involvement of glutathione system
    • Spina, M. B., Squinto, S. P., Miller, J., Lindsay, R. M., and Hyman, C., Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of glutathione system, J. Neurochem., 59, 99, 1992.
    • (1992) J. Neurochem. , vol.59 , pp. 99
    • Spina, M.B.1    Squinto, S.P.2    Miller, J.3    Lindsay, R.M.4    Hyman, C.5
  • 191
    • 8044239386 scopus 로고
    • Biological synthesis of nitric oxide from L-arginine
    • Calne, D. B., Horowski, R., Mizuno, Y., Poewe, W. H., Riederer, P., and Youdim, M.B.H., Eds, Birkhäuser, Boston
    • Hibbs, J. B., Biological synthesis of nitric oxide from L-arginine, in Advances in Research on Neurodegeneration, II: Etiopathogenesis, Calne, D. B., Horowski, R., Mizuno, Y., Poewe, W. H., Riederer, P., and Youdim, M.B.H., Eds, Birkhäuser, Boston, 1993, 79.
    • (1993) Advances in Research on Neurodegeneration, II: Etiopathogenesis , pp. 79
    • Hibbs, J.B.1
  • 192
    • 0023092102 scopus 로고
    • Macrophage cytotoxicity: Role for L-arginine deaminase activity and imino nitrogen oxidation to nitrite
    • Hibbs, J. B., Taintor, R. R., and Vavrin, Z., Macrophage cytotoxicity: role for L-arginine deaminase activity and imino nitrogen oxidation to nitrite, Science, 235, 473, 1987.
    • (1987) Science , vol.235 , pp. 473
    • Hibbs, J.B.1    Taintor, R.R.2    Vavrin, Z.3
  • 193
    • 0023940538 scopus 로고
    • Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effect cells
    • Drapier, J.-C. and Hibbs, J. B., Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effect cells, J. Immunol., 140, 2829, 1988.
    • (1988) J. Immunol. , vol.140 , pp. 2829
    • Drapier, J.-C.1    Hibbs, J.B.2
  • 194
    • 8044248780 scopus 로고
    • Glutamate receptors, nitric oxide, and cyclic GMP
    • Teichberg, V. I. and Turski, L., Eds., Springer, Berlin
    • Garthwaite, J., Southam, E., and East, S. J., Glutamate receptors, nitric oxide, and cyclic GMP, in Excitatory Amino Acids and Second Messenger Systems, Teichberg, V. I. and Turski, L., Eds., Springer, Berlin, 1991, 87.
    • (1991) Excitatory Amino Acids and Second Messenger Systems , pp. 87
    • Garthwaite, J.1    Southam, E.2    East, S.J.3
  • 195
    • 0027178135 scopus 로고
    • Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
    • Dawson, V. L., Dawson, T. M., Bartley, D. A., Uhl, G. R., and Snyder, S. H., Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures, J. Neurosci., 13, 2651, 1993.
    • (1993) J. Neurosci. , vol.13 , pp. 2651
    • Dawson, V.L.1    Dawson, T.M.2    Bartley, D.A.3    Uhl, G.R.4    Snyder, S.H.5
  • 196
    • 0027200128 scopus 로고
    • Neurotoxic effects of sodium nitroprusside in rat hippocampal slices
    • Izumi, Y., Benz, A. M., Clifford, D. B., and Zorumski, C. F., Neurotoxic effects of sodium nitroprusside in rat hippocampal slices, Exp. Neurol., 121, 14, 1993.
    • (1993) Exp. Neurol. , vol.121 , pp. 14
    • Izumi, Y.1    Benz, A.M.2    Clifford, D.B.3    Zorumski, C.F.4
  • 197
    • 0026716547 scopus 로고
    • Hippocampal lesions induced by microinjection of the nitric oxide donor nitroprusside
    • Loiacono, R. E. and Beart, P. M., Hippocampal lesions induced by microinjection of the nitric oxide donor nitroprusside, Eur. J. Pharmacol., 216, 331, 1993.
    • (1993) Eur. J. Pharmacol. , vol.216 , pp. 331
    • Loiacono, R.E.1    Beart, P.M.2
  • 200
    • 0028045985 scopus 로고
    • Systemic and local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism
    • Brouillet, E., Hyman, B. T., Jenkins, B. G., Henshaw, D. R., Schulz, J. B., Sodhi, P., Rosen, B. R., and Beal, M. F., Systemic and local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism, Exp. Neurol., 129, 175, 1994.
    • (1994) Exp. Neurol. , vol.129 , pp. 175
    • Brouillet, E.1    Hyman, B.T.2    Jenkins, B.G.3    Henshaw, D.R.4    Schulz, J.B.5    Sodhi, P.6    Rosen, B.R.7    Beal, M.F.8
  • 201
    • 0025940118 scopus 로고
    • Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse
    • Nowicki, J. P., Duval, H., Poignet, H., and Scatton, B., Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse, Eur. J. Pharmacol., 204, 339, 1991.
    • (1991) Eur. J. Pharmacol. , vol.204 , pp. 339
    • Nowicki, J.P.1    Duval, H.2    Poignet, H.3    Scatton, B.4
  • 202
    • 0028035916 scopus 로고
    • G-nitro-L-arginine protects against ischaemia-induced increases in nitric oxide and hippocampal neurodegeneration in the gerbil
    • G-nitro-L-arginine protects against ischaemia-induced increases in nitric oxide and hippocampal neurodegeneration in the gerbil, Eur. J. Pharmacol., 260, 191, 1994.
    • (1994) Eur. J. Pharmacol. , vol.260 , pp. 191
    • Caldwell, M.1    O'Neill, M.2    Earley, B.3    Leonard, B.4
  • 203
    • 0022446150 scopus 로고
    • Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
    • Beal, M. F., Kowall, N. W, Ellison, D. W., Mazurek, M. F., Swartz, K. J., and Martin, J. B., Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid, Nature, 321, 168, 1986.
    • (1986) Nature , vol.321 , pp. 168
    • Beal, M.F.1    Kowall, N.W.2    Ellison, D.W.3    Mazurek, M.F.4    Swartz, K.J.5    Martin, J.B.6
  • 205
    • 8044235403 scopus 로고
    • Endogenous nitric oxide inhibits glutamate-induced calcium influx exclusively in the NADPH diaphorase containing neurons
    • Ikeda, J., Kashimura, J., Morita, I., and Murota, S., Endogenous nitric oxide inhibits glutamate-induced calcium influx exclusively in the NADPH diaphorase containing neurons, J. Cereb. Blood Flow Metab., 13, S39, 1993.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13
    • Ikeda, J.1    Kashimura, J.2    Morita, I.3    Murota, S.4
  • 206
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., and Stamler, J. S., A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds, Nature, 364, 626, 1993.
    • (1993) Nature , vol.364 , pp. 626
    • Lipton, S.A.1    Choi, Y.-B.2    Pan, Z.-H.3    Lei, S.Z.4    Chen, H.-S.V.5    Sucher, N.J.6    Loscalzo, J.7    Singel, D.J.8    Stamler, J.S.9
  • 207
    • 0027255705 scopus 로고
    • Nitric oxide synthase activity endogenously modulates NMDA receptors
    • Manzoni, O. and Bockaert, J., Nitric oxide synthase activity endogenously modulates NMDA receptors, J. Neurochem., 61, 368, 1993.
    • (1993) J. Neurochem. , vol.61 , pp. 368
    • Manzoni, O.1    Bockaert, J.2
  • 209
    • 0023816358 scopus 로고
    • Cyclic AMP and cell death in rat cerebellar slices
    • Garthwaite, G. and Garthwaite, J., Cyclic AMP and cell death in rat cerebellar slices, Neuroscience, 26, 321, 1988.
    • (1988) Neuroscience , vol.26 , pp. 321
    • Garthwaite, G.1    Garthwaite, J.2
  • 210
    • 0028933347 scopus 로고
    • Excitotoxic action of NMDA agonists on nigrostriatal dopaminergic neurons: Modulation by inhibition of nitric oxide synthesis
    • Connop, B. P., Boegman, R. J., Jhmandas, K., and Beninger, R. J., Excitotoxic action of NMDA agonists on nigrostriatal dopaminergic neurons: modulation by inhibition of nitric oxide synthesis, Brain Res., 676, 124, 1995.
    • (1995) Brain Res. , vol.676 , pp. 124
    • Connop, B.P.1    Boegman, R.J.2    Jhmandas, K.3    Beninger, R.J.4
  • 211
    • 0008226253 scopus 로고
    • Chronic administration of nitroglycerin decreases cerebral infarct size
    • Manchester, K. S., Jensen, F. E., Warach, S., and Lipton, S. A., Chronic administration of nitroglycerin decreases cerebral infarct size, Neurology, 43, A365, 1993.
    • (1993) Neurology , vol.43
    • Manchester, K.S.1    Jensen, F.E.2    Warach, S.3    Lipton, S.A.4
  • 212
    • 0028244841 scopus 로고
    • Reduction of focal cerebral ischemic damage by delayed treatment with nitric oxide donors
    • Zhang, F. and Iadecola, C., Reduction of focal cerebral ischemic damage by delayed treatment with nitric oxide donors, J. Cereb. Blood Flow Metab., 14, 574, 1994.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 574
    • Zhang, F.1    Iadecola, C.2
  • 213
    • 0026615190 scopus 로고
    • G-nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils
    • G-nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils, Neurosci. Lett., 146, 139, 1992.
    • (1992) Neurosci. Lett. , vol.146 , pp. 139
    • Weissman, B.1    Kadar, T.2    Shapira, S.3
  • 214
    • 0026761385 scopus 로고
    • Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat
    • Yamamoto, S., Golanov, E. V., Berger, S. B., and Reis, D. J., Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat, J. Cereb. Blood Flow Metab., 12, 717, 1992.
    • (1992) J. Cereb. Blood Flow Metab. , vol.12 , pp. 717
    • Yamamoto, S.1    Golanov, E.V.2    Berger, S.B.3    Reis, D.J.4
  • 215
    • 0028796770 scopus 로고
    • Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP induced neurotoxicity in mice
    • Schulz, J. B., Matthews, R. T., Muqit, M. M. K., Browne, S. E., and Beal, M. F., Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP induced neurotoxicity in mice, J. Neurochem., 64, 936 1995.
    • (1995) J. Neurochem. , vol.64 , pp. 936
    • Schulz, J.B.1    Matthews, R.T.2    Muqit, M.M.K.3    Browne, S.E.4    Beal, M.F.5
  • 216
    • 0028274216 scopus 로고
    • Evidence for mitochondrial dysfunction in Parkinson's disease - A critical appraisal
    • Schapira, A. H. V., Evidence for mitochondrial dysfunction in Parkinson's disease - a critical appraisal, Mov. Disord., 9, 125, 1994.
    • (1994) Mov. Disord. , vol.9 , pp. 125
    • Schapira, A.H.V.1
  • 217
    • 0028068781 scopus 로고
    • Mitochondrial dysfunction in movement disorders
    • Schulz, J. B. and Beal, M. F., Mitochondrial dysfunction in movement disorders, Curr. Opinion Neurol., 7, 333, 1994.
    • (1994) Curr. Opinion Neurol. , vol.7 , pp. 333
    • Schulz, J.B.1    Beal, M.F.2
  • 218
    • 0026740057 scopus 로고
    • New insights into the cause of Parkinson's disease
    • Jenner, P., Schapira, A. H. V., and Marsden, C. D., New insights into the cause of Parkinson's disease, Neurology, 42, 2241, 1992.
    • (1992) Neurology , vol.42 , pp. 2241
    • Jenner, P.1    Schapira, A.H.V.2    Marsden, C.D.3
  • 220
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker, W. D., Boyson, S. J., and Parks, J. K., Abnormalities of the electron transport chain in idiopathic Parkinson's disease, Ann. Neurol., 26, 719, 1989.
    • (1989) Ann. Neurol. , vol.26 , pp. 719
    • Parker, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 221
  • 223
    • 8044235402 scopus 로고
    • Low platelet mitochondrial complex I activity in untreated early Parkinson's disease
    • Haas, R. H., Nasirian, F., Ward, D., Nakano, K., Pay, M., Hill, R., and Shults, C. W., Low platelet mitochondrial complex I activity in untreated early Parkinson's disease, Neurology, 44, A178, 1994.
    • (1994) Neurology , vol.44
    • Haas, R.H.1    Nasirian, F.2    Ward, D.3    Nakano, K.4    Pay, M.5    Hill, R.6    Shults, C.W.7
  • 224
    • 0025087726 scopus 로고
    • Evidence for a defect in NADH: Ubiquinone oxidoreductase (complex I) in Huntington's disease
    • Parker, W. D., Boyson, S. J., Luder, A. S., and Parks, J. K., Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease, Neurology, 40, 1231, 1990.
    • (1990) Neurology , vol.40 , pp. 1231
    • Parker, W.D.1    Boyson, S.J.2    Luder, A.S.3    Parks, J.K.4
  • 225
    • 8044238135 scopus 로고
    • Regional mitochondrial metabolism in Huntington's disease brain
    • Brennan, W. A., Bird, E. D., and Aprillo, V. R., Regional mitochondrial metabolism in Huntington's disease brain, J. Neurochem., 44, 1448, 1985.
    • (1985) J. Neurochem. , vol.44 , pp. 1448
    • Brennan, W.A.1    Bird, E.D.2    Aprillo, V.R.3
  • 226
    • 0025024024 scopus 로고
    • Cytochrome oxidase deficiency in Alzheimer's disease
    • Parker, W. D., Filley, C. M., and Parks, J. K., Cytochrome oxidase deficiency in Alzheimer's disease, Neurology, 40, 1302, 1990.
    • (1990) Neurology , vol.40 , pp. 1302
    • Parker, W.D.1    Filley, C.M.2    Parks, J.K.3
  • 227
    • 8044261241 scopus 로고
    • Cytochrome oxidase is altered in the hippocampal formation in Alzheimer's disease
    • Simonian, N. A. and Hyman, B. T., Cytochrome oxidase is altered in the hippocampal formation in Alzheimer's disease, Neurology, 43, A251, 1993.
    • (1993) Neurology , vol.43
    • Simonian, N.A.1    Hyman, B.T.2
  • 230
    • 0028110234 scopus 로고
    • Cortical cytochrome oxidase activity is reduced in Alzheimer's disease
    • Mutisya, E. M., Bowling, A. C., and Beal, M. F., Cortical cytochrome oxidase activity is reduced in Alzheimer's disease, J. Neurochem., 63, 2179, 1994.
    • (1994) J. Neurochem. , vol.63 , pp. 2179
    • Mutisya, E.M.1    Bowling, A.C.2    Beal, M.F.3
  • 231
    • 1842408252 scopus 로고
    • Dihydrorotenone binding in Alzheimer's disease: A preliminary study
    • Higgins, D. S. and Greenamyre, J. T., Dihydrorotenone binding in Alzheimer's disease: a preliminary study, Neurology, 43, A251, 1993.
    • (1993) Neurology , vol.43
    • Higgins, D.S.1    Greenamyre, J.T.2
  • 235
    • 0027447043 scopus 로고
    • Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism
    • Brouillet, E. P., Shinobu, L., McGarvey, U., and Beal, M. F., Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism, Exp. Neurol., 120, 89, 1993.
    • (1993) Exp. Neurol. , vol.120 , pp. 89
    • Brouillet, E.P.1    Shinobu, L.2    McGarvey, U.3    Beal, M.F.4
  • 237
    • 0028349046 scopus 로고
    • The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum
    • Greenamyre, J. T., Garcia-Osuna, M., and Greene, J. G., The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum, Neurosci. Lett., 171, 17, 1994.
    • (1994) Neurosci. Lett. , vol.171 , pp. 17
    • Greenamyre, J.T.1    Garcia-Osuna, M.2    Greene, J.G.3
  • 238
    • 0000308312 scopus 로고
    • Ubiquinone lowers occipital lactate levels in patients with Huntington's disease
    • Koroshetz, W. J., Jenkins, B., Rosen, B., and Beal, M. F., Ubiquinone lowers occipital lactate levels in patients with Huntington's disease, Neurology, 43, A334, 1993.
    • (1993) Neurology , vol.43
    • Koroshetz, W.J.1    Jenkins, B.2    Rosen, B.3    Beal, M.F.4
  • 240
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein, J. D., Martin, L. J., and Kuncl, R. W., Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis, N. Engl. J. Med., 326, 1464, 1992.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1464
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 241
    • 0023804850 scopus 로고
    • The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis
    • Plaitakis, A., Constantakakis, E., and Smith, J., The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis, Ann. Neurol., 24, 446, 1988.
    • (1988) Ann. Neurol. , vol.24 , pp. 446
    • Plaitakis, A.1    Constantakakis, E.2    Smith, J.3
  • 243
    • 0028983524 scopus 로고
    • Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury?
    • Prehn, J. H., Lippert, K., and Krieglstein, J., Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury? Eur. J. Pharmacol., 292, 179, 1995.
    • (1995) Eur. J. Pharmacol. , vol.292 , pp. 179
    • Prehn, J.H.1    Lippert, K.2    Krieglstein, J.3
  • 244
    • 0026563864 scopus 로고
    • Relief of experimental spasticity and anxiolytic/ anticonvulsant actions of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonist 2,3-dihydroxy-6-mtro-7-sulfamoyl-benzo(F)quinoxaline
    • Turski, L., Jacobsen, P., Honore, T., and Stephens, D. N., Relief of experimental spasticity and anxiolytic/ anticonvulsant actions of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonist 2,3-dihydroxy-6-mtro-7-sulfamoyl-benzo(F)quinoxaline, J. Pharmacol. Exp. Ther., 260, 742, 1992.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 742
    • Turski, L.1    Jacobsen, P.2    Honore, T.3    Stephens, D.N.4
  • 245
    • 0025350138 scopus 로고
    • Experimental biology of cerebral hypoxia-ischemia: Relation to perinatal brain damage
    • Vannucci, R. C., Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage, Pediatr. Res., 27, 317, 1990.
    • (1990) Pediatr. Res. , vol.27 , pp. 317
    • Vannucci, R.C.1
  • 246
    • 8044233471 scopus 로고
    • Trauma of the brain and spinal cord
    • Berg, B. O., Ed., Lippincott, Philadelphia
    • Edwards, M. S. B., Pitts, L. H., and Cogen, P. H., Trauma of the brain and spinal cord, in Child Neurology, Berg, B. O., Ed., Lippincott, Philadelphia, 1994, 155.
    • (1994) Child Neurology , pp. 155
    • Edwards, M.S.B.1    Pitts, L.H.2    Cogen, P.H.3
  • 247
    • 0027415444 scopus 로고
    • Pharmacologic management of neonatal cerebral ischemia and hemorrhage: Old and new directions
    • Miller, V. S., Pharmacologic management of neonatal cerebral ischemia and hemorrhage: old and new directions, J. Child Neurol., 8, 7, 1993.
    • (1993) J. Child Neurol. , vol.8 , pp. 7
    • Miller, V.S.1
  • 248
    • 0026709272 scopus 로고
    • Some animal models for the study of perinatal asphyxia
    • Raju, T. N. K., Some animal models for the study of perinatal asphyxia, Biol. Neonat., 62, 202, 1992.
    • (1992) Biol. Neonat. , vol.62 , pp. 202
    • Raju, T.N.K.1
  • 250
    • 0014937190 scopus 로고
    • Brain damage in infant mice following oral intake of glutamate, aspartate and cysteine
    • Olney, J. W. and Ho, O. L., Brain damage in infant mice following oral intake of glutamate, aspartate and cysteine, Nature, 227, 609, 1970.
    • (1970) Nature , vol.227 , pp. 609
    • Olney, J.W.1    Ho, O.L.2
  • 251
    • 0014984942 scopus 로고
    • Glutamate-induced neuronal necrosis in the infant mouse hypothalamus: An electron microscopic study
    • Olney, J. W., Glutamate-induced neuronal necrosis in the infant mouse hypothalamus: an electron microscopic study, J. Neuropathol. Exp. Neurol., 30, 75, 1971.
    • (1971) J. Neuropathol. Exp. Neurol. , vol.30 , pp. 75
    • Olney, J.W.1
  • 254
    • 0025790232 scopus 로고
    • Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic ischemia
    • Andiné, P., Sandberg, M., Bagenholm, R., Lehmann, A., and Hagberg, H., Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic ischemia, Dev. Brain Res., 64, 115, 1991.
    • (1991) Dev. Brain Res. , vol.64 , pp. 115
    • Andiné, P.1    Sandberg, M.2    Bagenholm, R.3    Lehmann, A.4    Hagberg, H.5
  • 255
    • 0026345956 scopus 로고
    • Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: An in vivo microdialysis study
    • Silverstein, F. S., Naik, B., and Simpson, J., Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study, Pediatr. Res., 30, 587, 1991.
    • (1991) Pediatr. Res. , vol.30 , pp. 587
    • Silverstein, F.S.1    Naik, B.2    Simpson, J.3
  • 256
    • 0038438634 scopus 로고
    • Excitotoxic mechanisms operative in youth and old age
    • Kozikowski, A., Ed., VCH, New York
    • Olney, J. W. and Ikonomidou, C., Excitotoxic mechanisms operative in youth and old age, in Neurobiology of the NMDA Receptor, Kozikowski, A., Ed., VCH, New York, 1991, 187.
    • (1991) Neurobiology of the NMDA Receptor , pp. 187
    • Olney, J.W.1    Ikonomidou, C.2
  • 257
    • 0024342862 scopus 로고
    • Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-D-aspartate neurotoxicity
    • Ikonomidou, C., Mosinger, J. L., Shahid Salles, K., Labruyere, J., and Olney, J. W., Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-D-aspartate neurotoxicity, J. Neurosci., 9, 2809, 1989.
    • (1989) J. Neurosci. , vol.9 , pp. 2809
    • Ikonomidou, C.1    Mosinger, J.L.2    Shahid Salles, K.3    Labruyere, J.4    Olney, J.W.5
  • 258
    • 0025257513 scopus 로고
    • Physiological and pathological roles of excitatory amino acids during central nervous system development
    • McDonald, J. W. and Johnston, M. V., Physiological and pathological roles of excitatory amino acids during central nervous system development, Brain Res. Rev., 15, 41, 1990.
    • (1990) Brain Res. Rev. , vol.15 , pp. 41
    • McDonald, J.W.1    Johnston, M.V.2
  • 259
    • 0028105903 scopus 로고
    • Developmental changes in the sensitivity of the neonatal rat brain to hypoxic/ischemic injury
    • Grafe, M. R., Developmental changes in the sensitivity of the neonatal rat brain to hypoxic/ischemic injury, Brain Res., 653, 161, 1994.
    • (1994) Brain Res. , vol.653 , pp. 161
    • Grafe, M.R.1
  • 260
    • 2642596026 scopus 로고
    • Antagonistic pharmacology of glutamate toxicity in infant rat brain
    • Ikonomidou, C., Labruyere, J., Benz, A., and Olney, J. W., Antagonistic pharmacology of glutamate toxicity in infant rat brain, Soc. Neurosci. Abstr., 15, 767, 1989.
    • (1989) Soc. Neurosci. Abstr. , vol.15 , pp. 767
    • Ikonomidou, C.1    Labruyere, J.2    Benz, A.3    Olney, J.W.4
  • 261
    • 0024363138 scopus 로고
    • MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain
    • Olney, J. W., Ikonomidou, C., Mosinger, J. L., and Friedrich, G., MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain, J. Neurosci., 9, 1701, 1989.
    • (1989) J. Neurosci. , vol.9 , pp. 1701
    • Olney, J.W.1    Ikonomidou, C.2    Mosinger, J.L.3    Friedrich, G.4
  • 262
    • 0007939888 scopus 로고
    • Hypoxic-ischemic brain damage in the newborn rat: Effect of NMDA- and AMPA-receptor antagonists
    • Hagberg, H., Diemer, N.-H., and Andiné, P., Hypoxic-ischemic brain damage in the newborn rat: effect of NMDA- and AMPA-receptor antagonists, Biol. Neonat., 62, 299, 1992.
    • (1992) Biol. Neonat. , vol.62 , pp. 299
    • Hagberg, H.1    Diemer, N.-H.2    Andiné, P.3
  • 263
    • 8044245728 scopus 로고
    • Developmental excitotoxicity for explaining neuropsychiatric disturbances
    • Ikonomidou, C. and Olney, J. W., Developmental excitotoxicity for explaining neuropsychiatric disturbances, Neuropsychopharmacology, 10, 448S, 1994.
    • (1994) Neuropsychopharmacology , vol.10
    • Ikonomidou, C.1    Olney, J.W.2
  • 264
  • 265
    • 0023039309 scopus 로고
    • Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia
    • Simon, R. P., Young, R. S. K., Stout, S., and Cheng, J., Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia, Neurosci. Lett., 71, 361, 1986.
    • (1986) Neurosci. Lett. , vol.71 , pp. 361
    • Simon, R.P.1    Young, R.S.K.2    Stout, S.3    Cheng, J.4
  • 266
    • 0023232943 scopus 로고
    • MK-801 protects the neonatal brain from hypoxic-ischemic damage
    • McDonald, J. W., Silverstein, F. S., and Johnston, M. V., MK-801 protects the neonatal brain from hypoxic-ischemic damage, Eur. J. Pharmacol., 140, 359, 1987.
    • (1987) Eur. J. Pharmacol. , vol.140 , pp. 359
    • McDonald, J.W.1    Silverstein, F.S.2    Johnston, M.V.3
  • 267
    • 0023934896 scopus 로고
    • The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection
    • Andine, P., Lehmann, A., Ellren, K., Wennberg, E., Kjellmer, I., Nielsen, T., and Hagberg, H., The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection, Neurosci. Lett, 90, 208, 1988.
    • (1988) Neurosci. Lett , vol.90 , pp. 208
    • Andine, P.1    Lehmann, A.2    Ellren, K.3    Wennberg, E.4    Kjellmer, I.5    Nielsen, T.6    Hagberg, H.7
  • 268
    • 0024457357 scopus 로고
    • MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats
    • Ford, L. M., Sanberg, P. R., Norman, A. B., and Gogelson, M. H., MK-801 prevents hippocampal neurodegeneration in neonatal hypoxic-ischemic rats, Arch. Neurol., 46, 1090, 1989.
    • (1989) Arch. Neurol. , vol.46 , pp. 1090
    • Ford, L.M.1    Sanberg, P.R.2    Norman, A.B.3    Gogelson, M.H.4
  • 269
    • 0025008661 scopus 로고
    • Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain
    • Silverstein, F. S., McDonald, J. W., Bommarito, M., and Johnston, M. V., Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain, Stroke, 21, 310, 1990.
    • (1990) Stroke , vol.21 , pp. 310
    • Silverstein, F.S.1    McDonald, J.W.2    Bommarito, M.3    Johnston, M.V.4
  • 270
    • 0024560080 scopus 로고
    • Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat
    • Hattori, H., Morin, A. M., Schwartz, P. H., Fujikawa, D. G., and Wasterlain, C. G., Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat, Neurology, 39, 713, 1989.
    • (1989) Neurology , vol.39 , pp. 713
    • Hattori, H.1    Morin, A.M.2    Schwartz, P.H.3    Fujikawa, D.G.4    Wasterlain, C.G.5
  • 271
    • 0027431451 scopus 로고
    • Posthypoxic treatment with felbamate is neuroprotective in a rat model of hypoxia-ischemia
    • Wasterlain, C. G., Adams, L. M., Schwartz, P. H., Hattori, H., Sofia, R. D., and Wichmann, J. K., Posthypoxic treatment with felbamate is neuroprotective in a rat model of hypoxia-ischemia, Neurology, 43, 2303, 1993.
    • (1993) Neurology , vol.43 , pp. 2303
    • Wasterlain, C.G.1    Adams, L.M.2    Schwartz, P.H.3    Hattori, H.4    Sofia, R.D.5    Wichmann, J.K.6
  • 273
    • 0026535226 scopus 로고
    • Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats
    • Nozaki, K. and Beal., M. F., Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats, J. Cereb. Blood Flow Metab., 12, 400, 1992.
    • (1992) J. Cereb. Blood Flow Metab. , vol.12 , pp. 400
    • Nozaki, K.1    Beal, M.F.2
  • 274
    • 0028158140 scopus 로고
    • Inhibitor of nitric oxide synthesis reduces hypoxic-ischemic brain damage in the neonatal rat
    • Hamada, Y., Hayakawa, T., Hattori, H., and Mikawa, H., Inhibitor of nitric oxide synthesis reduces hypoxic-ischemic brain damage in the neonatal rat, Pediatr. Res., 35, 10, 1993.
    • (1993) Pediatr. Res. , vol.35 , pp. 10
    • Hamada, Y.1    Hayakawa, T.2    Hattori, H.3    Mikawa, H.4
  • 275
    • 0026612237 scopus 로고
    • G-nitro-L-arginine in focal stroke in the 7-day old rat
    • G-nitro-L-arginine in focal stroke in the 7-day old rat, Eur. J. Pharmacol., 218, 197, 1992.
    • (1992) Eur. J. Pharmacol. , vol.218 , pp. 197
    • Trifiletti, R.R.1
  • 276
    • 0028153725 scopus 로고
    • Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats
    • Hayakawa, T., Hamada, Y., Maihara, T., Hattori, H., and Mikawa, H., Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats, Life Sci., 54, 387, 1994.
    • (1994) Life Sci. , vol.54 , pp. 387
    • Hayakawa, T.1    Hamada, Y.2    Maihara, T.3    Hattori, H.4    Mikawa, H.5
  • 278
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., and Seeburg, P., Developmental and regional expression in the rat brain and functional properties of four NMDA receptors, Neuron, 12, 529, 1994.
    • (1994) Neuron , vol.12 , pp. 529
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeburg, P.5
  • 279
    • 0027338241 scopus 로고
    • 2+ block of the N-methyl-D-aspartate receptor-mediated synaptic potentials in developing visual cortex
    • 2+ block of the N-methyl-D-aspartate receptor-mediated synaptic potentials in developing visual cortex, Proc. Natl. Acad. Sci. U.S.A., 90, 7114, 1993.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 7114
    • Kato, N.1    Yoshimura, H.2
  • 281
    • 0000866411 scopus 로고
    • Adverse effects of excitatory amino acid antagonists on the developing brain
    • Holmes, G. L., Werner, S., Liu, Z., Carmant, L., and Mikati, M., Adverse effects of excitatory amino acid antagonists on the developing brain, Ann. Neurol., 36, 494, 1994.
    • (1994) Ann. Neurol. , vol.36 , pp. 494
    • Holmes, G.L.1    Werner, S.2    Liu, Z.3    Carmant, L.4    Mikati, M.5
  • 282
    • 0027999588 scopus 로고
    • Chronic neonatal blockade of N-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic function in adult rat
    • Dall'olio, R., Facchinetti, F., Contestabile, A., and Gandolfi, O., Chronic neonatal blockade of N-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic function in adult rat, Neuroscience, 63, 451, 1994.
    • (1994) Neuroscience , vol.63 , pp. 451
    • Dall'olio, R.1    Facchinetti, F.2    Contestabile, A.3    Gandolfi, O.4
  • 283
    • 0026555736 scopus 로고
    • The effects of N-methyl-D-aspartate antagonism on the inspiratory activities of developing animals
    • Sica, A. L., Siddiqi, Z. A., and Pisana, F., The effects of N-methyl-D-aspartate antagonism on the inspiratory activities of developing animals, Dev. Brain Res., 65, 281, 1992.
    • (1992) Dev. Brain Res. , vol.65 , pp. 281
    • Sica, A.L.1    Siddiqi, Z.A.2    Pisana, F.3
  • 284
    • 0027986737 scopus 로고
    • Reduction of baroreceptor-related sympathetic discharge during NMDA receptor antagonism
    • Sica, A. L. and Siddiqi, Z. A., Reduction of baroreceptor-related sympathetic discharge during NMDA receptor antagonism, Brain Res., 665, 323, 1994.
    • (1994) Brain Res. , vol.665 , pp. 323
    • Sica, A.L.1    Siddiqi, Z.A.2
  • 285
    • 0018187162 scopus 로고
    • Ontogenetic development of kainate neurotoxicity: Correlates with glutamatergic innervation
    • Campociaro, P. and Coyle, J. T., Ontogenetic development of kainate neurotoxicity: correlates with glutamatergic innervation, Proc. Natl. Acad. Sci. U.S.A., 75, 2025, 1978.
    • (1978) Proc. Natl. Acad. Sci. U.S.A. , vol.75 , pp. 2025
    • Campociaro, P.1    Coyle, J.T.2
  • 286
    • 0020637892 scopus 로고
    • Intracortical and intrahippocampal injections of kainic acid in developing rats: An electrographic study
    • Cavalheiro, E. A., de Feo, M. R., and Ricci, G. F., Intracortical and intrahippocampal injections of kainic acid in developing rats: an electrographic study, Electroencephalogr. Clin. Neurophysiol., 56, 480, 1983.
    • (1983) Electroencephalogr. Clin. Neurophysiol. , vol.56 , pp. 480
    • Cavalheiro, E.A.1    De Feo, M.R.2    Ricci, G.F.3
  • 287
    • 0021173692 scopus 로고
    • Kainic acid-induced seizures: A developmental study
    • Albala, B. J., Moshe, S. L., and Okada, R., Kainic acid-induced seizures: a developmental study, Dev. Brain Res., 13, 139, 1984.
    • (1984) Dev. Brain Res. , vol.13 , pp. 139
    • Albala, B.J.1    Moshe, S.L.2    Okada, R.3
  • 288
    • 0021442734 scopus 로고
    • Kainic acid seizure syndrome and binding sites in developing rats
    • Ben-Ari, Y., Tremblay, E., Berger, M., and Nitecka, L., Kainic acid seizure syndrome and binding sites in developing rats, Dev. Brain Res., 14, 284, 1984.
    • (1984) Dev. Brain Res. , vol.14 , pp. 284
    • Ben-Ari, Y.1    Tremblay, E.2    Berger, M.3    Nitecka, L.4
  • 289
    • 0001870716 scopus 로고
    • Isolation and structural identification of naturally occurring excitatory amino acids
    • McGeer, E., Olney, J. W., and McGeer, P., Eds., Raven, New York
    • Takemoto, T., Isolation and structural identification of naturally occurring excitatory amino acids, in Kainic acid as a Tool in Neurobiology, McGeer, E., Olney, J. W., and McGeer, P., Eds., Raven, New York, 1978, 1.
    • (1978) Kainic Acid as a Tool in Neurobiology , pp. 1
    • Takemoto, T.1
  • 290
    • 0025366777 scopus 로고
    • An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid
    • Pearl, T. M., Bedard, L., Kosatsky, T., Hockin, J. C., Todd, E. C. D., and Remis, R. S., An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid, N. Engl. J. Med., 322, 1775, 1990.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1775
    • Pearl, T.M.1    Bedard, L.2    Kosatsky, T.3    Hockin, J.C.4    Todd, E.C.D.5    Remis, R.S.6
  • 293
    • 0025838264 scopus 로고
    • Age-related vulnerability to cerebral ischemia in spontaneously hypertensive rats
    • Yao, H., Sadoshima, S., Ooboshi, H., Sato, Y., Uchimura, H., and Fujishima, M., Age-related vulnerability to cerebral ischemia in spontaneously hypertensive rats, Stroke, 22, 1414, 1991.
    • (1991) Stroke , vol.22 , pp. 1414
    • Yao, H.1    Sadoshima, S.2    Ooboshi, H.3    Sato, Y.4    Uchimura, H.5    Fujishima, M.6
  • 294
    • 0024568727 scopus 로고
    • Trauma-induced proliferation of astrocytes in the brains of young and aged rats
    • Topp, K. S., Faddis, B. T., and Vijayan, V. K., Trauma-induced proliferation of astrocytes in the brains of young and aged rats, Glia., 2, 201, 1989.
    • (1989) Glia. , vol.2 , pp. 201
    • Topp, K.S.1    Faddis, B.T.2    Vijayan, V.K.3
  • 295
    • 0018763957 scopus 로고
    • Carotid artery ligation-induced cerebral ischemia in old, male, Sprague-Dawley rats
    • Wexler, B. C., Carotid artery ligation-induced cerebral ischemia in old, male, Sprague-Dawley rats, Age, 2, 39, 1979.
    • (1979) Age , vol.2 , pp. 39
    • Wexler, B.C.1
  • 296
    • 0022006655 scopus 로고
    • Brain metabolic changes in young vs. aged rats during hypoxia
    • Hoffman, W. E., Pelligrino, D., Miletich, D. J., and Albrecht, R. F., Brain metabolic changes in young vs. aged rats during hypoxia, Stroke, 16, 860, 1985.
    • (1985) Stroke , vol.16 , pp. 860
    • Hoffman, W.E.1    Pelligrino, D.2    Miletich, D.J.3    Albrecht, R.F.4
  • 299
    • 0028294612 scopus 로고
    • Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice
    • Ferrandiz, M. L., Martinez, M., De Juan, E., Diez, A., Bustos, G., and Miquel, J., Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice, Brain Res., 644, 335, 1994.
    • (1994) Brain Res. , vol.644 , pp. 335
    • Ferrandiz, M.L.1    Martinez, M.2    De Juan, E.3    Diez, A.4    Bustos, G.5    Miquel, J.6
  • 301
    • 0028152717 scopus 로고
    • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
    • Mecocci, P., MacGarvey, U., and Beal, M. F., Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease, Ann. Neurol., 36, 747, 1994.
    • (1994) Ann. Neurol. , vol.36 , pp. 747
    • Mecocci, P.1    MacGarvey, U.2    Beal, M.F.3


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