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Volumn 4, Issue 1, 2003, Pages 3-15

Cryopreservation of hepatocytes: A review of current methods for banking

Author keywords

Bioartificial liver; Cryopreservation; Hepatocyte transplantation; Hepatocytes; Pharmacotoxicology research

Indexed keywords

CYTOCHROME P450; LIQUID NITROGEN;

EID: 0344897639     PISSN: 13899333     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026392216017     Document Type: Review
Times cited : (39)

References (74)
  • 1
    • 0028824917 scopus 로고
    • Effective Cryopreservation and long term storage of primary human hepatocytes with recovery of viability, differentiation, and replicative potential
    • Adams R.M., Wang M., Crane A.-M., Brown B., Darlington G.J. and Ledley F.D. 1995. Effective Cryopreservation and long term storage of primary human hepatocytes with recovery of viability, differentiation, and replicative potential. Cell Transplantation 4: 579-586.
    • (1995) Cell Transplantation , vol.4 , pp. 579-586
    • Adams, R.M.1    Wang, M.2    Crane, A.-M.3    Brown, B.4    Darlington, G.J.5    Ledley, F.D.6
  • 4
    • 0025353404 scopus 로고
    • The basis for toxicity of certain cryoprotectants: A hypothesis
    • Arakawa T., Carpenter J.F., Kita Y.A. and Crowe J.H. 1990. The basis for toxicity of certain cryoprotectants: A hypothesis. Cryobiology 27: 401-415.
    • (1990) Cryobiology , vol.27 , pp. 401-415
    • Arakawa, T.1    Carpenter, J.F.2    Kita, Y.A.3    Crowe, J.H.4
  • 6
    • 0026902163 scopus 로고
    • Effects of Dimethyl sulfoxide on cultured rat hepatocytes in sandwich configuration
    • Borel-Rinkes I.H.M., Toner M., Ezzell R.M., Tompkins R.G. and Yarmush M.L. 1992a. Effects of Dimethyl sulfoxide on cultured rat hepatocytes in sandwich configuration. Cryobiology 29: 443-453.
    • (1992) Cryobiology , vol.29 , pp. 443-453
    • Borel-Rinkes, I.H.M.1    Toner, M.2    Ezzell, R.M.3    Tompkins, R.G.4    Yarmush, M.L.5
  • 7
    • 0027028291 scopus 로고
    • Long term functional recovery of hepatocytes after cryopreservation in a three-dimensional culture configuration
    • Borel-Rinkes I.H.M., Toner M., Sheehan S.J., Tompkins R.G. and Yarmush M.L. 1992b. Long term functional recovery of hepatocytes after cryopreservation in a three-dimensional culture configuration. Cell Transplantation 1: 281-292.
    • (1992) Cell Transplantation , vol.1 , pp. 281-292
    • Borel-Rinkes, I.H.M.1    Toner, M.2    Sheehan, S.J.3    Tompkins, R.G.4    Yarmush, M.L.5
  • 9
    • 0023787984 scopus 로고
    • Cryopreservation of isolated rat hepatocytes: A critical evaluation of freezing and thawing conditions
    • Chesne C. and Guillouzo A. 1988. Cryopreservation of isolated rat hepatocytes: A critical evaluation of freezing and thawing conditions. Cryobiology 25: 323-330.
    • (1988) Cryobiology , vol.25 , pp. 323-330
    • Chesne, C.1    Guillouzo, A.2
  • 10
    • 0027218230 scopus 로고
    • Viability and function in primary culture of adult hepatocytes from various animal species and human beings after cryopreservation
    • Chesne C., Guyomard C., Fautrel A., Poullain M., Fremond B., De Jong H. and Guillouzo A. 1993. Viability and function in primary culture of adult hepatocytes from various animal species and human beings after cryopreservation. Hepatology 18: 406-414.
    • (1993) Hepatology , vol.18 , pp. 406-414
    • Chesne, C.1    Guyomard, C.2    Fautrel, A.3    Poullain, M.4    Fremond, B.5    De Jong, H.6    Guillouzo, A.7
  • 11
    • 0027759816 scopus 로고
    • Cryopreservation of human adult hepatocytes for use in drug metabolism and toxicity studies
    • Coundouris J.A., Grant M.H., Engeset J., Petrie J.C. and Hawksworth G.M. 1993. Cryopreservation of human adult hepatocytes for use in drug metabolism and toxicity studies. Xenobiotica 23: 1399-1409.
    • (1993) Xenobiotica , vol.23 , pp. 1399-1409
    • Coundouris, J.A.1    Grant, M.H.2    Engeset, J.3    Petrie, J.C.4    Hawksworth, G.M.5
  • 12
    • 0035715265 scopus 로고    scopus 로고
    • Postthaw viability of Precultured Hepatocytes
    • Darr T.B. and Hubel A. 2001. Postthaw viability of Precultured Hepatocytes. Cryobiology 41: 11-20.
    • (2001) Cryobiology , vol.41 , pp. 11-20
    • Darr, T.B.1    Hubel, A.2
  • 13
    • 0028872249 scopus 로고
    • Artifical livers-what's keeping them
    • Davies E. and Hodgson H. 1995. Artifical livers-what's keeping them. Gut 36: 168-170.
    • (1995) Gut , vol.36 , pp. 168-170
    • Davies, E.1    Hodgson, H.2
  • 14
    • 0027546698 scopus 로고
    • Metabolic Activity of freshly prepared and cryopreserved hepatocytes in monolayer culture
    • De Loecker P., Fuller B.J., Koptelov V.A. and De Loecker W. 1993. Metabolic Activity of freshly prepared and cryopreserved hepatocytes in monolayer culture. Cryobiology 30: 12-18.
    • (1993) Cryobiology , vol.30 , pp. 12-18
    • De Loecker, P.1    Fuller, B.J.2    Koptelov, V.A.3    De Loecker, W.4
  • 15
    • 0032161436 scopus 로고    scopus 로고
    • Effects of cell concentration on viability and metabolic activity during cryopreservation
    • De Loecker W., Koptelov V.A., Grischenko V.I. and De Loecker P. 1998. Effects of cell concentration on viability and metabolic activity during cryopreservation. Cryobiology 37: 103-109.
    • (1998) Cryobiology , vol.37 , pp. 103-109
    • De Loecker, W.1    Koptelov, V.A.2    Grischenko, V.I.3    De Loecker, P.4
  • 16
    • 0025953527 scopus 로고
    • Freshly isolated or cryopreserved human hepayocytes in primary culture: Influence of drug metabolism on hepatotoxicity
    • De Sousa G., Dou M., Barbe D., Lacarelle B., Placidi M. and Rahmani R. 1991. Freshly isolated or cryopreserved human hepayocytes in primary culture: influence of drug metabolism on hepatotoxicity. Toxicology In Vitro 5: 483-486.
    • (1991) Toxicology in Vitro , vol.5 , pp. 483-486
    • De Sousa, G.1    Dou, M.2    Barbe, D.3    Lacarelle, B.4    Placidi, M.5    Rahmani, R.6
  • 17
    • 0029828084 scopus 로고    scopus 로고
    • Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation
    • De Sousa G., Langouet S., Nicolas F., Lorenzon G., Placidi M., Rahmani R. and Guillouzo A. 1996. Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation. Cell Biology and Toxicology 12: 351-358.
    • (1996) Cell Biology and Toxicology , vol.12 , pp. 351-358
    • De Sousa, G.1    Langouet, S.2    Nicolas, F.3    Lorenzon, G.4    Placidi, M.5    Rahmani, R.6    Guillouzo, A.7
  • 19
    • 0027586305 scopus 로고
    • A method for the cryopreservation of liver parenchymal cells for studies of Xenobiotics
    • Diener B., Utesch D., Beer N., Durk H. and Oesch F. 1993. A method for the cryopreservation of liver parenchymal cells for studies of Xenobiotics. Cryobiology 30: 116-127.
    • (1993) Cryobiology , vol.30 , pp. 116-127
    • Diener, B.1    Utesch, D.2    Beer, N.3    Durk, H.4    Oesch, F.5
  • 20
    • 0028276625 scopus 로고
    • Development of a bioartificial liver using isolated hepatocytes
    • Dixit V. 1994. Development of a bioartificial liver using isolated hepatocytes. Artificial Organs 18: 371-384.
    • (1994) Artificial Organs , vol.18 , pp. 371-384
    • Dixit, V.1
  • 21
    • 0027406599 scopus 로고
    • Cryopreserved microencapsulated hepatocytes-transplantation studies in Gunn rats
    • Dixit V., Darvasi R., Arthur M., Lewin K. and Gitnick G. 1993. Cryopreserved microencapsulated hepatocytes-transplantation studies in Gunn rats. Transplantation 55: 616-622.
    • (1993) Transplantation , vol.55 , pp. 616-622
    • Dixit, V.1    Darvasi, R.2    Arthur, M.3    Lewin, K.4    Gitnick, G.5
  • 25
    • 0026158432 scopus 로고
    • Long term in vitro function of adult hepatocytes in a collagen sandwich configuration
    • Dunn J.C.Y., Tompkins R.G. and Yarmush M.L. 1991. Long term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnology Progress 7: 237-245.
    • (1991) Biotechnology Progress , vol.7 , pp. 237-245
    • Dunn, J.C.Y.1    Tompkins, R.G.2    Yarmush, M.L.3
  • 26
    • 0026547439 scopus 로고
    • Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation
    • Dunn J.C.Y., Tompkins R.G. and Yarmush M.L. 1992. Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation. Journal of Cell Biology 116: 1043-1053.
    • (1992) Journal of Cell Biology , vol.116 , pp. 1043-1053
    • Dunn, J.C.Y.1    Tompkins, R.G.2    Yarmush, M.L.3
  • 27
    • 0030685776 scopus 로고    scopus 로고
    • Long-term maintenance of drug-metabolizing enzyme activities in rat hepatocytes after cryopreservation
    • Fautrel A., Joly B., Guyomard C. and Guillouzo A. 1997. Long-term maintenance of drug-metabolizing enzyme activities in rat hepatocytes after cryopreservation. Toxicology and Applied Pharmacology 147: 110-114.
    • (1997) Toxicology and Applied Pharmacology , vol.147 , pp. 110-114
    • Fautrel, A.1    Joly, B.2    Guyomard, C.3    Guillouzo, A.4
  • 28
    • 0021739484 scopus 로고
    • Biochemical functionality and recovery of hepatocytes after deep freezing storage
    • Gomez-Lechon M.J., Lopez P. and Castell J.V. 1984. Biochemical functionality and recovery of hepatocytes after deep freezing storage. In Vitro 20: 826-832.
    • (1984) In Vitro , vol.20 , pp. 826-832
    • Gomez-Lechon, M.J.1    Lopez, P.2    Castell, J.V.3
  • 30
    • 0030460927 scopus 로고    scopus 로고
    • Influence of alginate gel entrapement and cryopreservation on survival and xenobiotic metabolism capacity of rat hepatocytes
    • Guyomard C., Rialland L., Fremond B., Chesne C. and Guillouzo A. 1996. Influence of alginate gel entrapement and cryopreservation on survival and xenobiotic metabolism capacity of rat hepatocytes. Toxicology and Applied Pharmacology 141: 349-356.
    • (1996) Toxicology and Applied Pharmacology , vol.141 , pp. 349-356
    • Guyomard, C.1    Rialland, L.2    Fremond, B.3    Chesne, C.4    Guillouzo, A.5
  • 31
    • 0026235339 scopus 로고
    • Cryopreservation of Isolated hepatocytes: Intracellular ice formation under various chemical and physical conditions
    • Harris C.L., Toner M., Hubel A., Cravalho E.G., Yarmush M.L. and Tompkins R.G. 1991. Cryopreservation of Isolated hepatocytes: Intracellular ice formation under various chemical and physical conditions. Cryobiology 28: 436-444.
    • (1991) Cryobiology , vol.28 , pp. 436-444
    • Harris, C.L.1    Toner, M.2    Hubel, A.3    Cravalho, E.G.4    Yarmush, M.L.5    Tompkins, R.G.6
  • 33
    • 0344953871 scopus 로고    scopus 로고
    • Studies comparing in vivio: In vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures
    • Hewitt N., Buhring K.-U., Dasenbrock J., Haunschild J., Ladstetter B. and Utesch D. 2001. Studies comparing in vivio: in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures. Xenobiotica 28: 937-948.
    • (2001) Xenobiotica , vol.28 , pp. 937-948
    • Hewitt, N.1    Buhring, K.-U.2    Dasenbrock, J.3    Haunschild, J.4    Ladstetter, B.5    Utesch, D.6
  • 34
    • 0026254355 scopus 로고
    • Intracellular ice formation during the freezing of hepatocytes cultured in a double collagen gel
    • Hubel A., Toner M., Cravalho E.G., Yarmush M.L. and Tompkins R.G. 1991. Intracellular ice formation during the freezing of hepatocytes cultured in a double collagen gel. Biotechnology Progress 7: 554-559.
    • (1991) Biotechnology Progress , vol.7 , pp. 554-559
    • Hubel, A.1    Toner, M.2    Cravalho, E.G.3    Yarmush, M.L.4    Tompkins, R.G.5
  • 35
    • 0033959670 scopus 로고    scopus 로고
    • Cryopreserved mouse hepatocytes retain regenerative capacity in vivo
    • Jamal H.Z., Weglarz T.C. and Sandgren E.P. 2000. Cryopreserved mouse hepatocytes retain regenerative capacity in vivo. Gastroenterology 118: 390-394.
    • (2000) Gastroenterology , vol.118 , pp. 390-394
    • Jamal, H.Z.1    Weglarz, T.C.2    Sandgren, E.P.3
  • 36
    • 0034084045 scopus 로고    scopus 로고
    • Microbiological hazards of xenotransplantation. 1. Doubts and convictions to the risk of xenozoonosis
    • Julez J., Vannier P. and Wadham L. 2000. Microbiological hazards of xenotransplantation. 1. Doubts and convictions to the risk of xenozoonosis. Pathologie Biologie 48: 429-435.
    • (2000) Pathologie Biologie , vol.48 , pp. 429-435
    • Julez, J.1    Vannier, P.2    Wadham, L.3
  • 37
    • 0027551292 scopus 로고
    • Large-scale cryopreservation of isolated dog hepatocytes
    • Kasai S. and Mito M. 1993. Large-scale cryopreservation of isolated dog hepatocytes. Cryobiology 30: 1-11.
    • (1993) Cryobiology , vol.30 , pp. 1-11
    • Kasai, S.1    Mito, M.2
  • 39
    • 0029825274 scopus 로고    scopus 로고
    • Porcine hepatocytes for biohybrid artificial liver devices: A comparison of hypothermic storage techniques
    • Koebe H.G., Pahernik S.A., Thasler W.E. and Schildberg F.W. 1996a. Porcine hepatocytes for biohybrid artificial liver devices: A comparison of hypothermic storage techniques. Artificial Organs 20: 1181-1190.
    • (1996) Artificial Organs , vol.20 , pp. 1181-1190
    • Koebe, H.G.1    Pahernik, S.A.2    Thasler, W.E.3    Schildberg, F.W.4
  • 42
    • 0025969415 scopus 로고
    • Development of an optimal method for the cryopreservation of hepatocytes and their subsequent monolayer culture
    • Lawrence J.N. and Benford D.J. 1991. Development of an optimal method for the cryopreservation of hepatocytes and their subsequent monolayer culture. Toxicology In Vitro 5: 39-51.
    • (1991) Toxicology in Vitro , vol.5 , pp. 39-51
    • Lawrence, J.N.1    Benford, D.J.2
  • 43
    • 3543017295 scopus 로고    scopus 로고
    • The scientific basis of drug-drug interactions: Mechanism and preclinical evaluation
    • Li A.P. 1998. The scientific basis of drug-drug interactions: Mechanism and preclinical evaluation. Drug Information Journal 32: 657-664.
    • (1998) Drug Information Journal , vol.32 , pp. 657-664
    • Li, A.P.1
  • 44
    • 0030726508 scopus 로고    scopus 로고
    • Preclinical evaluation of drug-drug interaction potential: Present status of the application of primary hepatocytes in the evaluation of cytochrome P450 induction
    • Li A.P., Maurel P., Gomez-Lechon M.J., Cheng L.C. and Jurima-Romet M. 1997. Preclinical evaluation of drug-drug interaction potential: present status of the application of primary hepatocytes in the evaluation of cytochrome P450 induction. Chemico-Biological Interactions 107: 5-16.
    • (1997) Chemico-Biological Interactions , vol.107 , pp. 5-16
    • Li, A.P.1    Maurel, P.2    Gomez-Lechon, M.J.3    Cheng, L.C.4    Jurima-Romet, M.5
  • 45
    • 0032968777 scopus 로고    scopus 로고
    • Cryopreserved human hepatocytes: Characterisation of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential
    • Li A.P., Chuang L., Brent J.A., Pham C., Fackett A., Ruegg C.E. and Silber P.M. 1999a. Cryopreserved human hepatocytes: characterisation of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chemico-Biological Interactions 121: 17-35.
    • (1999) Chemico-Biological Interactions , vol.121 , pp. 17-35
    • Li, A.P.1    Chuang, L.2    Brent, J.A.3    Pham, C.4    Fackett, A.5    Ruegg, C.E.6    Silber, P.M.7
  • 47
    • 0024551516 scopus 로고
    • Optomization of cryopreservation procedures for rat and human hepatocytes
    • Loretz L.J., Li A.P. and Flye M.W. 1989. Optomization of cryopreservation procedures for rat and human hepatocytes. Xenobiotica 19: 489-498.
    • (1989) Xenobiotica , vol.19 , pp. 489-498
    • Loretz, L.J.1    Li, A.P.2    Flye, M.W.3
  • 50
    • 0013847020 scopus 로고
    • The role of the cell membrane in the freezing of yeast and other cells
    • Mazur P. 1965. The role of the cell membrane in the freezing of yeast and other cells. Annals of the New York Academy of Science 125: 658-676.
    • (1965) Annals of the New York Academy of Science , vol.125 , pp. 658-676
    • Mazur, P.1
  • 51
    • 0036153846 scopus 로고    scopus 로고
    • Cryopreservation of rat hepatocyte monolayers: Cell viability and cytochrome P450 content in postthaw cultures
    • McKay G.C., Henderson C., Goldie G., Westmorland C. and Grant M.H. 2002. Cryopreservation of rat hepatocyte monolayers: cell viability and cytochrome P450 content in postthaw cultures. Toxicology In Vitro 16: 71-79.
    • (2002) Toxicology In Vitro , vol.16 , pp. 71-79
    • McKay, G.C.1    Henderson, C.2    Goldie, G.3    Westmorland, C.4    Grant, M.H.5
  • 58
    • 0030266072 scopus 로고    scopus 로고
    • Hypothermic Storage of Pig Hepatocytes: Influence of different storage solutions and cell density
    • Pathernik S.A., Thasler W.E., Mueller-Hoecker J., Schildberg F.W. and Koebe H.G. 1996. Hypothermic Storage of Pig Hepatocytes: Influence of different storage solutions and cell density. Cryobiology 33: 552-566.
    • (1996) Cryobiology , vol.33 , pp. 552-566
    • Pathernik, S.A.1    Thasler, W.E.2    Mueller-Hoecker, J.3    Schildberg, F.W.4    Koebe, H.G.5
  • 59
    • 0033922984 scopus 로고    scopus 로고
    • Viability and drug metabolism capacity of alginate-entrapped hepatocytes after cryopreservation
    • Rialland L., Guyomard C., Scotte M., Chesne C. and Guillouzo A. 2000. Viability and drug metabolism capacity of alginate-entrapped hepatocytes after cryopreservation. Cell Biology and Toxicology 16: 105-116.
    • (2000) Cell Biology and Toxicology , vol.16 , pp. 105-116
    • Rialland, L.1    Guyomard, C.2    Scotte, M.3    Chesne, C.4    Guillouzo, A.5
  • 60
    • 0030865033 scopus 로고    scopus 로고
    • Cytochrome-P450 induction and conjugation metabolism in primary human hepatocytes after cryopreservation
    • Ruegg C.E., Silber P.M., Mughal R.A., Ismail J., Lu C., Bode D.C. and Li A.P. 1997. Cytochrome-P450 induction and conjugation metabolism in primary human hepatocytes after cryopreservation. In Vitro Toxicology 10: 217-222.
    • (1997) In Vitro Toxicology , vol.10 , pp. 217-222
    • Ruegg, C.E.1    Silber, P.M.2    Mughal, R.A.3    Ismail, J.4    Lu, C.5    Bode, D.C.6    Li, A.P.7
  • 61
    • 0034661619 scopus 로고    scopus 로고
    • Transplanted Cryopreserved Encapsulated Porcine hepatocytes are as effective as fresh hepatocytes in preventing death from acute liver failure in rats
    • Sarkis R., Benoisth S., Honiger J., Baudrimont M., Delelo R., Balladur P., Capeau J. and Nordlinger B. 2000. Transplanted Cryopreserved Encapsulated Porcine hepatocytes are as effective as fresh hepatocytes in preventing death from acute liver failure in rats. Transplantation 70: 58-64.
    • (2000) Transplantation , vol.70 , pp. 58-64
    • Sarkis, R.1    Benoisth, S.2    Honiger, J.3    Baudrimont, M.4    Delelo, R.5    Balladur, P.6    Capeau, J.7    Nordlinger, B.8
  • 63
    • 0029932214 scopus 로고    scopus 로고
    • Time for a consistent approach to preparing and culturing hepatocytes?
    • Skett P. and Bayliss M. 1996. Time for a consistent approach to preparing and culturing hepatocytes? Xenobiotica 26: 1-7.
    • (1996) Xenobiotica , vol.26 , pp. 1-7
    • Skett, P.1    Bayliss, M.2
  • 64
    • 0345385318 scopus 로고    scopus 로고
    • Optimisation of porcine hepatocyte cryopreservation by comparison of viability and enzymatic activity of fresh and cryopreserved cells
    • Smrzova J., Dvorak J., Lata J., Dite P., Machala M., Blaha V., Simanek J. and Ulrichova J. 2001. Optimisation of porcine hepatocyte cryopreservation by comparison of viability and enzymatic activity of fresh and cryopreserved cells. Acta Veterinaria Brunensis 70: 141-147.
    • (2001) Acta Veterinaria Brunensis , vol.70 , pp. 141-147
    • Smrzova, J.1    Dvorak, J.2    Lata, J.3    Dite, P.4    Machala, M.5    Blaha, V.6    Simanek, J.7    Ulrichova, J.8
  • 66
    • 0028293131 scopus 로고
    • Isolated hepatocytes: Use in experimental and clinical hepatology
    • Strain A.J. 1994. Isolated hepatocytes: use in experimental and clinical hepatology. Gut 35: 433-436.
    • (1994) Gut , vol.35 , pp. 433-436
    • Strain, A.J.1
  • 67
    • 0025246086 scopus 로고
    • Cryopreservation of cynomogus monkey (Macaca Fascicularis) Hepatocytes for subsequent culture and protein synthesis studies
    • Sun E.L., Aspar D.G., Ulrich R.G. and Melchior G.W. 1990. Cryopreservation of cynomogus monkey (Macaca Fascicularis) Hepatocytes for subsequent culture and protein synthesis studies. In Vitro Cell Development and Biology 25: 147-150.
    • (1990) In Vitro Cell Development and Biology , vol.25 , pp. 147-150
    • Sun, E.L.1    Aspar, D.G.2    Ulrich, R.G.3    Melchior, G.W.4
  • 68
    • 0027303803 scopus 로고
    • Isolation and culture of human hepatocytes from resected liver tissue as a bioreactor for a hybrid artificial liver
    • Takahashi M., Matsue H., Matsushita M., Nakajima Y. and Uchino J. 1993. Isolation and culture of human hepatocytes from resected liver tissue as a bioreactor for a hybrid artificial liver. Artificial Organs 17: 653-659.
    • (1993) Artificial Organs , vol.17 , pp. 653-659
    • Takahashi, M.1    Matsue, H.2    Matsushita, M.3    Nakajima, Y.4    Uchino, J.5
  • 70
    • 0026654736 scopus 로고
    • Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes
    • Utesch D., Diener B., Molitor E., Oesch F. and Platt K.-L. 1992. Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes. Biochemical Pharmacology 44: 309-315.
    • (1992) Biochemical Pharmacology , vol.44 , pp. 309-315
    • Utesch, D.1    Diener, B.2    Molitor, E.3    Oesch, F.4    Platt, K.-L.5
  • 72
    • 0031425422 scopus 로고    scopus 로고
    • Clinical experience with a bioartificial liver in the treatment of severe liver failure, a phase 1 clinical trial
    • Watanabe F.D., Mullen C.J.-P., Hewitt W.R., Arkadopoulos N. and Kahaku E. 1997. Clinical experience with a bioartificial liver in the treatment of severe liver failure, a phase 1 clinical trial Annals of Surgery 225: 484-494.
    • (1997) Annals of Surgery , vol.225 , pp. 484-494
    • Watanabe, F.D.1    Mullen, C.J.-P.2    Hewitt, W.R.3    Arkadopoulos, N.4    Kahaku, E.5
  • 73
    • 0030034342 scopus 로고    scopus 로고
    • Cryopreservation of rat hepatocyte monolayer cultures
    • Watts P. and Grant M.H. 1996. Cryopreservation of rat hepatocyte monolayer cultures. Human and Experimental Toxicology 15: 30-37.
    • (1996) Human and Experimental Toxicology , vol.15 , pp. 30-37
    • Watts, P.1    Grant, M.H.2


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