NASH: A mitochondrial disease

Journal of Hepatology

Volumn 42, Issue 6, 2005, Pages 928-940

  Pessayre, Dominique ^a   Fromenty, Bernard ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; REACTIVE OXYGEN METABOLITE;

AGING; APOPTOSIS; BACTERIUM; BIOGENESIS; CELL DEATH; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY; FATTY LIVER; FIBROSIS; GENETIC POLYMORPHISM; GLUCOSE TRANSPORT; HOMEOSTASIS; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; LIPID PEROXIDATION; LIPOGENESIS; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; MALLORY BODY; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; OXIDATION; PANCREAS ISLET BETA CELL; PHOSPHORYLATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SKELETAL MUSCLE; TRANSCRIPTION INITIATION;

ANIMALS; FATTY LIVER; HUMANS; MITOCHONDRIAL DISEASES;

EID: 18844389970     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.03.004     Document Type: Review

References (122)

1. P.G. Kopelman Obesity as a medical problem Nature 404 2000 635 643
2. J.M. Clark, L. Brancati, and A.M. Diehl Nonalcoholic fatty liver disease Gastroenterology 122 2002 1649 1657
3. D. Pessayre, A. Berson, B. Fromenty, and A. Mansouri Mitochondria in steatohepatitis Sem Liver Dis 21 2001 57 69
4. D. Pessayre, A. Mansouri, and B. Fromenty Mitochondrial dysfunction in steatohepatitis Am J Physiol (Gastrointest Liver Physiol) 282 2002 G193 G199
5. Pessayre, D. Mitochondrial injury in steatohepatitis. In: Frederick J Suchy, J Gregory Fitz and Jacquelyn J Maher, Course Directors. American Association for the Study of Liver Diseases Postgraduate Course: mechanisms of acute and chronic liver diseases: implications for diagnosis, pathogenesis and treatment. AASLD Postgraduate Course, 2002. pp. 97-103.
6. B. Fromenty, M.A. Robin, A. Igoudjil, A. Mansouri, and D. Pessayre The ins and outs of mitochondrial dysfunction in NASH Diabetes Metab 30 2004 121 138
7. D. Pessayre, B. Fromenty, and A. Mansouri Mitochondrial injury in steatohepatitis Eur J Gastroenterol Hepatol 16 2004 1095 1105
8. B. Fromenty, and D. Pessayre Mitochondrial injury and NASH G. Farrell J. Jacob P. Hall A. McCullough Mitochondrial injury and NASH 2005 Blackwell Publishing Oxford, UK 132 142
9. D. Yang, Y. Oyaizu, H. Oyaizu, G.J. Olsen, and C.R. Woese Mitochondrial origins Proc Natl Acad Sci USA 82 1985 4443 4447
10. J.W. Taanman The mitochondrial genome: structure, transcription, translation and replication Biochim Biophys Acta 1410 1999 103 123
11. T. Mourier, A.J. Hansen, E. Willerslev, and P. Arctander The human genome projects reveals a continuous transfer of large mitochondrial fragments to the nucleus Mol Biol Evol 18 2001 1833 1837
12. J.D. McGarry, and D.W. Foster Regulation of hepatic fatty acid oxidation and ketone body production Ann Rev Biochem 49 1980 395 420
13. R.C. Scarpulla Nuclear control of respiratory chain expression in mammalian cells J Bioenerg Biomembr 29 1997 109 119
14. C. Frøsig, S.B. Jørgensen, D.G. Hardie, E.A. Richter, and J.F.P. Wojtaszewski 5′-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle Am J Physiol Endocrinol Metab 286 2004 E411 E417
15. W.W. Winder, B.F. Holmes, D.S. Rubink, E.B. Jensen, M. Chen, and J.O. Holloszy Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle J Appl Physiol 88 2000 2219 2226
16. E.O. Ojuka Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle Proc Nutr Soc 63 2004 275 278
17. H. Wu, S.B. Kanatous, F.A. Thurmond, T. Gallardo, E. Isotani, and R. Bassel-Duby Regulation of mitochondrial biogenesis in skeletal muscle by CaMK Science 296 2002 349 352
18. R.B. Vega, J.M. Huss, and D.P. Kelly The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in the transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes Mol Cell Biol 20 2000 1868 1876
19. J.J. Lehman, P.M. Barger, A. Kovacs, J.E. Saffitz, D.M. Medeiros, and D.P. Kelly Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis J Clin Invest 106 2000 847 856
20. H. Zong, J.M. Ren, L.H. Young, M. Pypaert, J. Mu, and M.J. Birnbaum AMP kinase is required for mitochondrial biogenesis in response to chronic energy deprivation Proc Natl Acad Sci USA 25 2002 15983 15987
21. U. Wisløff, S.M. Najjar, Ø. Ellingsen, P.M. Haram, S. Swoap, and Q. Al-Share Cardiovascular risk factors emerge after artificial selection for low aerobic capacity Science 307 2005 418 420
22. S.R. Colberg, J.A. Simoneau, F.L. Thaete, and D.E. Kelley Skeletal muscle utilization of free fatty acids in women with visceral obesity J Clin Invest 95 1995 1846 1853
23. J.A. Simoneau, J.H. Veerkamp, L.P. Turcotte, and D.E. Kelley Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss FASEB J 13 1999 2051 2060
24. D.A. Antonetti, C. Reynet, and C.R. Kahn Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus J Clin Invest 95 1995 1383 1388
25. D.E. Kelley, J. He, E.V. Menshikova, and V.B. Ritov Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes Diabetes 51 2002 2944 2950
26. K.F. Petersen, S. Dufour, D. Befroy, R. Garcia, and G.I. Shulman Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N Engl J Med 350 2004 664 671
27. V.K. Mootha, C.M. Lindgren, K.F. Eriksson, A. Subramanian, S. Sihag, and J. Lehar PGC-1a-responsive genes involved in oxidative phosphorylation are coordinately down-regulated in human diabetes Nat Genet 34 2003 267 273
28. M.E. Patti, A.J. Butte, S. Crunkhorn, K. Cusi, R. Berria, and S. Kashyap Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1 Proc Natl Acad Sci USA 100 2003 8466 8471
29. Y.L. Muller, C. Bogardus, O. Pedersen, and L. Baier A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor γ coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima indians Diabetes 52 2003 895 898
30. J. Ek, G. Andersen, S.A. Urhammer, P.H. Gaede, T. Drivsholm, and K. Borch-Johnsen Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus Diabetologia 44 2001 2220 2226
31. K. Hara, K. Tobe, T. Okada, H. Kadowaki, Y. Akanuma, and C. Ito A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes Diabetologia 45 2003 740 743
32. K.F. Petersen, D. Befroy, S. Dufour, J. Dziura, C. Ariyan, and D.L. Rothman Mitochondrial dysfunction in the elderly: possible role in insulin resistance Science 300 2003 1140 1142
33. V. Rimbert, Y. Boirie, M. Bedu, J.F. Hocquette, P. Ritz, and B. Morio Muscle oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity FASEB J 18 2004 737 739
34. Y. Wang, Y. Michikawa, C. Mallidis, L. Woodhouse, K.E. Yarescheski, and C.A. Miller Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication Proc Natl Acad Sci USA 98 2001 4022 4027
35. 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents Diabetes 48 1999 1600 1606
36. P.R. Shepherd, and B.B. Kahn Glucose transporters and insulin action. Implications for insulin resistance and diabetes mellitus N Engl J Med 341 1999 248 257
37. J. Hirosumi, G. Tuncman, L. Chang, C.Z. Görgün, K.T. Uysal, and K. Maeda A central role for JNK in obesity and insulin resistance Nature 420 2002 353 356
38. J.K. Kim, J.J. Fillmore, M.J. Sunshine, B. Albrecht, T. Higashimori, and D.W. Kim PKC-θ knockout mice are protected from fat-induced insulin resistance J Clin Invest 114 2004 823 827
39. U. Özcan, Q. Cao, E. Yilmaz, A.H. Lee, N.N. Iwakoshi, and E. Özdelen Endoplasmic reticulum stress links obesity, insulin action and type 2 diabetes Science 306 2004 457 461
40. P. Maechler, and C.B. Wollheim Mitochondrial function in normal and diabetic β-cells Nature 414 2001 807 812
41. K.S. Polonsky, J. Sturis, and G.I. Bell Non-insulin-dependent diabetes mellitus: a genetically programmed failure of beta cell to compensate for insulin resistance N Engl J Med 334 1996 777 783
42. Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 2005;48:282-289.
43. N. Lameloise, P. Muzzin, M. Prentki, and F. Assimacopoulos-Jeannet Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50 2001 802 809
44. S. Krauss, C.Y. Zhang, L. Scorrano, L.T. Dalgaard, J. St-Pierre, and S.T. Grey Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β-cell dysfunction J Clin Invest 112 2003 1831 1842
45. J.W. Joseph, V. Koshkin, M.C. Saleh, W.I. Sivitz, C.Y. Zhang, and B.B. Lowell Free fatty acid-induced β-cell defects are dependent on uncoupling protein-2 expression J Biol Chem 279 2004 51049 51056
46. M. Sasahara, M. Nishi, H. Kawashima, K. Ueda, S. Sakagashira, and H. Furuta Uncoupling protein 2 promoter polymorphism - 866G/A affects its expression in β-cells and modulates clinical profiles of Japanese type 2 diabetic patients Diabetes 53 2004 482 485
47. G. Sesti, M. Gardellini, M.A. Marini, S. Frontoni, M. D'Adamo, and S. Del Guerra A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects Diabetes 52 2003 1280 1283
48. H. Esterbauer, C. Schneitler, H. Oberkofler, C. Ebenbichler, B. Paulweber, and F. Sandhofer A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans Nat Genet 28 2001 178 183
49. Leu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness Nat Genet 1 1992 368 371
50. S.W. Ballinger, J.M. Shoffner, E.V. Hedaya, I. Trounce, M.A. Polak, and A. Deborah Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion Nat Genet 1 1992 11 15
51. W. El-Assaad, J. Buteau, M.L. Peyot, C. Nolan, R. Roduit, and S. Hardy Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death Endocrinology 144 2003 4154 4163
52. A.E. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R.A. Rizza, and P.C. Butler β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes Diabetes 52 2003 102 110
53. P. Valet, G. Tavernier, I. Castan-Laurell, J. Sébastien, J.S. Saulnier-Blache, and D. Langin Understanding adipose tissue development from transgenic animal models J Lipid Res 43 2002 835 860
54. E.S. Gorden Non-esterified fatty acids in blood of obese and lean subjects Am J Clin Nutr 8 1960 740 747
55. J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 2004 147 152
56. H. Yamashita, M. Takenoshita, M. Sakurai, R.K. Bruick, W.J. Henzel, and W. Shillinglaw A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver Proc Natl Acad Sci USA 98 2001 9116 9121
57. K. Lizuka, R.K. Bruick, G. Liang, J.D. Horton, and K. Uyeda Deficiency of carbohydrate response element binding protein (ChREBP) reduces lipogenesis as well as glycolysis Proc Natl Acad Sci USA 101 2004 7281 7286
58. M. Matsumoto, W. Ogawa, K. Akimoto, H. Inoue, K. Miyake, and K. Furukawa PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity J Clin Invest 112 2003 935 944
59. M. Montminy, and S.H. Koo Outfoxing insulin resistance? Nature 432 2004 958 959
60. C. Wolfrum, E. Asilmaz, E. Luca, J.M. Friedman, and M. Stoffel Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes Nature 432 2004 1027 1032
61. F. Diraison, E. Dusserre, H. Vidal, M. Sothier, and M. Beylot Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity Am J Physiol Endocrinol Metab 282 2002 E46 E51
62. K. Tran, G. Thorne-Tjomsland, C.J. DeLong, Z. Cui, J. Shan, and L. Burton Intracellular assembly of very low density lipoproteins containing apolipoprotein B100 in rat hepatoma McA-RH777 cells J Biol Chem 277 2002 31187 31200
63. E.D. Bartels, M. Lauritsen, and L.B. Nielsen Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice Diabetes 51 2002 1233 1239
64. M.A. Austin, M.C. King, J.M. Vranizan, and R.M. Krauss Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk Circulation 82 1990 649 651
65. C.J. Packard Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein Biochem Soc Trans 31 2003 1066 1069
66. M. Charlton, R. Sreekumar, D. Rasmussen, K. Lindor, and S. Nair Apolipoprotein synthesis in nonalcoholic steatohepatitis Hepatology 35 2002 898 904
67. J.D. Sparks, and C.E. Sparks Obese Zucker (fa/fa) rats are resistant to insulin's inhibitory effects on hepatic apo B secretion Biochem Biophys Res Commun 205 1994 417 422
68. E. Levy, D. Sinnett, L. Thibault, T.D. Nguyen, E. Delvin, and D. Menard Insulin modulation of newly synthesized apolipoproteins B-100 and E in human fetal intestine: gene expression and mRNA editing are not involved FEBS Lett 393 1996 253 258
69. G. Musso, R. Gambino, F. De Michieli, M. Cassader, M. Rizzetto, and M. Durazzo Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis Hepatology 37 2003 909 916
70. L.J. Brady, P.S. Brady, D.R. Romsos, and C.L. Hoppel Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice Biochem J 231 1985 439 444
71. Z. Li, S. Yang, H. Lin, J. Huang, P.A. Watkins, and A.B. Moser Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology 37 2003 343 350
72. A.J. Sanyal, C. Campbell-Sargent, F. Mirshahi, W.B. Rizzo, M.J. Contos, and R.K. Sterling Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183 1192
73. N. Chalasani, J.C. Gorki, M.S. Asghar, A. Asghar, B. Foresman, and S.D. Hall Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis Hepatology 37 2003 544 550
74. 13C-octanoate breath test Am J Gastroenterol 98 2003 2335 2365
75. B. Fromenty, and D. Pessayre Inhibition of mitochondrial β-oxidation as a mechanism of hepatotoxicity Pharmacol Ther 67 1995 101 154
76. G.A. Cook, and M.S. Gamble Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA J Biol Chem 262 1987 2050 2055
77. J.C. Collins, I.H. Scheinberg, D.R. Giblin, and I. Sternlieb Hepatic peroxisomal abnormalities in abetalipoproteinemia Gastroenterology 97 1989 766 770
78. D. De Craemer, M. Pauwels, and C. Van den Branden Alterations of peroxisomes in steatosis of the human liver: a quantitative study Hepatology 22 1995 744 752
79. R.A. Memon, L.H. Tecott, K. Nonogaki, A. Beigneux, A.H. Moser, and C. Grunfeld Up-regulation of peroxisome proliferator-activated receptors (PPAR-α) and PPAR-γ messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-γ- responsive adipose tissue-specific genes in the liver of obese diabetic mice Endocrinology 41 2000 4021 4031
80. S. Kersten, J. Seydoux, J.M. Peters, F.J. Gonzalez, B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting J Clin Invest 103 1999 1489 1498
81. T. Nakatani, N. Tsuboyama-Kasaoka, M. Takahashi, S. Miura, and O. Ezaki Mechanism for peroxisome proliferator-activated receptor-α activator-induced up-regulation of UCP-2 mRNA in rodent hepatocytes J Biol Chem 277 2002 9562 9569
82. K.D. Chavin, S.Q. Yang, H.Z. Lin, J. Chatham, V.P. Chacko, and J.B. Hoek Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion J Biol Chem 274 1999 5692 5700
83. C. Pecqueur, M.C. Alves-Guerra, C. Gelly, C. Lévi-Meyrueis, E. Couplan, and S. Collins Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation J Biol Chem 276 2001 8705 8712
84. H. Cortez-Pinto, J. Chatham, V.P. Chacko, C. Arnold, A. Rashid, and A.M. Diehl Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis. A pilot study JAMA 282 1999 1659 1664
85. S.H. Caldwell, R.H. Swerdlow, E.M. Khan, J.C. Iezzoni, E.E. Hespenheide, and J.K. Parks Mitochondrial abnormalities in nonalcoholic steatohepatitis J Hepatol 31 1999 430 434
86. M. Haque, F. Mirshahi, C. Campbell-Sargent, R.K. Sterling, V.A. Luketic, and V.A. Shiffman Nonalcoholic steatohepatitis (NASH) is associated with hepatocyte mitochondrial DNA depletion Hepatology 36 2002 403A
87. M. Pérez-Carreras, P. Del Hoyo, M.A. Martin, J.C. Rubio, A. Martin, and G. Castellano Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis Hepatology 38 2003 999 1007
88. M.D. Weltman, G.C. Farrell, P. Hall, M. Ingelman-Sundberg, and C. Liddle Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis Hepatology 27 1998 128 133
89. R.N. Fiorini, S.F. Shafizadeh, and K.D. Chavin Primary non-function in steatotic livers is due to differential Toll-like expression and endotoxin sensitivity Hepatology 36 2002 198A
90. N. Enomoto, Y. Takei, M. Hirose, K. Ikejima, H. Miwa, and T. Kitamura Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-α production Gastroenterology 123 2002 291 300
91. P. Lettéron, B. Fromenty, B. Terris, C. Degott, and D. Pessayre Acute and chronic steatosis lead to in vivo lipid peroxidation in mice J Hepatol 24 1996 200 208
92. I.A. Leclercq, G.C. Farrell, J. Field, D.R. Bell, F.J. Gonzalez, and G.R. Robertson CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis J Clin Invest 105 2001 1067 1075
93. J. Chen, S. Schenker, T.A. Frosto, and G.I. Henderson Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE). Role of HNE adduct formation with the enzyme catalytic site Biochem Biophys Acta 1380 1998 336 344
94. J. Chen, D.R. Petersen, S. Schenker, and G.I. Henderson Formation of malondialdehyde adducts in livers of rats exposed to ethanol: role of ethanol-mediated inhibition of cytochrome c oxidase Alcohol Clin Exp Res 24 2000 544 552
95. P.A. Kern, M. Saghizadeh, J.M. Ong, R.J. Bosch, R. Deem, and R.B. Simsolo The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase J Clin Invest 95 1995 2111 2119
96. J. Crespo, A. Cayon, P. Fernadez-Gil, M. Hernandez-Guerra, M. Mayorga, and A. Dominguez-Diez Gene expression of tumor necrosis factor α and TNF-receptors p55 and p75 in nonalcoholic steatohepatitis patients Hepatology 34 2001 1158 1163
97. A.E. Feldstein, N.W. Werneburg, A. Canbay, M.E. Guicciardi, S.F. Bronk, and R. Rydzewski Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway Hepatology 40 2004 185 194
98. J. St-Pierre, J.A. Buckingham, S.J. Roebuck, and M.D. Brand Topology of superoxide production from different sites in the mitochondrial electron transport chain J Biol Chem 277 2002 44784 44790
99. X.L. Du, D. Edelstein, L. Rossetti, I.G. Fantus, H. Goldberg, and F. Ziyadeh Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation Proc Natl Acad Sci USA 97 2000 12222 12226
100. + oxidation-reduction state Biochem J 368 2002 545 553
101. S. Yang, H. Zhu, Y. Li, H. Lin, K. Gabrielson, and M.A. Trush Mitochondrial adaptations to obesity-related oxidant stress Arch Biochem Biophys 378 2000 259 268
102. 2 generation in liver mitochondria Carcinogenesis 21 2000 983 989
103. D. Gao, C. Wei, L. Chen, J. Huang, S. Yang, and A.M. Diehl Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease Am J Physiol Gastrointest Liver Physiol 287 2004 G1070 G1077
104. R.S. Strauss Comparison of serum concentrations of α-tocopherol and ß-carotene in a cross-sectional sample of obese and nonobese children (NHANES III) J Pediatr 134 1999 160 165
105. J.E. Lavine Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study J Pediatr 136 2000 734 738
106. K. Fukuda, M. Kojiro, and J.F. Chiu Induction of apoptosis by transforming growth factor-β1 in the rat hepatoma cell line McA-RH7777: a possible association with tissue transglutaminase expression Hepatology 18 1993 945 953
107. K. Fukuda, R. Xie, and J.F. Chiu Demonstration of cross-linked cytokeratin polypeptides in transplantable rat hepatoma cells Biochem Biophys Res Commun 176 1991 441 446
108. D. Pessayre, G. Feldmann, D. Haouzi, D. Fau, A. Moreau, and M. Neuman Hepatocyte apoptosis triggered by natural substances (cytokines, other endogenous substances and foreign toxins) R.G. Cameron G. Feuer Apoptosis and its modulation by drugs Handbook of experimental pharmacology 142 2000 Springer Heidelberg 59 108
109. A.E. Feldstein, A. Canbay, P. Angulo, M. Taniai, L.J. Burgart, and K.D. Lindor Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis Gastroenterology 125 2003 437 443
110. A.E. Feldstein, A. Canbay, M.E. Guicciardi, H. Higuchi, S.F. Bronk, and G.J. Gores Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice J Hepatol 39 2003 978 983
111. A. Nechushtan, C.L. Smith, I. Lamendorf, S.H. Yoon, and R.J. Youle Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis J Cell Biol 153 2001 1265 1276
112. R.A. Kirkland, J.A. Windelborn, J.M. Kasprzak, and J.L. Franklin A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death J Neuroscience 22 2002 6490 6840
113. G. Feldmann, D. Haouzi, A. Moreau, A.M. Durand-Schneider, A. Bringuier, and A. Berson Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas-mediated hepatic apoptosis in mice Hepatology 31 2000 674 683
114. V.A. Fadok, D.L. Bratton, A. Konowal, P.W. Freed, J.Y. Westcott, and P.M. Henson Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF J Clin Invest 101 1998 890 898
115. A. Canbay, P. Taimr, N. Torok, H. Higuchi, S. Friedman, and G.J. Gores Apoptotic body engulfment by a human stellate cell line is profibrogenic Lab Invest 83 2003 655 663
116. G. Leonarduzzi, A. Scavazza, F. Biasi, E. Chiarpotto, S. Camandola, and S. Vogel The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor ß1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis FASEB J 11 1997 851 857
117. M. Parola, M. Pinzani, A. Casini, E. Albano, G. Poli, and A. Gentilini Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen α1 (I) gene expression in human liver fat-storing cells Biochem Biophys Res Commun 194 1993 1044 1050
118. J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770
119. I.A. Leclercq, G.C. Farrell, R. Schriemer, and G.R. Robertson Leptin is essential for the hepatic fibrogenic response to chronic liver injury J Hepatol 37 2002 206 213
120. M. Tang, J.J. Potter, and E. Mezey Leptin enhances the effect of transforming growth factor beta in increasing type I collagen formation Biochem Biophys Res Commun 297 2002 906 911
121. K. Ikejima, Y. Takei, H. Honda, M. Hirose, M. Yoshikawa, and Y.J. Zhang Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat Gastroenterology 122 2002 1340 1399
122. N.K. Saxena, K. Ikeda, D.C. Rockey, S.L. Friedman, and F.A. Anania Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice Hepatology 35 2002 762 771