Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo

Chemical Research in Toxicology

Volumn 14, Issue 8, 2001, Pages 965-974

  Tettey, J N ^a,b   Maggs, J L ^a   Rapeport, W G ^c   Pirmohamed, M ^a   Park, B K ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOQUINONE; DEXAMETHASONE; DISULFIDE; GLUTATHIONE; SULFIDE; THIOESTER; TROGLITAZONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILE; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; DRUG STRUCTURE; ENZYME INDUCTION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LIVER TOXICITY; MALE; NONHUMAN; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMANS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ENZYME INDUCTION; GLUCOCORTICOIDS; HEPATOCYTES; HYPOGLYCEMIC AGENTS; OXIDOREDUCTASES, N-DEMETHYLATING; QUINONES; RATS; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0034868665     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0001981     Document Type: Article

References (39)

1. Troglitazone: A review of its use in the management of type 2 diabetes mellitus
2. Hepatotoxicity due to troglitazone: Report of two cases and review of adverse events reported to the United States Food and Drug Administration
3. Troglitazone and liver function abnormalities: Lessions from a prescription event monitoring study and spontaneous reporting
4. Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone
5. Troglitazone-induced hepatic failure leading to liver transplantation
6. Troglitazone-induced fulminant hepatic failure
7. Rosiglitazone and liver failure
8. Role of quinones in toxicology
9. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes
10. Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes
11. Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs
12. Rosiglitazone has no clinically significant effect on nifedipine pharmacokinetics
13. Covalent binding of troglitazone and other members of the thiazolidinedione family to human liver microsomes, implications for cases of idiosyncratic hepatotoxicity
14. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission
15. Intestinal absorption and excretion of troglitazone sulphate, a major biliary metabolite of troglitazone
16. The role of conjuagation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures
17. Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans
18. Effects of glucocorticoids on pharmacokinetics and pharmacodynamics of midazolam in rats
19. Preparation of [(alkoxy)-benzyl] dioxothiazolidines as antidiabetics
20. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man
21. Isolation and use of liver cells
22. Intracellular localization and metabolism of the phenanthridinium trypanocide, ethidium bromide, by isolated rat hepatocytes
23. Vitamin E oxidation in rat liver mitochondria
24. 14C]-troglitazone
25. Induction of drug metabolising enzymes: Pharmacokinetic and toxicological consequences in humans
26. Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate
27. One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450
28. Simultaneous determination of RRR- and SRR-alpha-tocopherols and their quinones in rat plasma and tissues by using chiral high-performance liquid chromatography
29. Determination of alpha-tocopherolquinone (vitamin E quinone) in human serum, platelets, and red cell membrane samples
30. Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low-density lipoprotein lipids
31. Reduction of alpha-tocopherolquinone to alpha-tocopherolhydroquinone in rat hepatocytes
32. Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing-solutions?
33. Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: Analysis with a novel reverse transcriptase-polymerase chain reaction assay
34. Modulation of benzoquinone-induced cytotoxicity by diethyldithiocarbamate in isolated hepatocytes
35. The chemistry and antioxidant properties of tocopherols and tocotrienols
36. Cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells
37. Quinone toxicity in hepatocytes without oxidative stress
38. Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and gamma-glutamylcysteine synthetase
39. The use of cultured hepatocytes to investigate the mechanisms of drug hepatotoxicity