-
1
-
-
0033043744
-
Chemokines: Extracellular messengers for all occasions?
-
Gale LM, McColl SR. 1999. Chemokines: extracellular messengers for all occasions? Bioessays 21:17-28.
-
(1999)
Bioessays
, vol.21
, pp. 17-28
-
-
Gale, L.M.1
McColl, S.R.2
-
2
-
-
0027279671
-
G protein-coupled signal transduction pathways for interleukin-8
-
Wu D, LaRosa GJ, Simon MI. 1993. G protein-coupled signal transduction pathways for interleukin-8. Science 261:101-103.
-
(1993)
Science
, vol.261
, pp. 101-103
-
-
Wu, D.1
LaRosa, G.J.2
Simon, M.I.3
-
3
-
-
0035260774
-
Dancing to the tune of chemokmes
-
Thelen M. 2001. Dancing to the tune of chemokmes. Nat Immunol 2:129-134.
-
(2001)
Nat Immunol
, vol.2
, pp. 129-134
-
-
Thelen, M.1
-
4
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE. 1998. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
5
-
-
0029978202
-
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
-
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, et al. 1996. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci USA 93:1689-1693.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1689-1693
-
-
Damen, J.E.1
Liu, L.2
Rosten, P.3
Humphries, R.K.4
Jefferson, A.B.5
-
6
-
-
0031574259
-
G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils
-
Thelen M, Didichenko SA. 1997. G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils. Ann N Y Acad Sci 832:368-382.
-
(1997)
Ann N Y Acad Sci
, vol.832
, pp. 368-382
-
-
Thelen, M.1
Didichenko, S.A.2
-
7
-
-
0027260461
-
Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins
-
Stephens L, Jackson T, Hawkins PT. 1993. Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. J Biol Chem 268:17162-17172.
-
(1993)
J Biol Chem
, vol.268
, pp. 17162-17172
-
-
Stephens, L.1
Jackson, T.2
Hawkins, P.T.3
-
8
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, et al. 2001. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70:535-602.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 535-602
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Ahmadi, K.3
Timms, J.4
Katso, R.5
-
9
-
-
0033581886
-
Structural insights into phosphoinositide 3-kinase catalysis and signalling
-
Walker EH, Perisic O, Ried C, Stephens L, Williams RL. 1999. Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature 402:313-320.
-
(1999)
Nature
, vol.402
, pp. 313-320
-
-
Walker, E.H.1
Perisic, O.2
Ried, C.3
Stephens, L.4
Williams, R.L.5
-
10
-
-
0028157767
-
PI 3-kinase: Structural and functional analysis of intersubunit interactions
-
Dhand R, Hara K, Hiles I, Bax B, Gout I, et al. 1994. PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J 13:511-521.
-
(1994)
EMBO J
, vol.13
, pp. 511-521
-
-
Dhand, R.1
Hara, K.2
Hiles, I.3
Bax, B.4
Gout, I.5
-
11
-
-
0028982198
-
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase
-
Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, et al. 1995. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol 15:4453-4465.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4453-4465
-
-
Pons, S.1
Asano, T.2
Glasheen, E.3
Miralpeix, M.4
Zhang, Y.5
-
12
-
-
0027403027
-
SH2 domains recognize specific phosphopeptide sequences
-
Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72: 767-778.
-
(1993)
Cell
, vol.72
, pp. 767-778
-
-
Songyang, Z.1
Shoelson, S.E.2
Chaudhuri, M.3
Gish, G.4
Pawson, T.5
-
13
-
-
0031887249
-
Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit
-
Yu J, Zhang Y, McIlroy J, Rordorf-Nikolic T, Orr GA, et al. 1998. Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol 18:1379-1387.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1379-1387
-
-
Yu, J.1
Zhang, Y.2
McIlroy, J.3
Rordorf-Nikolic, T.4
Orr, G.A.5
-
14
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, et al. 1994. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532.
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
-
15
-
-
0028338545
-
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
-
Zheng Y, Bagrodia S, Cerione RA. 1994. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem 269:18727-18730.
-
(1994)
J Biol Chem
, vol.269
, pp. 18727-18730
-
-
Zheng, Y.1
Bagrodia, S.2
Cerione, R.A.3
-
16
-
-
0030887632
-
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, et al. 1997. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 89:105-114.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
Eguinoa, A.2
Erdjument-Bromage, H.3
Lui, M.4
Cooke, F.5
-
17
-
-
0033546148
-
Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits
-
Krugmann S, Hawkins PT, Pryer N, Braselmann S. 1999. Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. J Biol Chem 274:17152-17158.
-
(1999)
J Biol Chem
, vol.274
, pp. 17152-17158
-
-
Krugmann, S.1
Hawkins, P.T.2
Pryer, N.3
Braselmann, S.4
-
18
-
-
0032549177
-
Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit
-
Leopoldt D, Hanck T, Exner T, Maier U, Wetzker R, et al. 1998. Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit. J Biol Chem 273:7024-7029.
-
(1998)
J Biol Chem
, vol.273
, pp. 7024-7029
-
-
Leopoldt, D.1
Hanck, T.2
Exner, T.3
Maier, U.4
Wetzker, R.5
-
19
-
-
0032828890
-
Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma
-
Maier U, Babich A, Nurnberg B. 1999. Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma. J Biol Chem 274:29311-29317.
-
(1999)
J Biol Chem
, vol.274
, pp. 29311-29317
-
-
Maier, U.1
Babich, A.2
Nurnberg, B.3
-
20
-
-
0037421204
-
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma
-
Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, et al. 2003. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol 160:89-99.
-
(2003)
J Cell Biol
, vol.160
, pp. 89-99
-
-
Brock, C.1
Schaefer, M.2
Reusch, H.P.3
Czupalla, C.4
Michalke, M.5
-
21
-
-
0029617615
-
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain
-
Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. 1995. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell 83:1037-1046.
-
(1995)
Cell
, vol.83
, pp. 1037-1046
-
-
Ferguson, K.M.1
Lemmon, M.A.2
Schlessinger, J.3
Sigler, P.B.4
-
22
-
-
0033084143
-
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
-
Currie RA, Walker KS, Gray A, Deak M, Casamayor A, et al. 1999. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J 337:575-583.
-
(1999)
Biochem J
, vol.337
, pp. 575-583
-
-
Currie, R.A.1
Walker, K.S.2
Gray, A.3
Deak, M.4
Casamayor, A.5
-
23
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, et al. 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7:261-269.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
-
24
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, et al. 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281:2042-2045.
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
-
25
-
-
0032563936
-
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
-
Chou MM, Hou W, Johnson J, Graham LK, Lee MH, et al. 1998. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol 8:1069-1077.
-
(1998)
Curr Biol
, vol.8
, pp. 1069-1077
-
-
Chou, M.M.1
Hou, W.2
Johnson, J.3
Graham, L.K.4
Lee, M.H.5
-
26
-
-
0037434790
-
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity
-
Etienne-Manneville S, Hall A. 2003. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421: 753-756.
-
(2003)
Nature
, vol.421
, pp. 753-756
-
-
Etienne-Manneville, S.1
Hall, A.2
-
27
-
-
0032514916
-
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis
-
Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. 1998. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem 273:30306-30315.
-
(1998)
J Biol Chem
, vol.273
, pp. 30306-30315
-
-
Laudanna, C.1
Mochly-Rosen, D.2
Liron, T.3
Constantin, G.4
Butcher, E.C.5
-
28
-
-
0037155727
-
P-Rex1, a PtdIns(3,4,5)P3- And Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
-
Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, et al. 2002. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108:809-821.
-
(2002)
Cell
, vol.108
, pp. 809-821
-
-
Welch, H.C.1
Coadwell, W.J.2
Ellson, C.D.3
Ferguson, G.J.4
Andrews, S.R.5
-
29
-
-
15144353776
-
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
-
Han J, Luby-Phelps K, Das B, Shu X, Xia Y, et al. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-560.
-
(1998)
Science
, vol.279
, pp. 558-560
-
-
Han, J.1
Luby-Phelps, K.2
Das, B.3
Shu, X.4
Xia, Y.5
-
30
-
-
0034685772
-
Control of intramolecular interactions between the pleckstrin homology and DbI homology domains of Vav and Sos1 regulates Rac binding
-
Das B, Shu X, Day GJ, Han J, Krishna UM, et al. 2000. Control of intramolecular interactions between the pleckstrin homology and DbI homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem 275:15074-15081.
-
(2000)
J Biol Chem
, vol.275
, pp. 15074-15081
-
-
Das, B.1
Shu, X.2
Day, G.J.3
Han, J.4
Krishna, U.M.5
-
31
-
-
0034306279
-
Regulation of the Rad-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components
-
Fleming IN, Gray A, Downes CP. 2000. Regulation of the Rad-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J 351:173-182.
-
(2000)
Biochem J
, vol.351
, pp. 173-182
-
-
Fleming, I.N.1
Gray, A.2
Downes, C.P.3
-
32
-
-
0141923912
-
Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1
-
Whetton AD, Lu Y, Pierce A, Carney L, Spooncer E. 2003. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood 102:2798-2802.
-
(2003)
Blood
, vol.102
, pp. 2798-2802
-
-
Whetton, A.D.1
Lu, Y.2
Pierce, A.3
Carney, L.4
Spooncer, E.5
-
33
-
-
0032583205
-
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
-
Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, et al. 1998. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol 143:1385-1398.
-
(1998)
J Cell Biol
, vol.143
, pp. 1385-1398
-
-
Sander, E.E.1
Van Delft, S.2
Ten Klooster, J.P.3
Reid, T.4
Van Der Kammen, R.A.5
-
34
-
-
0034306280
-
Cytohesins and centaurins: Mediators of PI 3-kinase-regulated Arf signaling
-
Jackson TR, Kearns BG, Theibert AB. 2000. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. Trends Biochem Sci 25: 489-495.
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 489-495
-
-
Jackson, T.R.1
Kearns, B.G.2
Theibert, A.B.3
-
35
-
-
0032805160
-
EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain
-
Venkateswarlu K, Gunn-Moore F, Tavare JM, Cullen PJ. 1999. EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. J Cell Sci 112:1957-1965.
-
(1999)
J Cell Sci
, vol.112
, pp. 1957-1965
-
-
Venkateswarlu, K.1
Gunn-Moore, F.2
Tavare, J.M.3
Cullen, P.J.4
-
36
-
-
0032499031
-
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase
-
Venkateswarlu K, Oatey PB, Tavare JM, Cullen PJ. 1998. Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Curr Biol 8:463-466.
-
(1998)
Curr Biol
, vol.8
, pp. 463-466
-
-
Venkateswarlu, K.1
Oatey, P.B.2
Tavare, J.M.3
Cullen, P.J.4
-
37
-
-
0029763997
-
Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain
-
Hammonds-Odie LP, Jackson TR, Profit AA, Blader IJ, Turck CW, et al. 1996. Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain. J Biol Chem 271:18859-18868.
-
(1996)
J Biol Chem
, vol.271
, pp. 18859-18868
-
-
Hammonds-Odie, L.P.1
Jackson, T.R.2
Profit, A.A.3
Blader, I.J.4
Turck, C.W.5
-
38
-
-
0033151946
-
Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1
-
Venkateswarlu K, Oatey PB, Tavare JM, Jackson TR, Cullen PJ. 1999. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. Biochem J 340:359-363.
-
(1999)
Biochem J
, vol.340
, pp. 359-363
-
-
Venkateswarlu, K.1
Oatey, P.B.2
Tavare, J.M.3
Jackson, T.R.4
Cullen, P.J.5
-
39
-
-
0035817625
-
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D
-
Santy LC, Casanova JE. 2001. Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J Cell Biol 154:599-610.
-
(2001)
J Cell Biol
, vol.154
, pp. 599-610
-
-
Santy, L.C.1
Casanova, J.E.2
-
40
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
-
Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. 1997. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 275:394-397.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
Gutkind, J.S.4
Wetzker, R.5
-
41
-
-
0032500730
-
Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
-
Bondeva T, Pirola L, Bulgarelli-Leva G, Rubio I, Wetzker R, et al. 1998. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science 282:293-296.
-
(1998)
Science
, vol.282
, pp. 293-296
-
-
Bondeva, T.1
Pirola, L.2
Bulgarelli-Leva, G.3
Rubio, I.4
Wetzker, R.5
-
42
-
-
0032737893
-
Differential regulation of lipid and protein kinase activities of phosphoinositide 3-kinase gamma in vitro
-
Bondev A, Rubio I, Wetzker R. 1999. Differential regulation of lipid and protein kinase activities of phosphoinositide 3-kinase gamma in vitro. Biol Chem 380:1337-1340.
-
(1999)
Biol Chem
, vol.380
, pp. 1337-1340
-
-
Bondev, A.1
Rubio, I.2
Wetzker, R.3
-
43
-
-
0039791449
-
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
-
Schonwasser DC, Marais RM, Marshall CJ, Parker PJ. 1998. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol 18:790-798.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 790-798
-
-
Schonwasser, D.C.1
Marais, R.M.2
Marshall, C.J.3
Parker, P.J.4
-
44
-
-
0037077201
-
A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid
-
Yart A, Roche S, Wetzker R, Laffargue M, Tonks N, et al. 2002. A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. J Biol Chem 277:21167-21178.
-
(2002)
J Biol Chem
, vol.277
, pp. 21167-21178
-
-
Yart, A.1
Roche, S.2
Wetzker, R.3
Laffargue, M.4
Tonks, N.5
-
45
-
-
0036172306
-
Chemokine signalling: Pivoting around multiple phosphoinositide 3-kinases
-
Curnock AP, Logan MK, Ward SG. 2002. Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases. Immunology 105:125-136.
-
(2002)
Immunology
, vol.105
, pp. 125-136
-
-
Curnock, A.P.1
Logan, M.K.2
Ward, S.G.3
-
46
-
-
0033486065
-
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
-
Sotsios Y, Whittaker GC, Westwick J, Ward SG. 1999. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J Immunol 163:5954-5963.
-
(1999)
J Immunol
, vol.163
, pp. 5954-5963
-
-
Sotsios, Y.1
Whittaker, G.C.2
Westwick, J.3
Ward, S.G.4
-
47
-
-
0033179690
-
Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration
-
Boehme SA, Sullivan SK, Crowe PD, Santos M, Conlon PJ, et al. 1999. Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration. J Immunol 163:1611-1618.
-
(1999)
J Immunol
, vol.163
, pp. 1611-1618
-
-
Boehme, S.A.1
Sullivan, S.K.2
Crowe, P.D.3
Santos, M.4
Conlon, P.J.5
-
48
-
-
2942594602
-
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP
-
Martinez-Quiles N, Ho HY, Kirschner MW, Ramesh N, Geha RS. 2004. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol 24: 5269-5280.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5269-5280
-
-
Martinez-Quiles, N.1
Ho, H.Y.2
Kirschner, M.W.3
Ramesh, N.4
Geha, R.S.5
-
49
-
-
0034635264
-
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, et al. 2000. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040-1046.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-dos-Santos, A.J.4
Stanford, W.L.5
-
50
-
-
0034635221
-
Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction
-
Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, et al. 2000. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287:1046-1049.
-
(2000)
Science
, vol.287
, pp. 1046-1049
-
-
Li, Z.1
Jiang, H.2
Xie, W.3
Zhang, Z.4
Smrcka, A.V.5
-
51
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, et al. 2000. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
-
52
-
-
0141569194
-
Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1
-
Jones GE, Prigmore E, Calvez R, Hogan C, Dunn GA, et al. 2003. Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1. Exp Cell Res 290:120-131.
-
(2003)
Exp Cell Res
, vol.290
, pp. 120-131
-
-
Jones, G.E.1
Prigmore, E.2
Calvez, R.3
Hogan, C.4
Dunn, G.A.5
-
53
-
-
0035575706
-
Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury
-
Yum HK, Arcaroli J, Kupfner J, Shenkar R, Penninger JM, et al. 2001. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol 167:6601-6608.
-
(2001)
J Immunol
, vol.167
, pp. 6601-6608
-
-
Yum, H.K.1
Arcaroli, J.2
Kupfner, J.3
Shenkar, R.4
Penninger, J.M.5
-
54
-
-
0842346270
-
Do phosphoinositide 3-kinases direct lymphocyte navigation?
-
Ward SG. 2004. Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol 25:67-74.
-
(2004)
Trends Immunol
, vol.25
, pp. 67-74
-
-
Ward, S.G.1
-
55
-
-
0029126042
-
RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase
-
Turner L, Ward SG, Westwick J. 1995. RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase. J Immunol 155:2437-2444.
-
(1995)
J Immunol
, vol.155
, pp. 2437-2444
-
-
Turner, L.1
Ward, S.G.2
Westwick, J.3
-
56
-
-
0032476036
-
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha
-
Turner SJ, Domin J, Waterfield MD, Ward SG, Westwick J. 1998. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. J Biol Chem 273:25987-25995.
-
(1998)
J Biol Chem
, vol.273
, pp. 25987-25995
-
-
Turner, S.J.1
Domin, J.2
Waterfield, M.D.3
Ward, S.G.4
Westwick, J.5
-
57
-
-
0033215149
-
Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis
-
Vicente-Manzanares M, Rey M, Jones DR, Sancho D, Mellado M, et al. 1999. Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis. J Immunol 163:4001-4012.
-
(1999)
J Immunol
, vol.163
, pp. 4001-4012
-
-
Vicente-Manzanares, M.1
Rey, M.2
Jones, D.R.3
Sancho, D.4
Mellado, M.5
-
58
-
-
0037369696
-
Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement
-
Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE. 2003. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol 170:2647-2654.
-
(2003)
J Immunol
, vol.170
, pp. 2647-2654
-
-
Sadhu, C.1
Masinovsky, B.2
Dick, K.3
Sowell, C.G.4
Staunton, D.E.5
-
59
-
-
0032475863
-
G protein signaling events are activated at the leading edge of chemotactic cells
-
Parent CA, Blacklock BJ, Froehlich WM, Murphy DB, Devreotes PN. 1998. G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95:81-91.
-
(1998)
Cell
, vol.95
, pp. 81-91
-
-
Parent, C.A.1
Blacklock, B.J.2
Froehlich, W.M.3
Murphy, D.B.4
Devreotes, P.N.5
-
60
-
-
0034635513
-
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
-
Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, et al. 2000. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287:1037-1040.
-
(2000)
Science
, vol.287
, pp. 1037-1040
-
-
Servant, G.1
Weiner, O.D.2
Herzmark, P.3
Balla, T.4
Sedat, J.W.5
-
61
-
-
0037205265
-
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
-
Funamoto S, Meili R, Lee S, Parry L, Firtel RA. 2002. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109:611-623.
-
(2002)
Cell
, vol.109
, pp. 611-623
-
-
Funamoto, S.1
Meili, R.2
Lee, S.3
Parry, L.4
Firtel, R.A.5
-
62
-
-
0037205230
-
Tumor suppressor PTEN mediates sensing of chemoattractant gradients
-
Iijima M, Devreotes P. 2002. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109:599-610.
-
(2002)
Cell
, vol.109
, pp. 599-610
-
-
Iijima, M.1
Devreotes, P.2
-
63
-
-
0032911044
-
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
-
Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR. 1999. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10:1163-1178.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 1163-1178
-
-
Servant, G.1
Weiner, O.D.2
Neptune, E.R.3
Sedat, J.W.4
Bourne, H.R.5
-
64
-
-
0030785793
-
Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis
-
Nieto M, Frade JM, Sancho D, Mellado M, Martinez AC, et al. 1997. Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. J Exp Med 186:153-158.
-
(1997)
J Exp Med
, vol.186
, pp. 153-158
-
-
Nieto, M.1
Frade, J.M.2
Sancho, D.3
Mellado, M.4
Martinez, A.C.5
-
65
-
-
0036308458
-
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
-
Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, et al. 2002. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol 4:513-518.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 513-518
-
-
Wang, F.1
Herzmark, P.2
Weiner, O.D.3
Srinivasan, S.4
Servant, G.5
-
66
-
-
0036308972
-
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
-
Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, et al. 2002. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4:509-513.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 509-513
-
-
Weiner, O.D.1
Neilsen, P.O.2
Prestwich, G.D.3
Kirschner, M.W.4
Cantley, L.C.5
-
67
-
-
0037415640
-
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
-
Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, et al. 2003. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160:375-385.
-
(2003)
J Cell Biol
, vol.160
, pp. 375-385
-
-
Srinivasan, S.1
Wang, F.2
Glavas, S.3
Ott, A.4
Hofmann, F.5
-
68
-
-
1842861718
-
Regulation of anoikis by Cdc42 and Rad
-
Cheng TL, Symons M, Jou TS. 2004. Regulation of anoikis by Cdc42 and Rad. Exp Cell Res 295:497-511.
-
(2004)
Exp Cell Res
, vol.295
, pp. 497-511
-
-
Cheng, T.L.1
Symons, M.2
Jou, T.S.3
-
69
-
-
0037077219
-
Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases
-
Lachance G, Levasseur S, Naccache PH. 2002. Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases. J Biol Chem 277:21537-21541.
-
(2002)
J Biol Chem
, vol.277
, pp. 21537-21541
-
-
Lachance, G.1
Levasseur, S.2
Naccache, P.H.3
-
70
-
-
0038221378
-
Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor
-
Gilbert C, Levasseur S, Desaulniers P, Dusseault AA, Thibault N, et al. 2003. Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor. J Immunol 170(10):5235-5243.
-
(2003)
J Immunol
, vol.170
, Issue.10
, pp. 5235-5243
-
-
Gilbert, C.1
Levasseur, S.2
Desaulniers, P.3
Dusseault, A.A.4
Thibault, N.5
-
71
-
-
0034332904
-
Leukocytes navigate by compass: Roles of PI3Kgamma and its lipid products
-
Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. 2000. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol 10:466-473.
-
(2000)
Trends Cell Biol
, vol.10
, pp. 466-473
-
-
Rickert, P.1
Weiner, O.D.2
Wang, F.3
Bourne, H.R.4
Servant, G.5
-
72
-
-
0033617576
-
A cell's sense of direction
-
Parent CA, Devreotes PN. 1999. A cell's sense of direction. Science 284:765-770.
-
(1999)
Science
, vol.284
, pp. 765-770
-
-
Parent, C.A.1
Devreotes, P.N.2
-
73
-
-
0041352963
-
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42
-
Li Z, Hannigan M, Mo Z, Liu B, Lu W, et al. 2003. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 114:215-227.
-
(2003)
Cell
, vol.114
, pp. 215-227
-
-
Li, Z.1
Hannigan, M.2
Mo, Z.3
Liu, B.4
Lu, W.5
-
74
-
-
0036532115
-
Regulation of cell polarity during eukaryotic chemotaxis: The Chemotactic compass
-
Weiner OD. 2002. Regulation of cell polarity during eukaryotic chemotaxis: the Chemotactic compass. Curr Opin Cell Biol 14:196-202.
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 196-202
-
-
Weiner, O.D.1
-
75
-
-
0035954430
-
Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis
-
Marshall JG, Booth JW, Stambolic V, Mak T, Balla T, et al. 2001. Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J Cell Biol 153:1369-1380.
-
(2001)
J Cell Biol
, vol.153
, pp. 1369-1380
-
-
Marshall, J.G.1
Booth, J.W.2
Stambolic, V.3
Mak, T.4
Balla, T.5
-
76
-
-
17944383782
-
Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis
-
Gomez-Mouton C, Lacalle RA, Mira E, Jimenez-Baranda S, Barber DF, et al. 2004. Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J Cell Biol 164:759-768.
-
(2004)
J Cell Biol
, vol.164
, pp. 759-768
-
-
Gomez-Mouton, C.1
Lacalle, R.A.2
Mira, E.3
Jimenez-Baranda, S.4
Barber, D.F.5
-
77
-
-
0030823258
-
The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces Chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils
-
Niggli V, Keller H. 1997. The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces Chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils. Eur J Pharmacol 335:43-52.
-
(1997)
Eur J Pharmacol
, vol.335
, pp. 43-52
-
-
Niggli, V.1
Keller, H.2
-
78
-
-
0037133606
-
Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis
-
Hannigan M, Zhan L, Li Z, Ai Y, Wu D, et al. 2002. Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc Natl Acad Sci USA 99: 3603-3608.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3603-3608
-
-
Hannigan, M.1
Zhan, L.2
Li, Z.3
Ai, Y.4
Wu, D.5
-
79
-
-
0344012484
-
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN
-
Attwell S, Mills J, Troussard A, Wu C, Dedhar S. 2003. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell 14:4813-4825.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 4813-4825
-
-
Attwell, S.1
Mills, J.2
Troussard, A.3
Wu, C.4
Dedhar, S.5
-
80
-
-
0042354714
-
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
-
Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, et al. 2003. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114:201-214.
-
(2003)
Cell
, vol.114
, pp. 201-214
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Herzmark, P.4
Straight, A.5
-
81
-
-
0035947085
-
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
-
Chung CY, Potikyan G, Firtel RA. 2001. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell 7:937-947.
-
(2001)
Mol Cell
, vol.7
, pp. 937-947
-
-
Chung, C.Y.1
Potikyan, G.2
Firtel, R.A.3
-
82
-
-
0141502119
-
Cross-linking of actin filaments by myosin II is a major contributor to cortical integrity and cell motility in restrictive environments
-
Laevsky G, Knecht DA. 2003. Cross-linking of actin filaments by myosin II is a major contributor to cortical integrity and cell motility in restrictive environments. J Cell Sci 116:3761-3770.
-
(2003)
J Cell Sci
, vol.116
, pp. 3761-3770
-
-
Laevsky, G.1
Knecht, D.A.2
-
83
-
-
1242294384
-
Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor
-
Barac A, Basile J, Vazquez-Prado J, Gao Y, Zheng Y, et al. 2004. Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J Biol Chem 279:6182-6189.
-
(2004)
J Biol Chem
, vol.279
, pp. 6182-6189
-
-
Barac, A.1
Basile, J.2
Vazquez-Prado, J.3
Gao, Y.4
Zheng, Y.5
-
84
-
-
2942687012
-
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
-
Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. 2004. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci USA 101:8951-8956.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8951-8956
-
-
Janetopoulos, C.1
Ma, L.2
Devreotes, P.N.3
Iglesias, P.A.4
-
85
-
-
0037743735
-
Eukaryotic chemotaxis: Distinctions between directional sensing and polarization
-
Devreotes P, Janetopoulos C. 2003. Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem 278:20445-20448.
-
(2003)
J Biol Chem
, vol.278
, pp. 20445-20448
-
-
Devreotes, P.1
Janetopoulos, C.2
-
86
-
-
2642684541
-
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
-
Helgason CD, Damen JE, Rosten P, Grewal R, Sorensen P, et al. 1998. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev 12:1610-1620.
-
(1998)
Genes Dev
, vol.12
, pp. 1610-1620
-
-
Helgason, C.D.1
Damen, J.E.2
Rosten, P.3
Grewal, R.4
Sorensen, P.5
-
88
-
-
0032843540
-
Impaired Fas response and autoimmunity in Pten+/- Mice
-
Di Cristofano A, Kotsi P, Peng YF, Cordon-Cardo C, Elkon KB, et al. 1999. Impaired Fas response and autoimmunity in Pten+/- mice. Science 285:2122-2125.
-
(1999)
Science
, vol.285
, pp. 2122-2125
-
-
Di Cristofano, A.1
Kotsi, P.2
Peng, Y.F.3
Cordon-Cardo, C.4
Elkon, K.B.5
-
89
-
-
0036644183
-
Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1
-
Fox JA, Ung K, Tanlimco SG, Jirik FR. 2002. Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1. J Immunol 169:49-54.
-
(2002)
J Immunol
, vol.169
, pp. 49-54
-
-
Fox, J.A.1
Ung, K.2
Tanlimco, S.G.3
Jirik, F.R.4
-
90
-
-
0033635157
-
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma
-
Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, et al. 2000. Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell 103:931-931.
-
(2000)
Cell
, vol.103
, pp. 931-931
-
-
Pacold, M.E.1
Suire, S.2
Perisic, O.3
Lara-Gonzalez, S.4
Davis, C.T.5
|