메뉴 건너뛰기




Volumn 86, Issue 11, 2004, Pages 771-778

Bile acid signaling to the nucleus: Finding new connections in the transcriptional regulation of metabolic pathways

Author keywords

Bile acids; Gene transcription; Glucose metabolism; Lipid metabolism; Liver; Nuclear receptors

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BEZAFIBRATE; BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CIPROFIBRATE; DETERGENT; FARNESOID X RECEPTOR; FATTY ACID; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 4; LIPID; OXYSTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 10044246126     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biochi.2004.09.027     Document Type: Short Survey
Times cited : (16)

References (78)
  • 2
    • 4143106645 scopus 로고    scopus 로고
    • Lipid-activated nuclear receptors: From gene transcription to the control of cellular metabolism
    • M. Crestani, N. Mitro, and E.D. Fabiani Lipid-activated nuclear receptors: from gene transcription to the control of cellular metabolism Eur. J. Lipid Sci. Technol. 106 2004 432 450
    • (2004) Eur. J. Lipid Sci. Technol. , vol.106 , pp. 432-450
    • Crestani, M.1    Mitro, N.2    Fabiani, E.D.3
  • 4
    • 0037428442 scopus 로고    scopus 로고
    • Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis
    • G. Cao, Y. Liang, C.L. Broderick, B.A. Oldham, T.P. Beyer, and R.J. Schmidt Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis J. Biol. Chem. 278 2003 1131 1136
    • (2003) J. Biol. Chem. , vol.278 , pp. 1131-1136
    • Cao, G.1    Liang, Y.2    Broderick, C.L.3    Oldham, B.A.4    Beyer, T.P.5    Schmidt, R.J.6
  • 5
    • 0037965630 scopus 로고    scopus 로고
    • Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
    • B.A. Laffitte, L.C. Chao, J. Li, R. Walczak, S. Hummasti, and S.B. Joseph Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue Proc. Natl. Acad. Sci. USA 100 2003 5419 5424
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5419-5424
    • Laffitte, B.A.1    Chao, L.C.2    Li, J.3    Walczak, R.4    Hummasti, S.5    Joseph, S.B.6
  • 6
    • 0348111308 scopus 로고    scopus 로고
    • Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor {alpha}
    • K.T. Dalen, S.M. Ulven, K. Bamberg, J.-A. Gustafsson, and H.I. Nebb Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor {alpha} J. Biol. Chem. 278 2003 48283 48291
    • (2003) J. Biol. Chem. , vol.278 , pp. 48283-48291
    • Dalen, K.T.1    Ulven, S.M.2    Bamberg, K.3    Gustafsson, J.-A.4    Nebb, H.I.5
  • 7
    • 0036318980 scopus 로고    scopus 로고
    • Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor {alpha} in adipocyte metabolism
    • S.E. Ross, R.L. Erickson, I. Gerin, P.M. DeRose, L. Bajnok, and K.A. Longo Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor {alpha} in adipocyte metabolism Mol. Cell. Biol. 22 2002 5989 5999
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5989-5999
    • Ross, S.E.1    Erickson, R.L.2    Gerin, I.3    Derose, P.M.4    Bajnok, L.5    Longo, K.A.6
  • 9
    • 1442348164 scopus 로고    scopus 로고
    • Peroxisomal proliferator-activated receptor a deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux
    • J. Xu, V. Chang, S.B. Joseph, C. Trujillo, S. Bassilian, and M.F. Saad Peroxisomal proliferator-activated receptor a deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux Endocrinology 145 2004 1087 1095
    • (2004) Endocrinology , vol.145 , pp. 1087-1095
    • Xu, J.1    Chang, V.2    Joseph, S.B.3    Trujillo, C.4    Bassilian, S.5    Saad, M.F.6
  • 11
    • 0035091701 scopus 로고    scopus 로고
    • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
    • J.M. Way, W.W. Harrington, K.K. Brown, W.K. Gottschalk, S.S. Sundseth, and T.A. Mansfield Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues Endocrinology 142 2001 1269 1277
    • (2001) Endocrinology , vol.142 , pp. 1269-1277
    • Way, J.M.1    Harrington, W.W.2    Brown, K.K.3    Gottschalk, W.K.4    Sundseth, S.S.5    Mansfield, T.A.6
  • 12
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • W. He, Y. Barak, A. Hevener, P. Olson, D. Liao, and J. Le Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle PNAS 100 2003 15712 15717
    • (2003) PNAS , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5    Le, J.6
  • 13
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • A.W. Norris, L. Chen, S.J. Fisher, I. Szanto, M. Ristow, and A.C. Jozsi Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones J. Clin. Invest. 112 2003 608 618
    • (2003) J. Clin. Invest. , vol.112 , pp. 608-618
    • Norris, A.W.1    Chen, L.2    Fisher, S.J.3    Szanto, I.4    Ristow, M.5    Jozsi, A.C.6
  • 15
    • 3242720242 scopus 로고    scopus 로고
    • Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity
    • J. Zhang, M. Fu, T. Cui, C. Xiong, K. Xu, and W. Zhong Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity PNAS 101 2004 10703 10708
    • (2004) PNAS , vol.101 , pp. 10703-10708
    • Zhang, J.1    Fu, M.2    Cui, T.3    Xiong, C.4    Xu, K.5    Zhong, W.6
  • 17
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR γ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • A. Chawla, W.A. Boisvert, C.H. Lee, B.A. Laffitte, Y. Barak, and S.B. Joseph A PPAR γ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Mol. Cell 7 2001 161 171
    • (2001) Mol. Cell , vol.7 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.H.3    Laffitte, B.A.4    Barak, Y.5    Joseph, S.B.6
  • 19
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
    • T.C. Leone, C.J. Weinheimer, and D.P. Kelly A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders Proc. Natl. Acad. Sci. USA 96 1999 7473 7478
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 20
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Y. Wang, C. Lee, S. Tiep, R. Yu, J. Ham, and H. Kang Peroxisome- proliferator-activated receptor δ activates fat metabolism to prevent obesity Cell 113 2003 159 170
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.1    Lee, C.2    Tiep, S.3    Yu, R.4    Ham, J.5    Kang, H.6
  • 21
    • 9144271149 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
    • T. Tanaka, J. Yamamoto, S. Iwasaki, H. Asaba, H. Hamura, and Y. Ikeda Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome PNAS 100 2003 15924 15929
    • (2003) PNAS , vol.100 , pp. 15924-15929
    • Tanaka, T.1    Yamamoto, J.2    Iwasaki, S.3    Asaba, H.4    Hamura, H.5    Ikeda, Y.6
  • 22
    • 0346849699 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells
    • U. Dressel, T.L. Allen, J.B. Pippal, P.R. Rohde, P. Lau, and G.E.O. Muscat The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells Mol. Endocrinol. 17 2003 2477 2493
    • (2003) Mol. Endocrinol. , vol.17 , pp. 2477-2493
    • Dressel, U.1    Allen, T.L.2    Pippal, J.B.3    Rohde, P.R.4    Lau, P.5    Muscat, G.E.O.6
  • 23
    • 0642303113 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ controls muscle development and oxidative capability
    • S. Luquet, J. Lopez-Soriano, D. Holst, A. Fredenrich, J. Melki, and M. Rassoulzadegan Peroxisome proliferator-activated receptor δ controls muscle development and oxidative capability FASEB J. 17 2003 2299 2301
    • (2003) FASEB J. , vol.17 , pp. 2299-2301
    • Luquet, S.1    Lopez-Soriano, J.2    Holst, D.3    Fredenrich, A.4    Melki, J.5    Rassoulzadegan, M.6
  • 24
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 26
    • 0037072732 scopus 로고    scopus 로고
    • Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
    • A. Grefhorst, B.M. Elzinga, P.J. Voshol, T. Plosch, T. Kok, and V.W. Bloks Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles J. Biol. Chem. 277 2002 34182 34190
    • (2002) J. Biol. Chem. , vol.277 , pp. 34182-34190
    • Grefhorst, A.1    Elzinga, B.M.2    Voshol, P.J.3    Plosch, T.4    Kok, T.5    Bloks, V.W.6
  • 27
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • G. Chen, G. Liang, J. Ou, J.L. Goldstein, and M.S. Brown Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver PNAS 101 2004 11245 11250
    • (2004) PNAS , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 28
    • 11144356074 scopus 로고    scopus 로고
    • Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression
    • J.B. Seo, H.M. Moon, W.S. Kim, Y.S. Lee, H.W. Jeong, and E.J. Yoo Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression Mol. Cell. Biol. 24 2004 3430 3444
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3430-3444
    • Seo, J.B.1    Moon, H.M.2    Kim, W.S.3    Lee, Y.S.4    Jeong, H.W.5    Yoo, E.J.6
  • 29
    • 0028971225 scopus 로고
    • Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR γ and stimulates adipogenesis
    • Z. Wu, Y. Xie, N. Bucher, and S. Farmer Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR γ and stimulates adipogenesis Genes Dev. 9 1995 2350 2363
    • (1995) Genes Dev. , vol.9 , pp. 2350-2363
    • Wu, Z.1    Xie, Y.2    Bucher, N.3    Farmer, S.4
  • 31
    • 0029035278 scopus 로고
    • LXR, a nuclear receptor that defines a distinct retinoid response pathway
    • P. Willy, K. Umesono, E. Ong, R. Evans, R. Heyman, and D. Mangelsdorf LXR, a nuclear receptor that defines a distinct retinoid response pathway Genes Dev. 9 1995 1033 1045
    • (1995) Genes Dev. , vol.9 , pp. 1033-1045
    • Willy, P.1    Umesono, K.2    Ong, E.3    Evans, R.4    Heyman, R.5    Mangelsdorf, D.6
  • 32
    • 0032814457 scopus 로고    scopus 로고
    • Regulation of gene expression by dietary fat
    • D. Jump, and S. Clarke Regulation of gene expression by dietary fat Annu. Rev. Nutr. 19 1999 63 90
    • (1999) Annu. Rev. Nutr. , vol.19 , pp. 63-90
    • Jump, D.1    Clarke, S.2
  • 33
    • 0026551309 scopus 로고
    • Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
    • M. Gottlicher, E. Widmark, Q. Li, and J. Gustafsson Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor Proc. Natl. Acad. Sci. USA 89 1992 4653 4657
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4653-4657
    • Gottlicher, M.1    Widmark, E.2    Li, Q.3    Gustafsson, J.4
  • 34
    • 0035932990 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
    • J. Ou, H. Tu, B. Shan, A. Luk, R.A. DeBose-Boyd, and Y. Bashmakov Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR Proc. Natl. Acad. Sci. USA 98 2001 6027 6032
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6027-6032
    • Ou, J.1    Tu, H.2    Shan, B.3    Luk, A.4    Debose-Boyd, R.A.5    Bashmakov, Y.6
  • 35
    • 18544388579 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
    • T. Yoshikawa, H. Shimano, N. Yahagi, T. Ide, M. Amemiya-Kudo, and T. Matsuzaka Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements J. Biol. Chem. 277 2002 1705 1711
    • (2002) J. Biol. Chem. , vol.277 , pp. 1705-1711
    • Yoshikawa, T.1    Shimano, H.2    Yahagi, N.3    Ide, T.4    Amemiya-Kudo, M.5    Matsuzaka, T.6
  • 36
    • 0142103471 scopus 로고    scopus 로고
    • The role of liver X receptor-α in the fatty acid regulation of hepatic gene expression
    • A. Pawar, D. Botolin, D.J. Mangelsdorf, and D.B. Jump The role of liver X receptor-α in the fatty acid regulation of hepatic gene expression J. Biol. Chem. 278 2003 40736 40743
    • (2003) J. Biol. Chem. , vol.278 , pp. 40736-40743
    • Pawar, A.1    Botolin, D.2    Mangelsdorf, D.J.3    Jump, D.B.4
  • 37
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRa
    • D.J. Peet, S.D. Turley, W. Ma, B.A. Janowski, J.-M.A. Lobaccaro, and R.E. Hammer Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRa Cell 93 1998 693 704
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.-M.A.5    Hammer, R.E.6
  • 38
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • P. Costet, Y. Luo, N. Wang, and A.R. Tall Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor J. Biol. Chem. 275 2000 28240 28245
    • (2000) J. Biol. Chem. , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 39
    • 0034637128 scopus 로고    scopus 로고
    • ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR
    • K. Schwartz, R.M. Lawn, and D.P. Wade ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR Biochem. Biophys. Res. Commun. 274 2000 794 802
    • (2000) Biochem. Biophys. Res. Commun. , vol.274 , pp. 794-802
    • Schwartz, K.1    Lawn, R.M.2    Wade, D.P.3
  • 41
    • 0036915379 scopus 로고    scopus 로고
    • Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors
    • P.A. Mak, H.R. Kast-Woelbern, A.M. Anisfeld, and P.A. Edwards Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors J. Lipid Res. 43 2002 2037 2041
    • (2002) J. Lipid Res. , vol.43 , pp. 2037-2041
    • Mak, P.A.1    Kast-Woelbern, H.R.2    Anisfeld, A.M.3    Edwards, P.A.4
  • 43
    • 0036295401 scopus 로고    scopus 로고
    • LXRa is the dominant regulator of CYP7A1 transcription
    • Gupta, Pandak, and Hylemon LXRa is the dominant regulator of CYP7A1 transcription Biochem. Biophys. Res. Commun. 293 2002 338 343
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 338-343
    • Gupta1    Pandak2    Hylemon3
  • 44
    • 0035834868 scopus 로고    scopus 로고
    • Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα)
    • J. Chiang, R. Kimmel, and D. Stroup Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα) Gene 262 2001 257 265
    • (2001) Gene , vol.262 , pp. 257-265
    • Chiang, J.1    Kimmel, R.2    Stroup, D.3
  • 45
    • 0037340125 scopus 로고    scopus 로고
    • Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-α
    • B. Goodwin, M.A. Watson, H. Kim, J. Miao, J.K. Kemper, and S.A. Kliewer Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-α Mol. Endocrinol. 17 2003 386 394
    • (2003) Mol. Endocrinol. , vol.17 , pp. 386-394
    • Goodwin, B.1    Watson, M.A.2    Kim, H.3    Miao, J.4    Kemper, J.K.5    Kliewer, S.A.6
  • 46
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • T. Plosch, T. Kok, V.W. Bloks, M.J. Smit, R. Havinga, and G. Chimini Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1 J. Biol. Chem. 277 2002 33870 33877
    • (2002) J. Biol. Chem. , vol.277 , pp. 33870-33877
    • Plosch, T.1    Kok, T.2    Bloks, V.W.3    Smit, M.J.4    Havinga, R.5    Chimini, G.6
  • 47
    • 0038614979 scopus 로고    scopus 로고
    • Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8
    • L. Yu, J. York, K. Von Bergmann, D. Lutjohann, J.C. Cohen, and H.H. Hobbs Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8 J. Biol. Chem. 278 2003 15565 15570
    • (2003) J. Biol. Chem. , vol.278 , pp. 15565-15570
    • Yu, L.1    York, J.2    Von Bergmann, K.3    Lutjohann, D.4    Cohen, J.C.5    Hobbs, H.H.6
  • 48
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • P. Costet, C. Legendre, J. More, A. Edgar, P. Galtier, and T. Pineau Peroxisome proliferator-activated receptor α-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis J. Biol. Chem. 273 1998 29577 29585
    • (1998) J. Biol. Chem. , vol.273 , pp. 29577-29585
    • Costet, P.1    Legendre, C.2    More, J.3    Edgar, A.4    Galtier, P.5    Pineau, T.6
  • 49
    • 84991145406 scopus 로고
    • Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: Reduced activity of cholesterol 7α-hydroxylase
    • D. Stahlberg, E. Reihner, M. Rudling, L. Berglund, K. Einarsson, and B. Angelin Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: reduced activity of cholesterol 7α-hydroxylase Hepatology 21 1995 1025 1030
    • (1995) Hepatology , vol.21 , pp. 1025-1030
    • Stahlberg, D.1    Reihner, E.2    Rudling, M.3    Berglund, L.4    Einarsson, K.5    Angelin, B.6
  • 50
    • 0029009265 scopus 로고
    • Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination
    • H. Vanhanen, and T. Miettinen Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination Atherosclerosis 115 1995 135 146
    • (1995) Atherosclerosis , vol.115 , pp. 135-146
    • Vanhanen, H.1    Miettinen, T.2
  • 51
    • 0035570381 scopus 로고    scopus 로고
    • Fibrates suppress bile acid synthesis via peroxisome proliferator- activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression
    • S.M. Post, H. Duez, P.P. Gervois, B. Staels, F. Kuipers, and H.M.G. Princen Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression Arterioscler. Thromb. Vasc. Biol. 21 2001 1840 1845
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1840-1845
    • Post, S.M.1    Duez, H.2    Gervois, P.P.3    Staels, B.4    Kuipers, F.5    Princen, H.M.G.6
  • 52
    • 0033999108 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription
    • M. Marrapodi, and J.Y. Chiang Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription J. Lipid Res. 41 2000 514 520
    • (2000) J. Lipid Res. , vol.41 , pp. 514-520
    • Marrapodi, M.1    Chiang, J.Y.2
  • 53
    • 0034666324 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor α (PPARα) regulates bile acid biosynthesis
    • M.C. Hunt, Y.-Z. Yang, G. Eggertsen, C.M. Carneheim, M. Gafvels, and C. Einarsson The peroxisome proliferator-activated receptor α (PPARα) regulates bile acid biosynthesis J. Biol. Chem. 275 2000 28947 28953
    • (2000) J. Biol. Chem. , vol.275 , pp. 28947-28953
    • Hunt, M.C.1    Yang, Y.-Z.2    Eggertsen, G.3    Carneheim, C.M.4    Gafvels, M.5    Einarsson, C.6
  • 54
    • 0037325403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (PPARα)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
    • T. Kok, V. Bloks, H. Wolters, R. Havinga, P. Jansen, and B. Staels Peroxisome proliferator-activated receptor alpha (PPARα)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice Biochem. J. 369 2003 539 547
    • (2003) Biochem. J. , vol.369 , pp. 539-547
    • Kok, T.1    Bloks, V.2    Wolters, H.3    Havinga, R.4    Jansen, P.5    Staels, B.6
  • 55
    • 0015472014 scopus 로고
    • Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia
    • S.M. Grundy, E.H. Ahrens Jr., G. Salen, P.H. Schreibman, and P.J. Nestel Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia J. Lipid Res. 13 1972 531 551
    • (1972) J. Lipid Res. , vol.13 , pp. 531-551
    • Grundy, S.M.1    Ahrens Jr., E.H.2    Salen, G.3    Schreibman, P.H.4    Nestel, P.J.5
  • 56
    • 0021276830 scopus 로고
    • Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man
    • Y.A. Kesaniemi, and S.M. Grundy Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man JAMA 251 1984 2241 2246
    • (1984) JAMA , vol.251 , pp. 2241-2246
    • Kesaniemi, Y.A.1    Grundy, S.M.2
  • 57
    • 0037369402 scopus 로고    scopus 로고
    • Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors
    • J.Y.L. Chiang Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors Am. J. Physiol. Gastro-intest. Liver Physiol. 284 2003 G349 G356
    • (2003) Am. J. Physiol. Gastro-intest. Liver Physiol. , vol.284
    • Chiang, J.Y.L.1
  • 59
    • 0026794030 scopus 로고
    • Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures
    • P.B. Hylemon, E.C. Gurley, R.T. Stravitz, J.S. Litz, W.M. Pandak, and J.Y.L. Chiang Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures J. Biol. Chem. 267 1992 16866 16871
    • (1992) J. Biol. Chem. , vol.267 , pp. 16866-16871
    • Hylemon, P.B.1    Gurley, E.C.2    Stravitz, R.T.3    Litz, J.S.4    Pandak, W.M.5    Chiang, J.Y.L.6
  • 60
    • 0028868818 scopus 로고
    • Hormonal regulation of the cholesterol 7α-hydroxylase gene (CYP7)
    • M. Crestani, D. Stroup, and J.Y.L. Chiang Hormonal regulation of the cholesterol 7α-hydroxylase gene (CYP7) J. Lipid Res. 36 1995 2419 2432
    • (1995) J. Lipid Res. , vol.36 , pp. 2419-2432
    • Crestani, M.1    Stroup, D.2    Chiang, J.Y.L.3
  • 61
    • 0031594714 scopus 로고    scopus 로고
    • Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene
    • D.K. Spady, J.A. Cuthbert, M.N. Willard, and R.S. Meidell Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene J. Biol. Chem. 273 1998 126 132
    • (1998) J. Biol. Chem. , vol.273 , pp. 126-132
    • Spady, D.K.1    Cuthbert, J.A.2    Willard, M.N.3    Meidell, R.S.4
  • 62
    • 85047684249 scopus 로고    scopus 로고
    • Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
    • C.R. Pullinger, C. Eng, G. Salen, S. Shefer, A.K. Batta, and S.K. Erickson Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype J. Clin. Invest. 110 2002 109 117
    • (2002) J. Clin. Invest. , vol.110 , pp. 109-117
    • Pullinger, C.R.1    Eng, C.2    Salen, G.3    Shefer, S.4    Batta, A.K.5    Erickson, S.K.6
  • 63
    • 0025269939 scopus 로고
    • Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
    • D. Jelinek, S. Andersson, C.A. Slaughter, and D.W. Russell Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis J. Biol. Chem. 265 1990 8190 8197
    • (1990) J. Biol. Chem. , vol.265 , pp. 8190-8197
    • Jelinek, D.1    Andersson, S.2    Slaughter, C.A.3    Russell, D.W.4
  • 64
    • 0024442549 scopus 로고
    • Molecular cloning of cDNA for cholesterol 7α-hydroxylase from rat liver microsomes: Nucleotide sequence and expression
    • M. Noshiro, M. Nishimoto, K. Morohashi, and K. Okuda Molecular cloning of cDNA for cholesterol 7α-hydroxylase from rat liver microsomes: nucleotide sequence and expression FEBS Lett. 257 1989 97 100
    • (1989) FEBS Lett. , vol.257 , pp. 97-100
    • Noshiro, M.1    Nishimoto, M.2    Morohashi, K.3    Okuda, K.4
  • 65
    • 0025353861 scopus 로고
    • Regulation of cholesterol 7α-hydroxylase in the liver: CDNA cloning, sequencing and regulation of cholesterol 7α-hydroxylase mRNA
    • Y.C. Li, D.P. Wang, and J.Y.L. Chiang Regulation of cholesterol 7α-hydroxylase in the liver: cDNA cloning, sequencing and regulation of cholesterol 7α-hydroxylase mRNA J. Biol. Chem. 265 1990 12012 12019
    • (1990) J. Biol. Chem. , vol.265 , pp. 12012-12019
    • Li, Y.C.1    Wang, D.P.2    Chiang, J.Y.L.3
  • 66
    • 0026774055 scopus 로고
    • Cloning of the human cholesterol 7α-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12
    • J.C. Cohen, J.J. Cali, D.F. Jelinek, M. Mehrabian, R.S. Sparkes, and A.J. Lusis Cloning of the human cholesterol 7α-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12 Genomics 14 1992 153 161
    • (1992) Genomics , vol.14 , pp. 153-161
    • Cohen, J.C.1    Cali, J.J.2    Jelinek, D.F.3    Mehrabian, M.4    Sparkes, R.S.5    Lusis, A.J.6
  • 67
    • 0027448743 scopus 로고
    • Genomic cloning, sequencing and analysis of hamster cholesterol 7α-hydroxylase gene (CYP7)
    • M. Crestani, G. Galli, and J.Y.L. Chiang Genomic cloning, sequencing and analysis of hamster cholesterol 7α-hydroxylase gene (CYP7) Arch. Biochem. Biophys. 306 1993 451 460
    • (1993) Arch. Biochem. Biophys. , vol.306 , pp. 451-460
    • Crestani, M.1    Galli, G.2    Chiang, J.Y.L.3
  • 68
    • 0030870025 scopus 로고    scopus 로고
    • Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene (CYP7A)
    • D. Stroup, M. Crestani, and J.Y. Chiang Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene (CYP7A) Am. J. Physiol. 273 1997 G508 G517
    • (1997) Am. J. Physiol. , vol.273
    • Stroup, D.1    Crestani, M.2    Chiang, J.Y.3
  • 71
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • H. Wang, J. Chen, K. Hollister, L.C. Sowers, and B.M. Forman Endogenous bile acids are ligands for the nuclear receptor FXR/BAR Mol. Cell 3 1999 543 553
    • (1999) Mol. Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 72
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • T.T. Lu, M. Makishima, J.J. Repa, K. Schoonjans, T.A. Kerr, and J. Auwerx Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors Mol. Cell 6 2000 507 515
    • (2000) Mol. Cell , vol.6 , pp. 507-515
    • Lu, T.T.1    Makishima, M.2    Repa, J.J.3    Schoonjans, K.4    Kerr, T.A.5    Auwerx, J.6
  • 73
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • B. Goodwin, S.A. Jones, R.R. Price, M.A. Watson, D.D. McKee, and L.B. Moore A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis Mol. Cell 6 2000 517 526
    • (2000) Mol. Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3    Watson, M.A.4    McKee, D.D.5    Moore, L.B.6
  • 74
    • 0036086509 scopus 로고    scopus 로고
    • Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
    • T. Kerr, S. Saeki, M. Schneider, K. Schaefer, S. Berdy, and T. Redder Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis Dev. Cell 2 2002 713 720
    • (2002) Dev. Cell , vol.2 , pp. 713-720
    • Kerr, T.1    Saeki, S.2    Schneider, M.3    Schaefer, K.4    Berdy, S.5    Redder, T.6
  • 75
    • 18444377348 scopus 로고    scopus 로고
    • Redundant pathways for negative feedback regulation of bile acid production
    • L. Wang, Y. Lee, D. Bundman, Y. Han, S. Thevananther, and C. Kim Redundant pathways for negative feedback regulation of bile acid production Dev. Cell 2 2002 721 731
    • (2002) Dev. Cell , vol.2 , pp. 721-731
    • Wang, L.1    Lee, Y.2    Bundman, D.3    Han, Y.4    Thevananther, S.5    Kim, C.6
  • 76
    • 0031751631 scopus 로고    scopus 로고
    • Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors
    • M. Crestani, A. Sadeghpour, D. Stroup, G. Galli, and J.Y.L. Chiang Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors J. Lipid Res. 39 1998 2192 2200
    • (1998) J. Lipid Res. , vol.39 , pp. 2192-2200
    • Crestani, M.1    Sadeghpour, A.2    Stroup, D.3    Galli, G.4    Chiang, J.Y.L.5
  • 77
    • 0035903105 scopus 로고    scopus 로고
    • The negative effects of bile acids and tumor necrosis factor-α on the transcription of cholesterol 7α-hydroxylase gene (CYP7A1) converge to hepatocyte nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors
    • E. De Fabiani, N. Mitro, A.C. Anzulovich, A. Pinelli, G. Galli, and M. Crestani The negative effects of bile acids and tumor necrosis factor-α on the transcription of cholesterol 7α-hydroxylase gene (CYP7A1) converge to hepatocyte nuclear factor-4. A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors J. Biol. Chem. 276 2001 30708 30716
    • (2001) J. Biol. Chem. , vol.276 , pp. 30708-30716
    • De Fabiani, E.1    Mitro, N.2    Anzulovich, A.C.3    Pinelli, A.4    Galli, G.5    Crestani, M.6
  • 78
    • 0141866661 scopus 로고    scopus 로고
    • Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle
    • E. De Fabiani, N. Mitro, F. Gilardi, D. Caruso, G. Galli, and M. Crestani Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle J. Biol. Chem. 278 2003 39124 39132
    • (2003) J. Biol. Chem. , vol.278 , pp. 39124-39132
    • De Fabiani, E.1    Mitro, N.2    Gilardi, F.3    Caruso, D.4    Galli, G.5    Crestani, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.