Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: A case report with autopsy examination

Human Pathology

Volumn 31, Issue 2, 2000, Pages 250-253

  Fukano, Miya ^a   Amano, Shigeru ^a   Sato, Jin ^a   Yamamoto, Kazuo ^a   Adachi, Hideyoshi ^a   Okabe, Hidetoshi ^a   Fujiyama, Yoshihide ^a   Bamba, Tadao ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Autopsy; Drug toxicity; Hepatic failure; NIDDM; Troglitazone

Indexed keywords

GLIBENCLAMIDE; THYROXINE; TROGLITAZONE;

ADULT; ARTICLE; AUTOPSY; CASE REPORT; CHOLESTASIS; DIABETES MELLITUS; DRUG ACCUMULATION; FEMALE; HUMAN; HYPOTHYROIDISM; LIVER FAILURE; LIVER NECROSIS; LIVER REGENERATION; LYMPHOCYTIC INFILTRATION; NEUTROPHIL; PLASMAPHERESIS; STEATOSIS;

EID: 0033983457     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(00)80229-4     Document Type: Article

References (13)

1. Schwartz S Raskin P Fonseca V Effect of troglitazone in insulin-treated patients with type II diabetes mellitus N Engl J Med 338 1998 861 866
2. Inzucchi SE Maggs DG Spollett GR Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus N Engl J Med 338 1998 867 872
3. Watkins PB Whitcomb RW Hepatic dysfunction associated with troglitazone N Engl J Med 338 1998 916 917
4. Kuramoto K Shimizu N Toda G Liver dysfunction associated with troglitazone (Noscal) Rinsho-Iyaku 14 1998 461 466
5. Imura H A novel antidiabetic drug, troglitazone—reason for hope and concern N Engl J Med 338 1998 908 909
6. Fujiwara T Yoshioka S Yoshioka T Characterization of new oral antidiabetic agent CS-045 Diabetes 37 1988 1549 1558
7. Kumar S Boulton AJ Beck-Nielsen H Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Troglitazone Study Group Diabetologia 39 1996 701 709
8. Kawai K Kawasaki-Tokui Y Odaka T Disposition and Metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs Arzneimittelforschung 47 1997 356 368
9. Kaneko T Troglitazone (CS-045): A new antidiabetic agent Horm Metab Res 29 1997 203 213
10. Ogata E Yamada Y Iga R Liver dysfunction due to troglitazone [in Japanese] Naika 83 1999 534 539
11. Shibuya A Watanabe M Fijita Y An autopsy case of troglitazone-induced fulminant hepatitis Diabetes Care 21 1998 2140 2143
12. Tetri BA Lsley WL Oki JC Troglitazone-induced hepatic failure leading to liver transplantation Ann Intern Med 129 1998 38 41
13. Zimmerman HJ Ishak KG Hepatic injury due to drugs and toxins MacSween RNM Anthony PP Scheuer PJ Pathology of the Liver ed 3 1994 Churchill Livingstone London, UK 563 633