Comparison of the effectiveness of two topical paromomycin treatments versus meglumine antimoniate for New World cutaneous leishmaniasis

Acta Tropica

Volumn 91, Issue 2, 2004, Pages 153-160

  Armijos, Rodrigo X ^a   Weigel, M Margaret ^a   Calvopiña, Manuel ^b   Mancheno, Manuel ^c   Rodriguez, Roberto ^d  

^a U   (United States)

^b KOCHI MEDICAL SCHOOL   (Japan)

^c Lat Amern Ctr for Health Studies   (Ecuador)

^d UNIVERSIDAD CENTRAL DEL ECUADOR   (Ecuador)

Author keywords

Antimonial drugs; Drug safety; Ecuador; Glucantime; Leishmaniasis; Methylbenzonium chloride; Paromomycin; Treatment; Urea

Indexed keywords

BENZENE DERIVATIVE; MEGLUMINE ANTIMONATE; METHYLBENZONIUM CHLORIDE; PARAFFIN; PAROMOMYCIN; UNCLASSIFIED DRUG; UREA;

LEISHMANIASIS;

ABDOMINAL PAIN; ADULT; ANOREXIA; ANXIETY; ARTHROPATHY; ARTICLE; BURNING SENSATION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; EPIGASTRIC PAIN; ERYTHEMA; ETHNIC GROUP; FEVER; FOLLOW UP; GOVERNMENT; HEADACHE; HEALTH CARE ORGANIZATION; HEART PALPITATION; HUMAN; INFECTION; INFLAMMATION; MAJOR CLINICAL STUDY; MUSCLE WEAKNESS; MYALGIA; NAUSEA; PATIENT; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SKIN LEISHMANIASIS; SKIN ULCER; STANDARD; TIME; ULCER HEALING;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; ANIMALS; ANTIPROTOZOAL AGENTS; BENZETHONIUM; DOUBLE-BLIND METHOD; HUMANS; INJECTIONS, INTRAMUSCULAR; LEISHMANIA; LEISHMANIASIS, CUTANEOUS; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; PAROMOMYCIN; TREATMENT FAILURE; UREA;

EID: 3242707018     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2004.03.009     Document Type: Article

References (25)

1. Arana B.A., Mendoza C.E., Rizzo N.R., Kroeger A. Randomized, controlled, double-blind trial of topical tratment of cutaneous leishmaniasis with paromomycin plus methylbenzothonium chloride in Guatemala. Am. J. Trop. Med. Hyg. 65:2001;466-470
2. Armijos R.X., Chico M.E., Cruz M.E. Human cutaneous leishmaniasis in Ecuador: characterization of parasites by isoenzyme electrophoresis. Am. J. Trop. Med. Hyg. 45(5):1990;424-428
3. Armijos R.X., Weigel M.M., Aviles H., Maldonado R., Racines J. Field trial of a vaccine against cutaneous leishmaniasis in a high-risk endemic Ecuadorian child population: safety, immunogenecity, and efficacy during the first 12 months of follow-up. J. Infect. Dis. 177:1998;1352-1357
4. Armijos R.X., Weigel M.M., Hidalgo A., Cevallos W., Correa J. Safety, immunogenecity, and efficacy of an autoclaved Leishmania amazonensis vaccine plus BCG adjuvant against New World Cutaneous Leishmaniasis. Vaccine. 22(9-10):2004;1320-1326
5. Armijos R.X., Weigel M.M., Izurieta R., Racines J., Zurita C., Herrera W., Vega M. Epidemiology of cutaneous leishmaniasis in an endemic area of subtropical Ecuador. Trop. Med. Int. Health. 2(2):1997;140-151
6. Armijos R.X., Rioux J.A., Racines J., et al. Analyse chimiotaxonomique de vingt-deux souches de Leishmania isolees au Nord-Ouest de l'Equateur. Parasite. 2:1995;301-305
7. Asilian A., Jalayer J., Whitworth J.A.G., Ghasemi R.L., Nilforooshzadeh M., Olliario P., 1995. A randomized, placebo-controlled trial of 2 week regimen of aminosidine (paromomycin) ointment for treatment of cutaneous leishmaniasis in Iran. Am. J. Trop. Med. Hyg. 53 (6), 648-651.
8. Ben Salah A., Zakraoui H., Zaatour A., Ftaiti A., Zaafouri B., Ahmadi Z., Garraoui A., Dellagi K. A randomized, placebo-controlled trial in Tunisia treating cutaneous leishmaniasis with paromomycin oitment. Am. J. Trop. Med. Hyg. 53:1995;162-166
9. Berman J.D. Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy and future strategies. Rev. Infect. Dis. 10:1988;560-586
10. Berman J.D., Melby P.C., Neva F.A. Concentration of Pentostam in human breast milk. Trans. R. Soc. Trop. Med. Hyg. 83(6):1989;784-785
11. Bryceson A.D.M., Murphy A., Moody A.H. Treatment of Old World cutaneous leishmaniasis with aminosidine oinment: results of an open study in London. Trans. R. Soc. Trop. Med. Hyg. 88:1994;226-228
12. Chulay J.D., Spencer H.C., Muganbi M. Electrocardiographic changes during treatent of leishmaniasis with pentavalent antimony. Am. J. Trop. Med. Hyg. 34:1985;702-709
13. El-On J., Halevy S., Grunwald M.H., Weinrauch L. Topical tratment of Old World cutaneous leishmaniasis caused by Leishmania major: a double blind control study. J. Am. Acad. Dermatol. 27:1992;227-231
14. El-On J., Hamburger A.D. Topical treatment of New World cutaneous leishmaniasis in experimental animales. Trans. R. Soc. Trop. Med. Hyg. 81:1987;174-737
15. El-On J., Messer G. Leishmania major: antileishmanial activity of methylbenzethonium chloride. Am. J. Trop. Med. Hyg. 35:1986;1110-1116
16. Grogl M., Thomason T.N., Franke E.D. Drug resistence in leishmaniasis: its implication in systemic chemotherapy of cutaneous and mucocutaneous disease. Am. J. Trop. Med. Hyg. 47:1992;117-126
17. Krause G., Kroeger A. Tropical treatment of American cutaneous leishmaniasis with paromomomycin and methylbenzaconium chloride: a clinical study under field condition en Ecuador. Trans. R. Soc. Trop. Med. Hyg. 88:1994;92-94
18. Matsumoto T., Hashiguchi Y., Gomez E., Calvopina M.H., Nonaka S., Saya H., Minori T. Comparison of PCR results using scrape/exudate, syringe-sucked fluid and biopsy samples for diagnosis of cutaneous leishmaniasis in Ecuador. Trans. R. Soc. Trop. Med. Hyg. 93:1999;606-607
19. Neal R.A., Murphy A.G., Olliaro P., et al. Aminosidine ointment for the treatment of experimental cutaneous leishmaniasis. Trans. R. Soc. Trop. Med. Hyg. 88:1994;223-225
20. Neva A.N., Ponce C., Ponce E., Kreutzer R., Modabber F., Olliaro P. Non-ulcerative cutaneous leishmaniasis in Honduras fails to respond to topical paromomycin. Trans. R. Soc. Trop. Med. Hyg. 91:1997;473-475
21. Soto J., Fuya P., Herrera R., Berman J. Topical paromomycin/ methylbenzethonium chloride plus parenteral meglumine antimoniate as tratment for American cutaneous leishmaniasis: controlled study. Clin. Infect. Dis. 26:1998;56-58
22. Weigel M.M., Armijos R.X. The traditional and conventional medical treatment of cutaneous leishmaniasis in rural Ecuador. Pan. Amer. J. Pub. Health. 10(6):2001;395-403
23. Weigel M.M., Armijos R.X., Racines J., Zurita C., Izurieta R., Herrera E., Hinojosa E. Cutaneous leishmaniasis in subtropical Ecuador: popular perceptions, knowledge, and treatment. Bull. Pan. Am. Health Organ. 28(2):1994;144-152
24. Weinrauch L., Cawich F., Craig P., Sosa J.X., El-On J. Topical treatment of New World leishmaniasis in Belize: a clinical study. J. Am. Acad. Dermatol. 29:1993;443-446
25. World Health Organization: control of the Leishmaniasis, 1990. Technical Report Series 793, Geneva, WHO.