In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 3, 2002, Pages 929-931

  Yardley, Vanessa ^a   Khan, Anis A ^a   Martin, Michael B ^a   Slifer, Teri R ^a   Araujo, Fausto G ^a   Moreno, Silvia N J ^a   Docampo, Roberto ^a   Croft, Simon L ^a   Oldfield, Eric ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; GERANYLTRANSFERASE; PAMIDRONIC ACID; RISEDRONIC ACID; STIBOGLUCONATE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; IN VIVO STUDY; LEISHMANIA DONOVANI; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII;

ADMINISTRATION, ORAL; ALENDRONATE; ALKYL AND ARYL TRANSFERASES; ANIMALS; CRICETINAE; DIPHOSPHONATES; ENZYME INHIBITORS; FEMALE; GERANYLTRANSTRANSFERASE; INJECTIONS, INTRAPERITONEAL; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MESOCRICETUS; MICE; MICE, INBRED BALB C; PRODRUGS; SURVIVAL ANALYSIS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL;

EID: 0036171419     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.3.929-931.2002     Document Type: Article

References (6)

1. The ketolide antibiotics HMR 3647 and HMR 3004 are active against Toxoplasma gondii in vitro and in murine models of infection
2. The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei
3. A peptide prodrug approach for improving bisphosphonate oral absorption
4. Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii and Plasmodium falciparum: A potential route to chemotherapy
5. Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase
6. Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs