메뉴 건너뛰기




Volumn 41, Issue 2, 2005, Pages 237-246

Troglitazone and liver injury: In search of answers

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIBIOTIC AGENT; BILE ACID; CORTICOSTEROID; CYCLOSPORIN A; CYTOCHROME P450 3A4; ESTROGEN; GLIBENCLAMIDE; INSULIN; METFORMIN; PIOGLITAZONE; PLACEBO; PREGNANE X RECEPTOR; RIFAMPICIN; ROSIGLITAZONE; SEDATIVE AGENT; SULFONYLUREA; TESTOSTERONE; TROGLITAZONE;

EID: 12844253684     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20567     Document Type: Review
Times cited : (116)

References (163)
  • 1
    • 0037353404 scopus 로고    scopus 로고
    • Troglitazone-induced liver failure: A case study
    • Graham DJ, Green L, Senior JR, Nourjah P. Troglitazone-induced liver failure: a case study. Am J Med 2002;114:299-306.
    • (2002) Am J Med , vol.114 , pp. 299-306
    • Graham, D.J.1    Green, L.2    Senior, J.R.3    Nourjah, P.4
  • 2
    • 12844263906 scopus 로고    scopus 로고
    • Pfizer wins diabetes drug liability case
    • Company News; May 28
    • Company News; Pfizer wins diabetes drug liability case. New York Times 2004 May 28;C:4.
    • (2004) New York Times , vol.C , pp. 4
  • 3
    • 0038650658 scopus 로고    scopus 로고
    • Mechanisms of troglitazone hepatotoxicity
    • Smith MT. Mechanisms of troglitazone hepatotoxicity. Chem Res Toxicol 2003;16:679-687.
    • (2003) Chem Res Toxicol , vol.16 , pp. 679-687
    • Smith, M.T.1
  • 4
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen K, Dufour S, Befroy D, Garcia R, Shulman G. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004;350:664-671.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.5
  • 5
    • 0347579845 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
    • Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 2003;299:896-899.
    • (2003) Science , vol.299 , pp. 896-899
    • Nisoli, E.1    Clementi, E.2    Paolucci, C.3    Cozzi, V.4    Tonello, C.5    Sciorati, C.6
  • 6
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
    • Petersen K, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman D, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003;300:1140-1142.
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.1    Befroy, D.2    Dufour, S.3    Dziura, J.4    Ariyan, C.5    Rothman, D.6
  • 7
    • 0032568257 scopus 로고    scopus 로고
    • Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus
    • Inzucchi SE, Maggs DG, Spollett GR, Page SL, Rife FS, Walton V, et al. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N Engl J Med 1998;338:867-872.
    • (1998) N Engl J Med , vol.338 , pp. 867-872
    • Inzucchi, S.E.1    Maggs, D.G.2    Spollett, G.R.3    Page, S.L.4    Rife, F.S.5    Walton, V.6
  • 8
    • 1442339091 scopus 로고    scopus 로고
    • Causation of type 2 diabetes - The Gordian knot unravels
    • Taylor R. Causation of type 2 diabetes - the Gordian knot unravels. N Engl J Med 2004;350:639-641.
    • (2004) N Engl J Med , vol.350 , pp. 639-641
    • Taylor, R.1
  • 10
    • 0032568310 scopus 로고    scopus 로고
    • Effect of troglitazone in insulin-treated patients with type II diabetes mellitus
    • Troglitazone and Exogenous Insulin Study Group
    • Schwart S, Raskin P, Fonseca V, Graveline JF. Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. Troglitazone and Exogenous Insulin Study Group. N Engl J Med 1998;338:861-866.
    • (1998) N Engl J Med , vol.338 , pp. 861-866
    • Schwart, S.1    Raskin, P.2    Fonseca, V.3    Graveline, J.F.4
  • 11
    • 0031054699 scopus 로고    scopus 로고
    • Cardiac and glycemic benefits of troglitazone treatment in NIDDM
    • The Troglitazone Study Group
    • Ghazzi MN, Perez JE, Antonucci TK, Driscoll JH, Huang SM, Faja BW, et al. Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group. Diabetes 1997;46:433-439.
    • (1997) Diabetes , vol.46 , pp. 433-439
    • Ghazzi, M.N.1    Perez, J.E.2    Antonucci, T.K.3    Driscoll, J.H.4    Huang, S.M.5    Faja, B.W.6
  • 12
    • 0344780882 scopus 로고    scopus 로고
    • Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus
    • Sung BH, Izzo JL Jr, Dandona P, Wilson MF. Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus. Hypertension 1999;34:83-88.
    • (1999) Hypertension , vol.34 , pp. 83-88
    • Sung, B.H.1    Izzo Jr., J.L.2    Dandona, P.3    Wilson, M.F.4
  • 13
    • 0034126428 scopus 로고    scopus 로고
    • Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects
    • Kruszynska YT, Yu JG, Olefsky JM, Sobel BE. Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Diabetes 2000;49:633-639.
    • (2000) Diabetes , vol.49 , pp. 633-639
    • Kruszynska, Y.T.1    Yu, J.G.2    Olefsky, J.M.3    Sobel, B.E.4
  • 14
    • 0036724346 scopus 로고    scopus 로고
    • Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women
    • Buchanan TA, Xiang AH, Peters RK, Kjos SL, Marroquin A, Goico J, et al. Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Diabetes 2002;51:2796-2803.
    • (2002) Diabetes , vol.51 , pp. 2796-2803
    • Buchanan, T.A.1    Xiang, A.H.2    Peters, R.K.3    Kjos, S.L.4    Marroquin, A.5    Goico, J.6
  • 15
    • 0035041906 scopus 로고    scopus 로고
    • Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: A multicenter, double blind, placebo-controlled trial
    • Azziz R, Ehrmann D, Legro RS, Whitcomb RW, Hanley R, Fereshetian AG, et al. Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. J Clin Endocrinol Metab 2001;86:1626-1632.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1626-1632
    • Azziz, R.1    Ehrmann, D.2    Legro, R.S.3    Whitcomb, R.W.4    Hanley, R.5    Fereshetian, A.G.6
  • 17
    • 0036789252 scopus 로고    scopus 로고
    • Troglitazone antagonizes metabolic effects of glucocorticoids in humans: Effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin
    • Willi SM, Kennedy A, Wallace P, Ganaway E, Rogers NL, Garvey WT. Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin. Diabetes 2002;51:2895-2902.
    • (2002) Diabetes , vol.51 , pp. 2895-2902
    • Willi, S.M.1    Kennedy, A.2    Wallace, P.3    Ganaway, E.4    Rogers, N.L.5    Garvey, W.T.6
  • 18
    • 0032568261 scopus 로고    scopus 로고
    • Hepatic dysfunction associated with troglitazone
    • Watkins PB, Whitcomb RW. Hepatic dysfunction associated with troglitazone. N Engl J Med 2001;338:916-917.
    • (2001) N Engl J Med , vol.338 , pp. 916-917
    • Watkins, P.B.1    Whitcomb, R.W.2
  • 19
    • 0035146444 scopus 로고    scopus 로고
    • Factors associated with the risk of liver enzyme elevation in patients with type 2 diabetes treated with a thiazolidinedione
    • St. Peter JV, Neafus KL, Khan MA, Vessey JT, Lockhart MS. Factors associated with the risk of liver enzyme elevation in patients with type 2 diabetes treated with a thiazolidinedione. Pharmacotherapy 2001;21:183-188.
    • (2001) Pharmacotherapy , vol.21 , pp. 183-188
    • St. Peter, J.V.1    Neafus, K.L.2    Khan, M.A.3    Vessey, J.T.4    Lockhart, M.S.5
  • 20
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease
    • Watkins PB, Zimmerman HJ, Knapp MJ, Gracon SI, Lewis KW. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 1994;271:1023-1024.
    • (1994) JAMA , vol.271 , pp. 1023-1024
    • Watkins, P.B.1    Zimmerman, H.J.2    Knapp, M.J.3    Gracon, S.I.4    Lewis, K.W.5
  • 22
    • 0035080157 scopus 로고    scopus 로고
    • Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin
    • Caldwell SH, Hespenheide EE, von Borstel RW. Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simvastatin. Dig Dis Sci 2001;46:376-378.
    • (2001) Dig Dis Sci , vol.46 , pp. 376-378
    • Caldwell, S.H.1    Hespenheide, E.E.2    Von Borstel, R.W.3
  • 23
    • 0032535749 scopus 로고    scopus 로고
    • Fatal hepatotoxicity associated with troglitazone
    • Vella A, de Groen PC, Dinneen SF. Fatal hepatotoxicity associated with troglitazone. Ann Intern Med 1998;129:1080.
    • (1998) Ann Intern Med , vol.129 , pp. 1080
    • Vella, A.1    De Groen, P.C.2    Dinneen, S.F.3
  • 25
    • 0033988825 scopus 로고    scopus 로고
    • Hepatotoxicity due to troglitazone: Report of two cases and review of adverse events reported to the United States Food and Drug Administration
    • Kohlroser J, Mathai J, Reichheld J, Banner BF, Bonkovsky HL. Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration. Am J Gastroenterol 2000;95:272-276.
    • (2000) Am J Gastroenterol , vol.95 , pp. 272-276
    • Kohlroser, J.1    Mathai, J.2    Reichheld, J.3    Banner, B.F.4    Bonkovsky, H.L.5
  • 26
    • 0033983457 scopus 로고    scopus 로고
    • Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: A case report with autopsy examination
    • Fukano M, Amano S, Sato J, Yamamota K, Adachi H, Okabe H, et al. Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination. Hum Pathol 2000;31:250-253.
    • (2000) Hum Pathol , vol.31 , pp. 250-253
    • Fukano, M.1    Amano, S.2    Sato, J.3    Yamamota, K.4    Adachi, H.5    Okabe, H.6
  • 28
    • 0034619424 scopus 로고    scopus 로고
    • Troglitazone-associated hepatotoxicity treated successfully with steroids
    • Prendergast KA, Berg CL, Wisniewski R. Troglitazone-associated hepatotoxicity treated successfully with steroids. Ann Intern Med 2000;133:751.
    • (2000) Ann Intern Med , vol.133 , pp. 751
    • Prendergast, K.A.1    Berg, C.L.2    Wisniewski, R.3
  • 31
    • 0034681974 scopus 로고    scopus 로고
    • Rapid-onset subfulminant liver failure associated with troglitazone
    • Jagannath S, Rai R. Rapid-onset subfulminant liver failure associated with troglitazone. Ann Intern Med 2000;132:677.
    • (2000) Ann Intern Med , vol.132 , pp. 677
    • Jagannath, S.1    Rai, R.2
  • 33
    • 0034090271 scopus 로고    scopus 로고
    • Severe but reversible hepatitis induced by troglitazone
    • Schiano T, Dolehide K, Hart J, Baker AL. Severe but reversible hepatitis induced by troglitazone. Dig Dis Sci 2000;45:1039-1042.
    • (2000) Dig Dis Sci , vol.45 , pp. 1039-1042
    • Schiano, T.1    Dolehide, K.2    Hart, J.3    Baker, A.L.4
  • 35
    • 0033582161 scopus 로고    scopus 로고
    • Severe hepatotoxicity associated with troglitazone
    • Herrine SK, Choudary C. Severe hepatotoxicity associated with troglitazone. Ann Intern Med 1999;130:163-164.
    • (1999) Ann Intern Med , vol.130 , pp. 163-164
    • Herrine, S.K.1    Choudary, C.2
  • 36
    • 0032125406 scopus 로고    scopus 로고
    • Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone
    • Gitlin N, Julie NL, Spurr CL, Lim KN, Juarbe HM. Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone. Ann Intern Med 2000;129:36-38.
    • (2000) Ann Intern Med , vol.129 , pp. 36-38
    • Gitlin, N.1    Julie, N.L.2    Spurr, C.L.3    Lim, K.N.4    Juarbe, H.M.5
  • 37
    • 0342502229 scopus 로고    scopus 로고
    • Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus
    • Menon KVN, Angulo P, Lindor KD. Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus. Am J Gastroenterol 2001;96:1631-1634.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1631-1634
    • Menon, K.V.N.1    Angulo, P.2    Lindor, K.D.3
  • 38
    • 0036311065 scopus 로고    scopus 로고
    • Severe cholestatic hepatitis caused by thiazolidinediones: Risks associated with substituting rosiglitazone for troglitazone
    • Bonkovsky HL, Azar R, Bird S, Szabo G, Banner B. Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone. Dig Dis Sci 2002;47:1632-1637.
    • (2002) Dig Dis Sci , vol.47 , pp. 1632-1637
    • Bonkovsky, H.L.1    Azar, R.2    Bird, S.3    Szabo, G.4    Banner, B.5
  • 40
    • 0034950046 scopus 로고    scopus 로고
    • Drug-induced liver disorders: Implications for drug development and regulation
    • Kaplowitz N. Drug-induced liver disorders: implications for drug development and regulation. Drug Safety 2001;24:483-490.
    • (2001) Drug Safety , vol.24 , pp. 483-490
    • Kaplowitz, N.1
  • 44
    • 0001299192 scopus 로고
    • Hepatic injury due to drugs and toxins
    • Macsween RNM, Anthony PP, Scheuer PJ, Burt AD, Portmann BC, eds. London, UK: Churchill Livingstone
    • Zimmerman HJ, Ishak KG. Hepatic injury due to drugs and toxins. In: Macsween RNM, Anthony PP, Scheuer PJ, Burt AD, Portmann BC, eds. Pathology of the Liver. London, UK: Churchill Livingstone, 1994:563-634.
    • (1994) Pathology of the Liver , pp. 563-634
    • Zimmerman, H.J.1    Ishak, K.G.2
  • 45
    • 0343940399 scopus 로고
    • Toxic and drug-induced hepatic injury
    • Klatskin G, Conn H, eds. New York: Oxford University Press
    • Klatskin G, Conn H. Toxic and drug-induced hepatic injury. In: Klatskin G, Conn H, eds. Histopathology of the Liver. New York: Oxford University Press, 1993:111-140.
    • (1993) Histopathology of the Liver , pp. 111-140
    • Klatskin, G.1    Conn, H.2
  • 46
    • 0027362542 scopus 로고
    • Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries
    • Danan G, Benichou C. Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993;46:1323-1330.
    • (1993) J Clin Epidemiol , vol.46 , pp. 1323-1330
    • Danan, G.1    Benichou, C.2
  • 47
    • 0027448634 scopus 로고
    • Causality assessment of adverse reactions to drugs - II. An original model for validation of drug causality assessment methods: Case reports with positive rechallenge
    • Benichou C, Danan G, Flahault A. Causality assessment of adverse reactions to drugs - II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol 1993;46:1331-1336.
    • (1993) J Clin Epidemiol , vol.46 , pp. 1331-1336
    • Benichou, C.1    Danan, G.2    Flahault, A.3
  • 48
    • 0037126649 scopus 로고    scopus 로고
    • Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    • Ostapowicz G, Fontana R, Schiodt F, Larson A, Davern T, Han S, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002;137:947-954.
    • (2002) Ann Intern Med , vol.137 , pp. 947-954
    • Ostapowicz, G.1    Fontana, R.2    Schiodt, F.3    Larson, A.4    Davern, T.5    Han, S.6
  • 49
    • 0037259315 scopus 로고    scopus 로고
    • Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone
    • Graham DJ, Drinkard CR, Shatin D. Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone. Am J Gastroenterol 2003;98:175-179.
    • (2003) Am J Gastroenterol , vol.98 , pp. 175-179
    • Graham, D.J.1    Drinkard, C.R.2    Shatin, D.3
  • 51
    • 0036086775 scopus 로고    scopus 로고
    • Diabetes increases the risk of acute hepatic failure
    • El-Serag HB, Everhart JE. Diabetes increases the risk of acute hepatic failure. Gastroenterology 2002;122:1822-1828.
    • (2002) Gastroenterology , vol.122 , pp. 1822-1828
    • El-Serag, H.B.1    Everhart, J.E.2
  • 52
    • 0037463895 scopus 로고    scopus 로고
    • A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents
    • Chan KA, Truman A, Gurwitz JH, Hurley JS, Martinson B, Platt R, et al. A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents. Arch Intern Med 2003;163:728-734.
    • (2003) Arch Intern Med , vol.163 , pp. 728-734
    • Chan, K.A.1    Truman, A.2    Gurwitz, J.H.3    Hurley, J.S.4    Martinson, B.5    Platt, R.6
  • 56
    • 0035861793 scopus 로고    scopus 로고
    • Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells
    • Yamamoto Y, Nakajima M, Yamazaki H, Yokoi T. Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells. Life Sci 2001;70:471-482.
    • (2001) Life Sci , vol.70 , pp. 471-482
    • Yamamoto, Y.1    Nakajima, M.2    Yamazaki, H.3    Yokoi, T.4
  • 57
  • 59
    • 0030438721 scopus 로고    scopus 로고
    • Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach
    • Izumi T, Enomoto S, Hosiyama K, Sasahara K, Shibukawa A, Nakagawa T, et al. Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach. J Pharm Exp Ther 1996;277:1630-1641.
    • (1996) J Pharm Exp Ther , vol.277 , pp. 1630-1641
    • Izumi, T.1    Enomoto, S.2    Hosiyama, K.3    Sasahara, K.4    Shibukawa, A.5    Nakagawa, T.6
  • 60
    • 0035813014 scopus 로고    scopus 로고
    • Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats
    • Funk C, Ponelle C, Scheuermann G, Pantze M. Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Toxicology 2001;167:83-98.
    • (2001) Toxicology , vol.167 , pp. 83-98
    • Funk, C.1    Ponelle, C.2    Scheuermann, G.3    Pantze, M.4
  • 61
    • 0035126136 scopus 로고    scopus 로고
    • Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: In vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat
    • Funk C, Ponelle C, Scheuermann G, Pantze M. Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol Pharmacol 2001;59:627-635.
    • (2001) Mol Pharmacol , vol.59 , pp. 627-635
    • Funk, C.1    Ponelle, C.2    Scheuermann, G.3    Pantze, M.4
  • 62
    • 12844281512 scopus 로고
    • Biopharmaceutical studies on a new antidiabetic, CI-991, VIII. Pharmacokinetic study of dose proportionality of CI-991 and its metabolites after a single-intravenous and oral administration of CI-991
    • Izumi T, Maeda E, Sasahara K, Semmes R, Koup J. Biopharmaceutical studies on a new antidiabetic, CI-991, VIII. Pharmacokinetic study of dose proportionality of CI-991 and its metabolites after a single-intravenous and oral administration of CI-991. Food and Drug Adminstration 1992;RR:764-01353.
    • (1992) Food and Drug Adminstration , vol.RR , pp. 764-01353
    • Izumi, T.1    Maeda, E.2    Sasahara, K.3    Semmes, R.4    Koup, J.5
  • 64
    • 0031764673 scopus 로고    scopus 로고
    • Pharmacokinetics of Troglitazone, a PPARgamma agonist, in patients with hepatic insufficiency
    • Ott P, Ranek L, Young MA. Pharmacokinetics of Troglitazone, a PPARgamma agonist, in patients with hepatic insufficiency. Eur J Clin Pharmacol 1998;54:567-571.
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 567-571
    • Ott, P.1    Ranek, L.2    Young, M.A.3
  • 65
  • 66
    • 0031406407 scopus 로고    scopus 로고
    • Lack of effect of type II diabetes on the pharmacokinetics of troglitazone in a multiple-dose study
    • Loi CM, Randinitis E, Vassos A, Kazierad DJ, Koup JR, Sedman AJ. Lack of effect of type II diabetes on the pharmacokinetics of troglitazone in a multiple-dose study. J Clin Pharmacol 1997;37:1114-1120.
    • (1997) J Clin Pharmacol , vol.37 , pp. 1114-1120
    • Loi, C.M.1    Randinitis, E.2    Vassos, A.3    Kazierad, D.J.4    Koup, J.R.5    Sedman, A.J.6
  • 67
    • 0034868665 scopus 로고    scopus 로고
    • Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo
    • Tettey JN, Maggs JL, Rapeport WG, Pirmohamed M, Park BK. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo. Chem Res Toxicol 2001;14:965-974.
    • (2001) Chem Res Toxicol , vol.14 , pp. 965-974
    • Tettey, J.N.1    Maggs, J.L.2    Rapeport, W.G.3    Pirmohamed, M.4    Park, B.K.5
  • 69
    • 0029127584 scopus 로고
    • Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
    • Fromenty B, Pessayre D. Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther 1995;67:101-154.
    • (1995) Pharmacol Ther , vol.67 , pp. 101-154
    • Fromenty, B.1    Pessayre, D.2
  • 70
    • 0034743328 scopus 로고    scopus 로고
    • Diabetic KKAγ mice exhibit increased hepatic PPARγ-1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
    • Bedoucha M, Atzpodien E, Boelsterli UA. Diabetic KKAγ mice exhibit increased hepatic PPARγ-1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J Hepatol 2001;35:17-23.
    • (2001) J Hepatol , vol.35 , pp. 17-23
    • Bedoucha, M.1    Atzpodien, E.2    Boelsterli, U.A.3
  • 73
    • 0030773456 scopus 로고    scopus 로고
    • Effects of troglitazone and metformin on glucose and lipid metabolism: Alterations of two distinct molecular pathways
    • Lenhard JM, Kliewer SA, Paulik MA, Plunket KD, Lehmann JM, Weiel JE. Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways. Biochem Pharmacol 1997;54:801-808.
    • (1997) Biochem Pharmacol , vol.54 , pp. 801-808
    • Lenhard, J.M.1    Kliewer, S.A.2    Paulik, M.A.3    Plunket, K.D.4    Lehmann, J.M.5    Weiel, J.E.6
  • 74
    • 0029859494 scopus 로고    scopus 로고
    • Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats
    • Fulgencio JP, Kohl C, Girard J, Pegorier JP. Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats. Diabetes 1996;45:1556-1562.
    • (1996) Diabetes , vol.45 , pp. 1556-1562
    • Fulgencio, J.P.1    Kohl, C.2    Girard, J.3    Pegorier, J.P.4
  • 75
    • 0033613181 scopus 로고    scopus 로고
    • Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
    • Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, Unget RH. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci U S A 1999;96:11513-11518.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 11513-11518
    • Higa, M.1    Zhou, Y.T.2    Ravazzola, M.3    Baetens, D.4    Orci, L.5    Unget, R.H.6
  • 77
    • 0032488968 scopus 로고    scopus 로고
    • Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
    • Shimabukuro M, Zhou YT, Lee Y, Unger RH. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem 1998;273:3547-3550.
    • (1998) J Biol Chem , vol.273 , pp. 3547-3550
    • Shimabukuro, M.1    Zhou, Y.T.2    Lee, Y.3    Unger, R.H.4
  • 78
    • 0035053339 scopus 로고    scopus 로고
    • Troglitazone prevents the rise in visceral adiposity and improves fatty liver associated with sulfonylurea therapy: A randomized controlled trial
    • Katoh S, Hata S, Matsushima M, Ikemoto S, Inoue Y, Yokoyama J, et al. Troglitazone prevents the rise in visceral adiposity and improves fatty liver associated with sulfonylurea therapy: a randomized controlled trial. Metabolism 2001;50:414-417.
    • (2001) Metabolism , vol.50 , pp. 414-417
    • Katoh, S.1    Hata, S.2    Matsushima, M.3    Ikemoto, S.4    Inoue, Y.5    Yokoyama, J.6
  • 79
    • 0036139065 scopus 로고    scopus 로고
    • Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes
    • Davies GF, McFie PJ, Khandelwal RL, Roesler WJ. Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes. J Pharm Exp Ther 2002;300:72-77.
    • (2002) J Pharm Exp Ther , vol.300 , pp. 72-77
    • Davies, G.F.1    McFie, P.J.2    Khandelwal, R.L.3    Roesler, W.J.4
  • 80
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biochem 1997;272:3406-3410.
    • (1997) J Biochem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 81
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 82
    • 0343415083 scopus 로고    scopus 로고
    • Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: Evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression
    • Maggi LB Jr, Sadeghi H, Weigand C, Scarim AL, Heitmeier MR, Corbett JA. Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. Diabetes 2000;49:346-355.
    • (2000) Diabetes , vol.49 , pp. 346-355
    • Maggi Jr., L.B.1    Sadeghi, H.2    Weigand, C.3    Scarim, A.L.4    Heitmeier, M.R.5    Corbett, J.A.6
  • 83
    • 0033855572 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    • Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, Batignani G, et al. Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology 2000;119:466-478.
    • (2000) Gastroenterology , vol.119 , pp. 466-478
    • Marra, F.1    Efsen, E.2    Romanelli, R.G.3    Caligiuri, A.4    Pastacaldi, S.5    Batignani, G.6
  • 84
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote M, Huang JT, Welch JS, Glass CK The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998;391:82.
    • (1998) Nature , vol.391 , pp. 82
    • Ricote, M.1    Huang, J.T.2    Welch, J.S.3    Glass, C.K.4
  • 85
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
    • Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J Neurosci 2000;20:558-567.
    • (2000) J Neurosci , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 86
    • 0034010651 scopus 로고    scopus 로고
    • Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes
    • Sigrist S, Bedoucha M, Boelsterli UA. Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes. Biochem Pharmacol 2000;60:67-75.
    • (2000) Biochem Pharmacol , vol.60 , pp. 67-75
    • Sigrist, S.1    Bedoucha, M.2    Boelsterli, U.A.3
  • 87
    • 0030885230 scopus 로고    scopus 로고
    • Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity
    • Shimabukuro M, Koyama K, Lee Y, Unger RH. Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity. J Clin Invest 1997;100:1750-1754.
    • (1997) J Clin Invest , vol.100 , pp. 1750-1754
    • Shimabukuro, M.1    Koyama, K.2    Lee, Y.3    Unger, R.H.4
  • 90
    • 0031764885 scopus 로고    scopus 로고
    • Another potential use of troglitazone in noninsulin-dependent diabetes mellitus
    • Minamikawa J, Yamauchi M, Inoue D, Koshiyama H. Another potential use of troglitazone in noninsulin-dependent diabetes mellitus. J Clin Endocrin Metab 1998;83:1041-1042.
    • (1998) J Clin Endocrin Metab , vol.83 , pp. 1041-1042
    • Minamikawa, J.1    Yamauchi, M.2    Inoue, D.3    Koshiyama, H.4
  • 91
    • 0036467866 scopus 로고    scopus 로고
    • Impact of troglitazone on coronary stem implantation using small stents in patients with type 2 diabetes mellitus
    • Takagi T, Yamamuro A, Tamita K, Yamabe K, Katayama M, Morioka S, et al. Impact of troglitazone on coronary stem implantation using small stents in patients with type 2 diabetes mellitus. Am J Cardiol 2002;89:318-322.
    • (2002) Am J Cardiol , vol.89 , pp. 318-322
    • Takagi, T.1    Yamamuro, A.2    Tamita, K.3    Yamabe, K.4    Katayama, M.5    Morioka, S.6
  • 93
    • 0036256463 scopus 로고    scopus 로고
    • Mechanisms of hepatic transport of drugs: Implications for cholestatic drug reactions
    • Bohan A, Boyer JL. Mechanisms of hepatic transport of drugs: implications for cholestatic drug reactions. Semin Liv Dis 2002;22:123-136.
    • (2002) Semin Liv Dis , vol.22 , pp. 123-136
    • Bohan, A.1    Boyer, J.L.2
  • 94
    • 0033984873 scopus 로고    scopus 로고
    • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
    • Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ. Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology 2000;118:422-430.
    • (2000) Gastroenterology , vol.118 , pp. 422-430
    • Stieger, B.1    Fattinger, K.2    Madon, J.3    Kullak-Ublick, G.A.4    Meier, P.J.5
  • 95
    • 0030159011 scopus 로고    scopus 로고
    • Stimulation of bile acid 6 alpha-hydroxylation by rifampin
    • Wietholtz H, Marschall HU, Sjovall J, Matern S. Stimulation of bile acid 6 alpha-hydroxylation by rifampin. J Hepatol 1996;24:713-718.
    • (1996) J Hepatol , vol.24 , pp. 713-718
    • Wietholtz, H.1    Marschall, H.U.2    Sjovall, J.3    Matern, S.4
  • 96
  • 97
    • 0023201591 scopus 로고
    • 6 Alpha-glucuronidation of hyodeoxycholic acid by human liver, kidney and small bowel microsomes
    • Marschall HU, Matern H, Egestad B, Matern S, Sjovall S. 6 Alpha-glucuronidation of hyodeoxycholic acid by human liver, kidney and small bowel microsomes. Biochem Biophys Acta 1987;921:392-397.
    • (1987) Biochem Biophys Acta , vol.921 , pp. 392-397
    • Marschall, H.U.1    Matern, H.2    Egestad, B.3    Matern, S.4    Sjovall, S.5
  • 98
    • 0033583336 scopus 로고    scopus 로고
    • 6Alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes
    • Araya Z, Wikvall K. 6Alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochem Biophys Acta 1999;1438:47-54.
    • (1999) Biochem Biophys Acta , vol.1438 , pp. 47-54
    • Araya, Z.1    Wikvall, K.2
  • 99
    • 0035036050 scopus 로고    scopus 로고
    • The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
    • Fattinger K, Funk C, Pantze M, Weber C, Reichen J, Stieger B, et al. The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin Pharmacol Ther 2001;69:223-231.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 223-231
    • Fattinger, K.1    Funk, C.2    Pantze, M.3    Weber, C.4    Reichen, J.5    Stieger, B.6
  • 101
    • 0034720287 scopus 로고    scopus 로고
    • Evaluation of abnormal liver-enzyme results in asymptomatic patients
    • Pratt DS, Kaplan M. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med 2000;342:1266-1271.
    • (2000) N Engl J Med , vol.342 , pp. 1266-1271
    • Pratt, D.S.1    Kaplan, M.2
  • 102
    • 0022540272 scopus 로고
    • The mechanism of elevated alkaline phosphatase activity after bile duct ligation in the rat
    • Seetharam S, Sussman NL, Komoda T, Alpers DH. The mechanism of elevated alkaline phosphatase activity after bile duct ligation in the rat. HEPATOLOGY 1986;6:374-380.
    • (1986) Hepatology , vol.6 , pp. 374-380
    • Seetharam, S.1    Sussman, N.L.2    Komoda, T.3    Alpers, D.H.4
  • 105
    • 0034028127 scopus 로고    scopus 로고
    • Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes
    • Sahi J, Hamilton G, Sinz M, Barros S, Huang SM, Lesko LJ, et al. Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. Xenobiotica 2000;30:273-284.
    • (2000) Xenobiotica , vol.30 , pp. 273-284
    • Sahi, J.1    Hamilton, G.2    Sinz, M.3    Barros, S.4    Huang, S.M.5    Lesko, L.J.6
  • 106
    • 0036082703 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    • Galli A, Crabb DW, Ceni E, Salzano R, Svegliati-Baroni G, Ridolfi F, et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology 2002;122:1924-1940.
    • (2002) Gastroenterology , vol.122 , pp. 1924-1940
    • Galli, A.1    Crabb, D.W.2    Ceni, E.3    Salzano, R.4    Svegliati-Baroni, G.5    Ridolfi, F.6
  • 107
    • 0033756474 scopus 로고    scopus 로고
    • Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
    • Guicciardi ME, Duessing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, et al. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 2000;106:1127-1137.
    • (2000) J Clin Invest , vol.106 , pp. 1127-1137
    • Guicciardi, M.E.1    Duessing, J.2    Miyoshi, H.3    Bronk, S.F.4    Svingen, P.A.5    Peters, C.6
  • 108
    • 0036139951 scopus 로고    scopus 로고
    • Interleukin-1 receptor type I gene-deficient bile duct-ligated mice are partially protected against endotoxin
    • Sewnath ME, van der Poll T, Ten Kate FJ, Van Noorden CJ, Gouma DJ. Interleukin-1 receptor type I gene-deficient bile duct-ligated mice are partially protected against endotoxin. HEPATOLOGY 2002;35:149-158.
    • (2002) Hepatology , vol.35 , pp. 149-158
    • Sewnath, M.E.1    Van Der Poll, T.2    Ten Kate, F.J.3    Van Noorden, C.J.4    Gouma, D.J.5
  • 109
    • 0037151079 scopus 로고    scopus 로고
    • An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
    • Kim Y, Nanjoo S, Sporn M, Reed J. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem 2002;277:22320-22329.
    • (2002) J Biol Chem , vol.277 , pp. 22320-22329
    • Kim, Y.1    Nanjoo, S.2    Sporn, M.3    Reed, J.4
  • 110
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor gamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner E, Muller C, Koshizuka K, Williamson EA, Park D, Asou H, et al. Ligands for peroxisome proliferator-activated receptor gamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci U S A 1998;95:8806-8811.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8806-8811
    • Elstner, E.1    Muller, C.2    Koshizuka, K.3    Williamson, E.A.4    Park, D.5    Asou, H.6
  • 111
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
    • Kubota T, Koshizuka K, Williamson EA, Asou H, Said JW, Holden S, et al. Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res 1998;58:3344-3352.
    • (1998) Cancer Res , vol.58 , pp. 3344-3352
    • Kubota, T.1    Koshizuka, K.2    Williamson, E.A.3    Asou, H.4    Said, J.W.5    Holden, S.6
  • 112
    • 0034643258 scopus 로고    scopus 로고
    • Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis
    • Tsubouchi Y, Sano H, Kawahito Y, Mukai S, Yamada R, Kohno M, et al. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Bioch Biophys Res Commun 2000;270:400-405.
    • (2000) Bioch Biophys Res Commun , vol.270 , pp. 400-405
    • Tsubouchi, Y.1    Sano, H.2    Kawahito, Y.3    Mukai, S.4    Yamada, R.5    Kohno, M.6
  • 113
    • 0035019640 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoprosis of human papillary thyroid carcinoma cells
    • Ohta K, Endo T, Haraguchi K, Hershman JM, Onaya T. Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoprosis of human papillary thyroid carcinoma cells. J Clin Endocrinol Metab 2001;86:2170-2177.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2170-2177
    • Ohta, K.1    Endo, T.2    Haraguchi, K.3    Hershman, J.M.4    Onaya, T.5
  • 114
    • 0036164609 scopus 로고    scopus 로고
    • Prosraglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells
    • Harris SG, Phipps RP. Prosraglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. Immunology 2002;105:23-34.
    • (2002) Immunology , vol.105 , pp. 23-34
    • Harris, S.G.1    Phipps, R.P.2
  • 116
    • 0037222025 scopus 로고    scopus 로고
    • Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes
    • Shishido S, Koga H, Harada M, Kumemura H, Hanada S, Taniguchi E, et al. Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes. HEPATOLOGY 2003;37:136-147.
    • (2003) Hepatology , vol.37 , pp. 136-147
    • Shishido, S.1    Koga, H.2    Harada, M.3    Kumemura, H.4    Hanada, S.5    Taniguchi, E.6
  • 117
    • 0035035402 scopus 로고    scopus 로고
    • Involvement of p21 (WAF1/Cp1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines
    • Koga H, Sakisaka S, Harada M, Takagi T, Hanada S, Taniguchi E, et al. Involvement of p21 (WAF1/Cp1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. HEPATOLOGY 2001;33:1087-1097.
    • (2001) Hepatology , vol.33 , pp. 1087-1097
    • Koga, H.1    Sakisaka, S.2    Harada, M.3    Takagi, T.4    Hanada, S.5    Taniguchi, E.6
  • 118
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green D, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004;305:626-629.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.1    Kroemer, G.2
  • 119
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003;114:181-190.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 120
    • 0035089354 scopus 로고    scopus 로고
    • Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway
    • Gouni-Berthold I, Berthold HK, Weber AA, Ko Y, Seul C, Vetter H, et al. Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway. Arch Pharmacol 2001;363:215-221.
    • (2001) Arch Pharmacol , vol.363 , pp. 215-221
    • Gouni-Berthold, I.1    Berthold, H.K.2    Weber, A.A.3    Ko, Y.4    Seul, C.5    Vetter, H.6
  • 121
    • 0034802960 scopus 로고    scopus 로고
    • Thiazolidinedione toxicity to isolated hepatocytes revealed by cohetent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes
    • Haskins JR, Rowse P, Rahbari R, de la Iglesia FA. Thiazolidinedione toxicity to isolated hepatocytes revealed by cohetent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes. Arch Toxicol 2001;75:425-438.
    • (2001) Arch Toxicol , vol.75 , pp. 425-438
    • Haskins, J.R.1    Rowse, P.2    Rahbari, R.3    De La Iglesia, F.A.4
  • 122
    • 0032852992 scopus 로고    scopus 로고
    • Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes
    • Ramachandran V, Kostrubsky VE, Komoroski BJ, Zhang S, Dorko K, Esplen JE, et al. Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes. Drug Metab Dispos 1999;27:1194-1199.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1194-1199
    • Ramachandran, V.1    Kostrubsky, V.E.2    Komoroski, B.J.3    Zhang, S.4    Dorko, K.5    Esplen, J.E.6
  • 123
    • 0035831025 scopus 로고    scopus 로고
    • Toxic effect of troglitazone on cultured rat hepatocytes
    • Toyoda Y, Tsuchida A, Iwami E, Miwa I. Toxic effect of troglitazone on cultured rat hepatocytes. Life Sci 2001;68:1867-1876.
    • (2001) Life Sci , vol.68 , pp. 1867-1876
    • Toyoda, Y.1    Tsuchida, A.2    Iwami, E.3    Miwa, I.4
  • 124
    • 0034602547 scopus 로고    scopus 로고
    • Troglitazone induces apoptosis via the P53 and Gadd45 pathway in vascular smooth muscle cells
    • Okura T, Nakamura M, Takata Y, Watanabe S, Kitami Y, Hiwada K. Troglitazone induces apoptosis via the P53 and Gadd45 pathway in vascular smooth muscle cells. Eur J Pharmacol 2000;407:227-235.
    • (2000) Eur J Pharmacol , vol.407 , pp. 227-235
    • Okura, T.1    Nakamura, M.2    Takata, Y.3    Watanabe, S.4    Kitami, Y.5    Hiwada, K.6
  • 125
    • 0037058255 scopus 로고    scopus 로고
    • Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes
    • Hewitt NJ, Lloyd S, Hayden M, Butler R, Sakai Y, Springer R, et al. Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes. Chem Biol Interact 2002;142:73-82.
    • (2002) Chem Biol Interact , vol.142 , pp. 73-82
    • Hewitt, N.J.1    Lloyd, S.2    Hayden, M.3    Butler, R.4    Sakai, Y.5    Springer, R.6
  • 129
    • 0022004113 scopus 로고
    • D-Galactosamine hepatotoxicity is associated with endotoxin-sensitivity and mediated by lymphoreticular cells in mice
    • Chojkier M, Fierer J. D-Galactosamine hepatotoxicity is associated with endotoxin-sensitivity and mediated by lymphoreticular cells in mice. Gastroenterology 1985;88:115-121.
    • (1985) Gastroenterology , vol.88 , pp. 115-121
    • Chojkier, M.1    Fierer, J.2
  • 130
    • 0024270553 scopus 로고
    • Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver
    • Benedetti A, Jezequel AM, Orlandi F. Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver. J Hepatol 1988;7:319-324.
    • (1988) J Hepatol , vol.7 , pp. 319-324
    • Benedetti, A.1    Jezequel, A.M.2    Orlandi, F.3
  • 131
  • 136
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oliver D, Bacon BR. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. HEPATOLOGY 2003;38:1008-1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 138
    • 0028814043 scopus 로고
    • Effects of female sex hormones on mitochondria: Possible role in acute fatty liver of pregnancy
    • Grimbert S, Fisch C, Deschamps D, Berson A, Fromenty B, Feldmann G, et al. Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy. Am J Physiol 1995;268:107-115.
    • (1995) Am J Physiol , vol.268 , pp. 107-115
    • Grimbert, S.1    Fisch, C.2    Deschamps, D.3    Berson, A.4    Fromenty, B.5    Feldmann, G.6
  • 139
    • 0027405002 scopus 로고
    • Decreased mitochondrial oxidation of fatty acids in pregnant mice: Possible relevance to development of acute fatty liver of pregnancy
    • Grimbert S, Fromenty B, Fisch C, Letteron P, Berson A, Durand-Schneider AM, et al. Decreased mitochondrial oxidation of fatty acids in pregnant mice: possible relevance to development of acute fatty liver of pregnancy. HEPATOLOGY 1993;17:628-637.
    • (1993) Hepatology , vol.17 , pp. 628-637
    • Grimbert, S.1    Fromenty, B.2    Fisch, C.3    Letteron, P.4    Berson, A.5    Durand-Schneider, A.M.6
  • 140
    • 0002691517 scopus 로고    scopus 로고
    • Hepatic stellate cells
    • Strain A, Diehl A, eds. London: Chapman & Hall
    • Ankoma-Sey V, Friedman S. Hepatic stellate cells. In: Strain A, Diehl A, eds. Liver Growth and Repair. London: Chapman & Hall, 1998:512-537.
    • (1998) Liver Growth and Repair , pp. 512-537
    • Ankoma-Sey, V.1    Friedman, S.2
  • 141
    • 0002830927 scopus 로고    scopus 로고
    • Regulation of collagen gene expression
    • Strain A, Diehl A, eds. London: Chapman & Hall
    • Chojkier M. Regulation of collagen gene expression. In: Strain A, Diehl A, eds. Liver Growth and Repair.London: Chapman & Hall, 1998:430-450.
    • (1998) Liver Growth and Repair , pp. 430-450
    • Chojkier, M.1
  • 143
    • 0001520008 scopus 로고
    • Hepatic lipocytes: The principal collagen-producing cells of the liver
    • Friedman S, Roll F, Boyles J, Bissell D. Hepatic lipocytes: the principal collagen-producing cells of the liver. Proc Natl Acad Sci U S A 1985;82:8681-8685.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 8681-8685
    • Friedman, S.1    Roll, F.2    Boyles, J.3    Bissell, D.4
  • 144
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGFα and collagen type I is mediated by oxidative stress through c-myb expression
    • Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGFα and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995;96:2461-2468.
    • (1995) J Clin Invest , vol.96 , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 145
    • 0036788277 scopus 로고    scopus 로고
    • Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
    • Canbay A, Higuchi H, Bronk SF, Taniai M, Sebo TJ, Gores GJ. Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Gastroenterology 2002;123:1323-1330.
    • (2002) Gastroenterology , vol.123 , pp. 1323-1330
    • Canbay, A.1    Higuchi, H.2    Bronk, S.F.3    Taniai, M.4    Sebo, T.J.5    Gores, G.J.6
  • 147
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: The nexus of liver injury and fibrosis
    • Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. HEPATOLOGY 2004;39:273-278.
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 148
    • 0030701875 scopus 로고    scopus 로고
    • Pentoxyfilline blocks stellate cell activation independently of its cAMP phosphodiesterase inhibitory activity
    • Lee KS, Cottam HB, Houglum K, Wasson DB, Carson D, Chojkier M. Pentoxyfilline blocks stellate cell activation independently of its cAMP phosphodiesterase inhibitory activity. Am J Physiol 1997;273:G1094-G1100.
    • (1997) Am J Physiol , vol.273
    • Lee, K.S.1    Cottam, H.B.2    Houglum, K.3    Wasson, D.B.4    Carson, D.5    Chojkier, M.6
  • 149
    • 0032447138 scopus 로고    scopus 로고
    • Long- and short-term D-α-tocopherol supplementation inhibits liver collagen α1(I) gene expression
    • Chojkier M, Houglum K, Lee KS, Buck M. Long- and short-term D-α-tocopherol supplementation inhibits liver collagen α1(I) gene expression. Am J Physiol 1998;275:G1480-1485.
    • (1998) Am J Physiol , vol.275
    • Chojkier, M.1    Houglum, K.2    Lee, K.S.3    Buck, M.4
  • 150
    • 0034680787 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and hepatic stellate cell activation
    • Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF Jr, Motomura K, et al. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem 2000;275:35715-35722.
    • (2000) J Biol Chem , vol.275 , pp. 35715-35722
    • Miyahara, T.1    Schrum, L.2    Rippe, R.3    Xiong, S.4    Yee Jr., H.F.5    Motomura, K.6
  • 151
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells
    • Galli A, Crabb DW, Price D, Ceni E, Salzano R, Surrenti C, et al. Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. HEPATOLOGY 2000;31:101-108.
    • (2000) Hepatology , vol.31 , pp. 101-108
    • Galli, A.1    Crabb, D.W.2    Price, D.3    Ceni, E.4    Salzano, R.5    Surrenti, C.6
  • 152
  • 153
    • 0032732626 scopus 로고    scopus 로고
    • Spontaneous and thiazolidinedione-induced B6C3F1 mouse hemangiosarcomas exhibit low ras oncogene mutation frequencies
    • Duddy SK, Gorospe SM, Bleavins MR, de la Iglesia FA. Spontaneous and thiazolidinedione-induced B6C3F1 mouse hemangiosarcomas exhibit low ras oncogene mutation frequencies. Toxicol Appl Pharmacol 1999;160:133-140.
    • (1999) Toxicol Appl Pharmacol , vol.160 , pp. 133-140
    • Duddy, S.K.1    Gorospe, S.M.2    Bleavins, M.R.3    De La Iglesia, F.A.4
  • 154
    • 0032970818 scopus 로고    scopus 로고
    • p53 is not inactivated in B6C3F1 mouse vascular tumors arising spontaneously or associated with long-term administration of the thiazolidinedione troglitazone
    • Duddy SK, Parker RF, Bleavins MR, Gough AW, Rowse P, Gorospe SM, et al. p53 is not inactivated in B6C3F1 mouse vascular tumors arising spontaneously or associated with long-term administration of the thiazolidinedione troglitazone. Toxicol Appl Pharmacol 1999;156:106-112.
    • (1999) Toxicol Appl Pharmacol , vol.156 , pp. 106-112
    • Duddy, S.K.1    Parker, R.F.2    Bleavins, M.R.3    Gough, A.W.4    Rowse, P.5    Gorospe, S.M.6
  • 155
    • 0035958868 scopus 로고    scopus 로고
    • SNP-ing Drugs to Size
    • Gura T. SNP-ing Drugs to Size. Science 2001;293:595.
    • (2001) Science , vol.293 , pp. 595
    • Gura, T.1
  • 156
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang L, Lin Y, Lamba J, Assem M, Schuetz J, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001;27:383-391.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, L.2    Lin, Y.3    Lamba, J.4    Assem, M.5    Schuetz, J.6
  • 157
    • 0035102719 scopus 로고    scopus 로고
    • CYP3A genetics in drug metabolism
    • Eichelbaum M, Burk O. CYP3A genetics in drug metabolism. Nature Medicine 2001;7:285-287.
    • (2001) Nature Medicine , vol.7 , pp. 285-287
    • Eichelbaum, M.1    Burk, O.2
  • 158
    • 0000783041 scopus 로고    scopus 로고
    • Evaluation of the genetic component of variability in CYP3A4 activity: A repeated drug administration method
    • Ozdemir V, Kalowa W, Tang BK, Paterson AD, Walker SE, Endrenyi L, et al. Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method. Pharmacogenetics 2000;10:373-388.
    • (2000) Pharmacogenetics , vol.10 , pp. 373-388
    • Ozdemir, V.1    Kalowa, W.2    Tang, B.K.3    Paterson, A.D.4    Walker, S.E.5    Endrenyi, L.6
  • 160
    • 0035214454 scopus 로고    scopus 로고
    • Early postoperative erythromycin breath test correlates with hepatic cytochrome P4503A activity in liver transplant recipients
    • Schmidt LE, Olsen AK, Stentoft K, Rasmussen A, Kirkegaard P, Dalhoff K. Early postoperative erythromycin breath test correlates with hepatic cytochrome P4503A activity in liver transplant recipients. Clin Pharmacol Ther 2001;70:446-454.
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 446-454
    • Schmidt, L.E.1    Olsen, A.K.2    Stentoft, K.3    Rasmussen, A.4    Kirkegaard, P.5    Dalhoff, K.6
  • 161
    • 2442707819 scopus 로고    scopus 로고
    • Metabolic activation of troglitazone: Identification of a reactive metabolite and mechanisms involved
    • He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges A, et al. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved. Drug Merab Dispos 2004;32:639-646.
    • (2004) Drug Merab Dispos , vol.32 , pp. 639-646
    • He, K.1    Talaat, R.E.2    Pool, W.F.3    Reily, M.D.4    Reed, J.E.5    Bridges, A.6
  • 162
    • 70349707099 scopus 로고    scopus 로고
    • Hepatotoxicity of cardiovascular and antidiabetic drugs
    • Kaplowitz N, DeLeve LD, eds. New York: Marcel Dekker
    • de la Iglesia FA, Haskins JR, Feuer G. Hepatotoxicity of cardiovascular and antidiabetic drugs. In: Kaplowitz N, DeLeve LD, eds. Drug-Induced Liver Disease. New York: Marcel Dekker, 2003:549-592.
    • (2003) Drug-Induced Liver Disease , pp. 549-592
    • De La Iglesia, F.A.1    Haskins, J.R.2    Feuer, G.3
  • 163
    • 0038708252 scopus 로고    scopus 로고
    • A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus
    • Watanabe I, Tomita A, Shimizu M, Sugawara M, Yasumo H, Koishi R, et al. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. Clin Pharmacol Ther 2003;73:435-455.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 435-455
    • Watanabe, I.1    Tomita, A.2    Shimizu, M.3    Sugawara, M.4    Yasumo, H.5    Koishi, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.