-
3
-
-
2642579709
-
Mitochondrial injury in steatohepatitis
-
In: Suchy FJ, Gregory FJ, Maher JJ. American Association for the Study of Liver Diseases Postgraduate Course 2002. AASLD Postgraduate Course
-
Pessayre D. Mitochondrial injury in steatohepatitis. In: Suchy FJ, Gregory FJ, Maher JJ. American Association for the Study of Liver Diseases Postgraduate Course 2002. Mechanisms of Acute and Chronic Liver Diseases: Implications for Diagnosis, Pathogenesis and Treatment. AASLD Postgraduate Course, 2002: 97-103.
-
(2002)
Mechanisms of Acute and Chronic Liver Diseases: Implications for Diagnosis, Pathogenesis and Treatment
, pp. 97-103
-
-
Pessayre, D.1
-
4
-
-
0037163096
-
Intracellular assembly of very-low-density lipoproteins containing apolipoprotein B100 in rat hepatoma McA- RH777 cells
-
Tran K, Thorne-Tjomsland G, DeLong CJ et al. Intracellular assembly of very-low-density lipoproteins containing apolipoprotein B100 in rat hepatoma McA- RH777 cells. J Biol Chem 2002; 277: 31187-200.
-
(2002)
J Biol Chem.
, vol.277
, pp. 31187-31200
-
-
Tran, K.1
Thorne-Tjomsland, G.2
DeLong, CJ.3
-
5
-
-
0032538638
-
Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full- length apolipoprotein B after translocation into the endoplamic reticulum
-
Liao W, Yeung SCJ, Chan L. Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full- length apolipoprotein B after translocation into the endoplamic reticulum. J Biol Chem 1998; 273: 27225-30.
-
(1998)
J Biol Chem.
, vol.273
, pp. 27225-27230
-
-
Liao, W.1
Yeung, SCJ.2
Chan, L.3
-
6
-
-
0018864840
-
Regulation of hepatic fatty acid oxidation and ketone body production
-
McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Ann Rev Biochem 1980; 49: 395-420.
-
(1980)
Ann Rev Biochem.
, vol.49
, pp. 395-420
-
-
McGarry, JD.1
Foster, DW.2
-
7
-
-
0029127584
-
Inhibition of mitochondrial p- oxidation as a mechanism of hepatotoxicity
-
Fromenty B, Pessayre D. Inhibition of mitochondrial p- oxidation as a mechanism of hepatotoxicity. Pharmacol Ther 1995; 67: 101-54.
-
(1995)
Pharmacol Ther.
, vol.67
, pp. 101-154
-
-
Fromenty, B.1
Pessayre, D.2
-
8
-
-
0034611791
-
Obesity as a medical problem
-
Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-43.
-
(2000)
Nature
, vol.404
, pp. 635-643
-
-
Kopelman, PG.1
-
9
-
-
0033595121
-
Glucose transporters and insulin action: implications for insulin resistance and diabetes mellitus
-
Shepherd PR, Kahn BB. Glucose transporters and insulin action: implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341: 248-57.
-
(1999)
N Engl J Med.
, vol.341
, pp. 248-257
-
-
Shepherd, PR.1
Kahn, BB.2
-
10
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 353-6.
-
(2002)
Nature
, vol.420
, pp. 353-356
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
-
11
-
-
18244364864
-
NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance
-
Chitturi S, Abeygunasekera S, Farrell GC et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance. Hepatology 2002; 35: 373-9.
-
(2002)
Hepatology
, vol.35
, pp. 373-379
-
-
Chitturi, S.1
Abeygunasekera, S.2
Farrell, GC.3
-
12
-
-
0035988340
-
Understanding adipose tissue development from transgenic animal models
-
Valet P, Tavernier G, Castan-Laurell I et al. Understanding adipose tissue development from transgenic animal models. J Lipid Res 2002; 43: 835-60.
-
(2002)
J Lipid Res.
, vol.43
, pp. 835-860
-
-
Valet, P.1
Tavernier, G.2
Castan-Laurell, I.3
-
13
-
-
0000847623
-
Non-esterified fatty acids in blood of obese and lean subjects
-
Gorden ES. Non-esterified fatty acids in blood of obese and lean subjects. Am J Clin Nutr 1960; 8: 740-7.
-
(1960)
Am J Clin Nutr.
, vol.8
, pp. 740-747
-
-
Gorden, ES.1
-
14
-
-
0033570119
-
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
-
Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 1999; 274: 30028-32.
-
(1999)
J Biol Chem.
, vol.274
, pp. 30028-30032
-
-
Shimomura, I.1
Bashmakov, Y.2
Horton, JD.3
-
15
-
-
0035084699
-
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
-
Sanyal AJ, Campbell-Sargent C, Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-92.
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, AJ.1
Campbell-Sargent, C.2
Mirshahi, F.3
-
16
-
-
0036207720
-
Apolipoprotein synthesis in non-alcoholic steatohepatitis
-
Charlton M, Sreekumar R, Rasmussen D, Lindor K, Nair S. Apolipoprotein synthesis in non-alcoholic steatohepatitis. Hepatology 2002; 35: 898-904.
-
(2002)
Hepatology
, vol.35
, pp. 898-904
-
-
Charlton, M.1
Sreekumar, R.2
Rasmussen, D.3
Lindor, K.4
Nair, S.5
-
17
-
-
0036225267
-
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice
-
Bartels ED, Lauritsen M, Nielsen LB. Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice. Diabetes 2002; 51: 1233-9.
-
(2002)
Diabetes
, vol.51
, pp. 1233-1239
-
-
Bartels, ED.1
Lauritsen, M.2
Nielsen, LB.3
-
18
-
-
0029047046
-
Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression
-
Lin MCM, Gordon DC, Wettereau JR. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J Lipid Res 1995; 36: 1073-81.
-
(1995)
J Lipid Res.
, vol.36
, pp. 1073-1081
-
-
Lin, MCM.1
Gordon, DC.2
Wettereau, JR.3
-
19
-
-
15144345947
-
Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines
-
Navasa M, Gordon DA, Hariharan N et al. Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines. J Lipid Res 1998; 39: 1220-30.
-
(1998)
J Lipid Res.
, vol.39
, pp. 1220-1230
-
-
Navasa, M.1
Gordon, DA.2
Hariharan, N.3
-
20
-
-
0141955312
-
Genetic evidence supporting the two-hit model of NASH pathogenesis
-
Day CP, Saksena S, Leathart J et al. Genetic evidence supporting the two-hit model of NASH pathogenesis. Hepatology 2002; 36: 82A.
-
(2002)
Hepatology
, vol.36
, pp. 82A
-
-
Day, CP.1
Saksena, S.2
Leathart, J.3
-
21
-
-
0033802236
-
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
-
Kono H, Rusyn I, Yin M et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000; 106: 867-72.
-
(2000)
J Clin Invest.
, vol.106
, pp. 867-872
-
-
Kono, H.1
Rusyn, I.2
Yin, M.3
-
22
-
-
0031962151
-
Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis
-
Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C. Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis. Hepatology 1998; 27: 128-33.
-
(1998)
Hepatology
, vol.27
, pp. 128-133
-
-
Weltman, MD.1
Farrell, GC.2
Hall, P.3
Ingelman-Sundberg, M.4
Liddle, C.5
-
23
-
-
2642531655
-
Primary nonfunction in steatotic livers is due to differential Toll-like expression and endotoxin sensitivity
-
Fiorini RN, Shafizadeh SF, Chavin KD. Primary nonfunction in steatotic livers is due to differential Toll-like expression and endotoxin sensitivity. Hepatology 2002; 36: 198A.
-
(2002)
Hepatology
, vol.36
, pp. 198A
-
-
Fiorini, RN.1
Shafizadeh, SF.2
Chavin, KD.3
-
24
-
-
0036307759
-
Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-a production
-
Enomoto N, Takei Y, Hirose M et al. Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-a production. Gastroenterology 2002; 123: 291-300.
-
(2002)
Gastroenterology
, vol.123
, pp. 291-300
-
-
Enomoto, N.1
Takei, Y.2
Hirose, M.3
-
25
-
-
0342716457
-
Acute and chronic steatosis lead to in vivo lipid peroxidation in mice
-
Letteron P, Fromenty B, Terris B, Degott C, Pessayre D. Acute and chronic steatosis lead to in vivo lipid peroxidation in mice. J Hepatol 1996; 24: 200-8.
-
(1996)
J Hepatol.
, vol.24
, pp. 200-208
-
-
Letteron, P.1
Fromenty, B.2
Terris, B.3
Degott, C.4
Pessayre, D.5
-
26
-
-
0034092716
-
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis
-
Leclercq IA, Farrell GC, Field J et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis. J Clin Invest 2001; 105: 1067-75.
-
(2001)
J Clin Invest.
, vol.105
, pp. 1067-1075
-
-
Leclercq, IA.1
Farrell, GC.2
Field, J.3
-
27
-
-
0023947327
-
Evidence for mitochondrial DNA damage by lipid peroxidation
-
Hruszkewycz AM. Evidence for mitochondrial DNA damage by lipid peroxidation. Biochem Biophys Res Commun 1988; 153: 191-7.
-
(1988)
Biochem Biophys Res Commun.
, vol.153
, pp. 191-197
-
-
Hruszkewycz, AM.1
-
28
-
-
0032496339
-
Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE): role of HNE adduct formation with the enzyme catalytic site
-
Chen J, Schenker S, Frosto TA, Hensderson GI. Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE): role of HNE adduct formation with the enzyme catalytic site. Biochem Biophys Acta 1998; 1380: 336-44.
-
(1998)
Biochem Biophys Acta.
, vol.1380
, pp. 336-344
-
-
Chen, J.1
Schenker, S.2
Frosto, TA.3
Hensderson, GI.4
-
29
-
-
2642552056
-
Nonalcoholic steatohepatitis (NASH) is associated with hepa- tocyte mitochondrial DNA depletion
-
Haque M, Mirshahi F, Campbell-Sargent C et al. Nonalcoholic steatohepatitis (NASH) is associated with hepa- tocyte mitochondrial DNA depletion. Hepatology 2002; 36: 403A.
-
(2002)
Hepatology
, vol.36
, pp. 403A
-
-
Haque, M.1
Mirshahi, F.2
Campbell-Sargent, C.3
-
30
-
-
0000074344
-
Activity of the mitochondrial respiratory chain enzymes is decreased in the liver of patients with non-alcoholic steatohepatitis
-
Perez-Carrera M, Del Hoyo P, Martin M et al. Activity of the mitochondrial respiratory chain enzymes is decreased in the liver of patients with non-alcoholic steatohepatitis. Hepatology 1999; 30: 379A.
-
(1999)
Hepatology
, vol.30
, pp. 379A
-
-
Perez-Carrera, M.1
Del Hoyo, P.2
Martin, M.3
-
31
-
-
0033520771
-
Alterations in liver ATP homeostasis in human non-alcoholic steatohepatitis: a pilot study
-
Cortez-Pinto H, Chatham J, Chacko VP et al. Alterations in liver ATP homeostasis in human non-alcoholic steatohepatitis: a pilot study. J Am Med Assoc 1999; 282: 1659-64.
-
(1999)
J Am Med Assoc.
, vol.282
, pp. 1659-1664
-
-
Cortez-Pinto, H.1
Chatham, J.2
Chacko, VP.3
-
32
-
-
0034659814
-
Mitochondrial adaptations to obesity-related oxidant stress
-
Yang SQ, Zhu H, Li Y et al. Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 2000; 378: 259-68.
-
(2000)
Arch Biochem Biophys.
, vol.378
, pp. 259-268
-
-
Yang, SQ.1
Zhu, H.2
Li, Y.3
-
33
-
-
0034019329
-
Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria
-
Hensley K, Kotake Y, Sang H et al. Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria. Carcinogenesis 2000; 21: 983-9.
-
(2000)
Carcinogenesis
, vol.21
, pp. 983-989
-
-
Hensley, K.1
Kotake, Y.2
Sang, H.3
-
34
-
-
0034762223
-
Alcohol-induced free radicals in mice: direct toxicants or signaling molecules?
-
Yin M, Gäbele E, Wheeler MD et al. Alcohol-induced free radicals in mice: direct toxicants or signaling molecules? Hepatology 2001; 34: 935-42.
-
(2001)
Hepatology
, vol.34
, pp. 935-942
-
-
Yin, M.1
Gäbele, E.2
Wheeler, MD.3
-
35
-
-
0033025969
-
Comparison of serum concentrations of a- tocopherol and β-carotene in a cross-sectional sample of obese and non-obese children (NHANES III)
-
Strauss RS. Comparison of serum concentrations of a- tocopherol and β-carotene in a cross-sectional sample of obese and non-obese children (NHANES III). J Pediatr 1999; 134: 160-5.
-
(1999)
J Pediatr.
, vol.134
, pp. 160-165
-
-
Strauss, RS.1
-
36
-
-
0034126755
-
Vitamin E treatment of non-alcoholic steato- hepatitis in children: a pilot study
-
Lavine JE. Vitamin E treatment of non-alcoholic steato- hepatitis in children: a pilot study. J Pediatr 2000; 136: 739-43.
-
(2000)
J Pediatr.
, vol.136
, pp. 739-743
-
-
Lavine, JE.1
-
37
-
-
0031921972
-
Steatohepatitis- inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
-
Berson A, De Beco V, Leteron P et al. Steatohepatitis- inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology 1998; 114: 764-74.
-
(1998)
Gastroenterology
, vol.114
, pp. 764-774
-
-
Berson, A.1
De Beco, V.2
Leteron, P.3
-
38
-
-
0002625797
-
Hepatocyte apoptosis triggered by natural substances (cytokines, other endogenous substances and foreign toxins)
-
In:Cameron RG, Feuer G, eds. Apoptosis and its Modulation by Drugs:Heidelberg: Springer Verlag
-
Pessayre D, Feldmann G, Haouzi D et al. Hepatocyte apoptosis triggered by natural substances (cytokines, other endogenous substances and foreign toxins). In:Cameron RG, Feuer G, eds. Apoptosis and its Modulation by Drugs: Handbook of Experimental Pharmacology. Heidelberg: Springer Verlag, 2000, 142: 59-108.
-
(2000)
Handbook of Experimental Pharmacology
, vol.142
, pp. 59-108
-
-
Pessayre, D.1
Feldmann, G.2
Haouzi, D.3
-
39
-
-
0035183475
-
Gene expression of tumor necrosis factor-a and TNF-receptors p55 and p75 in non-alcoholic steatohepatitis patients
-
Crespo J, Cayon A, Fernadez-Gil P et al. Gene expression of tumor necrosis factor-a and TNF-receptors p55 and p75 in non-alcoholic steatohepatitis patients. Hepatology 2001; 34: 1158-63.
-
(2001)
Hepatology
, vol.34
, pp. 1158-1163
-
-
Crespo, J.1
Cayon, A.2
Fernadez-Gil, P.3
-
40
-
-
0034003692
-
Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas-mediated hepatic apoptosis in mice
-
Feldmann G, Haouzi D, Moreau A et al. Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas-mediated hepatic apoptosis in mice. Hepatology 2000; 31: 674-83.
-
(2000)
Hepatology
, vol.31
, pp. 674-683
-
-
Feldmann, G.1
Haouzi, D.2
Moreau, A.3
-
41
-
-
0035111054
-
Hepatocyte apop- tosis is a pathologic feature of human alcoholic hepatitis
-
Natori S, Rust C, Stadheim LM et al. Hepatocyte apop- tosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001; 34: 248-53.
-
(2001)
J Hepatol.
, vol.34
, pp. 248-253
-
-
Natori, S.1
Rust, C.2
Stadheim, LM.3
-
42
-
-
2642578903
-
Apoptosis is a prominent feature of human alcoholic and non-alcoholic steatohepatitis
-
Rodriguez CM, Cortez-Pinto H, Sola S et al. Apoptosis is a prominent feature of human alcoholic and non-alcoholic steatohepatitis. Hepatology 2001; 34: 672A.
-
(2001)
Hepatology
, vol.34
, pp. 672A
-
-
Rodriguez, CM.1
Cortez-Pinto, H.2
Sola, S.3
-
43
-
-
0037339203
-
The Ala-9Val dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria
-
Sutton A, Khoury H, Prip-Buus C et al. The Ala-9Val dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics 2003; 13: 145-57.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 145-157
-
-
Sutton, A.1
Khoury, H.2
Prip-Buus, C.3
-
44
-
-
0036894470
-
Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis
-
Stewart SF, Leathart JB, Chen Y et al. Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis. Hepatology 2002; 36: 1355-60.
-
(2002)
Hepatology
, vol.36
, pp. 1355-1360
-
-
Stewart, SF.1
Leathart, JB.2
Chen, Y.3
-
45
-
-
0018422397
-
Effect of fasting on metabolite-mediated hepatotoxicity in the rat
-
Pessayre D, Dolder A, Artigou JY et al. Effect of fasting on metabolite-mediated hepatotoxicity in the rat. Gastroenterology 1979; 77: 264-71.
-
(1979)
Gastroenterology
, vol.77
, pp. 264-271
-
-
Pessayre, D.1
Dolder, A.2
Artigou, JY.3
-
46
-
-
0035029170
-
Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice
-
Haouzi D, Lekehal M, Tinel M et al. Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice. Hepatology 2001; 33: 1181-8.
-
(2001)
Hepatology
, vol.33
, pp. 1181-1188
-
-
Haouzi, D.1
Lekehal, M.2
Tinel, M.3
|