메뉴 건너뛰기




Volumn 5, Issue 6, 2005, Pages 468-479

Antisense therapy for cancer

Author keywords

[No Author keywords available]

Indexed keywords

AEG 35156; ANTISENSE OLIGONUCLEOTIDE; AS 750 15; CARBOPLATIN; CGP 69846A; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DEXAMETHASONE; DOCETAXEL; FLUDARABINE; GEM 240; GEMCITABINE; GENE EXPRESSION MODULATOR 231; GTI 2501; ISIS 20408; ISIS 345794; ISIS 3521; LR 3001; LY 2181308; LY 2275796; MG 98; MITOXANTRONE; OBLIMERSEN; OGX 011; OGX 225; OGX 427; PACLITAXEL; UNCLASSIFIED DRUG;

EID: 20344371233     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1631     Document Type: Review
Times cited : (337)

References (166)
  • 1
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • Zamecnik, P. C. & Stephenson, M. L. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl Acad. Sci. USA 75, 280-284 (1978). First report on the use of antisense oligodeoxynucleotides to suppress gene activity in cell culture.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 280-284
    • Zamecnik, P.C.1    Stephenson, M.L.2
  • 3
    • 1642430704 scopus 로고    scopus 로고
    • Antisense oligonucleotide-based therapeutics for cancer
    • Dean, N. M. & Bennett, C. F. Antisense oligonucleotide-based therapeutics for cancer. Oncogene 22, 9087-9096 (2003).
    • (2003) Oncogene , vol.22 , pp. 9087-9096
    • Dean, N.M.1    Bennett, C.F.2
  • 4
    • 0006081344 scopus 로고    scopus 로고
    • Antisense therapy for cancer
    • Orr, R. M. & Monia, B. P. Antisense therapy for cancer. Investig. Drugs 1, 199-205 (1998).
    • (1998) Investig. Drugs , vol.1 , pp. 199-205
    • Orr, R.M.1    Monia, B.P.2
  • 5
    • 0031922256 scopus 로고    scopus 로고
    • Molecular mechanisms of antisense drugs: RNase H
    • Croke, S. T. Molecular mechanisms of antisense drugs: RNase H. Antisense Nucleic Acid Drug Dev. 8, 133-134 (1998).
    • (1998) Antisense Nucleic Acid Drug Dev. , vol.8 , pp. 133-134
    • Croke, S.T.1
  • 6
    • 2342427578 scopus 로고    scopus 로고
    • Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs
    • Wu, H. et al. Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs. J. Biol. Chem. 279, 17181-17189 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 17181-17189
    • Wu, H.1
  • 7
    • 7944220070 scopus 로고    scopus 로고
    • Assay for evaluating ribonuclease H-mediated degradation of RNA-antisense oligonucleotide duplexes
    • Galarneau, A., Min, K. L., Mangos, M. M. & Damha, M. J. Assay for evaluating ribonuclease H-mediated degradation of RNA-antisense oligonucleotide duplexes. Methods Mol. Biol. 288, 65-80 (2005).
    • (2005) Methods Mol. Biol. , vol.288 , pp. 65-80
    • Galarneau, A.1    Min, K.L.2    Mangos, M.M.3    Damha, M.J.4
  • 8
    • 0033230505 scopus 로고    scopus 로고
    • Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice
    • Carpentier, A. F., Chen, L., Maltonti, F. & Delattre, J. Y. Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice. Cancer Res. 59, 5429-5432 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5429-5432
    • Carpentier, A.F.1    Chen, L.2    Maltonti, F.3    Delattre, J.Y.4
  • 9
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998). First report on the use of double-stranded siRNA duplexes to suppress gene activity in animal cells.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 10
    • 10644237968 scopus 로고    scopus 로고
    • RNAi-mediated pathways in the nucleus
    • Matzke, M. A. & Birchler, J. A. RNAi-mediated pathways in the nucleus. Nature Rev. Genet. 6, 24-35 (2005).
    • (2005) Nature Rev. Genet. , vol.6 , pp. 24-35
    • Matzke, M.A.1    Birchler, J.A.2
  • 11
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified SiRNAs
    • Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified SiRNAs. Nature 432, 173-178 (2004). The first demonstration of siRNA activity in mammals following administration through routes other than the digestive tract.
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1
  • 12
    • 0027168725 scopus 로고
    • Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression
    • Monia, B. P. et al. Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression. J. Biol. Chem. 268, 14514-14522 (1993). This report demonstrates that RNase H is a key terminating mechanism by which antisense drugs exert their effects on gene expression. This report also demonstrates the use of 2′-modefied chimeric antisense oligonucleotides in cells.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14514-14522
    • Monia, B.P.1
  • 13
    • 24144492298 scopus 로고    scopus 로고
    • Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo
    • Shen, L. et al. Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo. Antisense Nucleic Acid Drug Dev. 13, 129-142(2003).
    • (2003) Antisense Nucleic Acid Drug Dev. , vol.13 , pp. 129-142
    • Shen, L.1
  • 14
    • 0022546957 scopus 로고
    • Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma
    • Tsujimoto, Y. & Croce, C. M. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Natl Acad. Sci. USA 83, 5214-5218 (1986).
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5214-5218
    • Tsujimoto, Y.1    Croce, C.M.2
  • 15
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6 (1994).
    • (1994) J. Cell Biol. , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 16
    • 0027389763 scopus 로고
    • Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
    • Miyashita, T. & Reed, J. C. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81, 151-157 (1993).
    • (1993) Blood , vol.81 , pp. 151-157
    • Miyashita, T.1    Reed, J.C.2
  • 17
    • 0027093255 scopus 로고
    • Expression of the protooncogene bol-2 in the prostate and its association with emergence of androgen-independent prostate cancer
    • McDonnell, T. J. et al. Expression of the protooncogene bol-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res. 52, 6940-6944 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 6940-6944
    • McDonnell, T.J.1
  • 18
    • 0031045967 scopus 로고    scopus 로고
    • bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells
    • Kyprianou, N., King, E. D., Bradbury, D. & Rhee, J. G. bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Int. J. Cancer 70, 341-348 (1997).
    • (1997) Int. J. Cancer , vol.70 , pp. 341-348
    • Kyprianou, N.1    King, E.D.2    Bradbury, D.3    Rhee, J.G.4
  • 19
    • 0029077281 scopus 로고
    • Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo
    • Raffo, A. J. et al. Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo. Cancer Res. 55, 4438-4445 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 4438-4445
    • Raffo, A.J.1
  • 20
    • 0033567003 scopus 로고    scopus 로고
    • Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model
    • Miyake, H., Tolcher, A. & Gleave, M. E. Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model. Cancer Res. 59, 4030-4034 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 4030-4034
    • Miyake, H.1    Tolcher, A.2    Gleave, M.E.3
  • 21
    • 0032741282 scopus 로고    scopus 로고
    • Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model
    • Gleave, M. et al. Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model. Clin Cancer Res. 5, 2891-2898 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2891-2898
    • Gleave, M.1
  • 22
    • 0034096268 scopus 로고    scopus 로고
    • A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells
    • Zangemeister-Wittke, U. et al. A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells. Clin. Cancer Res. 6, 2547-2555 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2547-2555
    • Zangemeister-Wittke, U.1
  • 23
    • 0031907428 scopus 로고    scopus 로고
    • bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
    • Jansen, B. et al. bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nature Med. 4, 232-234 (1998).
    • (1998) Nature Med. , vol.4 , pp. 232-234
    • Jansen, B.1
  • 24
    • 0030888664 scopus 로고    scopus 로고
    • BCL-2 antisense therapy in patients with non-Hodgkin lymphoma
    • Webb, A. et al. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet 349, 1137-1141 (1997). This Phase I/IIa trial is the first report of the activity of BCL2 antisense in cancer patients.
    • (1997) Lancet , vol.349 , pp. 1137-1141
    • Webb, A.1
  • 25
    • 0034015672 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
    • Waters, J. S. et al. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. J. Clin. Oncol. 18, 1812-1823 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1812-1823
    • Waters, J.S.1
  • 26
    • 0034684471 scopus 로고    scopus 로고
    • Chemosensitisation of malignant melanoma by BCL2 antisense therapy
    • Jansen, B. et al. Chemosensitisation of malignant melanoma by BCL2 antisense therapy. Lancet 356, 1728-1733 (2000). This Phase I/IIa trial was the first to report reduced BCL2 protein levels in serial melanoma biopsies and higher-than-expected response rates using G3139 plus DTIC in a small cohort of patients with metastatic melanoma.
    • (2000) Lancet , vol.356 , pp. 1728-1733
    • Jansen, B.1
  • 27
    • 20344387097 scopus 로고    scopus 로고
    • Phase 3 randomized trial of fludarabine/cyclophosphamide chemotherapy with or without oblimersen sodium (Bcl-2 antisense; genasense; G3139) for patients with relapsed or refractory chronic lymphocytic leukemia (CLL)
    • Rai, K. R. & Moore, J. O. Phase 3 randomized trial of fludarabine/cyclophosphamide chemotherapy with or without oblimersen sodium (Bcl-2 antisense; genasense; G3139) for patients with relapsed or refractory chronic lymphocytic leukemia (CLL). Blood 104, 100a (2004).
    • (2004) Blood , vol.104
    • Rai, K.R.1    Moore, J.O.2
  • 28
    • 15244355253 scopus 로고    scopus 로고
    • Bcl-2 antisense therapy in B-cell malignancies
    • Chanan-Khan, A. Bcl-2 antisense therapy in B-cell malignancies. Blood Rev. 19, 213-221 (2005).
    • (2005) Blood Rev. , vol.19 , pp. 213-221
    • Chanan-Khan, A.1
  • 29
    • 0035678781 scopus 로고    scopus 로고
    • A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer
    • Chi, K. N. et al. A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer. Clin. Cancer Res. 7, 3920-3927 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3920-3927
    • Chi, K.N.1
  • 30
    • 0000023014 scopus 로고    scopus 로고
    • Phase I pharmacokinetic (PK) and pharmacodynamic (PD) trial of bcl-2 antisense (genasense) and docetaxel (D) in hormone refractory prostate cancer
    • De Bono, J. S., Rowinsky, E. K. & Kuhn, J. Phase I pharmacokinetic (PK) and pharmacodynamic (PD) trial of bcl-2 antisense (genasense) and docetaxel (D) in hormone refractory prostate cancer. Proc. Am. Soc. Clin. Oncol. 20, A119 (2001).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • De Bono, J.S.1    Rowinsky, E.K.2    Kuhn, J.3
  • 31
    • 0345321151 scopus 로고    scopus 로고
    • A phase II study of oblimersen sodium (G3139) and docetaxel (D) in patients (pts) with metastatic hormone-refractory prostate cancer (HRPC)
    • Chi, K. N., Murray, R. N. & Gleave, M. E. A phase II study of oblimersen sodium (G3139) and docetaxel (D) in patients (pts) with metastatic hormone-refractory prostate cancer (HRPC). Proc. Am. Soc. Clin. Oncol. 22, 393 (2003).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 393
    • Chi, K.N.1    Murray, R.N.2    Gleave, M.E.3
  • 32
    • 0029965057 scopus 로고    scopus 로고
    • Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL
    • Man, Z. et al. Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL. Cancer Res. 56, 1621-1628 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 1621-1628
    • Man, Z.1
  • 33
    • 0034071150 scopus 로고    scopus 로고
    • Induction of apoptosis in lung-cancer cells following bcl-xL anti-sense treatment
    • Leech, S. H. et al. Induction of apoptosis in lung-cancer cells following bcl-xL anti-sense treatment. Int. J. Cancer 86, 570-576 (2000).
    • (2000) Int. J. Cancer , vol.86 , pp. 570-576
    • Leech, S.H.1
  • 34
    • 0033902003 scopus 로고    scopus 로고
    • Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells
    • Simoes-Wust, A. P. et al. Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells. Int. J. Cancer 87, 582-590 (2000).
    • (2000) Int. J. Cancer , vol.87 , pp. 582-590
    • Simoes-Wust, A.P.1
  • 35
    • 0034326272 scopus 로고    scopus 로고
    • L in prostate cancer cells: Effects of overexpression and down-regulation on chemosensitivity
    • L in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity. Cancer Res. 60, 6052-6060 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 6052-6060
    • Lebedeva, I.1    Rando, R.2    Ojwang, J.3    Cossum, P.4    Stein, C.A.5
  • 36
    • 0035869667 scopus 로고    scopus 로고
    • Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model
    • Leung, S., Miyake, H., Zellweger, T., Tolcher, A. & Gleave, M. E. Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model. Int. J. Cancer 91, 846-850 (2001).
    • (2001) Int. J. Cancer , vol.91 , pp. 846-850
    • Leung, S.1    Miyake, H.2    Zellweger, T.3    Tolcher, A.4    Gleave, M.E.5
  • 37
    • 0034659691 scopus 로고    scopus 로고
    • L and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model
    • L and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model. Int. J. Cancer 86, 855-862 (2000).
    • (2000) Int. J. Cancer , vol.86 , pp. 855-862
    • Miyake, H.1    Monia, B.P.2    Gleave, M.E.3
  • 38
    • 0035925537 scopus 로고    scopus 로고
    • Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins
    • Gautschi, O. et al. Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J. Natl Cancer Inst. 93, 463-471 (2001).
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 463-471
    • Gautschi, O.1
  • 39
    • 0030987070 scopus 로고    scopus 로고
    • Regulation of protein kinase C
    • Newton, A. C. Regulation of protein kinase C. Curr. Opin. Cell Biol. 9, 161-167 (1997).
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 161-167
    • Newton, A.C.1
  • 40
    • 0027959058 scopus 로고
    • 12(S)-HETE enhancement of prostate tumor cell invasion: Selective role of PKCα
    • Liu, B., Maher, R. J., Hannun, Y. A., Porter, A. T. & Honn, K. V. 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKCα. J. Natl Cancer Inst. 86, 1145-1151 (1994).
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 1145-1151
    • Liu, B.1    Maher, R.J.2    Hannun, Y.A.3    Porter, A.T.4    Honn, K.V.5
  • 41
    • 0028903545 scopus 로고
    • MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
    • Ways, D. K. et al. MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J. Clin. Invest. 95, 1906-1915 (1995).
    • (1995) J. Clin. Invest. , vol.95 , pp. 1906-1915
    • Ways, D.K.1
  • 42
    • 0034818582 scopus 로고    scopus 로고
    • Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes α and τ
    • Gill, P. K., Gescher, A. & Gant, T. W. Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes α and τ. Eur. J. Biochem. 268, 4151-4157 (2001).
    • (2001) Eur. J. Biochem. , vol.268 , pp. 4151-4157
    • Gill, P.K.1    Gescher, A.2    Gant, T.W.3
  • 44
    • 0033988448 scopus 로고    scopus 로고
    • Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13- acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells
    • Isonishi, S., Ohkawa, K., Tanaka, T. & Howell, S. B. Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells. Br. J. Cancer 82, 34-38 (2000).
    • (2000) Br. J. Cancer , vol.82 , pp. 34-38
    • Isonishi, S.1    Ohkawa, K.2    Tanaka, T.3    Howell, S.B.4
  • 45
    • 0033019842 scopus 로고    scopus 로고
    • Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Cα antisense oligonucleotide
    • Shen, L., Dean, N. M. & Glazer, R. I. Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Cα antisense oligonucleotide. Mol. Pharmacol. 55, 396-402 (1999).
    • (1999) Mol. Pharmacol. , vol.55 , pp. 396-402
    • Shen, L.1    Dean, N.M.2    Glazer, R.I.3
  • 46
    • 0033542806 scopus 로고    scopus 로고
    • Antisense inhibition of protein kinase Cα reverses the transformed phenotype in human lung carcinoma cells
    • Wang, X. Y., Repasky, E. & Liu, H. T. Antisense inhibition of protein kinase Cα reverses the transformed phenotype in human lung carcinoma cells. Exp. Cell Res. 250, 253-263 (1999).
    • (1999) Exp. Cell Res. , vol.250 , pp. 253-263
    • Wang, X.Y.1    Repasky, E.2    Liu, H.T.3
  • 47
    • 0028062847 scopus 로고
    • Inhibition of protein kinase Cα expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides
    • Dean, N. M. & McKay, R. Inhibition of protein kinase Cα expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc. Natl Acad. Sci. USA 91, 11762-11766 (1994). Demonstrated for the first time that antisense oligonucleotides can inhibit gene expression in a highly specific manner when administered parenterally to normal mice.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11762-11766
    • Dean, N.M.1    McKay, R.2
  • 48
    • 0029833019 scopus 로고    scopus 로고
    • Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-α phosphorothioate oligodeoxynucleotide
    • Yazaki, T. et al. Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-α phosphorothioate oligodeoxynucleotide. Mol. Pharmacol. 50, 236-242 (1996).
    • (1996) Mol. Pharmacol. , vol.50 , pp. 236-242
    • Yazaki, T.1
  • 49
    • 0031963427 scopus 로고    scopus 로고
    • Antitumor activity of a PKC-α antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice
    • Geiger, T., Muller, M., Dean, N. M. & Fabbro, D. Antitumor activity of a PKC-α antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice. Anticancer Drug Des. 13, 35-45(1998).
    • (1998) Anticancer Drug Des. , vol.13 , pp. 35-45
    • Geiger, T.1    Muller, M.2    Dean, N.M.3    Fabbro, D.4
  • 50
    • 0032486223 scopus 로고    scopus 로고
    • Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-α
    • Dennis, J. U. et al. Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-α. Cancer Lett. 128, 65-70 (1998).
    • (1998) Cancer Lett. , vol.128 , pp. 65-70
    • Dennis, J.U.1
  • 51
    • 0032730429 scopus 로고    scopus 로고
    • Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-α, in patients with advanced cancer
    • Nemunaitis, J. et al. Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-α, in patients with advanced cancer. J. Clin. Oncol. 17, 3586-3595 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3586-3595
    • Nemunaitis, J.1
  • 52
    • 0032730633 scopus 로고    scopus 로고
    • Phase I study of an antisense oligonucleotide to protein kinase C-α (ISIS 3521/CGP 64128A) in patients with cancer
    • Yuen, A. R. et al. Phase I study of an antisense oligonucleotide to protein kinase C-α (ISIS 3521/CGP 64128A) in patients with cancer. Clin. Cancer Res. 5, 3357-3363 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3357-3363
    • Yuen, A.R.1
  • 53
    • 0034026007 scopus 로고    scopus 로고
    • A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer
    • Cunningham, C. C. et al. A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer. Clin. Cancer Res. 6, 1626-1631 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1626-1631
    • Cunningham, C.C.1
  • 54
    • 0036023413 scopus 로고    scopus 로고
    • A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer
    • Tolcher, A. W. et al. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin. Cancer Res. 8, 2530-2535 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2530-2535
    • Tolcher, A.W.1
  • 55
    • 0000262572 scopus 로고    scopus 로고
    • Phase I/II trial of ISIS 3521, an antisense inhibitor of PKC-α, with carboplatin and paclitaxel in non-small cell lung cancer
    • Yuen, A. R. et al. Phase I/II trial of ISIS 3521, an antisense inhibitor of PKC-α, with carboplatin and paclitaxel in non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. A1234 (2001).
    • (2001) Proc. Am. Soc. Clin. Oncol.
    • Yuen, A.R.1
  • 56
    • 0009682705 scopus 로고    scopus 로고
    • Phase I/II trial of ISIS 3521/LY900003, an antisense inhibitor of PKC-α, with cisplatin and gemcitabine in advanced non-small cell lung cancer
    • Ritch, P. et al. Phase I/II trial of ISIS 3521/LY900003, an antisense inhibitor of PKC-α, with cisplatin and gemcitabine in advanced non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. 21, 309a (2002).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Ritch, P.1
  • 57
    • 0034647738 scopus 로고    scopus 로고
    • Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB
    • Cervellera, M. et al. Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB. J. Biol. Chem. 275, 21055-21060 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 21055-21060
    • Cervellera, M.1
  • 58
    • 0034661519 scopus 로고    scopus 로고
    • Detection of differentially expressed genes in lymphomas using cDNA arrays: Identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas
    • Wellmann, A. et al. Detection of differentially expressed genes in lymphomas using cDNA arrays: identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas. Blood 96, 398-404 (2000).
    • (2000) Blood , vol.96 , pp. 398-404
    • Wellmann, A.1
  • 59
    • 0030843011 scopus 로고    scopus 로고
    • Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer
    • Steinberg, J. et al. Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer. Clin. Cancer Res. 3, 1707-1711 (1997).
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1707-1711
    • Steinberg, J.1
  • 60
    • 0033903190 scopus 로고    scopus 로고
    • Overexpression of clusterin in human breast carcinoma
    • Redondo, M. et al. Overexpression of clusterin in human breast carcinoma. Am. J. Pathol. 157, 393-399 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 393-399
    • Redondo, M.1
  • 61
    • 0036144277 scopus 로고    scopus 로고
    • Overexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence
    • Miyake, H., Gleave, M., Kamidono, S. & Hara, I. Overexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence. Urology 59, 150-154 (2002).
    • (2002) Urology , vol.59 , pp. 150-154
    • Miyake, H.1    Gleave, M.2    Kamidono, S.3    Hara, I.4
  • 62
    • 0028366242 scopus 로고
    • Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas
    • Parczyk, K., Pilarsky, C., Rachel, U. & Koch-Brandt, C. Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas. J. Cancer Res. Clin. Oncol. 120, 186-188 (1994).
    • (1994) J. Cancer Res. Clin. Oncol. , vol.120 , pp. 186-188
    • Parczyk, K.1    Pilarsky, C.2    Rachel, U.3    Koch-Brandt, C.4
  • 63
    • 0034663183 scopus 로고    scopus 로고
    • Apolipoprotein J (clusterin) and Alzheimer's disease
    • Calero, M. et al. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc. Res. Tech. 50, 305-315 (2000).
    • (2000) Microsc. Res. Tech. , vol.50 , pp. 305-315
    • Calero, M.1
  • 65
    • 0022627063 scopus 로고
    • Androgen-repressed messages in the rat ventral prostate
    • Montpetit, M. L., Lawless, K. R. & Tenniswood, M. Androgen-repressed messages in the rat ventral prostate. Prostate 8, 25-36 (1986).
    • (1986) Prostate , vol.8 , pp. 25-36
    • Montpetit, M.L.1    Lawless, K.R.2    Tenniswood, M.3
  • 66
    • 0033978525 scopus 로고    scopus 로고
    • Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer
    • Myake, H., Nelson, C., Rennie, P. S. & Gleave, M. E. Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer. Cancer Res. 60, 170-176 (2000). Reported that increased levels of clusterin after hormone therapy conferred therapeutic resistance, identifying clusterin for the first time as a cytoprotective protein and therapeutic target.
    • (2000) Cancer Res. , vol.60 , pp. 170-176
    • Myake, H.1    Nelson, C.2    Rennie, P.S.3    Gleave, M.E.4
  • 67
    • 0025298231 scopus 로고
    • Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation
    • Kyprianou, N., English, H. F. & Isaacs, J. T. Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation. Cancer Res. 50, 3748-3753 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 3748-3753
    • Kyprianou, N.1    English, H.F.2    Isaacs, J.T.3
  • 68
    • 0033589283 scopus 로고    scopus 로고
    • Hormone therapy failure in human prostate cancer: Analysis by complementary DNA and tissue microarrays
    • Bubendorf, L. et al. Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays. J. Natl Cancer Inst. 91, 1758-1764 (1999).
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1758-1764
    • Bubendorf, L.1
  • 69
    • 0037083472 scopus 로고    scopus 로고
    • Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
    • July, L. V. et al. Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy. Prostate 50, 179-188 (2002).
    • (2002) Prostate , vol.50 , pp. 179-188
    • July, L.V.1
  • 70
    • 0030348155 scopus 로고    scopus 로고
    • Clusterin: A role in cell survival in the face of apoptosis?
    • Koch-Brandt, C. & Morgans, C. Clusterin: a role in cell survival in the face of apoptosis? Prog. Mol. Subcell. Biol. 16, 130-149 (1996).
    • (1996) Prog. Mol. Subcell. Biol. , vol.16 , pp. 130-149
    • Koch-Brandt, C.1    Morgans, C.2
  • 72
    • 0030664673 scopus 로고    scopus 로고
    • Stress-induced transcription of the clusterin/apoJ gene
    • Michel, D., Chatelain, G., North, S. & Brun, G. Stress-induced transcription of the clusterin/apoJ gene. Biochem. J. 328, 45-50 (1997).
    • (1997) Biochem. J. , vol.328 , pp. 45-50
    • Michel, D.1    Chatelain, G.2    North, S.3    Brun, G.4
  • 73
    • 0033548566 scopus 로고    scopus 로고
    • Clusterin has chaperone-like activity similar to that of small heat shock proteins
    • Humphreys, D. T., Carver, J. A., Easterbrook-Smith, S. B. & Wilson, M. R. Clusterin has chaperone-like activity similar to that of small heat shock proteins. J. Biol. Chem. 274, 6875-6881 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 6875-6881
    • Humphreys, D.T.1    Carver, J.A.2    Easterbrook-Smith, S.B.3    Wilson, M.R.4
  • 74
    • 0029061350 scopus 로고
    • Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin)
    • Sansibar, J. A. et al. Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin). Cancer Res. 55, 2431-2437 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 2431-2437
    • Sansibar, J.A.1
  • 75
    • 0036796026 scopus 로고    scopus 로고
    • Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin
    • Zellweger, T. et al. Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin. Clin. Cancer Res. 8, 3276-3284 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3276-3284
    • Zellweger, T.1
  • 76
    • 0034112089 scopus 로고    scopus 로고
    • Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo
    • Miyake, H., Chi, K. N. & Gleave, M. E. Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo. Clin. Cancer Res. 6, 1655-1663 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 1655-1663
    • Miyake, H.1    Chi, K.N.2    Gleave, M.E.3
  • 77
    • 0034883854 scopus 로고    scopus 로고
    • Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy)ethyl chemistry
    • Zellweger, T. et al. Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy)ethyl chemistry. J. Phamacol. Exp. Ther. 298, 934-940 (2001). A preclinical pharmacology paper that demonstrated that tissue half-life and target suppression was superior using a second-generation 2′-MOE OGX-011 compared to unmodified phosphorthioate ASO. These data provided the preclinical proof of principle to proceed into human trials using OGX-011.
    • (2001) J. Phamacol. Exp. Ther. , vol.298 , pp. 934-940
    • Zellweger, T.1
  • 78
    • 4444222462 scopus 로고    scopus 로고
    • Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo
    • July, L. V. et al. Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo. Mol. Cancer Ther. 3, 223-232 (2004).
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 223-232
    • July, L.V.1
  • 79
    • 0034870685 scopus 로고    scopus 로고
    • Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin
    • Zellweger, T. et al. Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin. Neoplasia 3, 360-367 (2001).
    • (2001) Neoplasia , vol.3 , pp. 360-367
    • Zellweger, T.1
  • 80
    • 0035675829 scopus 로고    scopus 로고
    • Synergistic chemsensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model
    • Miyake, H., Hara, I., Kamidono, S. & Gleave, M. E. Synergistic chemsensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model. Clin. Cancer Res. 7, 4245-4252 (2001).
    • (2001) Clin Cancer Res. , vol.7 , pp. 4245-4252
    • Miyake, H.1    Hara, I.2    Kamidono, S.3    Gleave, M.E.4
  • 81
    • 20344402686 scopus 로고    scopus 로고
    • Antisense clusterin oligodeoxynucleotides increase the response of HER-2 gene amplified breast cancer cells to trastuzumab
    • 31 Jan (doi:10.1002/jcp.20295)
    • Biroccio, A., D'Angelo, C., Gleave, M. & Gonos, E. S. Antisense clusterin oligodeoxynucleotides increase the response of HER-2 gene amplified breast cancer cells to trastuzumab. J. Cell Physiol. 31 Jan 2005 (doi:10.1002/jcp.20295).
    • (2005) J. Cell Physiol.
    • Biroccio, A.1    D'Angelo, C.2    Gleave, M.3    Gonos, E.S.4
  • 82
    • 1642282641 scopus 로고    scopus 로고
    • Silencing expression of the clusterin/apolipoprotein J gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress
    • Trougakos, I. P., So, A., Jansen, B., Gleave, M. E. & Gonos, E. S. Silencing expression of the clusterin/ apolipoprotein J gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. Cancer Res. 64, 1834-1842 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 1834-1842
    • Trougakos, I.P.1    So, A.2    Jansen, B.3    Gleave, M.E.4    Gonos, E.S.5
  • 83
    • 15944413669 scopus 로고    scopus 로고
    • A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of OGX-011, a 2′methoxyethyl phosphorothioate antisense to clusterin, in patients with prostate cancer prior to radical prostatectomy
    • Chi, K. et al. A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of OGX-011, a 2′methoxyethyl phosphorothioate antisense to clusterin, in patients with prostate cancer prior to radical prostatectomy. J. Clin. Oncol. 22, 3033 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3033
    • Chi, K.1
  • 84
    • 0032506524 scopus 로고    scopus 로고
    • Control of apoptosis and mitotic spindle checkpoint by survivin
    • Li, F. et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396, 580-584 (1998).
    • (1998) Nature , vol.396 , pp. 580-584
    • Li, F.1
  • 85
    • 5644259587 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice
    • Schimmer, A. D. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 64, 7183-7190 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7183-7190
    • Schimmer, A.D.1
  • 86
    • 3543092021 scopus 로고    scopus 로고
    • Pathways of apoptotic and non-apoptotic death in tumour cells
    • Okada, H. & Mak, T. W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nature Rev. Cancer 4, 592-603 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 592-603
    • Okada, H.1    Mak, T.W.2
  • 87
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    • LaCasse, E. C., Baird, S., Korneluk, R. G. & MacKenzie, A. E. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 17, 3247-3259 (1998).
    • (1998) Oncogene , vol.17 , pp. 3247-3259
    • LaCasse, E.C.1    Baird, S.2    Korneluk, R.G.3    MacKenzie, A.E.4
  • 88
    • 0030746636 scopus 로고    scopus 로고
    • A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma
    • Ambrosini, G., Adida, C. & Altieri, D. C. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma. Nature Med. 3, 917-921 (1997).
    • (1997) Nature Med. , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 89
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
    • Tamm, I. et al. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58, 5315-5320 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 5315-5320
    • Tamm, I.1
  • 90
    • 0032080378 scopus 로고    scopus 로고
    • Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p 53 accumulation in gastric carcinomas
    • Lu, C. D., Altieri, D. C. & Tanigawa, N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res. 58, 1808-1812 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1808-1812
    • Lu, C.D.1    Altieri, D.C.2    Tanigawa, N.3
  • 91
    • 0033231026 scopus 로고    scopus 로고
    • A public database for gene expression in human cancers
    • Lal, A. et al. A public database for gene expression in human cancers. Cancer Res. 59, 5403-5407 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5403-5407
    • Lal, A.1
  • 92
    • 0346250160 scopus 로고    scopus 로고
    • Survivin, versatile modulation of cell division and apoptosis in cancer
    • Altieri, D. C. Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene 22, 8581-8589 (2003).
    • (2003) Oncogene , vol.22 , pp. 8581-8589
    • Altieri, D.C.1
  • 93
    • 0033258543 scopus 로고    scopus 로고
    • Pleiotropic cell-division defects and apoptosis induced by interference with survivin function
    • Li, F. et al. Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nature Cell Biol. 1, 461-466 (1999).
    • (1999) Nature Cell Biol. , vol.1 , pp. 461-466
    • Li, F.1
  • 94
    • 9144247196 scopus 로고    scopus 로고
    • Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth
    • Chen, J. et al. Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth. Neoplasia 2, 235-241 (2000).
    • (2000) Neoplasia , vol.2 , pp. 235-241
    • Chen, J.1
  • 95
    • 1542608418 scopus 로고    scopus 로고
    • Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lyrnphoma
    • Ansell, S. M. et al. Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lyrnphoma. Leukemia 18, 616-623 (2004).
    • (2004) Leukemia , vol.18 , pp. 616-623
    • Ansell, S.M.1
  • 96
    • 0030810926 scopus 로고    scopus 로고
    • X-linked IAP is a direct inhibitor of cell-death proteases
    • Deveraux, Q. L., Takahashi, R., Salvesen, G. S. & Reed, J. C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388, 300-304 (1997).
    • (1997) Nature , vol.388 , pp. 300-304
    • Deveraux, Q.L.1    Takahashi, R.2    Salvesen, G.S.3    Reed, J.C.4
  • 97
    • 0036544535 scopus 로고    scopus 로고
    • The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    • Silke, J. et al. The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites. J. Cell Biol. 157, 115-124 (2002).
    • (2002) J. Cell Biol. , vol.157 , pp. 115-124
    • Silke, J.1
  • 98
  • 99
    • 0037478904 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo
    • Hu, Y. et al. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin. Cancer Res. 9, 2826-2836 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2826-2836
    • Hu, Y.1
  • 100
    • 0034667372 scopus 로고    scopus 로고
    • Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells
    • Sasaki, H., Sheng, Y., Kotsuji, F. & Tsang, B. K. Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res. 60, 5659-5666 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 5659-5666
    • Sasaki, H.1    Sheng, Y.2    Kotsuji, F.3    Tsang, B.K.4
  • 101
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E. Jr., Kerr, I. M. & Stark, G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 102
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu, C. L. et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269, 81-83 (1995).
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1
  • 103
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - New molecular targets come of age
    • Yu, H. & Jove, R. The STATs of cancer - new molecular targets come of age. Nature Rev. Cancer 4, 97-105 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 104
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner, R., Mora, L. B. & Jove, R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. 8, 945-954 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 105
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in human prostate tumors and cell lines: Direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
    • Mora, L. B. et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 62, 6659-6666 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6659-6666
    • Mora, L.B.1
  • 106
    • 0141790820 scopus 로고    scopus 로고
    • A critical role for Stat 3 signaling in immune tolerance
    • Cheng, F. et al. A critical role for Stat3 signaling in immune tolerance. Immunity 19, 425-436 (2003).
    • (2003) Immunity , vol.19 , pp. 425-436
    • Cheng, F.1
  • 107
    • 0035136846 scopus 로고    scopus 로고
    • Inhibitbn of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
    • Epling-Burnette, P. K. et al. Inhibitbn of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J. Clin. Invest. 107, 351-362 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 351-362
    • Epling-Burnette, P.K.1
  • 108
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson, J. & Jove, R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19, 6613-6626 (2000).
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 109
    • 33747881099 scopus 로고    scopus 로고
    • HSP27 and HSP70: Potentially oncogenic apoptosis inhibitors
    • Garrido, C. et al. HSP27 and HSP70: potentially oncogenic apoptosis inhibitors. Cell Cycle 2, 579-584 (2003).
    • (2003) Cell Cycle , vol.2 , pp. 579-584
    • Garrido, C.1
  • 110
    • 0037246247 scopus 로고    scopus 로고
    • On the role of Hsp27 in regulating apoptosis
    • Concannon, C. G., Gorman, A. M. & Samali, A. On the role of Hsp27 in regulating apoptosis. Apoptosis 8, 61-70 (2003).
    • (2003) Apoptosis , vol.8 , pp. 61-70
    • Concannon, C.G.1    Gorman, A.M.2    Samali, A.3
  • 112
    • 0033502429 scopus 로고    scopus 로고
    • Geldanamycin as a potential anti-cancer agent: Its molecular target and biochemical activity
    • Neckers, L., Schulte, T. W. & Mimnaugh, E. Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. Invest New Drugs 17, 361-373 (1999).
    • (1999) Invest New Drugs , vol.17 , pp. 361-373
    • Neckers, L.1    Schulte, T.W.2    Mimnaugh, E.3
  • 113
    • 20344381691 scopus 로고    scopus 로고
    • A phase I pharmacokinetic (PK) and pharmacodynamic (PD) trial of weekly 17-allylamino-17 demethoxygeldanamycin (17AAG, NSC-704057) in patients with advanced tumors
    • Ramanathan, R. K., Trump, D. L. & Eiseman, J. L. A phase I pharmacokinetic (PK) and pharmacodynamic (PD) trial of weekly 17-allylamino-17 demethoxygeldanamycin (17AAG, NSC-704057) in patients with advanced tumors. J. Clin. Oncol. 22, 3031 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3031
    • Ramanathan, R.K.1    Trump, D.L.2    Eiseman, J.L.3
  • 114
    • 0030802287 scopus 로고    scopus 로고
    • Molecular chaperones and the cytoskeleton
    • Liang, P. & MacRae, T. H. Molecular chaperones and the cytoskeleton. J. Cell Sci. 110, 1431-1440 (1997).
    • (1997) J. Cell Sci. , vol.110 , pp. 1431-1440
    • Liang, P.1    MacRae, T.H.2
  • 116
    • 0029775839 scopus 로고    scopus 로고
    • Do heat shock proteins have a role in breast cancer?
    • Conroy, S. E. & Latchman, D. S. Do heat shock proteins have a role in breast cancer? Br. J. Cancer 74, 717-721 (1996).
    • (1996) Br. J. Cancer , vol.74 , pp. 717-721
    • Conroy, S.E.1    Latchman, D.S.2
  • 117
    • 0032990651 scopus 로고    scopus 로고
    • Heat-shock-protein-27 (hsp27) expression in ovarian carcinoma: Relation in response to chemotherapy and prognosis
    • Arts, H. J. et al. Heat-shock-protein-27 (hsp27) expression in ovarian carcinoma: relation in response to chemotherapy and prognosis. Int. J. Cancer 64, 234-238 (1999).
    • (1999) Int. J. Cancer , vol.64 , pp. 234-238
    • Arts, H.J.1
  • 118
    • 0038326942 scopus 로고    scopus 로고
    • Identification of deferentially expressed proteins in human glioblastoma cell lines and tumors
    • Zhang, R., Tremblay, T. L., McDermid, A., Thibault, P. & Stanimirovic, D. Identification of deferentially expressed proteins in human glioblastoma cell lines and tumors. Glia 42, 194-208 (2003).
    • (2003) Glia , vol.42 , pp. 194-208
    • Zhang, R.1    Tremblay, T.L.2    McDermid, A.3    Thibault, P.4    Stanimirovic, D.5
  • 119
    • 0034671358 scopus 로고    scopus 로고
    • Heat shock protein expression independently predicts clinical outcome in prostate cancer
    • Cornford, P. A. et al. Heat shock protein expression independently predicts clinical outcome in prostate cancer. Cancer Res. 60, 7099-7105 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 7099-7105
    • Cornford, P.A.1
  • 120
    • 0034609765 scopus 로고    scopus 로고
    • Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo
    • Bruey, J. M. et al. Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. Oncogene 19, 4855-4863 (2000).
    • (2000) Oncogene , vol.19 , pp. 4855-4863
    • Bruey, J.M.1
  • 121
    • 4644237335 scopus 로고    scopus 로고
    • Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer
    • Rocchi, P. et al. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res. 64, 6595-6602 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 6595-6602
    • Rocchi, P.1
  • 122
    • 0030785821 scopus 로고    scopus 로고
    • HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs
    • Garrido, C. et al. HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res. 57, 2661-2667 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 2661-2667
    • Garrido, C.1
  • 123
    • 0031708908 scopus 로고    scopus 로고
    • Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy
    • Vargas-Roig, L. M., Gago, F. E., Tello, O., Aznar, J. C. & Ciocca, D. R. Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int. J. Cancer 79, 468-475 (1998).
    • (1998) Int. J. Cancer , vol.79 , pp. 468-475
    • Vargas-Roig, L.M.1    Gago, F.E.2    Tello, O.3    Aznar, J.C.4    Ciocca, D.R.5
  • 124
    • 0032722324 scopus 로고    scopus 로고
    • HSP27 inhibits cytochrome c-dependent activation of procaspase-9
    • Garrido, C. et al. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J. 13, 2061-2070 (1999).
    • (1999) FASEB J. , vol.13 , pp. 2061-2070
    • Garrido, C.1
  • 125
    • 0036143720 scopus 로고    scopus 로고
    • Hsp27 as a negative regulator of cytochrome C release
    • Paul, C. et al. Hsp27 as a negative regulator of cytochrome C release. Mol. Cell. Biol. 22, 816-834 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 816-834
    • Paul, C.1
  • 126
    • 0034963578 scopus 로고    scopus 로고
    • Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c
    • Concannon, C. G., Orrenius, S. & Samali, A. Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. Gene Expr. 9, 195-201 (2001).
    • (2001) Gene Expr. , vol.9 , pp. 195-201
    • Concannon, C.G.1    Orrenius, S.2    Samali, A.3
  • 127
    • 0003038882 scopus 로고    scopus 로고
    • Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries
    • Ho, S. P. et al. Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries. Nature Biotechnol. 16, 59-63 (1998).
    • (1998) Nature Biotechnol. , vol.16 , pp. 59-63
    • Ho, S.P.1
  • 128
    • 0031574209 scopus 로고    scopus 로고
    • A rapid in vitro method for obtaining RNA accessibility patterns for complementary DNA probes: Correlation with an intracellular pattern and known RNA structures
    • Matveeva, O., Felden, B., Audlin, S., Gesteland, R. F. & Atkins, J. F. A rapid in vitro method for obtaining RNA accessibility patterns for complementary DNA probes: correlation with an intracellular pattern and known RNA structures. Nucleic Acids Res. 25, 5010-5016 (1997).
    • (1997) Nucleic Acids Res. , vol.25 , pp. 5010-5016
    • Matveeva, O.1    Felden, B.2    Audlin, S.3    Gesteland, R.F.4    Atkins, J.F.5
  • 129
    • 0026770701 scopus 로고
    • Predicting antisense oligonucleotide inhibitory efficacy: A computational approach using histograms and thermodynamic indices
    • Stull, R. A., Taylor, L. A. SSzoka, F. C. Jr. Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices. Nucleic Acids Res. 20, 3501-3508 (1992).
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3501-3508
    • Stull, R.A.1    Taylor, L.A.2    Sszoka Jr., F.C.3
  • 130
    • 0036231778 scopus 로고    scopus 로고
    • Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice
    • Butler, M. et al. Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes 51, 1028-1034 (2002).
    • (2002) Diabetes , vol.51 , pp. 1028-1034
    • Butler, M.1
  • 131
    • 0035119936 scopus 로고    scopus 로고
    • Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats
    • Geary, R. S. et al. Pharmacokinetic properties of 2′-O-(2- methoxyethyl)-modified oligonucleotide analogs in rats. J. Pharmacol. Exp. Ther. 296, 890-897 (2001). Describes the pharmacokinetic attributes of second-generation 2′-MOE antisense oligonucleotides in animals.
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 890-897
    • Geary, R.S.1
  • 132
    • 0034780950 scopus 로고    scopus 로고
    • Drug properties of second-generation antisense oligonucleotides: How do they measure up to their predecessors?
    • Henry, S. P., Geary, R. S., Yu, R. & Levin, A. A. Drug properties of second-generation antisense oligonucleotides: how do they measure up to their predecessors? Curr. Opin. Investig. Drugs 2, 1444-1449 (2001).
    • (2001) Curr. Opin. Investig. Drugs , vol.2 , pp. 1444-1449
    • Henry, S.P.1    Geary, R.S.2    Yu, R.3    Levin, A.A.4
  • 133
    • 0030797705 scopus 로고    scopus 로고
    • Toxicological and pharmacokinetic properties of chemically modified antisense oligonucleotide inhibitors of PKC-α and C-raf kinase
    • Henry, S. P., Monteith, D., Bennett, F. & Levin, A. A. Toxicological and pharmacokinetic properties of chemically modified antisense oligonucleotide inhibitors of PKC-α and C-raf kinase. Anticancer Drug Des. 12, 409-420 (1997).
    • (1997) Anticancer Drug Des. , vol.12 , pp. 409-420
    • Henry, S.P.1    Monteith, D.2    Bennett, F.3    Levin, A.A.4
  • 134
    • 0032697942 scopus 로고    scopus 로고
    • A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
    • Levin, A. A. A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim. Biophys. Acta 1489, 69-84 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1489 , pp. 69-84
    • Levin, A.A.1
  • 135
    • 0030860587 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibitors for the treatment of cancer: 2. Toxicological properties of phosphorothioate oligodeoxynucleotides
    • Henry, S. P., Monteith, D. & Levin, A. A. Antisense oligonucleotide inhibitors for the treatment of cancer: 2. Toxicological properties of phosphorothioate oligodeoxynucleotides. Anticancer Drug Des. 12, 395-408 (1997).
    • (1997) Anticancer Drug Des. , vol.12 , pp. 395-408
    • Henry, S.P.1    Monteith, D.2    Levin, A.A.3
  • 136
    • 10744226217 scopus 로고    scopus 로고
    • Pharmacokinetics of a tumor necrosis factor-α phosphorothioate 2′-O-(2-methoxyethyl) modified antisense oligonucleotide: Comparison across species
    • Geary, R. S. et al. Pharmacokinetics of a tumor necrosis factor-α phosphorothioate 2′-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species. Drug Metab. Dispos. 31, 1419-1428 (2003).
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 1419-1428
    • Geary, R.S.1
  • 137
    • 77956770649 scopus 로고    scopus 로고
    • Second generation antisense oligonucleotides: 2′-modifications
    • Cook, P. Second generation antisense oligonucleotides: 2′-modifications. Annu. Rep. Med. Chem. 33, 313 (1998).
    • (1998) Annu. Rep. Med. Chem. , vol.33 , pp. 313
    • Cook, P.1
  • 138
    • 6344277190 scopus 로고    scopus 로고
    • LNA (locked nucleic acid): High-affinity targeting of complementary RNA and DNA
    • Vester, B. & Wengel, J. LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. Biochemistry 43, 13233-13241 (2004).
    • (2004) Biochemistry , vol.43 , pp. 13233-13241
    • Vester, B.1    Wengel, J.2
  • 139
    • 3042781558 scopus 로고    scopus 로고
    • Insulin-like growth factors and neoplasia
    • Pollak, M. N., Schernhammer, E. S. & Hankinson, S. E. Insulin-like growth factors and neoplasia. Nature Rev. Cancer 4, 505-518 (2004). Excellent contemporary review on the IGF1 axis in cancer.
    • (2004) Nature Rev. Cancer , vol.4 , pp. 505-518
    • Pollak, M.N.1    Schernhammer, E.S.2    Hankinson, S.E.3
  • 140
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: Biological actions
    • Jones, J. I. & Clemmons, D. R. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16, 3-34 (1995).
    • (1995) Endocr. Rev. , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 141
    • 0034455310 scopus 로고    scopus 로고
    • Overexpresston of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway
    • Myake, H., Nelson, C., Rennie, P. S. & Gleave, M. E. Overexpresston of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway. Endocrinology 141, 2257-2265 (2000).
    • (2000) Endocrinology , vol.141 , pp. 2257-2265
    • Myake, H.1    Nelson, C.2    Rennie, P.S.3    Gleave, M.E.4
  • 142
    • 0034213320 scopus 로고    scopus 로고
    • Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models
    • Miyake, H., Pollak, M. & Gleave, M. E. Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models. Cancer Res. 60, 3058-3064 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3058-3064
    • Miyake, H.1    Pollak, M.2    Gleave, M.E.3
  • 143
    • 0038756444 scopus 로고    scopus 로고
    • Castration-induced increases in insulin-like growth factor-binding protein 2 promotes proliferation of androgen-independent human prostate LNCaP tumors
    • Kiyama, S. et al. Castration-induced increases in insulin-like growth factor-binding protein 2 promotes proliferation of androgen-independent human prostate LNCaP tumors. Cancer Res. 83, 3575-3584 (2003).
    • (2003) Cancer Res. , vol.83 , pp. 3575-3584
    • Kiyama, S.1
  • 144
    • 0034682837 scopus 로고    scopus 로고
    • MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
    • Bae, J., Leo, C. P., Hsu, S. Y. & Hsueh, A. J. MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J. Biol. Chem. 275, 25255-25261 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 25255-25261
    • Bae, J.1    Leo, C.P.2    Hsu, S.Y.3    Hsueh, A.J.4
  • 146
    • 0036659905 scopus 로고    scopus 로고
    • L is an essential survival protein of human myeloma cells
    • L is an essential survival protein of human myeloma cells. Blood 100, 194-199 (2002).
    • (2002) Blood , vol.100 , pp. 194-199
    • Derenne, S.1
  • 147
    • 0031034078 scopus 로고    scopus 로고
    • Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions
    • Zhou, P., Qian, L., Kozopas, K. M. & Craig, R. W. Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. Blood 89, 630-643 (1997).
    • (1997) Blood , vol.89 , pp. 630-643
    • Zhou, P.1    Qian, L.2    Kozopas, K.M.3    Craig, R.W.4
  • 148
    • 0032928807 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers
    • Miyamoto, Y. et al. Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers. Oncology 56, 73-82 (1999).
    • (1999) Oncology , vol.56 , pp. 73-82
    • Miyamoto, Y.1
  • 149
    • 0037030583 scopus 로고    scopus 로고
    • Expression of apoptotic regulators and their significance in cervical cancer
    • Chung, T. K. et al. Expression of apoptotic regulators and their significance in cervical cancer. Cancer Lett. 180, 63-68 (2002).
    • (2002) Cancer Lett. , vol.180 , pp. 63-68
    • Chung, T.K.1
  • 150
    • 4444365042 scopus 로고    scopus 로고
    • MCL-1 expression in B-cell non-Hodgkin's lymphomas
    • Cho-Vega, J. H. et al. MCL-1 expression in B-cell non-Hodgkin's lymphomas. Hum. Pathol. 35, 1095-1100 (2004)
    • (2004) Hum. Pathol. , vol.35 , pp. 1095-1100
    • Cho-Vega, J.H.1
  • 151
    • 0036568524 scopus 로고    scopus 로고
    • Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy
    • Heere-Ress, E. et al. Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy. Int. J. Cancer 99, 29-34 (2002).
    • (2002) Int. J. Cancer , vol.99 , pp. 29-34
    • Heere-Ress, E.1
  • 152
    • 3042570258 scopus 로고    scopus 로고
    • Mcl-1 is a novel therapeutic target for human sarcoma: Synergistic inhibition of human sarcoma xenotransplants by a combination of mcl-1 antisense oligonucleotides with low-dose cyclophosphamide
    • Thallinger, C. et al. Mcl-1 is a novel therapeutic target for human sarcoma: synergistic inhibition of human sarcoma xenotransplants by a combination of mcl-1 antisense oligonucleotides with low-dose cyclophosphamide. Clin. Cancer Res. 10, 4185-4191 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4185-4191
    • Thallinger, C.1
  • 153
    • 0242329764 scopus 로고    scopus 로고
    • L antisense oligonucleotides radiosensitise colon cancer cells
    • L antisense oligonucleotides radiosensitise colon cancer cells. Br. J. Cancer 89, 1352-1357 (2003).
    • (2003) Br. J. Cancer , vol.89 , pp. 1352-1357
    • Wacheck, V.1
  • 154
    • 0029824669 scopus 로고    scopus 로고
    • Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
    • Sigalas, I., Calvert, A. H., Anderson, J. J., Neal, D. E. & Lunec, J. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nature Med. 2, 912-917 (1996).
    • (1996) Nature Med. , vol.2 , pp. 912-917
    • Sigalas, I.1    Calvert, A.H.2    Anderson, J.J.3    Neal, D.E.4    Lunec, J.5
  • 155
    • 0037441417 scopus 로고    scopus 로고
    • Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: In vitro and in vivo activities and mechanisms
    • Wang, H., Yu, D., Agrawal, S. & Zhang, R. Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms. Prostate 54, 194-205 (2003).
    • (2003) Prostate , vol.54 , pp. 194-205
    • Wang, H.1    Yu, D.2    Agrawal, S.3    Zhang, R.4
  • 156
    • 0141482040 scopus 로고    scopus 로고
    • Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy
    • Zhang, Z., Li, M., Wang, H., Agrawal, S. & Zhang, R. Antisense therapy targeting MDM2 oncogene in prostate cancer: effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc. Natl Acad. Sci. USA 100, 11636-11641 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11636-11641
    • Zhang, Z.1    Li, M.2    Wang, H.3    Agrawal, S.4    Zhang, R.5
  • 157
    • 12244260756 scopus 로고    scopus 로고
    • A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer
    • Adjei, A. A. et al. A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer. Clin. Cancer Res. 9, 115-123 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 115-123
    • Adjei, A.A.1
  • 158
    • 12444297637 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
    • Davis, A. J. et al. Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks. Invest. New Drugs 21, 85-97 (2003).
    • (2003) Invest. New Drugs , vol.21 , pp. 85-97
    • Davis, A.J.1
  • 159
    • 0032079761 scopus 로고    scopus 로고
    • BCR-ABL antisense oligodeoxynucleotide in vitro purging and autologous bone marrow transplantation for patients with chronic myelogenous leukemia in advanced phase
    • deFabritiis, P. et al. BCR-ABL antisense oligodeoxynucleotide in vitro purging and autologous bone marrow transplantation for patients with chronic myelogenous leukemia in advanced phase. Blood 91, 3156-3162 (1998).
    • (1998) Blood , vol.91 , pp. 3156-3162
    • DeFabritiis, P.1
  • 160
    • 0034608892 scopus 로고    scopus 로고
    • Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2
    • Nylandsted, J. et al. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc. Natl Acad. Sci. USA 97, 7871-7876 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7871-7876
    • Nylandsted, J.1
  • 161
    • 0026754351 scopus 로고
    • Acute- and chronic-phase chronic myelogenous leukemia colony-forming units are highly sensitive to the growth inhibitory effects of c-myb antisense oligodeoxynucleotides
    • Ratajczak, M. Z. et al. Acute- and chronic-phase chronic myelogenous leukemia colony-forming units are highly sensitive to the growth inhibitory effects of c-myb antisense oligodeoxynucleotides. Blood 79, 1956-1961 (1992).
    • (1992) Blood , vol.79 , pp. 1956-1961
    • Ratajczak, M.Z.1
  • 162
    • 0034130453 scopus 로고    scopus 로고
    • Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production
    • Tortora, G. et al. Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production. Clin. Cancer Res. 6, 2506-2512 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2506-2512
    • Tortora, G.1
  • 163
    • 0029977448 scopus 로고    scopus 로고
    • Antitumor activity of a osphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
    • Monia, B. P., Johnston, J. F., Geiger, T., Muller, M. & Fabbro, D. Antitumor activity of a osphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nature Med. 2, 668-675 (1996).
    • (1996) Nature Med. , vol.2 , pp. 668-675
    • Monia, B.P.1    Johnston, J.F.2    Geiger, T.3    Muller, M.4    Fabbro, D.5
  • 164
    • 0032984099 scopus 로고    scopus 로고
    • Phase I clinical/pharmacokinetic and pharmacodynamic trial of the c-raf-1 antisense oligonucleotide ISIS 5132 (CGP 69846A)
    • Stevenson, J. P. et al. Phase I clinical/pharmacokinetic and pharmacodynamic trial of the c-raf-1 antisense oligonucleotide ISIS 5132 (CGP 69846A). J. Clin. Oncol. 17, 2227-2236 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2227-2236
    • Stevenson, J.P.1
  • 165
    • 9244223546 scopus 로고    scopus 로고
    • Phase I trial of an antisense oligonucleotide OL(1)p 53 in hematologic malignancies
    • Bishop, M. R. et al. Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies. J. Clin. Oncol. 14, 1320-1326 (1996).
    • (1996) J. Clin. Oncol. , vol.14 , pp. 1320-1326
    • Bishop, M.R.1
  • 166
    • 85047697645 scopus 로고    scopus 로고
    • Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor
    • Eder, I. E. et al. Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor. Cancer Gene Ther. 9, 117-125 (2002).
    • (2002) Cancer Gene Ther. , vol.9 , pp. 117-125
    • Eder, I.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.