Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats

Diabetes

Volumn 45, Issue 11, 1996, Pages 1556-1562

  Fulgencio, Jean Pierre ^a   Kohl, Claude ^a   Girard, Jean ^a   Pégorier, Jean Paul ^a,b  

^a Ctr Rech sur l'Endocrinol Molec   (France)

^b Ceremod   (France)

Author keywords

[No Author keywords available]

Indexed keywords

TROGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; ESTERIFICATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLUCOSE UTILIZATION; INSULIN RESISTANCE; LIVER CELL MEMBRANE; LIVER MICROSOME; MITOCHONDRIAL MEMBRANE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT;

EID: 0029859494     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.11.1556     Document Type: Article

References (38)

1. DeFronzo RA, Bonadonna RC, Ferrannini E: Pathogenesis of NIDDM. Diabetes Care 15:317-368, 1992
2. McGarry JD: What if Minkowski had been ageusic? An alternate angle on diabetes. Science 258:766-770, 1992
3. McGarry JD: Disordered metabolism in diabetes: have we underemphasized the fat component. J Cell Biochem 558:29-38, 1994
4. Wolf HPO: Possible new therapeutic approach in diabetes mellitus by inhibition of carnitine palmitoyltransferase 1 (CPT1). Horm Metab Res 26:62-67, 1992
5. Randle PJ, Kerbey AL, Espinal J: Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes Metab Ren 4:523-638, 1988
6. Reaven GM, Chang H, Hoffman BB: Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozotocin-induced diabetes. Diabetes 37:28-32, 1988
7. Fulcher GR, Walker M, Catalano C, Agius L, Alberti KGMM: Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects. Diabetes 41:1400-1408, 1992
8. Oakos ND, Kennedy CJ, Jenkins AB, Laybutt DR, Chisholm DJ, Kraegen EW: A new antidiabetic agent, BRL 49653), reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 43:1203-1210, 1994
9. Saloranta C, Taskinen MR, Widen E, Harkonen M, Melander A, Groop L: Metabolic consequences of sustained suppression of free fatty acids by acipimox in patients with NIDDM. Diabetes 42:1559-1566, 1993
10. Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J: Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 331:1188-1193, 1994
11. Fujiwara T, Wada M, Fukuda K, Fukami M, Yoshioka S, Yoshioka T, Horikoshi M: Characterization of CS-045, a new oral antidiabetic agent. II. Effects on glycemic control and pancreatic islet structure at a late stage of diabetic syndrome in C57BL/KsJ-db/db mice. Metabolism 40:1213-1218, 1991
12. Lee MK, Miles PDG, Khourseed M, Gao KM, Moossa AR, Olefsky JM: Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes 43:1435-1439, 1994
13. Iwamoto Y, Kuzuya T, Matsuda A, Awata T, Kumakura S, Inooka G, Shiraishi I: Effect of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patients with NIDDM. Diabetes Care 14:1083-1086, 1991
14. Suter SL, Nolan JL, Wallace P, Gumbinger B, Olefski JM: Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 15:193-203, 1992
15. Firjiwara T, Okiino A, Yoshioka S, Horikoshi H: Suppression of hepatic gluconeogenesis in long term troglitazone treated diabetic KK and C57BL/KsJ-db/db mice. Metabolism 44:486-490, 1995
16. Ciaraldi TP, Gilmore A, Olefski JM, Goldberg M, Heidenreich KA: In vitro studies on the action of CS-045, a new antidiabetic agent. Metabolism 39:1056-1062, 1990
17. Pégorier JP, Duée PH, Herbin C, Laulan PY, Bladé C, Peret J, Girard J: Fatty acid metabolism in hepatocytes isolated from rats adapted to high-fat diets containing long- or medium-chain triacylglycerols. Biochem J 249:801-806, 1988
18. Mannaerts GP, Debeer LJ, Thomas J, DeSchepper PJ: Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate treated rats. J Biol Chem 254:4584-4595, 1979
19. McGarry JD, Foster DW: Regulation of ketogenesis from octanoic acid: the role of the tricarboxylic acid cycle and fatty acid synthesis. J Biol Chem 246:1149-1159, 1971
20. Duée PH, Pégorier JP, El Manoubi L, Herbin C, Girard J: Hepatic triglyceride hydrolysis and development of ketogenesis in rabbits. Am J Physiol 249:E478-E484, 1985
21. Henne V, Söling HD: Guanosine 5′-triphosphate releases calcium from rat liver and guinea pig parotid gland endoplasmic reticulum independently of inositol 1,4,5-triphosphate. FEBS Lett 202:267-273, 1986
22. Herbin C, Pégorier JP, Duée PH, Kohl C, Girard J: Regulation of fatty acid oxidation in isolated hepatocytes and liver mitochondria from newborn rabbits. Eur J Biochem 165:201-207, 1987
23. Lowry OH, Rosebrough NJ, Lewis Farr A, Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275, 1951
24. Krisans SK, Mortensen RM, Lazarow PB: Acyl-CoA synthetase in rat liver peroxisomes: computer-assisted analysis of cell fractionation experiments. J Biol Chem 255:9599-9607, 1980
25. Ferré P, Pégorier JP, Williamson DH, Girard J: Interactions in vivo between oxidation of non-esterified fatty acids and gluconeogenesis in the newborn rat. Biochem J 182:593-598, 1979
26. Bremer J, Osmundsen H: Fatty acid oxidation and its regulation. In Fatty Acid Metabolism and Its Regulation. Numa S, Ed. Amsterdam, Elsevier Science Publishers B.V., 1984, p. 113-154
27. McGarry JD, Woeltje KF, Kuwajima M, Foster DW: Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes Metab Rev 5:271-284, 1989
28. Girard J, Malewiak MI: Fatty acid oxidation and ketogenesis in isolated hepatocytes. In Isolated and Cultured Hepatocytes. Guillouzo A, Guguen-Guillouzo C, Eds. Paris, John Libbey Eurotext/INSERM, 1986, p. 87-112
29. Girard J: Role of free fatty acids in insulin resistance of subjects with non-insulin-dependent diabetes. Diabète Métabolisme 21:79-88, 1995
30. Van Schaftingen E, Hers HG: Inhibition of fructose-l,6-bisphosphatase by fructose-2,6-bisphosphate. Proc Natl Acad Sci USA 78:2861-2863, 1981
31. Hue L, Maisin L, Rider MH: Palmitate inhibits liver glycolysis: involvement of fructose-2,6-bisphosphate in the glucose/fatty acid cycle. Biochem J 251:541-545, 1988
32. Murano K, Inoue Y, Emoto M, Kaku K, Kaneko T: CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-phosphate production in rat hepatocytes. Eur J Pharmacol 254:257-262, 1994
33. Tanaka T, Hosaka K, Hoshimaru M, Numa S: Purification and properties of long-chain acyl-coenzyme A synthetase from rat liver. Eur J Biochem 98:165-172, 1979
34. Miyazawa S, Hashimoto T, Yokota S: Identity of long-chain acyl coenzyme A synthetase of microsomes, mitochondria and peroxisomes in rat liver. J Biochem (Tokyo) 98:723-733, 1985
35. Lawson N, Pollard AD, Jennings RJ, Gurr MI, Brindley DN: The activities of lipoprotein lipase and of enzymes involved in triacylglycerol synthesis in rat adipose tissue. Biochem J 200:285-294, 1981
36. Suzuki H, Kawarabayasi Y, Kondo J, Abe T, Nishikawa K, Kimura S, Hashimoto T, Yamamoto T: Structure and regulation of rat long-chain acyl-CoA synthetase. J Biol Chem 265:8681-8685, 1990
37. Weiner FR, Smith PJ, Wertheimer S, Rubin CS: Regulation of gene expression by insulin and tumor necrosis factor α in 3T3-L1 cells: modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase. J Biol Chem 266:23525-23528, 1991
38. Inoue I, Takahashi K, Katayama S, Harada Y, Negishi K, Itabashi A, Ishii J: Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, liver glycogen synthase activity and β-oxidation in fructose-fed rats. Metabolism 44:1626-1630, 1995