Induction of p53-dependent, insulin-like growth factor-binding protein- 3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Cα antisense oligonucleotide

Molecular Pharmacology

Volumn 55, Issue 2, 1999, Pages 396-402

  Shen, Li ^a   Dean, Nicholas M ^c   Glazer, Robert I ^a,b,d  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c ISIS PHARMACEUTICALS   (United States)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MONOCLONAL ANTIBODY; PROTEIN BAX; PROTEIN BCL X; PROTEIN KINASE C; PROTEIN P21; PROTEIN P53; SOMATOMEDIN BINDING PROTEIN 3;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN TUMOR; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GLIOBLASTOMA; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0033019842     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.2.396     Document Type: Article

References (54)

1. Ahmad S, Mineta T, Martuza RL and Glazer RI (1994) Antisense expression of protein kinase Cα inhibits the growth and tumorigenicity of human glioblastoma cells. Neurosurgery 35:904-909
2. Baltuch GH, Couldwell WT, Villemure JG and Yong VW (1993) Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen. Neurosurgery 33:495-501.
3. Bartek J, Iggo R, Gannon J and Lane DP (1990) Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 5:893-899.
4. Baserga R, Hongo A, Rubini M, Prisco M and Valentinis B (1997) The IGF-1 receptor in cell growth, transformation and apoptosis. Biochim Biophys Acta 1332:F105-F126.
5. Batistatou A and Green LA (1993) Internucleosomal DNA cleavage and neuronal cell survival/death. J Cell Biol 122:523-532.
6. Behrens M, Martinez JL, Mortatilla C and Renart J (1995) Apoptosis induced by protein kinase C inhibition in a neuroblastoma cell line. Cell Growth Diff 6:1375-1380.
7. Berchem GJ, Bosseler M, Sugars LY, Voeller, HJ, Zeitlin S and Gelmann EP (1995) Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells. Cancer Res 56:735-738.
8. Blobe G, Obeid LM and. Hannun YA (1994) Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev 13:411-431.
9. Borellini F and Glazer RI (1993) Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erytnroleukemia cell line TF-1. J Biol Chem 268:7923-7928.
10. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR and Kley N (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature (London) 377:646-649.
11. Canman CE and Kastan MB (1997) Role of p53 in apoptosis. Adv Pharmacol 41:429-460.
12. Couldwell WT, Antel JP and Yong VW (1992) Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C. Neurosurgery 31:717-724.
13. Couldwell WT, Hilton DR, He A, Chen TC, Sebat I, Weiss MH and Law RE (1994) Protein kinase C inhibitors induce apoptosis in human malignant cell lines. FEBS Lett 345:43-46.
14. Couldwell WT, Uhm JH, Antel JP and Yong VW (1991) Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro. Neurosurgery 29:880-887.
15. Couldwell WT, Weiss MH, Weiner LP, Degiogio CM, Hinton DR, Ehresmann GR, Conti PS and Apuzzo MJ (1993) Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high dose tamoxifen. Neurosurgery 32:485-490.
16. D'Ambrosio C, Ferber A, Resnicoff M and Baserga R (1996) A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res 56:4013-4020.
17. Dean N, McKay R, Miraglia L, Howard R, Cooper S, Giddings J, Nicklin P, Meister L, Ziel R, Geiger T, Muller M and Fabbro D (1996a) Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression. Cancer Res 56:3499-3507.
18. Dean NM, McKay R, Condon T and Bennett CF (1994) Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of ICAM raRNA by phorbol esters. J Biol Chem 269:16416-16424.
19. Dean NM, McKay R, Miraglia L, Geiger T, Muller M, Fabbro D and Bennett CF (1996b) Antisense oligonucleotides as inhibitors of signal transduction: Development from research tools to therapeutic agents. Biochem Soc Trans 24:623-629.
20. Drici M, Burklow TR, Haridasse V, Glazer RI and Woosley RL (1996) Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation 94:1471-1474.
21. Gescher A (1992) Towards a selective pharmacological modulation of protein kinase C-opportunities for the development of novel antineoplastic agents. Br J Cancer 66:10-19.
22. Gill ZP, Perks CM, Newcomb PV and Holly JMP (1997) Insulin-like growth factor-binding protein (IGFBP3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. J Biol Chem 272:25602-25607.
23. Glazer R (1994) Protein kinase C in multidrug resistance, neoplastic transformation and differentiation, in Protein Kinase C (Kuo J ed) pp. 171-198, Oxford University Press, Oxford.
24. Glazer RI (1997) Protein kinase C as a target for cancer therapy. Antisense Nucl Acid Drug Dev 7:235-238.
25. Haimovitz-Friedman A, Balaban N, McLoughlin M, Ehleiter D, Michaeli J, Vlodavsky I and Fuks Z (1994) Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation induced apoptosis. Cancer Res 54:2591-2597.
26. Herrmann M, Lorenz HM, Voll R, Grunke M, Woith W and Kalden JR (1994) A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res 22:5506-5507.
27. Ikemoto H, Tani E, Matsumoto T, Nakano A and Furuyama J-I (1995) Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor. J Neurosurg 83:1008-1016.
28. Kikkawa U, Kishimoto A and Nishizuka Y (1989) The protein kinase C family: Heterogeneity and its implications Annu Rev Biochem 58:31-44.
29. Ko LJ and Prives C (1996) p53: Puzzle and paradigm. Genes Dev 10:1054-1076.
30. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
31. Lopes UG, Erhardt P, Yao R and Cooper GM (1997) p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem 272:12893-12896.
32. Maki CG, Hulbregtse JM and Howley PM (1996) In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res 56:2649-2654.
33. Matsumoto H, Shimura M, Omatsu T, Okaichi K, Majima H and Ohnishi T (1994) p53 proteins accumulated by heat stress associate with heat shock proteins HSP72/HSC73 in human glioblastoma cells. Cancer Lett 87:39-46.
34. McConkey DJ, Hartzell P, Amador-Perez JF, Orrenius S and Jondal M (1989) Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex. J Immunol 143:1801-1806.
35. Mishima K, Ohno S, Shitara N, Yamaoka K and Suzuki K (1994) Opposite effects of the overexpression of protein kinase C and on the growth properties of human glioma cell line U251 MG. Biochem Biophys Res Commun 201:363-372.
36. Misra-Press A, Fields AP, Samols D and Goldthwait DA (1992) Protein kinase C isoforms in human glioblastoma cells. Glia 8:188-197.
37. Motyka B, Griebel PJ and Reynolds JD (1993) Agents that activate protein kinase C rescue sheep ileal Peyer's patch B cells from apoptosis. Eur J Immunol 23:1314-1321.
38. Nickerson T, Huynh H and Pollak M (1997) Insulin-like growth factor binding protein-3 induces apoptosis in MCF7 breast cancer cells. Biochem Biophys Res Commun 237:690-693.
39. Oh Y (1998) IGF-dependent regulation of breast cancer growth by IGF binding proteins. Breast Cancer Res Treat 47:283-293.
40. Rajah R, Valentine B and Cohen P (1997) Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53- and IGF-independent mechanism. J Biol Chem 172:12181-12188.
41. Reifenberger G, Deckert M and Wechsler W (1989) Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors. Acta Neuropathol 78:166-175.
42. Resnicoff M, Sell C, Rubini M, Coppola D, Ambrose D, Baserga R and Rubin R (1994) Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 64:2218-2222.
43. Schwartz GK, Haimovitz-Friedman A, Dhupar SK, Ehleiter D, Maslak P, Lai L, Loganzo EJ, Kelsen DP, Fuks Z and Albino AP (1995) Potentiation of apoptosis by treatment with the protein kinase C -specific inhibitor safingol in mitomycin C-treated gastric cancer cells. J Natl Cancer Inst 87:1394-1399.
44. Sharma N, Norman-O'Guin K and Shafit-Zagardo B (1991) Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary protein (GFAP) mRNA levels. Glia 4:572-579.
45. Shen L and Glazer RI (1998) Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-I-binding protein-3. Biochem Pharmacol 55:1711-1719.
46. Shimasaki SS, Shimonaka M, Zhang HP and Ling N (1991) Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. J Biol Chem 266:10646-10653.
47. Todo T, Shitara N, Nakamura H, Takakura K and Ikeda K (1991) Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors. Neurosurgery 29:399-404.
48. Van der Krol AR, Mol JNM and Stuitje AR (1988) Modulation of eukaryotic gene expression by complementary RNA or DNA sequences. BioTechniques 6:958-976.
49. Vertosick F (1992) The role of protein kinase C in the growth of human gliomas: Implications for therapy. Cancer J 5:328-331.
50. Xiao H, Goldthwait DA and Mapstone T (1994) The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC α,γ,ε, and ζ. J Neurosurg 81:734-740.
51. Yazaki T, Ahmad S, Chahlavi A, Zylber-Katz E, Dean NM, Martuza RL and Glazer RI (1996) Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C a phosphorothioate oligodeoxynucleotide. Mol Pharmacol 80:236-242.
52. Yong VW, Kim SU and Pleasure DE (1988) Growth factors for fetal and adult human astrocytes in culture. Brain Res 444:59-66.
53. Yu G, Ahmad S, Aquino A, Fairchild CR, Trepel JB, Cowan KH, Tsuruo T, Ohno S and Glazer RI (1991) Transfection with protein kinase C-a confers increased multidrug resistaace in MCF-7 cells expressing P-glycoprotein. Cancer Commun 3:181-189.
54. Zhan Q, Carrier F and Fornace AJ Jr (1993) Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol Cell Biol 13:4242-4250.