Antiparasitic alkaloids from Psychotria klugii

Journal of Natural Products

Volumn 66, Issue 7, 2003, Pages 962-967

  Muhammad, Ilias ^a   Dunbar, D Chuck ^a   Khan, Shabana I ^a   Tekwani, Babu L ^a   Bedir, Erdal ^a   Takamatsu, Satoshi ^a   Ferreira, Daneel ^a   Walker, Larry A ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 O METHYLIPECOSIDE; 7' O NORISOCEPHAELINE; ALKALOID DERIVATIVE; AMPHOTERICIN B; CEPHAELINE; EMETINE; ISOCEPHAELINE; KLUGINE; PENTAMIDINE; PLANT EXTRACT; PSYCHOTRIA KLUGII EXTRACT; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEISHMANIA DONOVANI; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM FALCIPARUM; PSYCHOTRIA KLUGII; STEREOCHEMISTRY; STRUCTURE ANALYSIS; VERO CELL; WOODY STEM;

ALKALOIDS; ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA DONOVANI; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PERU; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM; PSYCHOTRIA; QUINAZOLINES; TUMOR CELLS, CULTURED;

LEISHMANIA DONOVANI; PLASMODIUM FALCIPARUM; PROTOZOA; PSYCHOTRIA;

EID: 0042844748     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np030086k     Document Type: Article

References (27)

1. Schultes, R. E., Raffauf, R. F., Eds. The Healing Forest; Dioscorides Press: Portland, OR, 1990; pp 392-396.
2. Jannic, V.; Gueritte, F.; Laprevote, O.; Serani, L.; Martin, M.-T.; Sevenet, T.; Potier, P. J. Nat. Prod. 1999, 62, 838-843.
3. Verotta, L.; Pilati, T.; Tato, M. J. Nat. Prod. 1998, 61, 392-396.
4. Murillo, R.; Castro, V. Ing. Cienc. Quim. 1998, 18, 61-62.
5. Solis, P.; Ravelo, A. G.; Palenzuela, J. A.; Gupta, M. P.; Gonzalez, A.; Phillipson, J. D. Phytochemistry 1997, 44, 963-969.
6. Beretz, A.; Roth-Georger, A.; Corre, G.; Kuballa, B.; Anton, R.; Cazenava, J. P. Planta Med. 1985, 4, 300-303.
7. Solis, P. N.; Lang'at, C.; Gupta, M. P.; Kirby, G.; Geoffrey, C.; Warhurst, D. C.; Phillipson, J. D. Planta Med. 1995, 61, 62-65.
8. Lee, K. H.; Lin, Y. M.; Wu, T. S.; Zhang, D. C.; Yamagishi, T.; Hayashi, T.; Hall, I. H.; Chang, J. J.; Wu, R. Y.; Yang, T. H. Planta Med. 1988, 54, 308-311.
9. Macbride, J. F. In Flora of Peru; Dahlgren, B. E., Ed.; Field Museum of Natural History, Botanical Series: Chicago, 1936; Vol. 13, Part 6, No. 1, pp 3-261.
10. Itoh, A.; Ikuta, Y.; Baba, Y.; Tanahashi, T.; Nagakura, N. Phytochemistry 1999, 52, 1169-1176.
11. Itoh, A.; Tanahashi, T.; Nagakura, N.; Nayeshiro, H. Phytochemistry 1994, 36, 383-387.
12. Itoh, A.; Tanahashi, T.; Nagakura, N. Phytochemistry 1991, 30, 3117-3123.
13. Wiegrebe, W.; Kramer, W. J.; Shamma, M. J. Nat. Prod. 1984, 47, 397-408.
14. Fujii, T.; Ohba, M. Chem. Pharm. Bull. 1985, 33, 5264-5269.
15. 1H NMR signals for the H-14 protons were reported as two ddd's at δ 1.42 (J = 15.0, 11.0, 3.5 Hz) and 2.10 (J = 15.0, 11.0, 2.5 Hz).
16. Fujii, T.; Kogen, H.; Ohba, M. Tetrahedron Lett. 1978, 34, 3111-3114.
17. De Angelis, G. G.; Wildman, W. C. Tetrahedron 1969, 25, 5099-5112.
18. Neal, R. A. Ann. Trop. Med. Parasitol. 1970, 64, 159-164.
19. Cazorla, D.; Yepez, J.; Anez, N.; Sanchez de Mirt, A. Invest. Clin. 2001, 42, 5-21.
20. Sauvain, M.; Moretti, C.; Bravo, J.-A.; Callapa, J.; Munoz, V.; Ruiz, E.; Richard, B.; Le Men-Olivier, L. Phytother. Res. 1996, 10, 198-201.
21. Springer, T. A. Nature (London) 1990, 346, 425-434.
22. Hynes, R. O. Cell 1992, 69, 11-25.
23. Carlos, T. M.; Harlan, J. M. Blood 1994, 84, 2068-2101.
24. Dou, J.; McChesney, J. D.; Sindelar, R. D.; Goins, D. K.; Walker, L. A. J. Nat. Prod. 1996, 59, 73-76.
25. Makler, M. T.; Ries, J. M.; Williams, J. A.; Bancroft, J. E.; Piper, R. C.; Gibbins, B. L.; Hinriches, D. J. Am. J. Trop. Med. Hyg. 1993, 48, 739-741.
26. Makler, M. T.; Hinriches, D. J. Am. J. Trop. Med. Hyg. 1993, 48, 205-210.
27. Muhammad, I.; Dunbar, D. C.; Takamatsu, S.; Walker, L. A.; Clark, A. M. J. Nat. Prod. 2001, 64, 559-562.