Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus

American Journal of Gastroenterology

Volumn 96, Issue 5, 2001, Pages 1631-1634

  Menon, K V Narayanan ^a   Angulo, Paul ^a   Lindor, Keith D ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TROGLITAZONE;

ADULT; ARTICLE; CASE REPORT; CHOLESTATIC HEPATITIS; CLINICAL FEATURE; DRUG EFFECT; DRUG EFFICACY; DRUG USE; FATTY LIVER; FEMALE; HUMAN; INCIDENCE; LIVER TOXICITY; LIVER TRANSPLANTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SYMPTOM;

ADULT; CHOLESTASIS; CHROMANS; DIABETES MELLITUS, TYPE 1; FATTY LIVER; FEMALE; HEPATITIS; HEPATITIS, TOXIC; HUMANS; HYPOGLYCEMIC AGENTS; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0342502229     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(01)02372-3     Document Type: Article

References (12)

1. Spencer C.M., Markham A. Troglitazone. Drugs. 54:1997;89-101.
2. Gitlin N., Julie N.L., Spurr C.L., et al. Two cases of severe clinical and histologic hepatotoxity associated with troglitazone. Ann Intern Med. 12:1998;36-38.
3. Neuschwander-Tetri B.A., Isley W.L., Oki J.C., et al. Troglitazone-induced hepatic failure leading to liver transplantation. Ann Intern Med. 129:1998;38-41.
4. Nightingale S.L. Rezulin labeling updated to recommend more frequent patient monitoring. JAMA. 279:1998;9.
5. Prescribing information for Rezulin. Ann Arbor, MI. Parke-Davis; 6 July 1998.
6. Ludwig J., Viggiano T.R., McGill D.B., Ott B.J. Nonalcoholic steatohepatitis. Mayo Clinic experience with a hitherto unnamed disease. Mayo Clin Proc. 55:1980;434-438.
7. Battle E.H., Hespenheide E.E., Caldwell S.H. Pilot study of troglitazone (Rezulin) for nonalcoholic steatohepatitis. Hepatology. 28:1998;304A.
8. Marsman W.A., Wiesner R.H., Rodriguez L., et al. Use of fatty donor liver is associated with diminished early patient and graft survival. Transplantation. 62:1996;1246-1251.
9. Drenick E.J., Fisler J., Johnson D. Hepatic steatosis after intestinal bypass Prevention and eversal by metronidazole, irrespective of protein-calorie malnutrition . Gastroenterology. 82:1982;532-548.
10. Pappo I., Becovier H., Berry E.M., Freund H.R. Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parentral nutrition in the rat. J Surg Res. 51:1991;106-112.
11. Laurin J., Lindor K.D., Crippin J.S., et al. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis A pilot study . Hepatology. 23:1996;1464-1467.
12. Watkins P.B., Witcomb R.W. Hepatic dysfunction associated with troglitazone. N Engl J Med. 338:1998;916-917. (letter).