Cardiovascular risk factors emerge after artificial selection for low aerobic capacity

Science

Volumn 307, Issue 5708, 2005, Pages 418-420

  Wisløff, Ulrik ^a,b   Najjar, Sonia M ^c   Ellingsen, Øyvind ^a,b   Haram, Per Magnus ^a   Swoap, Steven ^d   Al Share, Qusai ^c   Fernström, Mats ^c   Rezaei, Khadijeh ^c   Lee, Sang Jun ^c   Koch, Lauren Gerard ^e   Britton, Steven L ^e  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c MEDICAL COLLEGE OF OHIO   (United States)

^d WILLIAMS COLLEGE   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR SYSTEM; DISEASES; ENZYMES; METABOLISM; MUSCLE; OXYGEN; RISK ASSESSMENT;

ARTIFICIAL SELECTION; OXIDATIVE ENZYMES; SKELETAL MUSCLES;

HUMAN ENGINEERING;

OXIDOREDUCTASE; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR;

MEDICINE;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; BIOGENESIS; BLOOD PRESSURE; BODY WEIGHT; CARDIOVASCULAR RISK; CONTROLLED STUDY; EXERCISE; METABOLIC SYNDROME X; MITOCHONDRION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

ADIPOSE TISSUE; AEROBIOSIS; AGING; ANIMALS; BLOOD PRESSURE; BODY WEIGHT; BREEDING; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; EXERCISE; EXERCISE TOLERANCE; EXERTION; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERTENSION; INSULIN; INSULIN RESISTANCE; LIPIDS; MALE; METABOLIC SYNDROME X; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; PPAR GAMMA; RATS; RISK FACTORS; RUNNING; SELECTION (GENETICS); TRANS-ACTIVATORS; VENTRICULAR FUNCTION, LEFT;

EID: 19944431011     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1108177     Document Type: Article

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20. We thank M. Nelson, K. Pettee, A. Gilbert, M. Kaufmann, T. Kennedy, O. J. Kemi, L. Gilligan, and A Duvall for technical assistance and J. W. Britton for helpful discussions. Supported by NIH grants HL 64270 and RR 17718 (S.LB. and L.G.K.) and DK 54254 and DK 57497 (S.M.N.), the American Diabetes Association (S.M.N.), NSF grant IBN 9984170 (S.S.), and the Norwegian Council on Cardiovascular Research (U.W. and O.E.).