SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases

Molecules and Cells

Volumn 16, Issue 1, 2003, Pages 1-12

  Freeman, Robert S ^a   Hasbani, Daphne M ^a,b   Lipscomb, Elizabeth A ^a,c   Straub, Jennifer A ^a   Xie, Liang ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN EGL 9; PROTEIN SM 20; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DNA BINDING PROTEIN; EGL 9 PROTEIN, C ELEGANS; EGL-9 PROTEIN, C ELEGANS; EGLN1 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMEDIATE EARLY PROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

CELL DEATH; EGG LAYING; ENZYME ACTIVITY; HYDROXYLATION; NONHUMAN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; SHORT SURVEY; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NERVE CELL; PHYSIOLOGY; REVIEW; SEQUENCE ALIGNMENT;

MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS PROTEINS; DNA-BINDING PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMEDIATE-EARLY PROTEINS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NEURONS; NUCLEAR PROTEINS; PROCOLLAGEN-PROLINE DIOXYGENASE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 1842627462     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (56)

1. Agani, F. H., Pichiule, P., Chavez, J. C., and LaManna, J. C. (2000) The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J. Biol. Chem. 275, 35863-35867.
2. Aravind, L. and Koonin, E. V. (2001) The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol. 2, 7.1-7.8.
3. Bruick, R. K. and McKnight, S. L. (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340.
4. Chan, D. A., Sutphin, P. D., Denko, N. C., and Giaccia, A. J. (2002) Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α. J. Biol. Chem. 277, 40112-40117.
5. Cioffi, C. L., Liu, X. Q., Kosinski, P. A., Garay, M., and Bowen, B. R. (2003) Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem. Biophys Res. Commun. 303, 947-953.
6. Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. (2000) Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275, 25733-25741.
7. Conaway, R. C. and Conaway, J. W. (2002) The Von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription. Adv. Cancer Res. 85, 1-12.
8. D'Angelo, G., Duplan, E., Vigne, P., and Frelin, C. (2003) Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1α Pro-564 hydroxylation. J. Biol. Chem. 278, 15406-15411.
9. Darby, C., Cosma, C. L., Thomas, J. H., and Manoil, C. (1999) Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 96, 15202-15207.
10. Ebinu, J. O. and Yankner, B. A. (2002) A RIP tide in neuronal signal transduction. Neuron 34, 499-502.
11. Epstein, A. C., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., Tian, Y. M., Masson, N., Hamilton, D. L., Jaakkola, P., Barstead, R., Hodgkin, J., Maxwell, P. H., Pugh, C. W., Schofield, C. J., and Ratcliffe, P. J. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54.
12. Erez, N., Milyavsky, M., Goldfinger, N., Peles, E., Gudkov, A. V., and Rotter, V. (2002) Falkor, a novel cell growth regulator isolated by a functional genetic screen. Oncogene 21, 6713-6721.
13. Freeman, R. S., Burch, R. L., Crowder, R. J., Lomb, D. J., Schoell, M. C., Straub, J. A., and Xie, L. (2003) NGF deprivation-induced gene expression: after ten years, where do we stand? Prog. Brain Res. (in press).
14. Gallagher, L. A. and Manoil, C. (2001) Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning. J. Bacteriol. 183, 6207-6214.
15. Graves, J. D. and Krebs, E. G. (1999) Protein phosphorylation and signal transduction. Pharmacol. Ther. 82, 111-121.
16. Groulx, I. and Lee, S. (2002) Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 22, 5319-5336.
17. Günzler, V. and Weidmann, K. (1998) Prolyl 4-hydroxylase inhibitors; in Prolyl hydroxylase, Protein Disulfide Isomerase, and Other Structurally Related Proteins, Guzman, N. A. (ed.), pp. 65-95, Marcel Dekker, New York.
18. Hon, W. C., Wilson, M. I., Harlos, K., Claridge, T. D., Schofield, C. J., Pugh, C. W., Maxwell, P. H., Ratcliffe, P. J., Stuart, D. I., and Jones, E. Y. (2002) Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL. Nature 417, 975-978.
19. Huang, J., Zhao, Q., Mooney, S. M., and Lee, F. S. (2002) Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J. Biol. Chem. 277, 39792-39800.
20. 2 sensing. Science 292, 464-468.
21. Ivan, M., Haberberger, T., Gervasi, D. C., Michelson, K. S., Gunzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R. C., Conaway, J. W., and Kaelin, W. G. Jr. (2002) Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc. Natl. Acad. Sci. USA 99, 13459-13464.
22. 2-regulated prolyl hydroxylation. Science 292, 468-472.
23. Jeong, J. W, Bae, M. K., Ahn, M. Y, Kim, S. H., Sohn, T. K., Bae, M. H., Yoo, M. A., Song, E. J., Lee, K. J, and Kim, K. W. (2002) Regulation and destabilization of HIF-1α by ARD1-mediated acetylation. Cell 111, 709-720.
24. Kivirikko, K. I. and Pihlajaniemi, T. (1998) Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases; in Advances in Enzymology & Related Areas of Molecular Biology, Purich, D. L. (ed.), Vol. 72, pp. 325-398, Wiley, New York.
25. Kuznetsova, A. V., Meller, J., Schnell, P. O., Nash, J. A., Ignacak, M. L., Sanchez, Y., Conaway, J. W., Conaway, R. C., and Czyzyk-Krzeska, M. F. (2003) von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc. Natl. Acad. Sci. USA 100, 2706-2711.
26. Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., and Whitelaw, M. L. (2002) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295, 858-861.
27. Lavista-Llanos, S., Centanin, L., Irisarri, M., Russo, D. M., Gleadle, J. M., Bocca, S. N., Muzzopappa, M., Ratcliffe, P. J., and Wappner, P. (2002) Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Mol. Cell. Biol. 22, 6842-6853.
28. Lieb, M. E., Menzies, K., Moschella, M. C., Ni, R., and Taubman, M. B. (2002) Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. Biochem. Cell Biol. 80, 421-426.
29. Lipscomb, E. A., Sarmiere, P. D., Crowder, R. J., and Freeman, R. S. (1999) Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons. J. Neurochem. 73, 429-432.
30. Lipscomb, E. A., Sarmiere, P. D., and Freeman, R. S. (2001) SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons. J. Biol. Chem. 276, 5085-5092.
31. Madden, S. L., Galella, E. A., Riley, D., Bertelsen, A. H., and Beaudry, G. A. (1996) Induction of cell growth regulatory genes by p53. Cancer Res. 56, 5384-5390.
32. Magnaghi-Jaulin, L., Ait-Si-Ali, S., and Harel-Bellan, A. (1999) Histone acetylation in signal transduction by growth regulatory signals. Semin. Cell Dev. Biol. 10, 197-203.
33. Mahon, P. C., Hirota, K., and Semenza, G. L. (2001) FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 2675-2686.
34. Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206.
35. Maxwell, P. H. and Ratcliffe, P. J. (2002) Oxygen sensors and angiogenesis. Semin. Cell Dev. Biol. 13, 29-37.
36. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275.
37. Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J. H., Stolze, I., Klinger, M., Huang, W. Q., Wotzlaw, C., Hellwig-Burgel, T., Jelkmann, W., Acker, H., and Fandrey, J. (2002) Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing. J. Cell Sci. 116, 1319-1326.
38. Min, J. H., Yang, H., Ivan, M., Gertler, F., Kaelin, W. G. Jr., and Pavletich, N. P. (2002) Structure of an HIF-1α/pVHL complex: hydroxyproline recognition in signaling. Science 296, 1886-1889.
39. Mole, D. R., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. IUBMB Life 52, 43-47.
40. Moschella, M. C., Menzies, K., Tsao, L., Lieb, M. A., Kohtz, J. D., Kohtz, D. S., and Taubman, M. B. (1999) SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation. Gene Exp. 8, 59-66.
41. Pereira, T., Zheng, X. W., Ruast, J. L., Tanimoto, K., and Poellinger, L. (2003) Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor gene product. J. Biol. Chem. 278, 6816-6823.
42. Peterkofsky, B. and Udenfriend, S. (1965) Enzymatic hydroxylation of proline in microsomal polypeptide leading to formation of collagen. Proc. Natl. Acad. Sci. USA 53, 335-342.
43. Resh, M. D. (1996) Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins. Cell Signal. 8, 403-412.
44. 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15, 551-578.
45. Semenza, G. L. (2001) HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol. 13, 167-171.
46. Seth, P., Krop, I., Porter, D., and Polyak, K. (2002) Novel estrogen and tamoxifen induced genes identified by SAGE (serial analysis of gene expression). Oncogene 21, 836-843.
47. Straub, J. A., Lipscomb, E. A., Yoshida, E. S., and Freeman, R. S. (2003) Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death. J. Neurochem. 85, 318-328.
48. Taylor, M. S. (2001) Characterization and comparative analysis of the EGLN gene family. Gene 275, 125-132.
49. Trent, C., Tsuing, N., and Horvitz, H. R. (1983) Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
50. Wang, F., Sekine, H., Kikuchi, Y., Takasaki, C., Miura, C., Heiwa, O., Shuin, T., Fujii-Kuriyama, Y., and Sogawa, K. (2002) HIF-1α prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway. Biochem. Biophys. Res. Commun. 295, 657-662.
51. Wax, S. D., Rosenfield, C. L., and Taubman, M. B. (1994) Identification of a novel growth factor-responsive gene in vascular smooth muscle cells. J. Biol. Chem. 269, 13041-13047.
52. Wax, S. D., Tsao, L., Lieb, M. E., Fallon, J. T., and Taubman, M. B. (1996) SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle. Lab. Invest. 74, 797-808.
53. Willam, C., Masson, N., Tian, Y. M., Mahmood, S. A., Wilson, M. I., Bicknell, R., Eckardt, K. U., Maxwell, P. H., Ratcliffe, P. J., and Pugh, C. W. (2002) Peptide blockade of HIF-α degradation modulates cellular metabolism and angiogenesis. Proc. Natl. Acad. Sci. USA 99, 10423-10428.
54. Wolf, G., Harendza, S., Schroeder, R., Wenzel, U., Zahner, G., Butzmann, U., Freeman, R. S., and Stahl, R. A. (2002) Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20. Lab. Invest. 82, 1305-1317.
55. Yang, Y. and Yu, X. (2003) Regulation of apoptosis: the ubiquitous way. FASEB J. 17, 790-799.
56. Yu, F., White, S. B., Zhao, Q., and Lee, F. S. (2001) HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA 98, 9630-9635.