Trypanothione reductase activity prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 19, Issue 1, 2004, Pages 57-63

  Castro Pinto, Denise B ^a   Echevarria, Aurea ^b   Genestra, Marcelo S ^a   Cysne Finkelstein, Léa ^a   Leon, Leonor L ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Amastigotes; Drug target; Infectivity; Leishmania amazonensis; Promastigotes; Trypanothione reductase

Indexed keywords

AMIDINE; ENZYME INHIBITOR; GLUTATHIONE REDUCTASE; N,N' DIPHENYL 4 METHOXYBENZAMIDINE; PENTAMIDINE ISETHIONATE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL DESIGN; LEISHMANIA; LEISHMANIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN EXPRESSION;

AMIDINES; ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; DRUG DESIGN; ENZYME INHIBITORS; GLUTATHIONE REDUCTASE; LEISHMANIA MEXICANA; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NADH, NADPH OXIDOREDUCTASES;

LEISHMANIA AMAZONENSIS; PROTOZOA;

EID: 1242285471     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360310001624966     Document Type: Article

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