Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy) ethyl chemistry

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 3, 2001, Pages 934-940

  Zellweger, Tobias ^a   Miyake, Hideaki ^a   Cooper, Scott ^b   Chi, Kim ^a   Conklin, Boyd S ^b   Monia, Brett P ^b   Gleave, Martin E ^a,c  

^a VANCOUVER PROSTATE CENTRE   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CLUSTERIN; DOCETAXEL; LIPOFECTIN; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENTIATION; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN MODIFICATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, NORTHERN; CLUSTERIN; ELECTROPHORESIS, CAPILLARY; GLYCOPROTEINS; HALF-LIFE; HUMANS; MALE; MICE; MOLECULAR CHAPERONES; NEOPLASM PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; PACLITAXEL; PROSTATIC NEOPLASMS; RNA, MESSENGER; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0034883854     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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