Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy

International Journal of Cancer

Volumn 79, Issue 5, 1998, Pages 468-475

  Vargas Roig, Laura M ^a   Gago, Francisco E ^b   Tello, Olga ^b   Aznar, Juan C ^b   Ciocca, Daniel R ^a  

^a Laboratorio de Reproduccion y Lactancia Mendoza   (Argentina)

^b Prov Regulatory Agency of Mendoza   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; METHOTREXATE;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOPSY; BREAST NEOPLASMS; CELL DIVISION; CISPLATIN; CYCLOPHOSPHAMIDE; DISEASE-FREE SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; EPIRUBICIN; FLUOROURACIL; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; METHOTREXATE; MIDDLE AGED; NUCLEOLUS ORGANIZER REGION; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; SILVER STAINING;

EID: 0031708908     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19981023)79:5<468::AID-IJC4>3.0.CO;2-Z     Document Type: Article

References (21)

1. CIOCCA, D.R., CLARK, G.M., TANDON, A.K., FUQUA, S.A.W., WELCH, W.J. and MCGUIRE, W.L., Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J. nat. Cancer Inst., 85, 570-574 (1993a).
2. CIOCCA, D.R., FUQUA, S.A.W., LOCK-LIM, S., TOFT, D.O., WELCH, W.J. and MCGUIRE, W.L., Response of human breast cancer cells to heat shock and chemotherapeutic drugs. Cancer Res., 52, 2648-3654 (1992).
3. CIOCCA, D.R., OESTERREICH, S., CHAMNESS, G.C., MCGUIRE, W.L. and FUQUA, S.A.W., Biological and clinical implications of heat shock protein 27000 (Hsp27): a review. J. nat. Cancer Inst., 85, 1558-1570 (19936).
4. CIOCCA, D.R. and VARGAS-ROIG, L.M., Heat shock proteins and drug resistance in breast cancer. In: S.D. Bernal (ed.). Drug resistance in oncology, pp. 167-190, Marcel Dekker, New York (1997).
5. ELIA, G. and SANTORO, M.G., Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells. Biochem. J., 300, 201-209 (1994).
6. ENGEL, K., KNAUF, U. and GAESTEL, M., Generation of antibodies against human hsp27 and murine hsp25 by immunization with a chimeric small heat shock protein. Biomed. Biochem. Acta, 9, 1065-1071 (1991).
7. GARRIDO, C., MEHLEN, P., FROMENTIN, A., HAMMANN, A., ASSEM, M., ARRIGO, A.-P. and CHAUFFERT, B., Inconstant association between 27-kDa heat-shock protein (Hsp27) content and doxorubicin resistance in human colon cancer cells. Europ. J. Biochem., 237, 653-659 (1996).
8. HUOT, J., ROY, G., LAMBERT, H., CHRETIEN, P. and LANDRY, J., Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Cancer Res., 51, 5245-5252 (1991).
9. HURLIMANN, J., GEBHARD, S. and GOMEZ, F., Oestrogen receptor, progesterone receptor, pS2, ERD5, HSP27 and cathepsin D in invasive ductal breast carcinomas. Histopathology, 23, 239-248 (1993).
10. LEE, Y.J. and DEWEY, W.C., Thermotolerance induced by heat, sodium arsenite, or puromycin: its inhibition and differences between 43°C and 45°C. J. cell. Physiol., 135, 397-406 (1988).
11. LIU, F.-F., MILLER, N., LEVIN, W., ZANKE, B., COOPER, B., HENRY, M., SHERAR, M.D., PINTILIE, M., HUNT, J.W. and HILL, R.P., The potential role of HSP70 as an indicator of response to radiation and hyperthermia treatments for recurrent breast cancer. Int. J. Hyperthermia, 12, 197-208 (1996).
12. LO, S.-S., WANG, H.-C., SHYR, Y.-M. and LUI, W.-Y, Can the hormonal status of primary breast cancer be altered by neoadjuvant chemotherapy? J. surg. Oncol., 57, 94-96 (1994).
13. MAKRIS, A., POWLES, T.J., ALLRED, D.C., DOWSETT, M., GREGORY, R.K., FERNANDO, I.N., ASHLEY, S.E., TROTT, P.A., TITLEY, J., ORMEROD, M.G. and OSBORNE, C.K., Predicting response to neoadjuvant chemoendocrine therapy in primary breast cancer. Breast Cancer Res. Treat., 37, 35 (A12) (1996).
14. OESTERREICH, S., HILSENBECK, S.G., CIOCCA, D.R., ALLRED, D.C., CLARK, G.M., CHAMNESS, G.C., OSBORNE, C.K. and FUQUA, S.A.W., The small heat shock protein hsp27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients. Clin. Cancer Res., 2, 1199-1206 (1996).
15. RASBRIDGE, S.A., GILLETT, C.E., SEYMOUR, A.-M., PATEL, K., RICHARDS, M.A., RUBENS, R.D. and MILLIS, R.R., The effects of chemotherapy on morphology, cellular proliferation, apoptosis and oncoprotein expression in primary breast carcinoma. Brit. J. Cancer, 70, 335-341 (1994).
16. RICHARDS, E.H., HICKEY, E., WEBER, L. and MASTERS, J.R.W., Effect of overexpression of the small heat shock protein hsp27 on the heat and drug sensitivities of human testis tumor cells. Cancer Res., 56, 2446-2451 (1996).
17. SEYMOUR, L., BEZWODA, W.R. and MEYER, K., Tumor factors predicting for prognosis in metastatic breast cancer. Cancer,; 66, 2390-2394 (1990).
18. SHI, S.-R., IMAM, S.A., YOUNG, L., COTE, R.J. and TAYLOR, C.R., Antigen retrieval immunohistochemistry under the influence of pH using monoclonal antibodies. J. Histochem. Cytochem., 43, 193-201 (1995).
19. VARGAS-ROIG, L.M., FANELLI, M.A., LÓPEZ, L.A., GAGO, F.E., TELLO, O., AZNAR, J.C. and CIOCCA, D.R., Heat shock proteins and cell proliferation in human breast cancer biopsy samples. Cancer Detect. Prevent., 21, 441-451 (1997).
20. VELAZQUEZ, J.M. and LINDQUIST, S., Hsp70: nuclear concentration during environmental stress and cytoplasmic storage during recovery. Cell, 36, 655-662 (1984).
21. YUN, J., TOMIDA, A., NAGATA, K. and TSURUO, T., Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncol. Res., 7, 583-590 (1995).