Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 20, 2003, Pages 11636-11641

  Zhang, Zhuo ^a   Li, Mao ^a   Wang, Hui ^a   Agrawal, Sudhir ^b   Zhang, Ruiwen ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b HYBRIDON INC   (United States)

Author keywords

Bax; E2F1; Oligonucleotides; p21; p51

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; MUTANT PROTEIN; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CELL DIVISION; DNA PRIMERS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; NUCLEAR PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2;

ANIMALIA;

EID: 0141482040     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1934692100     Document Type: Article

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