Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides

Molecular and Biochemical Parasitology

Volumn 127, Issue 1, 2003, Pages 23-35

  Bera, Ananya ^a   Singh, Shashi ^a   Nagaraj, Ramakrishnan ^a   Vaidya, Tushar ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Antimicrobial peptides; Autophagy; Leishmania; Membrane functions; Programmed cell death

Indexed keywords

ANTILEISHMANIAL AGENT; CASPASE; DANSYLCADAVERINE; DNA FRAGMENT; GREEN FLUORESCENT PROTEIN; INDOLICIDIN; ION; LIPOPHOSPHOGLYCAN; PEPTIDE DERIVATIVE; PLASMIN; PROLYLLYSYLLEUCYLLEUCYLLYSYLTHREONYLPHENYLALANYLLEUCYLSERYLLYSYLTRYPTOPHYLL YSINE; SEMEN PLASMIN; SERYLLEUCYLSERYLARGINYLTYROSYLALANYLLYSYLLEUCYLALANYLASPARAGINYLARGINYLLEUC YLALANYLASPARAGINYLPROLYLLYSYLLEUCYLLEUCYLGLUTAMYLTHREONYLPHENYLALANYLLEUCYLSERY LLYSYLTRYPTOPHYLISOLEUCYLGLYCINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL DAMAGE; CELL DEATH; CELL MEMBRANE; CELL PH; CELL VACUOLE; CHEMICAL INTERACTION; CLONE; CONTROLLED STUDY; CYTOPLASM; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; EXTRACELLULAR SPACE; LEISHMANIA DONOVANI; LETHAL DOSE; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; TRANSMISSION ELECTRON MICROSCOPY;

LEISHMANIA DONOVANI; PROTOZOA;

EID: 0037373689     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00300-6     Document Type: Article

References (55)

1. Alexander J., Abhay R.S., Russell D.G. Leishmania species: models of intracellular parasitism. J. Cell Sci. 112:1999;2993-3002.
2. WHO fact sheet http://www.who.int/inf-fs/en/fact116.html.
3. Croft S.L., Yardley V. Chemotherapy of leishmaniasis. Curr. Pharm. Des. 8:2002;319-342.
4. Hancock R.E.W. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect. Dis. 1:2001;156-164.
5. Sitaram N., Nagaraj R. Host-defense antimicrobial peptides: importance of structure for activity. Curr. Pharm. Des. 8:2002;727-742.
6. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 415:2002;389-395.
7. Hernandez C., Mor A., Dagger F., Nicolas P., Hernandez A., Benedetti E.L.et al. Functional and structural damage in Leishmania mexicana exposed to the cationic peptide dermaseptin. Eur. J. Cell Biol. 59:1992;414-424.
8. Vouldoukis I., Shai Y., Nicolas P., Mor A. Broad spectrum antibiotic activity of the skin-PYY. FEBS Lett. 380:1996;237-240.
9. Diaz-Achirica P., Ubach J., Guinea A., Andreu D., Rivas L. The plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide. Biochem. J. 330:1998;453-460.
10. Silva P.I. Jr., Daffre S., Bulet P. Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family. J. Biol. Chem. 275:2000;33464-33470.
11. Moreira M.E., Del Portillo H.A., Milder R.V., Balanco J.M., Barcinski M.A. Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania amazonensis. J. Cell Physiol. 167:1996;305-313.
12. Das M., Mukherjee S.B., Shaha C. Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes. J. Cell Sci. 114:2001;2461-2469.
13. Lee N., Bertholet S., Debrabant A., Muller J., Duncan R., Nakhasi H.L. Programmed cell death in the unicellular protozoan parasite Leishmania. Cell Death Differ. 9:2002;53-64.
14. Selsted M.E., Novotny M.J., Morris W.L., Tang Y.Q., Smith W., Cullor J.S. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J. Biol. Chem. 267:1992;4292-4295.
15. Subbalakshmi C., Bikshapathy E., Sitaram N., Nagaraj R. Antibacterial and hemolytic activities of single tryptophan analogs of indolicidin. Biochem. Biophys. Res. Commun. 274:1992;714-716.
16. Reddy E.S., Bhargava P.M. Seminalplasmin: an antimicrobial protein from bovine seminal plasma which acts in E. coli by specific inhibition of rRNA synthesis. Nature. 279:1979;725-728.
17. Sitaram N., Nagaraj R. A synthetic 13-residue peptide corresponding to the hydrophobic region of bovine seminalplasmin has antibacterial activity and also causes lysis of red blood cells. J. Biol. Chem. 265:1990;10438-10442.
18. Sitaram N., Subbalakshmi C., Krishnakumari V., Nagaraj R. Identification of the region that plays an important role in determining antibacterial activity of bovine seminalplasmin. FEBS Lett. 400:1997;289-292.
19. Sitaram N., Nagaraj R. Seminal plasmin. Bioessays. 17:1995;415-422.
20. Subbalakshmi C., Krishnakumari V., Nagaraj R., Sitaram N. Requirements for antibacterial and hemolytic activities in the bovine neutrophil derived 13-residue peptide indolicidin. FEBS Lett. 395:1996;48-52.
21. Sitaram N., Chandy M., Pillai V.N.R., Nagaraj R. Change of Glutamic acid to Lysine in a 13-residue antibacterial and hemolytic peptide results in enhanced antibacterial activity without increase in hemolytic activity. Antimicrob. Agents Chemother. 36:1992;2468-2472.
22. King D.L., Turco S.J. A ricin agglutinin-resistant clone of Leishmania donovani deficient in lipophosphoglycan. Mol. Biochem. Parasitol. 28:1988;285-293.
23. Vieira L., Lavan A., Dagger F., Cabantchik Z.I. The role of anions in pH regulation of Leishmania major promastigotes. J. Biol. Chem. 269:1994;16254-16259.
24. + pumping by Leishmania major promastigotes. J. Biol. Chem. 270:1995;5299-5304.
25. Munafo D.B., Colombo M.I. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J. Cell Sci. 114:2001;3619-3629.
26. Steiner H., Andreu D., Merrifield R.B. Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects. Biochim. Biophys. Acta. 939:1988;260-266.
27. Sitaram N., Nagaraj R. Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Biochim. Biophys. Acta. 1462:1999;29-54.
28. Turco S.J., Descoteaux A. The lipophosphoglycan of Leishmania parasites. Annu. Rev. Microbiol. 46:1992;65-94.
29. Falla T.J., Karunaratne D.N., Hancock R.E. Mode of action of the antimicrobial peptide indolicidin. J. Biol. Chem. 271:1996;19298-19303.
30. 2+ in lymphocytes. J. Cell Biol. 95:1982;189-196.
31. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
32. Dunn W.A. Jr. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J. Cell Biol. 110:1990;1923-1933.
33. Dunn W.A. Jr. Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. J. Cell Biol. 110:1990;1935-1945.
34. Vaux D.L., Strasser A. The molecular biology of apoptosis. Proc. Natl. Acad. Sci. 93:1996;2239-2244.
35. Hengartner M.O. The biochemistry of apoptosis. Nature. 407:2000;770-776.
36. Biederbick A., Kern H.F., Elsasser H.P. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur. J. Cell Biol. 66:1995;3-14.
37. Niemann A., Baltes J., Elsasser H.P. Fluorescence properties and staining behavior of monodansylpentane, a structural homologue of the lysosomotropic agent monodansylcadaverine. J. Histochem. Cytochem. 49:2001;177-185.
38. Tossi A., Sandri L., Giangaspero A. Amphipathic, α-helical antimicrobial peptides. Biopolymers. 55:2000;4-30.
39. McConville M.J., Homans S.W., Thomas-Oates J.E., Dell A., Bacic A. Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids. J. Biol. Chem. 265:1990;7385-7394.
40. McConville M.J., Turco S.J., Ferguson M.A., Sacks D.L. Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage. EMBO J. 11:1992;3593-3600.
41. Friedrich C.L., Rozek A., Patrzykat A., Hancock R.E. Structure and mechanism of action of an indolicidin peptide derivative with improved activity against gram-positive bacteria. J. Biol. Chem. 276:2001;24015-24022.
42. Subbalakshmi C., Sitaram N. Mechanism of antimicrobial action of indolicidin. FEMS Microbiol. Lett. 160:1998;91-96.
43. Salzet M. Antimicrobial peptides are signaling molecules. Trends Immunol. 23:2002;283-284.
44. Hancock R.E., Scott M.G. The role of cationic antimicrobial peptides in animal defences. Proc. Natl. Acad. Sci. 97:2000;8856-8861.
45. Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ. 8:2001;568-569.
46. Ameisen J.C. On the origin, evolution, and nature of programmed cell death: a timeline of 4 billion years. Cell Death Differ. 9:2002;367-393.
47. Cornillon S., Foa C., Davoust J., Buonavista N., Gross J.D., Golstein P. Programmed cell death in Dictyostelium. J. Cell Sci. 107:1994;2691-2704.
48. Christensen S.T., Chemnitz J., Straarup E.M., Kristiansen K., Wheatley D.N., Rasmussen L. Staurosporine-induced cell death in Tetrahymena thermophila has mixed characteristics of both apoptotic and autophagic degeneration. Cell Biol. Int. 22:1998;591-598.
49. Vardi A., Berman-Frank I., Rozenberg T., Hadas O., Kaplan A., Levine A. Programmed cell death of the dinoflagellate Peridinium gatunense is mediated by CO(2) limitation and oxidative stress. Curr. Biol. 9:1999;1061-1064.
50. Welburn S.C., Barcinski M.A., Williams G.T. Programmed cell death in trypanosomatids. Parasitol. Today. 13:1997;22-26.
51. Arnoult D., Akarid K., Grodet A., Petit P.X., Estaquier J., Ameisen J.C. On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization. Cell Death Differ. 9:2002;65-68.
52. Klionsky D.J., Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science. 290:2000;1717-1721.
53. Welburn S.C., Dale C., Ellis D., Beecroft R., Pearson T.W. Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Cell Death Differ. 3:1996;229-236.
54. Abeliovich H., Klionsky D.J. Autophagy in yeast: mechanistic insights and physiological function. Microbiol. Mol. Biol. Rev. 65:2001;463-479.
55. 24(25)-sterol methyl transferase inhibitor, on promastigote and amastigote forms of Leishmania amzonensis. Antimicrob. Agents Chemother. 46:2002;487-599.