Metallothioneins are highly expressed in astrocytes and microcapillaries in Alzheimer's disease

Journal of Chemical Neuroanatomy

Volumn 15, Issue 1, 1998, Pages 21-26

  Zambenedetti, Pamela ^a   Giordano, Renzo ^b   Zatta, Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Regione Piemonte USL 49   (Italy)

Author keywords

Alzheimer's disease; Astrocytes; Cerebellum; Metallothionein; Microcapillaries

Indexed keywords

AMYLOID BETA PROTEIN; ANTIBODY; BRAIN PROTEIN; METALLOTHIONEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN MICROCIRCULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE; WHITE MATTER;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ASTROCYTES; CAPILLARIES; CEREBELLUM; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; MALE; METALLOTHIONEIN; MICROCIRCULATION;

EID: 0032127594     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-0618(98)00024-6     Document Type: Article

References (28)

1. Araujo D.M., Cotman C.W. Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res. 569:1992;141-145.
2. Aschner M. The functional significance of brain metallothioneins. FASEB J. 10:1996;1129-1136.
3. Aschner M., Cherian M.G., Klaassen C.D., Palmiter R.D., Erickson J.C., Bush A.I. Metallothioneins in brain. The role in physiology and pathology. Toxicol. Appl. Pharmacol. 142:1997;229-242.
4. Bakka A., Johnson A.S., Rugstad H.E. Radioresistance in cells with high content of metallothionein. Experientia. 38:1982;381-383.
5. Busciglio J., Gabuzda D.H., Matsudaira P., Yanker B.A. Generation of beta-amyloid in the secretory pathway in neuronal and non neuronal cells. Proc. Natl. Acad. Sci. USA. 90:1993;2092-2096.
6. Bush A.I., Pettingell W.H., Multhaup G., Paradis M., Vonsattel J.-P., Gusella J.F., Beyreuther K., Masters C.L., Tanzi R.E. Rapid induction of Alzheimer Aβ-amyloid formation by zinc. Science. 265:1994;1464-1467.
7. Chen C.-F., Wang S.-H., Lin L.-Y. Identification and characterization of metallothionein III (Growth Inhibitory Factor) from porcine brain. Comp. Biochem. Physiol. 115B:1996;27-32.
8. Ebadi M., Iversen P.L., Hao R., Cerutis D.R., Rojas P., Happe H.K., Murrin L.C., Pfeiffer R.F. Expression and regulation of brain metallothionein. Neurochem. Int. 27:1995;1-22.
9. Ebadi M., Leuschen M.P., el-Refaey H., Hamada F.M., Rojas P. The antioxidant properties of zinc and metallothionein. Neurochem. Int. 29:1996;159-166.
10. Erickson J.C., Sewell A.K., Jensen L.T., Winge D.R., Palmiter R.D. Enhanced neurotrophic activity in Alzheimer's disease associated with down regulation of metallothionein III (GIF). Brain Res. 649:1994;297-304.
11. Hensley K., Butterfield D.A., Hall N., Cole P., Subramanian R., Mark R., Mattson M.P., Markesbery W.R. Reactive oxygen species as causal agent in the neurotoxicity of Alzheimer's disease associated amyloid beta peptide. Ann. New York Acad. Sci. 786:1996;120-134.
12. Hidalgo J., Chapmany L., Marti O., Armario A. Metallothionein-I induction by stress in specific brain areas. Neurochem. Res. 16:1991;1145-1148.
13. Jorgensen, O.S., Balazs, R., 1993. Plastic neuronal changes in Alzheimer's disease associated with activation of astrocytes and enhanced neurotrophic activity. In: Corain, B., Iqbal, K., Nicolini, M., Winblad, B., Wisniewski, H., Zatta, P.F. (Eds.), Alzheimer's Disease: Advances in Clinical and Basic Research. Wiley, Chichester, UK, pp. 189-198
14. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services and Task Force on Alzheimer's disease. Neurology. 34:1989;939-944.
15. McGeer P.L., Rogers J., McGeer E.G. Neuroimmune mechanisms in Alzheimer's disease pathogenesis. Alzheimer's Dis. Rel. Dis. 8:1994;148-158.
16. Margoshes M., Vallee B.L. A cadmium protein from equine kidney cortex. J. Am. Chem. Soc. 79:1957;4813-4814.
17. Otsuka N., Tomonaga M., Ikeda K. Rapid appearance of beta-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury. Brain Res. 568:1991;335-338.
18. Palmiter R.D., Findley S.D., Whitemore T.E., Durnam D.M. MT-III, a brain specific member of the metallothionein family. Proc. Natl. Acad. Sci. USA. 89:1992;6333-6337.
19. Pike C.J., Cummings B.J., Monzavi R., Cotman C.W. Beta-amyloid changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease. Neuroscience. 63:1994;517-531.
20. Poirier J.M., Hess M., May P.C., Finch C.E. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Brain Res. Mol. Brain Res. 11:1991;97-106.
21. Privat, A., Gimenez-Ribotta, M., Ridet, J.-L., 1995. Morphology of astrocytes. In: Kettenman, H., Ransom, B.R. (Eds.), Neuroglia. Oxford University Press, Oxford, pp. 3-43.
22. Sawada J., Kikuchi Y., Shibutani M., Mitsumori K., Inoue K., Kasahara T. Induction of metallothionein in astrocytes by cytokines and heavy metals. Biol. Signals. 3:1994;157-168.
23. Schmidt C.J., Hamer D.H., McBride O.W. Chromosome location and human metallothionein genes: implications in Menkes' disease. Science. 224:1984;1104-1106.
24. Suzuki K., Nakajiama K., Otaki N., Kimura M., Kawaharada U., Uehara K., Hara F., Nakazato Y., Takatama M. Localization of metallothionein in aged human brain. Pathol. Int. 44:1994;20-26.
25. Thornalley P.J., Vasak M. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide dismutase and hydroxyl radicals. Biochim. Biophys. Acta. 827:1985;36-44.
26. Uchida Y., Takio K., Titani K., Ihara Y., Tomonaga M. The growth inhibitory factor that is deficient in Alzheimer's disease a 68 amino acid metallothionein-like protein. Neuron. 7:1991;337-347.
27. Uchida Y. Growth-inhibitory factor, metallothionein-like protein, and neurodegenerative disease. Biol. Signals. 3:1994;211-215.
28. Vermersch P., Roche J., Hamon M., Daems-Monpeurt C., Pruvo J.P., Dewailly P., Petit H. White matter magnetic resonance imaging hyperintensity in Alzheimer's disease: correlation with corpus callosum atrophy. J. Neurol. 243:1996;231-234.