-
1
-
-
0032830488
-
Cell biology of Leishmania
-
Handman E: Cell biology of Leishmania. Adv Parasitol (1999) 44:1-39.
-
(1999)
Adv Parasitol
, vol.44
, pp. 1-39
-
-
Handman, E.1
-
2
-
-
3042555141
-
Leishmaniasis: Current situation and new perspectives
-
Desjeux P: Leishmaniasis: Current situation and new perspectives. Comp Immunol Microbiol Infect Dis (2004) 27(5):305-318.
-
(2004)
Comp Immunol Microbiol Infect Dis
, vol.27
, Issue.5
, pp. 305-318
-
-
Desjeux, P.1
-
4
-
-
0036698235
-
Interaction of Leishmania with the host macrophage
-
Handman E, Bullen DV: Interaction of Leishmania with the host macrophage. Trends Parasitol (2002) 18(8):332-334.
-
(2002)
Trends Parasitol
, vol.18
, Issue.8
, pp. 332-334
-
-
Handman, E.1
Bullen, D.V.2
-
5
-
-
1642458466
-
Immunotherapy of American cutaneous leishmaniasis in Venezuela during the period 1990-99
-
Convit J, Ulrich M, Zerpa O, Borges R, Aranzazu N, Valera M, Villarroel H, Zapata Z, Tomedes I: Immunotherapy of American cutaneous leishmaniasis in Venezuela during the period 1990-99. Trans R Soc Trop Med Hyg (2003) 97(4):469-472.
-
(2003)
Trans R Soc Trop Med Hyg
, vol.97
, Issue.4
, pp. 469-472
-
-
Convit, J.1
Ulrich, M.2
Zerpa, O.3
Borges, R.4
Aranzazu, N.5
Valera, M.6
Villarroel, H.7
Zapata, Z.8
Tomedes, I.9
-
6
-
-
0035067363
-
Leishmaniasis: Current status of vaccine development
-
Handman E: Leishmaniasis: Current status of vaccine development. Clin Microbiol Rev (2001) 14(2):229-243.
-
(2001)
Clin Microbiol Rev
, vol.14
, Issue.2
, pp. 229-243
-
-
Handman, E.1
-
7
-
-
2942620631
-
Progress in the treatment of a neglected infectious disease: Visceral leishmaniasis
-
Murray HW: Progress in the treatment of a neglected infectious disease: Visceral leishmaniasis. Expert Rev Anti Infect Ther (2004) 2(2):279-292. A thorough review of developments in the treatment of visceral leishmaniasis over the last ten years.
-
(2004)
Expert Rev Anti Infect Ther
, vol.2
, Issue.2
, pp. 279-292
-
-
Murray, H.W.1
-
8
-
-
1642432131
-
Drugs against leishmaniasis: A synergy of technology and partnerships
-
Davis AJ, Murray HW, Handman E: Drugs against leishmaniasis: A synergy of technology and partnerships. Trends Parasitol (2004) 20(2):73-76.
-
(2004)
Trends Parasitol
, vol.20
, Issue.2
, pp. 73-76
-
-
Davis, A.J.1
Murray, H.W.2
Handman, E.3
-
9
-
-
0142258171
-
Leishmaniasis - Current chemotherapy and recent advances in the search for novel drugs
-
Croft SL, Coombs GH: Leishmaniasis - current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol (2003) 19(11):502-508.
-
(2003)
Trends Parasitol
, vol.19
, Issue.11
, pp. 502-508
-
-
Croft, S.L.1
Coombs, G.H.2
-
10
-
-
0142043920
-
Current treatment approaches to leishmaniasis
-
Berman J: Current treatment approaches to leishmaniasis. Curr Opin Infect Dis (2003) 16(5):397-401.
-
(2003)
Curr Opin Infect Dis
, vol.16
, Issue.5
, pp. 397-401
-
-
Berman, J.1
-
11
-
-
0036919858
-
Advances in the treatment of leishmaniasis
-
Sundar S, Rai M: Advances in the treatment of leishmaniasis. Curr Opin Infect Dis (2002) 15(6):593-598.
-
(2002)
Curr Opin Infect Dis
, vol.15
, Issue.6
, pp. 593-598
-
-
Sundar, S.1
Rai, M.2
-
13
-
-
0034451615
-
Failure of pentavalent antimony in visceral leishmaniasis in India: Report from the center of the Indian epidemic
-
Sundar S, More DK, Singh MK, Singh VP, Sharma S, Makharia A, Kumar PC, Murray HW: Failure of pentavalent antimony in visceral leishmaniasis in India: Report from the center of the Indian epidemic. Clin Infect Dis (2000) 31(4):1104-1107.
-
(2000)
Clin Infect Dis
, vol.31
, Issue.4
, pp. 1104-1107
-
-
Sundar, S.1
More, D.K.2
Singh, M.K.3
Singh, V.P.4
Sharma, S.5
Makharia, A.6
Kumar, P.C.7
Murray, H.W.8
-
14
-
-
0034780949
-
Drug resistance in Indian visceral leishmaniasis
-
Sundar S: Drug resistance in Indian visceral leishmaniasis. Trop Med Int Health (2001) 6(11):849-854.
-
(2001)
Trop Med Int Health
, vol.6
, Issue.11
, pp. 849-854
-
-
Sundar, S.1
-
15
-
-
17544387144
-
Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries
-
Berman JD, Badaro R, Thakur CP, Wasunna KM, Behbehani K, Davidson R, Kuzoe F, Pang L, Weerasuriya K, Bryceson AD: Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries. Bull World Health Organ (1998) 76(1):25-32.
-
(1998)
Bull World Health Organ
, vol.76
, Issue.1
, pp. 25-32
-
-
Berman, J.D.1
Badaro, R.2
Thakur, C.P.3
Wasunna, K.M.4
Behbehani, K.5
Davidson, R.6
Kuzoe, F.7
Pang, L.8
Weerasuriya, K.9
Bryceson, A.D.10
-
16
-
-
0037191710
-
Oral miltefosine for Indian visceral leishmaniasis
-
Sundar S, Jha TK, Thakur CP, Engel J, Sindermann H, Fischer C, Junge K, Bryceson A, Berman J: Oral miltefosine for Indian visceral leishmaniasis. N Engl J Med (2002) 347(22):1739-1746.
-
(2002)
N Engl J Med
, vol.347
, Issue.22
, pp. 1739-1746
-
-
Sundar, S.1
Jha, T.K.2
Thakur, C.P.3
Engel, J.4
Sindermann, H.5
Fischer, C.6
Junge, K.7
Bryceson, A.8
Berman, J.9
-
17
-
-
1342308517
-
Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent
-
Soto J, Toledo J, Gutierrez P, Nicholls RS, Padilla J, Engel J, Fischer C, Voss A, Berman J: Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent. Clin Infect Dis (2001) 33(7):E57-E61.
-
(2001)
Clin Infect Dis
, vol.33
, Issue.7
-
-
Soto, J.1
Toledo, J.2
Gutierrez, P.3
Nicholls, R.S.4
Padilla, J.5
Engel, J.6
Fischer, C.7
Voss, A.8
Berman, J.9
-
18
-
-
2342538350
-
Miltefosine for new world cutaneous leishmaniasis
-
Soto J, Arana BA, Toledo J, Rizzo N, Vega JC, Diaz A, Luz M, Gutierrez P, Arboleda M, Berman JD, Junge K et al: Miltefosine for new world cutaneous leishmaniasis. Clin Infect Dis (2004) 38(9):1266-1272.
-
(2004)
Clin Infect Dis
, vol.38
, Issue.9
, pp. 1266-1272
-
-
Soto, J.1
Arana, B.A.2
Toledo, J.3
Rizzo, N.4
Vega, J.C.5
Diaz, A.6
Luz, M.7
Gutierrez, P.8
Arboleda, M.9
Berman, J.D.10
Junge, K.11
-
19
-
-
0041767590
-
Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug
-
Perez-Victoria FJ, Castanys S, Gamarro F: Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug. Antimicrob Agents Chemother (2003) 47(8):2397-2403.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, Issue.8
, pp. 2397-2403
-
-
Perez-Victoria, F.J.1
Castanys, S.2
Gamarro, F.3
-
20
-
-
0346118937
-
Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance
-
Perez-Victoria FJ, Gamarro F, Ouellette M, Castanys S: Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance. J Biol Chem (2003) 278(50):49965-49971.
-
(2003)
J Biol Chem
, vol.278
, Issue.50
, pp. 49965-49971
-
-
Perez-Victoria, F.J.1
Gamarro, F.2
Ouellette, M.3
Castanys, S.4
-
21
-
-
0033843320
-
Treatment of visceral leishmaniasis with injectable paromomycin (aminosidine). An open-label randomized phase-II clinical study
-
Thakur CP, Kanyok TP, Pandey AK, Sinha GP, Messick C, Olliaro P: Treatment of visceral leishmaniasis with injectable paromomycin (aminosidine). An open-label randomized phase-II clinical study. Trans R Soc Trop Med Hyg (2000) 94(4):432-433.
-
(2000)
Trans R Soc Trop Med Hyg
, vol.94
, Issue.4
, pp. 432-433
-
-
Thakur, C.P.1
Kanyok, T.P.2
Pandey, A.K.3
Sinha, G.P.4
Messick, C.5
Olliaro, P.6
-
22
-
-
0026689982
-
Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major. A double-blind control study
-
el-On J, Halevy S, Grunwald MH, Weinrauch L: Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major. A double-blind control study. J Am Acad Dermatol (1992) 27(2 Pt 1):227-231.
-
(1992)
J Am Acad Dermatol
, vol.27
, Issue.2 PART 1
, pp. 227-231
-
-
El-On, J.1
Halevy, S.2
Grunwald, M.H.3
Weinrauch, L.4
-
23
-
-
0036314069
-
Treatment of cutaneous leishmaniasis with a topical antileishmanial drug (WR279396): Phase 2 pilot study
-
Soto JM, Toledo JT, Gutierrez P, Arboleda M, Nicholls RS, Padilla JR, Berman JD, English CK, Grogl M: Treatment of cutaneous leishmaniasis with a topical antileishmanial drug (WR279396): Phase 2 pilot study. Am J Trop Med Hyg (2002) 66(2):147-151.
-
(2002)
Am J Trop Med Hyg
, vol.66
, Issue.2
, pp. 147-151
-
-
Soto, J.M.1
Toledo, J.T.2
Gutierrez, P.3
Arboleda, M.4
Nicholls, R.S.5
Padilla, J.R.6
Berman, J.D.7
English, C.K.8
Grogl, M.9
-
24
-
-
3242707018
-
Comparison of the effectiveness of two topical paromomycin treatments versus meglumine antimoniate for New World cutaneous leishmaniasis
-
Armijos RX, Weigel MM, Calvopina M, Mancheno M, Rodriguez R: Comparison of the effectiveness of two topical paromomycin treatments versus meglumine antimoniate for New World cutaneous leishmaniasis. Acta Trop (2004) 91(2):153-160.
-
(2004)
Acta Trop
, vol.91
, Issue.2
, pp. 153-160
-
-
Armijos, R.X.1
Weigel, M.M.2
Calvopina, M.3
Mancheno, M.4
Rodriguez, R.5
-
25
-
-
0028213959
-
Treatment of 'Old World' cutaneous leishmaniasis with aminosidine ointment: Results of an open study in London
-
Bryceson AD, Murphy A, Moody AH: Treatment of 'Old World' cutaneous leishmaniasis with aminosidine ointment: Results of an open study in London. Trans R Soc Trop Med Hyg (1994) 88(2):226-228.
-
(1994)
Trans R Soc Trop Med Hyg
, vol.88
, Issue.2
, pp. 226-228
-
-
Bryceson, A.D.1
Murphy, A.2
Moody, A.H.3
-
26
-
-
0032973750
-
Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (Aminosidine) and gentamicin
-
Grogl M, Schuster BG, Ellis WY, Berman JD: Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (Aminosidine) and gentamicin. J Parasitol (1999) 85(2):354-359.
-
(1999)
J Parasitol
, vol.85
, Issue.2
, pp. 354-359
-
-
Grogl, M.1
Schuster, B.G.2
Ellis, W.Y.3
Berman, J.D.4
-
27
-
-
4544247606
-
New generation of non-profit initiatives tackles world's 'neglected' diseases
-
Mandelbaum-Schmid J: New generation of non-profit initiatives tackles world's 'neglected' diseases. Bull World Health Organ (2004) 82(5):395-396.
-
(2004)
Bull World Health Organ
, vol.82
, Issue.5
, pp. 395-396
-
-
Mandelbaum-Schmid, J.1
-
28
-
-
0027948991
-
Phase 2 efficacy trial of an oral 8-aminoquinoline (WR6026) for treatment of visceral leishmaniasis
-
Sherwood JA, Gachihi GS, Muigai RK, Skillman DR, Mugo M, Rashid JR, Wasunna KM, Were JB, Kasili SK, Mbugua JM et al: Phase 2 efficacy trial of an oral 8-aminoquinoline (WR6026) for treatment of visceral leishmaniasis. Clin Infect Dis (1994) 19(6):1034-1039.
-
(1994)
Clin Infect Dis
, vol.19
, Issue.6
, pp. 1034-1039
-
-
Sherwood, J.A.1
Gachihi, G.S.2
Muigai, R.K.3
Skillman, D.R.4
Mugo, M.5
Rashid, J.R.6
Wasunna, K.M.7
Were, J.B.8
Kasili, S.K.9
Mbugua, J.M.10
-
29
-
-
0035687445
-
Phase 2 trial of WR6026, an orally administered 8-aminoquinoline, in the treatment of visceral leishmaniasis caused by Leishmania chagasi
-
Dietze R, Carvalho SF, Valli LC, Berman J, Brewer T, Milhous W, Sanchez J, Schuster B, Grogl M: Phase 2 trial of WR6026, an orally administered 8-aminoquinoline, in the treatment of visceral leishmaniasis caused by Leishmania chagasi. Am J Trop Med Hyg (2001) 65(6):685-689.
-
(2001)
Am J Trop Med Hyg
, vol.65
, Issue.6
, pp. 685-689
-
-
Dietze, R.1
Carvalho, S.F.2
Valli, L.C.3
Berman, J.4
Brewer, T.5
Milhous, W.6
Sanchez, J.7
Schuster, B.8
Grogl, M.9
-
30
-
-
0036782986
-
Sitamaquine (GlaxoSmithKline/Walter Reed Army Institute)
-
Yeates C: Sitamaquine (GlaxoSmithKline/Walter Reed Army Institute). Curr Opin Investig Drugs (2002) 3(10):1446-1452.
-
(2002)
Curr Opin Investig Drugs
, vol.3
, Issue.10
, pp. 1446-1452
-
-
Yeates, C.1
-
31
-
-
0023194873
-
In vitro antileishmanial activity of inhibitors of steroid biosynthesis and combinations of antileishmanial agents
-
Berman JD, Gallalee JV: In vitro antileishmanial activity of inhibitors of steroid biosynthesis and combinations of antileishmanial agents. J Parasitol (1987) 73(3):671-673.
-
(1987)
J Parasitol
, vol.73
, Issue.3
, pp. 671-673
-
-
Berman, J.D.1
Gallalee, J.V.2
-
32
-
-
0023765496
-
Effects of antimycotic azoles on growth and sterol biosynthesis of Leishmania promastigotes
-
Beach DH, Goad LJ, Holz GG Jr: Effects of antimycotic azoles on growth and sterol biosynthesis of Leishmania promastigotes. Mol Biochem Parasitol (1988) 31(2):149-162.
-
(1988)
Mol Biochem Parasitol
, vol.31
, Issue.2
, pp. 149-162
-
-
Beach, D.H.1
Goad, L.J.2
Holz Jr., G.G.3
-
33
-
-
0024507364
-
Perturbation of sterol biosynthesis by itraconazole and ketoconazole in Leishmania mexicana mexicana infected macrophages
-
Hart DT, Lauwers WJ, Willemsens G, Vanden Bossche H, Opperdoes FR: Perturbation of sterol biosynthesis by itraconazole and ketoconazole in Leishmania mexicana mexicana infected macrophages. Mol Biochem Parasitol (1989) 33(2):123-134.
-
(1989)
Mol Biochem Parasitol
, vol.33
, Issue.2
, pp. 123-134
-
-
Hart, D.T.1
Lauwers, W.J.2
Willemsens, G.3
Vanden Bossche, H.4
Opperdoes, F.R.5
-
34
-
-
0037149717
-
Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major
-
Alrajhi AA, Ibrahim EA, De Vol EB, Khairat M, Fans RM, Maguire JH: Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major. N Engl J Med (2002) 346(12):891-895.
-
(2002)
N Engl J Med
, vol.346
, Issue.12
, pp. 891-895
-
-
Alrajhi, A.A.1
Ibrahim, E.A.2
De Vol, E.B.3
Khairat, M.4
Fans, R.M.5
Maguire, J.H.6
-
35
-
-
4644219747
-
Itraconazole in the treatment of New World mucocutaneous leishmaniasis
-
Calvopina M, Guevara AG, Armijos RX, Hashiguchi Y, Davidson RN, Cooper PJ: Itraconazole in the treatment of New World mucocutaneous leishmaniasis. Int J Dermatol (2004) 43(9):659-663.
-
(2004)
Int J Dermatol
, vol.43
, Issue.9
, pp. 659-663
-
-
Calvopina, M.1
Guevara, A.G.2
Armijos, R.X.3
Hashiguchi, Y.4
Davidson, R.N.5
Cooper, P.J.6
-
36
-
-
0032763329
-
Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases
-
Al-Abdely HM, Graybill JR, Loebenberg D, Melby PC: Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases. Antimicrob Agents Chemother (1999) 43(12):2910-2914.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, Issue.12
, pp. 2910-2914
-
-
Al-Abdely, H.M.1
Graybill, J.R.2
Loebenberg, D.3
Melby, P.C.4
-
37
-
-
0027958391
-
Cytokine induction in mice by the immunomodulator imiquimod
-
Reiter MJ, Testerman TL, Miller RL, Weeks CE, Tomai MA: Cytokine induction in mice by the immunomodulator imiquimod. J Leukocyte Biol (1994) 55(2):234-240.
-
(1994)
J Leukocyte Biol
, vol.55
, Issue.2
, pp. 234-240
-
-
Reiter, M.J.1
Testerman, T.L.2
Miller, R.L.3
Weeks, C.E.4
Tomai, M.A.5
-
38
-
-
0028875151
-
Immunomodulating and antiviral activities of the imidazoquinoline S-28463
-
Tomai MA, Gibson SJ, Imbertson LM, Miller RL, Myhre PE, Reiter MJ, Wagner TL, Tamulinas CB, Beaurline JM, Gerster JF, Horton VL: Immunomodulating and antiviral activities of the imidazoquinoline S-28463. Antiviral Res (1995) 28(3):253-264.
-
(1995)
Antiviral Res
, vol.28
, Issue.3
, pp. 253-264
-
-
Tomai, M.A.1
Gibson, S.J.2
Imbertson, L.M.3
Miller, R.L.4
Myhre, P.E.5
Reiter, M.J.6
Wagner, T.L.7
Tamulinas, C.B.8
Beaurline, J.M.9
Gerster, J.F.10
Horton, V.L.11
-
39
-
-
0029099053
-
Cytokine induction by the immunomodulators imiquimod and S-27609
-
Testerman TL, Gerster JF, Imbertson LM, Reiter MJ, Miller RL, Gibson SJ, Wagner TL, Tomai MA: Cytokine induction by the immunomodulators imiquimod and S-27609. J Leukocyte Biol (1995) 58(3):365-372.
-
(1995)
J Leukocyte Biol
, vol.58
, Issue.3
, pp. 365-372
-
-
Testerman, T.L.1
Gerster, J.F.2
Imbertson, L.M.3
Reiter, M.J.4
Miller, R.L.5
Gibson, S.J.6
Wagner, T.L.7
Tomai, M.A.8
-
40
-
-
0033057209
-
Treatment of experimental leishmaniasis with the immunomodulators imiquimod and S-28463: Efficacy and mode of action
-
Buates S, Matlashewski G: Treatment of experimental leishmaniasis with the immunomodulators imiquimod and S-28463: Efficacy and mode of action. J Infect Dis (1999) 179(6):1485-1494.
-
(1999)
J Infect Dis
, vol.179
, Issue.6
, pp. 1485-1494
-
-
Buates, S.1
Matlashewski, G.2
-
41
-
-
0035577828
-
Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator
-
Arevalo I, Ward B, Miller R, Meng TC, Najar E, Alvarez E, Matlashewski G, Llanos-Cuentas A: Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator. Clin Infect Dis (2001) 33(11):1847-1851.
-
(2001)
Clin Infect Dis
, vol.33
, Issue.11
, pp. 1847-1851
-
-
Arevalo, I.1
Ward, B.2
Miller, R.3
Meng, T.C.4
Najar, E.5
Alvarez, E.6
Matlashewski, G.7
Llanos-Cuentas, A.8
-
42
-
-
0037931526
-
Transient effect of topical treatment of cutaneous leishmaniasis with imiquimod
-
Seeberger J, Daoud S, Pammer J: Transient effect of topical treatment of cutaneous leishmaniasis with imiquimod. Int J Dermatol (2003) 42(7):576-579.
-
(2003)
Int J Dermatol
, vol.42
, Issue.7
, pp. 576-579
-
-
Seeberger, J.1
Daoud, S.2
Pammer, J.3
-
43
-
-
0037165196
-
Antimicrobial peptides of multicellular organisms
-
Zasloff M: Antimicrobial peptides of multicellular organisms. Nature (2002) 415(6870):389-395.
-
(2002)
Nature
, vol.415
, Issue.6870
, pp. 389-395
-
-
Zasloff, M.1
-
44
-
-
0028829183
-
Peptides as weapons against microorganisms in the chemical defense system of vertebrates
-
Nicolas P, Mor A: Peptides as weapons against microorganisms in the chemical defense system of vertebrates. Annu Rev Microbiol (1995) 49:277-304.
-
(1995)
Annu Rev Microbiol
, vol.49
, pp. 277-304
-
-
Nicolas, P.1
Mor, A.2
-
45
-
-
0036861894
-
Antimicrobial peptides versus parasitic infections?
-
Vizioli J, Salzet M: Antimicrobial peptides versus parasitic infections? Trends Parasitol (2002) 18(11):475-476.
-
(2002)
Trends Parasitol
, vol.18
, Issue.11
, pp. 475-476
-
-
Vizioli, J.1
Salzet, M.2
-
46
-
-
0030023749
-
Broad spectrum antibiotic activity of the skin-PYY
-
Vouldoukis I, Shai Y, Nicolas P, Mor A: Broad spectrum antibiotic activity of the skin-PYY. FEBS Lett (1996) 380(3):237-240.
-
(1996)
FEBS Lett
, vol.380
, Issue.3
, pp. 237-240
-
-
Vouldoukis, I.1
Shai, Y.2
Nicolas, P.3
Mor, A.4
-
47
-
-
0034635367
-
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity
-
Feder R, Dagan A, Mor A: Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity. J Biol Chem (2000) 275(6):4230-4238.
-
(2000)
J Biol Chem
, vol.275
, Issue.6
, pp. 4230-4238
-
-
Feder, R.1
Dagan, A.2
Mor, A.3
-
48
-
-
0037053317
-
Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives
-
Kustanovich I, Shalev DE, Mikhlin M, Gaidukov L, Mor A: Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives. J Biol Chem (2002) 277(19):16941-16951.
-
(2002)
J Biol Chem
, vol.277
, Issue.19
, pp. 16941-16951
-
-
Kustanovich, I.1
Shalev, D.E.2
Mikhlin, M.3
Gaidukov, L.4
Mor, A.5
-
49
-
-
0242424143
-
Analysis of membrane-binding properties of dermaseptin analogues: Relationships between binding and cytotoxicity
-
Gaidukov L, Fish A, Mor A: Analysis of membrane-binding properties of dermaseptin analogues: Relationships between binding and cytotoxicity. Biochemistry (2003) 42(44):12866-12874.
-
(2003)
Biochemistry
, vol.42
, Issue.44
, pp. 12866-12874
-
-
Gaidukov, L.1
Fish, A.2
Mor, A.3
-
50
-
-
0031598639
-
Drosophila antibacterial protein, cecropin A, differentially affects non-bacterial organisms such as Leishmania in a manner different from other amphipathic peptides
-
Akuffo H, Hultmark D, Engstom A, Frohlich D, Kimbrell D: Drosophila antibacterial protein, cecropin A, differentially affects non-bacterial organisms such as Leishmania in a manner different from other amphipathic peptides. Int J Mol Med (1998) 1(1):77-82.
-
(1998)
Int J Mol Med
, vol.1
, Issue.1
, pp. 77-82
-
-
Akuffo, H.1
Hultmark, D.2
Engstom, A.3
Frohlich, D.4
Kimbrell, D.5
-
51
-
-
0032519748
-
The plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide
-
Diaz-Achirica P, Ubach J, Guinea A, Andreu D, Rivas L: The plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide. Biochem J (1998) 330(1):453-460.
-
(1998)
Biochem J
, vol.330
, Issue.1
, pp. 453-460
-
-
Diaz-Achirica, P.1
Ubach, J.2
Guinea, A.3
Andreu, D.4
Rivas, L.5
-
52
-
-
0034721871
-
Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family
-
Silva PI Jr, Daffre S, Bulet P: Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J Biol Chem (2000) 275(43):33464-33470.
-
(2000)
J Biol Chem
, vol.275
, Issue.43
, pp. 33464-33470
-
-
Silva Jr., P.I.1
Daffre, S.2
Bulet, P.3
-
53
-
-
0037373689
-
Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides
-
Bera A, Singh S, Nagaraj R, Vaidya T: Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides. Mol Biochem Parasitol (2003) 127(1):23-35.
-
(2003)
Mol Biochem Parasitol
, vol.127
, Issue.1
, pp. 23-35
-
-
Bera, A.1
Singh, S.2
Nagaraj, R.3
Vaidya, T.4
-
54
-
-
3342905060
-
Role of positional hydrophobicity in the leishmanicidal activity of magainin 2
-
Guerrero E, Saugar JM, Matsuzaki K, Rivas L: Role of positional hydrophobicity in the leishmanicidal activity of magainin 2. Antimicrob Agents Chemother (2004) 48(8):2980-2986.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.8
, pp. 2980-2986
-
-
Guerrero, E.1
Saugar, J.M.2
Matsuzaki, K.3
Rivas, L.4
-
55
-
-
12544252687
-
Temporins: Small antimicrobial peptides with leishmanicidal activity
-
Mangoni ML, Saugar JM, Dellisanti M, Barra D, Simmaco M, Rivas L: Temporins: Small antimicrobial peptides with leishmanicidal activity. J Biol Chem (2005) 280(5):984-990.
-
(2005)
J Biol Chem
, vol.280
, Issue.5
, pp. 984-990
-
-
Mangoni, M.L.1
Saugar, J.M.2
Dellisanti, M.3
Barra, D.4
Simmaco, M.5
Rivas, L.6
-
56
-
-
24344442307
-
Antiprotozoan and antiviral activities of non-cytotoxic truncated and variant analogues of mussel defensin
-
Roch P, Beschin A, Bernard E: Antiprotozoan and antiviral activities of non-cytotoxic truncated and variant analogues of mussel defensin. Evid Based Complement Alternat Med (2004) 1(2):167-174.
-
(2004)
Evid Based Complement Alternat Med
, vol.1
, Issue.2
, pp. 167-174
-
-
Roch, P.1
Beschin, A.2
Bernard, E.3
-
57
-
-
0942301299
-
Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis
-
Alberola J, Rodriguez A, Francino O, Roura X, Rivas L, Andreu D: Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis. Antimicrob Agents Chemother (2004) 48(2):641-643. This paper describes a small animal trial conducted in dogs testing the efficacy of a synthetic antimicrobial peptide against canine leishmaniasis.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.2
, pp. 641-643
-
-
Alberola, J.1
Rodriguez, A.2
Francino, O.3
Roura, X.4
Rivas, L.5
Andreu, D.6
-
58
-
-
0036606951
-
Mammalian defensins in immunity: More than just microbicidal
-
Yang D, Biragyn A, Kwak LW, Oppenheim JJ: Mammalian defensins in immunity: More than just microbicidal. Trends Immunol (2002) 23(6):291-296.
-
(2002)
Trends Immunol
, vol.23
, Issue.6
, pp. 291-296
-
-
Yang, D.1
Biragyn, A.2
Kwak, L.W.3
Oppenheim, J.J.4
-
59
-
-
0036607940
-
Antimicrobial peptides are signaling molecules
-
Salzet M: Antimicrobial peptides are signaling molecules. Trends Immunol (2002) 23(6):283-284.
-
(2002)
Trends Immunol
, vol.23
, Issue.6
, pp. 283-284
-
-
Salzet, M.1
-
60
-
-
0035543633
-
Plant natural products with leishmanicidal activity
-
Chan-Bacab MJ, Pena-Rodriguez LM: Plant natural products with leishmanicidal activity. Nat Prod Rep (2001) 18(6):674-688.
-
(2001)
Nat Prod Rep
, vol.18
, Issue.6
, pp. 674-688
-
-
Chan-Bacab, M.J.1
Pena-Rodriguez, L.M.2
-
61
-
-
0036833567
-
Natural products as trypanocidal, antileishmanial and antimalarial drugs
-
Fournet A, Munoz V: Natural products as trypanocidal, antileishmanial and antimalarial drugs. Curr Top Med Chem (2002) 2(11):1215-1237. A review summarizing the current status of natural products against parasitic diseases and recent developments in this field.
-
(2002)
Curr Top Med Chem
, vol.2
, Issue.11
, pp. 1215-1237
-
-
Fournet, A.1
Munoz, V.2
-
63
-
-
0042844748
-
Antiparasitic alkaloids from Psychotria klugii
-
Muhammad I, Dunbar DC, Khan SI, Tekwani BL, Bedir E, Takamatsu S, Ferreira D, Walker LA: Antiparasitic alkaloids from Psychotria klugii. J Nat Prod (2003) 66(7):962-967.
-
(2003)
J Nat Prod
, vol.66
, Issue.7
, pp. 962-967
-
-
Muhammad, I.1
Dunbar, D.C.2
Khan, S.I.3
Tekwani, B.L.4
Bedir, E.5
Takamatsu, S.6
Ferreira, D.7
Walker, L.A.8
-
64
-
-
0035199840
-
Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: New source of tanshinones
-
Sairafianpour M, Christensen J, Staerk D, Budnik BA, Kharazmi A, Bagherzadeh K, Jaroszewski JW: Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: New source of tanshinones. J Nat Prod (2001) 64(11):1398-1403.
-
(2001)
J Nat Prod
, vol.64
, Issue.11
, pp. 1398-1403
-
-
Sairafianpour, M.1
Christensen, J.2
Staerk, D.3
Budnik, B.A.4
Kharazmi, A.5
Bagherzadeh, K.6
Jaroszewski, J.W.7
-
65
-
-
0034816339
-
New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities
-
Fuchino H, Koide T, Takahashi M, Sekita S, Satake M: New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities. Planta Med (2001) 67(7):647-653.
-
(2001)
Planta Med
, vol.67
, Issue.7
, pp. 647-653
-
-
Fuchino, H.1
Koide, T.2
Takahashi, M.3
Sekita, S.4
Satake, M.5
-
66
-
-
0034736133
-
Antileishmanial activity of neolignans from Virola species and synthetic analogues
-
Barata LE, Santos LS, Ferri PH, Phillipson JD, Paine A, Croft SL: Antileishmanial activity of neolignans from Virola species and synthetic analogues. Phytochemistry (2000) 55(6):589-595.
-
(2000)
Phytochemistry
, vol.55
, Issue.6
, pp. 589-595
-
-
Barata, L.E.1
Santos, L.S.2
Ferri, P.H.3
Phillipson, J.D.4
Paine, A.5
Croft, S.L.6
-
67
-
-
0034547932
-
In vitro leishmanicidal activity of monomeric and dimeric naphthoquinones
-
Kayser O, Kiderlen AF, Laatsch H, Croft SL: In vitro leishmanicidal activity of monomeric and dimeric naphthoquinones. Acta Trop (2000) 77(3):307-314.
-
(2000)
Acta Trop
, vol.77
, Issue.3
, pp. 307-314
-
-
Kayser, O.1
Kiderlen, A.F.2
Laatsch, H.3
Croft, S.L.4
-
68
-
-
0037379518
-
Trypanocidal and leishmanicidal properties of substitution-containing chalcones
-
Lunardi F, Guzela M, Rodrigues AT, Correa R, Eger-Mangrich I, Steindel M, Grisard EC, Assreuy J, Calixto JB, Santos AR: Trypanocidal and leishmanicidal properties of substitution-containing chalcones. Antimicrob Agents Chemother (2003) 47(4):1449-1451.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, Issue.4
, pp. 1449-1451
-
-
Lunardi, F.1
Guzela, M.2
Rodrigues, A.T.3
Correa, R.4
Eger-Mangrich, I.5
Steindel, M.6
Grisard, E.C.7
Assreuy, J.8
Calixto, J.B.9
Santos, A.R.10
-
69
-
-
0034951496
-
Inhibition of fumarate reductase in Leishmania major and L donovani by chalcones
-
Chen M, Zhai L, Christensen SB, Theander TG, Kharazmi A: Inhibition of fumarate reductase in Leishmania major and L donovani by chalcones. Antimicrob Agents Chemother (2001) 45(7):2023-2029.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, Issue.7
, pp. 2023-2029
-
-
Chen, M.1
Zhai, L.2
Christensen, S.B.3
Theander, T.G.4
Kharazmi, A.5
-
70
-
-
0025320783
-
Berberine derivatives as antileishmanial drugs
-
Vennerstrom JL, Lovelace JK, Waits VB, Hanson WL, Klayman DL: Berberine derivatives as antileishmanial drugs. Antimicrob Agents Chemother (1990) 34(5):918-921.
-
(1990)
Antimicrob Agents Chemother
, vol.34
, Issue.5
, pp. 918-921
-
-
Vennerstrom, J.L.1
Lovelace, J.K.2
Waits, V.B.3
Hanson, W.L.4
Klayman, D.L.5
-
71
-
-
0344420369
-
Effects of topoisomerases inhibitors protoberberine on Leishmania donovani growth, macrophage function, and infection
-
Marquis JF, Makhey D, LaVoie EJ, Olivier M: Effects of topoisomerases inhibitors protoberberine on Leishmania donovani growth, macrophage function, and infection. J Parasitol (2003) 89(5):1048-1052.
-
(2003)
J Parasitol
, vol.89
, Issue.5
, pp. 1048-1052
-
-
Marquis, J.F.1
Makhey, D.2
LaVoie, E.J.3
Olivier, M.4
-
72
-
-
0028223416
-
Antileishmanial activity of licochalcone a in mice infected with Leishmania major and in hamsters infected with Leishmania donovani
-
Chen M, Christensen SB, Theander TG, Kharazmi A: Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani. Antimicrob Agents Chemother (1994) 38(6):1339-1344.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, Issue.6
, pp. 1339-1344
-
-
Chen, M.1
Christensen, S.B.2
Theander, T.G.3
Kharazmi, A.4
-
73
-
-
0027381266
-
Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania
-
Chen M, Christensen SB, Blom J, Lemmich E, Nadelmann L, Fich K, Theander TG, Kharazmi A: Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrob Agents Chemother (1993) 37(12):2550-2556.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, Issue.12
, pp. 2550-2556
-
-
Chen, M.1
Christensen, S.B.2
Blom, J.3
Lemmich, E.4
Nadelmann, L.5
Fich, K.6
Theander, T.G.7
Kharazmi, A.8
-
74
-
-
0028853602
-
The antileishmanial agent licochalcone a interferes with the function of parasite mitochondria
-
Zhai L, Blom J, Chen M, Christensen SB, Kharazmi A: The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria. Antimicrob Agents Chemother (1995) 39(12):2742-2748.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, Issue.12
, pp. 2742-2748
-
-
Zhai, L.1
Blom, J.2
Chen, M.3
Christensen, S.B.4
Kharazmi, A.5
-
75
-
-
4344668984
-
Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases
-
Rao KV, Kasanah N, Wahyuono S, Tekwani BL, Schinazi RF, Hamann MT: Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases. J Nat Prod (2004) 67(8):1314-1318.
-
(2004)
J Nat Prod
, vol.67
, Issue.8
, pp. 1314-1318
-
-
Rao, K.V.1
Kasanah, N.2
Wahyuono, S.3
Tekwani, B.L.4
Schinazi, R.F.5
Hamann, M.T.6
-
76
-
-
1542318539
-
Antileishmanial activity of isolated triterpenoids from Pourouma guianensis
-
Torres-Santos EC, Lopes D, Oliveira RR, Carauta JP, Falcao CA, Kaplan MA, Rossi-Bergmann B: Antileishmanial activity of isolated triterpenoids from Pourouma guianensis. Phytomedicine (2004) 11(2-3):114-120.
-
(2004)
Phytomedicine
, vol.11
, Issue.2-3
, pp. 114-120
-
-
Torres-Santos, E.C.1
Lopes, D.2
Oliveira, R.R.3
Carauta, J.P.4
Falcao, C.A.5
Kaplan, M.A.6
Rossi-Bergmann, B.7
-
77
-
-
9144272543
-
Antiparasitic activities of medicinal plants used in Ivory Coast
-
Okpekon T, Yolou S, Gleye C, Roblot F, Loiseau P, Bories C, Grellier P, Frappier F, Laurens A, Hocquemiller R: Antiparasitic activities of medicinal plants used in Ivory Coast. J Ethnopharmacol (2004) 90(1):91-97.
-
(2004)
J Ethnopharmacol
, vol.90
, Issue.1
, pp. 91-97
-
-
Okpekon, T.1
Yolou, S.2
Gleye, C.3
Roblot, F.4
Loiseau, P.5
Bories, C.6
Grellier, P.7
Frappier, F.8
Laurens, A.9
Hocquemiller, R.10
-
78
-
-
4043176952
-
In vitro leishmanicidal activity of some scarce natural products
-
Takahashi M, Fuchino H, Sekita S, Satake M: In vitro leishmanicidal activity of some scarce natural products. Phytother Res (2004) 18(7):573-578.
-
(2004)
Phytother Res
, vol.18
, Issue.7
, pp. 573-578
-
-
Takahashi, M.1
Fuchino, H.2
Sekita, S.3
Satake, M.4
-
79
-
-
0347992035
-
In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species
-
Maes L, Vanden Berghe D, Germonprez N, Quirijnen L, Cos P, De Kimpe N, Van Puyvelde L: In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species. Antimicrob Agents Chemother (2004) 48(1):130-136.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.1
, pp. 130-136
-
-
Maes, L.1
Vanden Berghe, D.2
Germonprez, N.3
Quirijnen, L.4
Cos, P.5
De Kimpe, N.6
Van Puyvelde, L.7
-
80
-
-
2542434992
-
In vitro activity of the β-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum
-
Di Giorgio C, Delmas F, Ollivier E, Elias R, Balansard G, Timon-David P: In vitro activity of the β-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum. Exp Parasitol (2004) 106(3-4):67-74.
-
(2004)
Exp Parasitol
, vol.106
, Issue.3-4
, pp. 67-74
-
-
Di Giorgio, C.1
Delmas, F.2
Ollivier, E.3
Elias, R.4
Balansard, G.5
Timon-David, P.6
-
81
-
-
2142695761
-
Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: Antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes
-
Luque-Ortega JR, Martinez S, Saugar JM, Izquierdo LR, Abad T, Luis JG, Pinero J, Valladares B, Rivas L: Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: Antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes. Antimicrob Agents Chemother (2004) 48(5):1534-1540.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.5
, pp. 1534-1540
-
-
Luque-Ortega, J.R.1
Martinez, S.2
Saugar, J.M.3
Izquierdo, L.R.4
Abad, T.5
Luis, J.G.6
Pinero, J.7
Valladares, B.8
Rivas, L.9
-
82
-
-
0345732505
-
Antileishmanial activity of aqueous onion extract in vitro
-
Saleheen D, Ali SA, Yasinzai MM: Antileishmanial activity of aqueous onion extract in vitro. Fitoterapia (2004) 75(1):9-13.
-
(2004)
Fitoterapia
, vol.75
, Issue.1
, pp. 9-13
-
-
Saleheen, D.1
Ali, S.A.2
Yasinzai, M.M.3
-
83
-
-
3042550882
-
Antimalarial drug discovery: Efficacy models for compound screening
-
Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S: Antimalarial drug discovery: Efficacy models for compound screening. Nat Rev Drug Discov (2004) 3(6):509-520.
-
(2004)
Nat Rev Drug Discov
, vol.3
, Issue.6
, pp. 509-520
-
-
Fidock, D.A.1
Rosenthal, P.J.2
Croft, S.L.3
Brun, R.4
Nwaka, S.5
-
84
-
-
0038646796
-
Thiol-based redox metabolism of protozoan parasites
-
Muller S, Liebau E, Walter RD, Krauth-Siegel RL: Thiol-based redox metabolism of protozoan parasites. Trends Parasitol (2003) 19(7):320-328.
-
(2003)
Trends Parasitol
, vol.19
, Issue.7
, pp. 320-328
-
-
Muller, S.1
Liebau, E.2
Walter, R.D.3
Krauth-Siegel, R.L.4
-
85
-
-
0036166378
-
The therapeutic potential of inhibitors of the trypanothione cycle
-
D'Silva C, Daunes S: The therapeutic potential of inhibitors of the trypanothione cycle. Expert Opin Investig Drugs (2002) 11(2):217-231.
-
(2002)
Expert Opin Investig Drugs
, vol.11
, Issue.2
, pp. 217-231
-
-
D'Silva, C.1
Daunes, S.2
-
86
-
-
0035062226
-
Glycolysis as a target for the design of new anti-trypanosome drugs
-
Verlinde CL, Hannaert V, Blonski C, Willson M, Perie JJ, Fothergill-Gilmore LA, Opperdoes FR, Gelb MH, Hol WG, Michels PA: Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resistance Updates (2001) 4(1):50-65.
-
(2001)
Drug Resistance Updates
, vol.4
, Issue.1
, pp. 50-65
-
-
Verlinde, C.L.1
Hannaert, V.2
Blonski, C.3
Willson, M.4
Perie, J.J.5
Fothergill-Gilmore, L.A.6
Opperdoes, F.R.7
Gelb, M.H.8
Hol, W.G.9
Michels, P.A.10
-
87
-
-
7944224890
-
Biogenesis of peroxisomes and glycosomes: Trypanosomatid glycosome assembly is a promising new drug target
-
Moyersoen J, Choe J, Fan E, Hol WG, Michels PA: Biogenesis of peroxisomes and glycosomes: Trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol Rev (2004) 28(5):603-643.
-
(2004)
FEMS Microbiol Rev
, vol.28
, Issue.5
, pp. 603-643
-
-
Moyersoen, J.1
Choe, J.2
Fan, E.3
Hol, W.G.4
Michels, P.A.5
-
88
-
-
4143091399
-
Cysteine peptidases as virulence factors of Leishmania
-
Mottram JC, Coombs GH, Alexander J: Cysteine peptidases as virulence factors of Leishmania. Curr Opin Microbiol (2004) 7(4):375-381.
-
(2004)
Curr Opin Microbiol
, vol.7
, Issue.4
, pp. 375-381
-
-
Mottram, J.C.1
Coombs, G.H.2
Alexander, J.3
-
89
-
-
0035898610
-
Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability
-
Garami A, Ilg T: Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability. EMBO J (2001) 20(14):3657-3666.
-
(2001)
EMBO J
, vol.20
, Issue.14
, pp. 3657-3666
-
-
Garami, A.1
Ilg, T.2
-
90
-
-
0035171565
-
Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants
-
Garami A, Mehlert A, Ilg T: Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate- mannose synthase gene deletion mutants. Mol Cell Biol (2001) 21(23):8168-8183.
-
(2001)
Mol Cell Biol
, vol.21
, Issue.23
, pp. 8168-8183
-
-
Garami, A.1
Mehlert, A.2
Ilg, T.3
-
91
-
-
1842425027
-
Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana
-
Davis AJ, Perugini MA, Smith BJ, Stewart JD, Ilg T, Hodder AN, Handman E: Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana. J Biol Chem (2004) 279(13):12462-12468.
-
(2004)
J Biol Chem
, vol.279
, Issue.13
, pp. 12462-12468
-
-
Davis, A.J.1
Perugini, M.A.2
Smith, B.J.3
Stewart, J.D.4
Ilg, T.5
Hodder, A.N.6
Handman, E.7
-
92
-
-
0036171419
-
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii
-
Yardley V, Khan AA, Martin MB, Slifer TR, Araujo FG, Moreno SN, Docampo R, Croft SL, Oldfield E: In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob Agents Chemother (2002) 46(3):929-931.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, Issue.3
, pp. 929-931
-
-
Yardley, V.1
Khan, A.A.2
Martin, M.B.3
Slifer, T.R.4
Araujo, F.G.5
Moreno, S.N.6
Docampo, R.7
Croft, S.L.8
Oldfield, E.9
-
93
-
-
0030921823
-
A structure-based approach to drug discovery; crystallography and implications for the development of antiparasite drugs
-
Hunter WN: A structure-based approach to drug discovery; crystallography and implications for the development of antiparasite drugs. Parasitology (1997) 114(Suppl):S17-S29.
-
(1997)
Parasitology
, vol.114
-
-
Hunter, W.N.1
-
94
-
-
0032866917
-
Rational drug design using trypanothione reductase as a target for anti-trypanosomal and antileishmanial drug leads
-
Austin SE, Khan MO, Douglas KT: Rational drug design using trypanothione reductase as a target for anti-trypanosomal and antileishmanial drug leads. Drug Des Discov (1999) 16(1):5-23.
-
(1999)
Drug des Discov
, vol.16
, Issue.1
, pp. 5-23
-
-
Austin, S.E.1
Khan, M.O.2
Douglas, K.T.3
-
95
-
-
1242285471
-
Trypanothione reductase activity is prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target
-
Castro-Pinto DB, Echevarria A, Genestra MS, Cysne-Finkelstein L, Leon LL: Trypanothione reductase activity is prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target. J Enzyme Inhib Med Chem (2004) 19(1):57-63.
-
(2004)
J Enzyme Inhib Med Chem
, vol.19
, Issue.1
, pp. 57-63
-
-
Castro-Pinto, D.B.1
Echevarria, A.2
Genestra, M.S.3
Cysne-Finkelstein, L.4
Leon, L.L.5
-
96
-
-
0033927095
-
Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis
-
Werbovetz KA: Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis. Curr Med Chem (2000) 7(8):835-860.
-
(2000)
Curr Med Chem
, vol.7
, Issue.8
, pp. 835-860
-
-
Werbovetz, K.A.1
-
97
-
-
0037785388
-
Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis
-
Dardonville C, Rinaldi E, Hanau S, Barrett MP, Brun R, Gilbert IH: Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem (2003) 11(14):3205-3214.
-
(2003)
Bioorg Med Chem
, vol.11
, Issue.14
, pp. 3205-3214
-
-
Dardonville, C.1
Rinaldi, E.2
Hanau, S.3
Barrett, M.P.4
Brun, R.5
Gilbert, I.H.6
-
98
-
-
0035927424
-
Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design
-
Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH: Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem (2001) 44(13):2080-2093.
-
(2001)
J Med Chem
, vol.44
, Issue.13
, pp. 2080-2093
-
-
Bressi, J.C.1
Verlinde, C.L.2
Aronov, A.M.3
Shaw, M.L.4
Shin, S.S.5
Nguyen, L.N.6
Suresh, S.7
Buckner, F.S.8
Van Voorhis, W.C.9
Kuntz, I.D.10
Hol, W.G.11
Gelb, M.H.12
-
99
-
-
0037130297
-
Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes
-
Gilbert IH: Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes. Biochim Biophys Acta (2002) 1587(2-3):249-257.
-
(2002)
Biochim Biophys Acta
, vol.1587
, Issue.2-3
, pp. 249-257
-
-
Gilbert, I.H.1
-
100
-
-
0038529740
-
A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase
-
Atreya CE, Johnson EF, Irwin JJ, Dow A, Massimine KM, Coppens I, Stempliuk V, Beverley S, Joiner KA, Shoichet BK, Anderson KS: A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase. J Biol Chem (2003) 278(16):14092-14100.
-
(2003)
J Biol Chem
, vol.278
, Issue.16
, pp. 14092-14100
-
-
Atreya, C.E.1
Johnson, E.F.2
Irwin, J.J.3
Dow, A.4
Massimine, K.M.5
Coppens, I.6
Stempliuk, V.7
Beverley, S.8
Joiner, K.A.9
Shoichet, B.K.10
Anderson, K.S.11
-
101
-
-
0036164796
-
Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis
-
Zhang P, Nicholson DE, Bujnicki JM, Su X, Brendle JJ, Ferdig M, Kyle DE, Milhous WK, Chiang PK: Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis. J Biomed Sci (2002) 9(1):34-40.
-
(2002)
J Biomed Sci
, vol.9
, Issue.1
, pp. 34-40
-
-
Zhang, P.1
Nicholson, D.E.2
Bujnicki, J.M.3
Su, X.4
Brendle, J.J.5
Ferdig, M.6
Kyle, D.E.7
Milhous, W.K.8
Chiang, P.K.9
-
102
-
-
0038387389
-
Hit and lead generation: Beyond high-throughput screening
-
Bleicher KH, Bohm HJ, Muller K, Alanine Al: Hit and lead generation: Beyond high-throughput screening. Nat Rev Drug Discov (2003) 2(5):369-378.
-
(2003)
Nat Rev Drug Discov
, vol.2
, Issue.5
, pp. 369-378
-
-
Bleicher, K.H.1
Bohm, H.J.2
Muller, K.3
Alanine, Al.4
-
103
-
-
0037394124
-
Designing screens: How to make your hits a hit
-
Walters WP, Namchuk M: Designing screens: How to make your hits a hit. Nat Rev Drug Discov (2003) 2(4):259-266.
-
(2003)
Nat Rev Drug Discov
, vol.2
, Issue.4
, pp. 259-266
-
-
Walters, W.P.1
Namchuk, M.2
-
104
-
-
0034683233
-
The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: Application of a combinatorial peptide library approach
-
St Hilaire PM, Alves LC, Sanderson SJ, Mottram JC, Juliano MA, Juliano L, Coombs GH, Meldal M: The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: Application of a combinatorial peptide library approach. Chembiochem (2000) 1(2):115-122.
-
(2000)
Chembiochem
, vol.1
, Issue.2
, pp. 115-122
-
-
St Hilaire, P.M.1
Alves, L.C.2
Sanderson, S.J.3
Mottram, J.C.4
Juliano, M.A.5
Juliano, L.6
Coombs, G.H.7
Meldal, M.8
-
105
-
-
0035458539
-
Combinatorial library of peptide isosters based on Diels-Alder reactions: Identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana
-
Graven A, St Hilaire PM, Sanderson SJ, Mottram JC, Coombs GH, Meldal M: Combinatorial library of peptide isosters based on Diels-Alder reactions: Identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana. J Combinatorial Chem (2001) 3(5):441-452.
-
(2001)
J Combinatorial Chem
, vol.3
, Issue.5
, pp. 441-452
-
-
Graven, A.1
St Hilaire, P.M.2
Sanderson, S.J.3
Mottram, J.C.4
Coombs, G.H.5
Meldal, M.6
-
106
-
-
2542542164
-
Combinatorial library of peptidotriazoles: Identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease
-
Tornoe CW, Sanderson SJ, Mottram JC, Coombs GH, Meldal M: Combinatorial library of peptidotriazoles: Identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease. J Combinatorial Chem (2004) 6(3):312-324.
-
(2004)
J Combinatorial Chem
, vol.6
, Issue.3
, pp. 312-324
-
-
Tornoe, C.W.1
Sanderson, S.J.2
Mottram, J.C.3
Coombs, G.H.4
Meldal, M.5
-
107
-
-
1642575101
-
Diamine derivatives with antiparasitic activities
-
Labadie GR, Choi SR, Avery MA: Diamine derivatives with antiparasitic activities. Bioorg Med Chem Lett (2004) 14(3):615-619.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, Issue.3
, pp. 615-619
-
-
Labadie, G.R.1
Choi, S.R.2
Avery, M.A.3
-
108
-
-
0141457812
-
Oxidosqualene cyclase inhibitors as antimicrobial agents
-
Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD: Oxidosqualene cyclase inhibitors as antimicrobial agents. J Med Chem (2003) 46(20):4240-4243.
-
(2003)
J Med Chem
, vol.46
, Issue.20
, pp. 4240-4243
-
-
Hinshaw, J.C.1
Suh, D.Y.2
Garnier, P.3
Buckner, F.S.4
Eastman, R.T.5
Matsuda, S.P.6
Joubert, B.M.7
Coppens, I.8
Joiner, K.A.9
Merali, S.10
Nash, T.E.11
Prestwich, G.D.12
-
109
-
-
3342936476
-
Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: Chemical library screen and antileishmanial activity
-
Grant KM, Dunion MH, Yardley V, Skaltsounis AL, Marko D, Eisenbrand G, Croft SL, Meijer L, Mottram JC: Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: Chemical library screen and antileishmanial activity. Antimicrob Agents Chemother (2004) 48(8):3033-3042.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.8
, pp. 3033-3042
-
-
Grant, K.M.1
Dunion, M.H.2
Yardley, V.3
Skaltsounis, A.L.4
Marko, D.5
Eisenbrand, G.6
Croft, S.L.7
Meijer, L.8
Mottram, J.C.9
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