Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1

Journal of Immunology

Volumn 169, Issue 1, 2002, Pages 49-54

  Fox, Joanne A ^a   Ung, Karen ^a   Tanlimco, Sonia G ^a   Jirik, Frank R ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL ISOLATION; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE DISRUPTION; HETEROZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 0036644183     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.1.49     Document Type: Article

References (52)

1. Chemokines and leukocyte traffic
2. The role of cytokine receptor signaling in lymphocyte development
3. Molecular cloning and structure of a pre-B-cell growth-stimulating factor
4. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
5. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
6. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
7. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
8. The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways
9. Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 α-induced lymphocyte polarization and chemotaxis
10. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
11. Signal transduction by CXC chemokine receptor 4: Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes
12. The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
13. PTEN, a unique tumor suppressor gene
14. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
15. Pten is essential for embryonic development and tumour suppression
16. +/- mice
17. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
18. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
19. +/- mice
20. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
21. Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
22. T cell-specific loss of Pten leads to defects in central and peripheral tolerance
23. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
24. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: Differential involvement of focal adhesion kinase and p130Cas
25. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
26. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
27. Altered responsiveness to chemokines due to targeted disruption of SHIP
28. Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes
29. TCR activation inhibits chemotaxis toward stromal cell-derived factor-1: Evidence for reciprocal regulation between CXCR4 and the TCR
30. Phosphorylation of the PTEN tail regulates protein stability and function
31. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus: Implications for PTEN stability to proteasome-mediated degradation
32. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
33. L levels in vivo
34. -/- knockout mice
35. The chemokine SDF-1α triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway
36. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
37. Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: Roles of phosphoinositide-3 kinase and protein kinase C
38. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
39. Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
40. Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways
41. PTEN inhibits insulinstimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
42. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
43. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G-cell cycle arrest in human glioblastoma cells
44. The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes
45. Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium
46. The molecular genetics of chemotaxis: Sensing and responding to chemoattractant gradients
47. Aktmediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
48. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
49. Chemokines and their role in tumor growth and metastasis
50. Involvement of chemokine receptors in breast cancer metastasis
51. Molecular characterization of CXCR-4: A potential brain tumor-associated gene
52. Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)