Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-α

Molecular Endocrinology

Volumn 14, Issue 5, 2000, Pages 741-752

  Tobin, Kari Anne Risan ^a   Steineger, Hilde Hermansen ^a   Albert, Siegfried ^b   Spydevold, Øystein ^a   Auwerx, Johan ^c   Gustafsson, Jan Åke ^b   Nebb, Hilde Irene ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b Center for Biotechnology   (Sweden)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; CELL NUCLEUS RECEPTOR; CHOLESTEROL; FATTY ACID; FATTY ACID DERIVATIVE; LIVER X RECEPTOR ALPHA; LUCIFERASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; PROTEIN OR 1; SATURATED FATTY ACID; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; GENE EXPRESSION REGULATION; HEPATOMA CELL; LIVER CELL; MALE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION TIME; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; REPORTER GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ALPHA-LINOLENIC ACID; ANIMALS; CELLS, CULTURED; CHOLESTEROL; DIETARY FATS; DNA-BINDING PROTEINS; FASTING; FATTY ACIDS; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION; GENES, REPORTER; HALF-LIFE; HUMANS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUCIFERASES; MALE; MICE; NEOPLASM PROTEINS; PEROXISOME PROLIFERATORS; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR CROSS-TALK; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFIDES; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034453225     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.14.5.741     Document Type: Article

References (49)

1. Regulation of peroxisome proliferator-activated receptors
2. Peroxisome proliferator-activated receptors, orphans with ligands and functions
3. PPAR: A key nuclear factor in nutrient/gene interactions
4. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
5. PPARγ and the molecular control of adipogenesis
6. Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid- induced transcription
7. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
8. Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways
9. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
10. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
11. ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
12. Sterol regulation of acetyl coenzyme A carboxylase: A mechanism for coordinate control of cellular lipid
13. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
14. Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1
15. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
16. LXR, a nuclear receptor that defines a distinct retinoid response pathway
17. The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism
18. An oxysterol signalling pathway mediated by the nuclear receptor LXRα
19. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
20. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR α
21. Gene transcription of the retinoid X receptor (RXRα) is regulated by fatty acids and hormones in rat hepatic cells
22. Retinoid X receptor (RXRα) gene expression is regulated by fatty acids and dexamethasone in hepatic cells
23. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
24. Induction of peroxisomal β-oxidation in 7800 C1 Morris hepatoma cells in steady state by fatty acids and fatty acid analogues
25. Induction of the three peroxisomal β-oxidation enzymes is synergistically regulated by dexamethasone and fatty acids, and counteracted by insulin in Morris 7800C1 hepatoma cells in culture
26. Synergistic actions of tetradecylthioacetic acid (TTA) and dexamethasone on induction of the peroxisomal beta-oxidation and on growth inhibition of Morris hepatoma cells. Both effects are counteracted by insulin
27. Induction of peroxisomal acyl-CoA oxidase by 3-thia fatty acid, in hepatoma cells and hepatocytes in culture is modified by dexamethasone and insulin
28. Uptake and receptor binding of dexamethasone in cultured 7800 C1 hepatoma cells in relation to regulation of cell growth and peroxisomal β-oxidation
29. Fasting in the rat does not induce hyperfibrinogenaemia
30. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
31. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
32. Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
33. Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins
34. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein
35. Effect of marine oil and rapeseed oil on composition of fatty acids in lipoprotein triacylglycerols from rat blood plasma and liver perfusate
36. Establishment of a clonal strain of hepatoma cells which secrete albumin
37. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study
38. Preparation of rat liver cells. Enzymatic requirements for tissue dispersion
39. A new technique for the assay of infectivity of human adenovirus 5 DNA
40. Pretranslational regulation of cytochrome P4504A1 by free fatty acids in primary cultures of rat hepatocytes
41. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor
42. The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: Evidence for multiple mRNA species
43. Structural characterization of the mouse nuclear oxysterol receptor genes in LXRa, LXRb
44. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
45. Cyclic AMP downregulates c-myc expression by inhibition of transcript initiation in human B-precursor Reh cells
46. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
47. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
48. Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription
49. The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid ω-hydroxylase, by clofibric acid