Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers

Oncology

Volumn 56, Issue 1, 1999, Pages 73-82

  Miyamoto, Yoshiharu ^a   Hosotani, Ryo ^a   Wada, Michihiko ^a   Lee, Jeon Uk ^a   Koshiba, Takatomo ^a   Fujimoto, Koji ^a   Tsuji, Shouichirou ^a   Nakajima, Sanae ^a   Doi, Ryuichiro ^a   Kato, Masayuki ^a   Shimada, Yuta ^a   Imamura, Masayuki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Bcl 2 family protein; Carcinogenesis; Immunohistochemistry; Pancreatic cancer; Western blotting

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2;

ARTICLE; CARCINOGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; CARCINOMA, PAPILLARY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0032928807     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000011933     Document Type: Article

References (40)

1. Manning FC, Patierno SR: Apoptosis: Inhibitor or instigator of carcinogenesis? Cancer Invest 1996;14:455-465.
2. Kerr JF, Winterford CM, Harmon BV: Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994;73:2013-2026.
3. Korsmeyer SJ: Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood 1992;80:879-886.
4. Tsujimoto Y, Cossman J, Jaffe E, Croce CM: Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985;228:1440-1443.
5. Williams GT, Smith CA: Molecular regulation of apoptosis: Genetic controls on cell death. Cell 1993;74:777-779.
6. Yin XM, Oltval ZN, Korsmeyer SJ: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax (see comments). Nature 1994;369:321-323.
7. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994;124:1-6.
8. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heteodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-619.
9. Boise LH, Gonzalez Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G. Thompson CB: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993;74:597-608.
10. Hanada M, Aime Sempe C, Sato T: Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J Biol Chem 1995;270:11962-11969.
11. Datta R, Manome Y, Taneja N, Boise LH, Weichselbaum R. Thompson CB, Slapak CA, Kufe D: Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation. Cell Growth Differ 1995;6:363-370.
12. Dole MG, Jasty R, Cooper MJ, Thompson CB, Nunez G, Castle VP: Bcl-XL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis. Cancer Res 1995;55: 2576-2582.
13. Gauthier ER, Piche L, Lemieux G, Lemieux R: Role of bcl-X(L) in the control of apoptosis in murine myeloma cells. Cancer Res 1996;56: 1451-1456.
14. Han Z, Chatterjee D, Early J, Pantazis P, Hendrickson EA. and Wyche JH: Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-XL. Cancer Res 1996;56:1621-1628.
15. Zhan Q, Alamo I, Yu K, Boise LH, Cherney B, Tosato G, O'Connor PM, Fornace AJ Jr: The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p53 function. Oncogene 1996;13:2287-2293.
16. Krajewska M, Krajewski S, Epstein JI, Shabaik A, Sauvageot J, Song K, Kitada S, Reed JC: Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol 1996;148:1567-1576.
17. Krajewska M, Moss SF, Krajewski S, Song K, Holt PR, Reed JC: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 1996;56:2422-2427.
18. Krajewska M, Fenoglio Preiser CM, Krajewski S, Song K, Macdonald JS, Stemmerman G, Reed JC: Immunohistochemical analysis of Bcl-2 family proteins in adenocarcinomas of the stomach. Am J Pathol 1996;149:1449-1457.
19. Pezzella F, Tse AGD, Cordell JL, Pulford KAF, Gatter KC. Mason Y: Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol 1990;137:225-232.
20. Strobel T, Swanson L, Korsmeyer S, Cannistra SA: Radiation induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells. Oncogene 1997; 14:2753-2758.
21. Cherbonnel-Lasserre C, Gauny S, Kronenberg A: Suppression of apoptosis by Bcl-2 or Bcl-XL promotes susceptibility to mutagenesis. Oncogene 1996;13:1489-1497.
22. Wada M, Doi R, Hosotani R, Lee J-U, Fujimoto K, Koshiba T, Miyamoto Y, Imamura M: Expression of Bcl-2 and PCNA in ductal cells after pancreatic duct ligation in rats. Pancreas 1997;15:176-182.
23. Bronner MP, Culin C, Reed JC, Furth EE: The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 1995;146:20-26.
24. Bosari S, Moneghini L, Graziani D, Lee AK, Murray JJ, Coggi G, Viale G: bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum Pathol 1995;26: 534-540.
25. Castle VP, Heidelberger KP, Bromberg J, Ou X, Dole M, Nunez G: Expression of the apoptosis-suppressing protein bcl-2 in neuroblastoma is associated with unfavorable histology and N-myc amplification. Am J Pathol 1993; 143:1543-1550.
26. Bubendorf L, Sauter G, Moch H, Jordan P, Blochlinger A, Gasser TC, Mihatasch MJ: Prognostic significance of Bcl-2 in clinically localized prostate cancer. Am J Pathol 1996; 148:1557-1565.
27. Binder C, Marx D, Overhoff R, Binder L, Schauer A, Hiddemann W: Bcl-2 protein expression in breast cancer in relation to established prognostic factors and other clinico-pathological variables. Ann Oncol 1995;6: 1005-1010.
28. Herod JJ, Eliopoulos AG, Warwick J, Niedobitek G, Young LS, Kerr DJ: The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma. Cancer Res 1996;56:2178-2184.
29. Pezzella F, Turley H, Kuzu I, Tungekar MF, Dunnill MS, Pierce CB, Harris A, Gatter KC, Mason DY: bcl-2 protein in non-small-cell lung carcinoma (see comments). N Engl J Med 1993;329:690-694.
30. Ohhashi K, Murakami Y, Maruyama M, Takekoshi T, Ohta H, Ohhashi I: Four cases of mucous secreting pancreatic cancer (Japanese). Prog Dig Endosc 1982;20:348-351.
31. Longnecker DS: Intraductal papillary-mucinous tumors of the pancreas (editorial comment). Arch Pathol Lab Med 1995;119:197-198.
32. Pellegata NS, Sessa F, Renault B, Bonato M, Leone BE, Solcia E, Ranzani GN: K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions. Cancer Res 1994;54: 1556-1560.
33. Zhang SY, Ruggeri B, Agarwal P, Sorling AF, Obara T, Ura H, Namiki M, Klein Szanto AJ: Immunohistochemical analysis of p53 expression in human pancreatic carcinomas. Arch Pathol Lab Med 1994;118:150-154.
34. Lemoine NR, Jain S, Hughes CM, Staddon SL, Maillet B, Hall PA, Kloppel G: Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 1992;102:230-236.
35. Krajewski S, Krajewska M, Shabaik A, Wang HG, Irie S, Fong L, Reed JC: Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res 1994;54:5501-5507.
36. Reed JC: Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 1995;7:541-546.
37. Lee J-U, Hosotani R, Fujimoto K, Koshiba T, Miyamoto Y, Doi R, Imamura M: Relationship between oncoproteins (Bax, Bcl-2 and Bcl-X) and cellular susceptibility to radiation in pancreatic cancer cells (abstract 998). Gastroenterology 1997;112:A601.
38. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 1995;80:285-291.
39. Farrow SN, White JH, Martinou I, Raven T, Pun KT, Grinham CJ, Martinou JC, Brown R: Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature 1995;374: 731-733.
40. TNM: Classification of Malignant Tumors, ed 4. Berlin, Springer, 1987.