Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance

New England Journal of Medicine

Volumn 334, Issue 12, 1996, Pages 777-783

  Polonsky, Kenneth S ^a,c   Sturis, Jeppe ^a   Bell, Graeme I ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ETIOLOGY; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INHERITANCE; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; ANIMAL; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; PANCREAS ISLET; PHYSIOLOGY;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; ISLETS OF LANGERHANS;

EID: 0030596338     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199603213341207     Document Type: Review

References (68)

1. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37 1595-607.
2. Idem. Syndrome X: 6 years later. J Intern Med Suppl 1994;736:13-22.
3. DeFronzo RA. The triumvirate: β-cell, muscle, liver, a collusion responsi ble for NIDDM. Diabetes 1988,37 667-87.
4. Beck-Nielsen H. The pathogenic role of an insulin-receptor defect in diabetes mellitus of the obese. Diabetes 1978;27 1175-81.
5. DeFronzo RA, Deibert D, Hendler R, Felig P, Soman V. Insulin sensitivity and insulin binding to monocytes in maturity-onset diabetes. J Clin Invest 1979;63:939-46
6. Olefsky JM, Reaven GM. Decreased insulin binding to lymphocytes from diabetic subjects J Clin Invest 1974,54 1323-8.
7. Idem Insulin binding in diabetes: relationships with plasma insulin levels and insulin sensitivity. Diabetes 1977;26:680-8
8. Freidenberg GR, Henry RR, Klein HH, Reichart DR, Olefsky JM Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. J Clin Invest 1987;79:240-50
9. Caro JF, Sinha MK, Raju SM, et al. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J Clin Invest 1987,79:1330-7.
10. Maegawa H, Shigeta Y, Egawa K, Kobayashi M Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM. Diabetes 1991;40:815-9.
11. Golay A, DeFronzo RA, Ferrannini E, et al Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1988;31:585-91.
12. Golay A, Felber JP, Jequier E, DeFronzo RA, Ferrannini E Metabolic basis of obesity and noninsulin-dependent diabetes mellitus Diabetes Metab Rev 1988,4 727-47
13. Ciaraldi TP, Kolterman OG, Scarlett JA, Kao M, Olefsky JM. Role of glucose transport in the postreceptor defect of non-insulin-dependent diabetes mellitus Diabetes 1982,31.1016-22.
14. Dohm GL, Tapscott EB, Pories WJ, et al. An in vitro human muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects J Clin Invest 1988;82.486-94.
15. Erikkson J, Koranyi L, Bourey R, et al Insulin resistance in type 2 (noninsulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle Diabetologia 1992;35 143-7 [Erratum, Diabetologia 1992,35 594 ]
16. Garvey WT, Maianu L, Hancock JA, Golichowski AM, Baron A Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM Diabetes 1992;41.465-75.
17. Handberg A, Vaag A, Damsbo P, Beck Nielsen H, Vinten J Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 (noninsulin-dependent) diabetic patients Diabetologia 1990,33 625-7.
18. Vaag A, Henriksen JE, Beck-Nielsen H Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1992;89:782-8.
19. Vestergaard H, Lund S, Larsen FS, Bjerrum OJ, Pedersen O. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus J Clin Invest 1993,91:2342-50.
20. Groop LC, Kankuri M, Schalin-Jantri C, et al. Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 1993;328.10-4.
21. Taylor SI, Cama A, Accili D, et al. Mutations in the insulin receptor gene. Endocr Rev 1992;13 566-95.
22. Taylor SI. Molecular mechanisms of insulin resistance, lessons from patients with mutations in the insulin-receptor gene. Diabetes 1992,41:1473-90
23. Ramachandran A, Snehalatha C, Mohan V, Bhattacharyya PK, Viswanathan M. Decreased insulin sensitivity in offspring whose parents both have type 2 diabetes. Diabet Med 1990,7.331-4
24. Osei K, Cottrell DA, Orabella MM. Insulin sensitivity, glucose effectiveness, and body fat distribution pattern in nondiabetic offspring of patients with NIDDM. Diabetes Care 1991,14:890-6.
25. Laws A, Stefanick ML, Reaven GM Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus J Clin Endocrinol Metab 1989,69:343-7.
26. Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 1992;340:925-9.
27. Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo RA. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents Diabetes 1992;41:1575-86.
28. Leslie RDG, Volkmann HP, Poncher M, Hanning I, Orskov H, Alberti KGMM Metabolic abnormalities in children of non-insulin dependent diabetics. BMJ 1986,293 840-2
29. Eriksson KF, Lindgarde F Prevention of type 2 (non-insuhn-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmo feasibility study Diabetologia 1991,34:891-8
30. Polonsky KS, Given BD, Hirsch L, et al. Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 1988,81:435-41
31. Polonsky KS, Given BD, Van Cauter E. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest 1988;81 442-8.
32. Polonsky KS, Given BD, Hirsch L, et al. Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus N Engl J Med 1988;318:1231-9
33. Bergman RN, Phillips LS, Cobelli C Physiologic evaluation of factors controlling glucose tolerance in man, measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 1981;68:1456-67
34. Kahn SE, Prigeon RL, McCulloch DK, et al Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 1993;42:1663-72.
35. Coleman DL Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978,14:141-8.
36. Tokuyama Y, Sturis J, DePaoli AM, et al. Evolution of beta cell dysfunction in the male Zucker diabetes fatty rat. Diabetes 1995;44:1447-57.
37. Polonsky KS The β-cell in diabetes from molecular genetics to clinical research. Diabetes 1995;44 705-17
38. Leahy JL. Natural history of β-cell dysfunction in NIDDM. Diabetes Care 1990;13:992-1010
39. Weir GC Non-insulin-dependent diabetes mellitus interplay between β-cell inadequacy and insulin resistance. Am J Med 1982,73 461-4.
40. Lang DA, Matthews DR, Burnett M, Turner RC. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes 1981,30:435-9.
41. O'Meara NM, Stuns J, Van Cauter E, Polonsky KS. Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. J Clin Invest 1993;92:262-71.
42. Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D Jr. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 1987,30.698-702.
43. Gorden P, Sherman BM, Simopoulus AP. Glucose intolerance with hypokalemia, an increased proportion of circulating proinsulin-like component. J Clin Endocrinol Metab 1972;34:235-40.
44. Mako ME, Starr JI, Rubenstein AH Circulating proinsulin in patients with maturity onset diabetes. Am J Med 1977;63.865-9.
45. Heaton DA, Millward BA, Gray IP, et al. Increased proinsulin levels as an early indicator of beta-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. Diabetologia 1988;31:182-4.
46. Leahy JH, Bonner-Weir S, Weir GC. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 1988;81:1407-14
47. Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 1987;80:1037-44.
48. Gumbiner B, Polonsky KS, Beltz WF, et al. Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab 1990;70:1594-602.
49. Mitrakou A, Kelley D, Mokan M, et al. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 1992,326.22-9.
50. Byrne MM, Sturis J, Polonsky KS. Insulin secretory defects in prediabetes. Diabetes 1995;44;Suppl 1:195A. abstract.
51. Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS. Insulin secretory defects in polycystic ovary syndrome: relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 1995;96:520-7.
52. O'Rahilly S, Turner RC, Matthews DR. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 1988;318:1225-30.
53. Larsson H, Berglund G, Ahren B Glucose modulation of insulin and glucagon secretion is altered in impaired glucose tolerance. J Clin Endocrinol Metab 1995;80:1778-82.
54. Knowler WC, Narayan KMV, Hanson RL, et al Preventing non-insulin-dependent diabetes Diabetes 1995;44:483-8
55. Pimenta W, Korytkowski M, Mitrakou A, et al. Pancreatic beta-cell dys3 function as the primary genetic lesion in NIDDM: evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative JAMA 1995;273:1855-61.
56. Bell GL Xiang KS, Newman MV, et al. Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci USA 1991;88:1484-8.
57. Froguel P, Vaxillaire M, Sun F, et al. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 1992;356.162-4 [Erratum. Nature 1992;357:607.]
58. Vionnet N, Stoffel M, Takeda J, et al. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes zellitus. Nature 1992;356:721-2.
59. Hattersley AT, Turner RC, Permutt MA, et al Linkage of type 2 diabetes to the glucokinase gene. Lancet 1992,339:1307-10
60. Froguel P, Zouali H, Vionnet N, et al. Familal hyperglycemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. N Engl J Med 1993;328.697-702
61. Vaxillaire M, Boccio V, Philippi A, et al. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nat Genet 1995;9:418-23
62. Menzel S, Yamagata K, Trabb JB, et al Localization of MODY3 to a 5 cM region of human chromosome 12. Diabetes 1995,44:1408-13.
63. Byrne MM, Sturis J, Fajans SS, et al. Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 1995,44:699-704.
64. Byrne MM, Sturis J, Clément K, et al Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest 1994,93:1120-30.
65. Sturis J, Polonsky KS, Mosekilde E, Van Cauter E. Computer model for mechanisms underlying ultradian oscillations of insulin and glucose. Am J Physiol 1991;260.E801-E809.
66. Herman WH, Fajass SS, Ortiz FJ, et al. Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree. Diabetes 1994;43:40-6. [Erratum, Diabetes 1994;43:1171.]
67. Velho G, Froguel P, Clément K, et al Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 1992;340.444-8.
68. Khan A, Efendic S. Evidence that increased glucose cycling in islets of diabetic ob/ob mice is a primary feature of the disease. Am J Physiol 1995; 269:E623-E626.