Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (aminosidine) and gentamicin

Journal of Parasitology

Volumn 85, Issue 2, 1999, Pages 354-359

  Grogl, Max ^a   Schuster, Brian G ^a   Ellis, William Y ^a   Berman, Jonathan D ^a  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY; GENTAMICIN; MEGLUMINE ANTIMONATE; METHYLBENZETHONIUM CHLORIDE; PARAFFIN; PAROMOMYCIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; UREA; WR 279 396;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENTIATION; DRUG RESPONSE; ESTHETICS; EXPERIMENTAL INFECTION; HAMSTER; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; NONHUMAN; SKIN LEISHMANIASIS; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIPROTOZOAL AGENTS; BENZETHONIUM; CRICETINAE; DRUG THERAPY, COMBINATION; GENTAMICINS; LEISHMANIA; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; PAROMOMYCIN; TREATMENT OUTCOME; UREA;

EID: 0032973750     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.2307/3285646     Document Type: Article

References (25)

1. ANONYMOUS. 1992. Humantin (paromomycin sulfate). Physicians Desk Reference 1992, 46th ed., p. 1726.
2. ASILIAN, A., T. JALAYER, J. A. G. WHITHWORTH, R. L. GHASEMI, M. NILFOROOSHZADEH, AND P. OLLIARO. 1995. A randomized, placebocontrolled trial of a two-week regimen of aminosidine (paromomycin) ointment for treatment of cutaneous leishmaniasis in Iran. American Journal of Tropical Medicine and Hygiene 53: 648-651.
3. BEN SALAH, A., H. ZAKRAOUI, A. ZAATOUR, A. FTAITI, B. ZAAFOURI, A. GARRAOUI, P. L. OLLIARO, K. DELLAGI, AND R. BEN ISMAIL. 1995. A randomized, placebo-controlled trial in Tunisia treating cutaneous leishmaniasis with paromomycin ointment. American Journal of Tropical Medicine and Hygiene 53: 162-166.
4. BRADLEY, D. J. 1977. Regulation of Leishmania populations within the host II. Genetic control of acute susceptibility of mice to Leishmania donovani infection. Clinical and Experimental Immunology 30: 130-140.
5. BRYCESON, A. D. M., A. MURPHY, AND A. H. MOODY. 1994. Treatment of Old World cutaneous leishmaniasis with aminosidine ointment: Results of an open study in London. Transactions of the Royal Society of Tropical Medicine and Hygiene 88: 226-228.
6. CHUNGE, C. N., J. OWATE, H. O. PAMBA, AND L. DONNO. 1990. Treatment of visceral leishmanasis in Kenya by aminosidine alone or combined with sodium stibogluconate. Transactions of the Royal Society of Tropical Medicine and Hygiene 84: 221-225.
7. EL-ON, J., AND C. L. GREENBLATT. 1983. An in vitro model for testing the effect of anti-leishmanial drugs of possible use in topical treatment. Current Therapeutic Research Clinical and Experimental 33: 660-669.
8. _, S. HALEVY, M. H. GRUNWALD, AND L. WEINRAUCH. 1992. Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major. A double blind control study. Journal of the American Academy of Dermatology 27: 227-231.
9. _, AND A. D. HAMBURGER. 1987. Topical treatment of New and Old World cutaneous leishmaniasis in experimental animals. Transactions of the Royal Society of Tropical Medicine and Hygiene 81: 734-737.
10. _, G. P. JACOBS, E. WITZTUM, AND C. L. GREENBLATT. 1984. Development of topical treatment for cutaneous leishmaniasis caused by Leishmania major in experimental animals. Antimicrobial Agents and Chemotherapy 26: 745-751.
11. _, R. LIVSHIN, Z. EVAN-PAZ, A. D. HAMBURGER, AND L. WEINRAUCH. 1986. Topical treatment of cutaneous leishmanasis. Journal of Investigative Dermatology 87: 284-288.
12. _, AND G. MESSER. 1986. Leishmania major. Antileishmanial activity of methylbenzethonium chloride. American Journal of Tropical Medicine and Hygiene 35: 1110-1116.
13. _, L. WEINRAUCH, R. LIVSHIN, Z. EVEN-PAZ, AND G. P. JACOBS. 1985. Topical treatment of recurrent cutaneous leishmaniasis with ointment containing paromomycin and methylbenzcthonium chloride. British Medical Journal 291: 704-705.
14. EL-SAFI, S. H., A. G. MURPHY, A. D. M. BRYCESON, AND R. A. NEAL. 1990. A double blind clinical trial of the treatment of cutaneous leishmaniasis with paromomycin ointment. Transactions of the Royal Society of Tropical Medicine and Hygiene 84: 690-691.
15. GASSER R. A., A. J. MAGILL, C. N. OSTER, E. D. FRANKE, M. GROGL, AND J. D. BERMAN. 1994. Pancreatitis induced by pentavalent antimonial agents during treatment of leishmaniasis. Clinical Infectious Diseases 18: 83-90.
16. GROGL, M., J. L. DAUGIRDA, D. L. HOOVER, A. J. MAGILI, AND J. D. BERMAN. 1993. Survivability and infectivity of viscerotropic Leishmania tropica from Operation Desert Storm participants in human blood products maintained under blood bank conditions. American Journal of Tropical Medicine and Hygiene 49: 308-315.
17. HANSON, W. L., W. L. CHAPMAN, AND K. E. KINNAMON. 1977. Testing of drugs for antileishmanial activity in golden hamsters infected with Leishmania donovani. International Journal for Parasitology 7: 443-447.
18. HERWALDT, B. L., AND J. D. BERMAN. 1992. Recommendations for treating leishmaniasis with sodium stibogluconate (Pentostam) and review of pertinent clinical studies. American Journal of Tropical Medicine and Hygiene 46: 296-306.
19. JACKSON, P. R., M. G. PAPPAS, AND B. D. HANSEN. 1985. Fluorogenic substrate detection of viable intracellular and extracellular pathogenic protozoa. Science 227: 435-438.
20. NEAL, R. A., A. G. MURPHY, P. OLLIARO, AND S. L. CROFT. 1994. Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 88: 223-225.
21. NEVA, F. A., C. PONCE, E. PONCE, R. KREUTZER, F. MODABBER, AND P. OLLIARO. 1997. Nonulcerative cutaneous leishmaniasis in Honduras fails to respond to topical paromomycin. Transactions of the Royal Society of Tropical Medicine and Hygiene 91: 473-175.
22. SAENZ, R., H. PAZ, AND J. D. BERMAN. 1990. Efficacy of ketoconazole against Leishmania braziliensis panamensis cutaneous leishmaniasis. American Journal of Medicine 89: 147-156.
23. SCHILLINGS, R. T, AND C. P. SCHAFFNER. 1961. Differentiation of catenulin-neomycin antibiotics; identity of catenulin, paromomycin, hydromycin, and aminosidin. Antimicrobial Agents and Chemotherapy 4: 274-285.
24. SCOTT, J. A. G., R. N. DAVIDSON, A. H. MOODY, H. R. GRANT, D. FELMINGHAM, G. M. S. SCOTT, P. OLLIARO, AND A. D. M. BRYCESON. 1992. Aminosidine (paromomycin) in the treatment of leishmaniasis imported into the United Kingdom. Transactions of the Royal Society of Tropical Medicine and Hygiene 86: 617-619.
25. THAKUR, C. P., P. OLLIARO, S. GOTHOSKAR, S. BHOWMICK, B. K. CHOUDHURY, S. PRASAD, M. MUKAR, AND B. B. VERMA. 1992. Treatment of visceral leishmaniasis (kala-azar) with aminosidine (paromomycin)-antimonial combinations, a pilot study in Bihar, India. Transactions of the Royal Society of Tropical Medicine and Hygiene 86: 615-616.