Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor γ (PPARγ) heterodimer: A basis for new therapeutic strategies

Journal of Experimental Medicine

Volumn 193, Issue 7, 2001, Pages 827-838

  Desreumaux, Pierre ^a   Dubuquoy, Laurent ^a   Nutten, Sophie ^a   Peuchmaur, Michel ^b   Englaro, Walter ^c   Schoonjans, Kristina ^d   Derijard, Benoit ^c   Desvergne, Beatrice ^e   Wahli, Walter ^e   Chambon, Pierre ^d   Leibowitz, Mark D ^f   Colombel, Jean Frédéric ^a   Auwerx, Johan ^d  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c CNRS   (France)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

^f LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

Colitis; Inflammatory bowel disease; Nuclear receptors; Signal transduction pathway; Tumor necrosis factor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR; ROSIGLITAZONE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRINITROBENZENESULFONIC ACID; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; DNA BINDING; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; ENTERITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 0035794293     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.7.827     Document Type: Article

References (50)

1. Peroxisome proliferator-activated receptors, orphans with ligands and functions
2. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
3. The PPARs: From orphan receptors to drug discovery
4. Thiazolidinediones: An update
5. PPARγ agonists inhibit production of monocyte inflammatory cytokines
6. The peroxisome proliferator-activated receptorgamma is a negative regulator of macrophage activation
7. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response
8. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation
9. MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of 1kappaB-alpha
10. TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways
11. Min/+ mice
12. Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease
13. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumor necrosis factor a production in trinitrobenzene sulfonic acid induced colitis
14. The organization, promoter analysis, and expression of the human PPARγ gene
15. Inflammatory alterations in mesenteric adipose tissue in Crohn's disease
16. Streptococcal pyrogenic exotoxin A (SPE A) superantigen induced production of hematopoietic cytokines, IL-12 and IL-13 by human peripheral blood mononuclear cells
17. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease
18. Tumor necrosis factor alpha-mediated inhibition of melanogenesis is dependent on nuclear factor kappa B activation
19. A cytoplasmic inhibitor of the JNK signal transduction pathway
20. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
21. Urinary 8-hydroxy-deoxyguanosine excretion as a non-invasive marker of neutrophil activation in animal models of inflammatory bowel disease
22. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice
23. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
24. The mechanism of altered neural function in a rat model of acute colitis
25. Reduction of acute and reactivated colitis in rats by an inhibitor of neutrophil activation
26. Chronic intrajejunal TNBS application in TNBS-sensitized rats: A new model of chronic inflammatory bowel diseases
27. Effects of local budesonide treatment on the cell-mediated immune response in acute and relapsing colitis in rats
28. Mechanism and prevention of chronic colonic inflammation with trinitrobenzene sulfonic acid in rats
29. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: No alteration in adipose tissue of obese and NIDDM patients
30. Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells
31. An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer
32. PPAR-γ dependent and independent effects on macrophages gene expression in lipid metabolism and inflammation
33. The role of PPAK-γ in macrophage differentiation and cholesterol uptake
34. Anti-CD11b/CD18 antibodies reduce inflammation in acute colitis in rats
35. Non-lymphoid and lymphoid cells in acute, chronic and relapsing experimental colitis
36. Multiple signals converging on NF-kappaB
37. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
38. Catalysis by a multiprotein IkappaB kinase complex
39. Signaling by proinflammatory cytokines: Oligo-merization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
40. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
41. MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta
42. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases. NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
43. Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK/ERK kinase 1 in macrophages
44. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
45. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase
46. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival
47. Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation
48. JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?
49. Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase
50. Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation