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Volumn 20, Issue 3, 2003, Pages 215-227

Angiogenesis and the role of epigenetics in metastasis

Author keywords

Angiogenesis; Epigenetic; Microenvironment; Microvasculature; Tumor progression

Indexed keywords

ANGIOGENESIS INHIBITOR; GROWTH FACTOR; SEMAXANIB;

EID: 0242500847     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022935117193     Document Type: Review
Times cited : (25)

References (168)
  • 1
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • Fidler IJ, Ellis LM. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994; 79: 185-8.
    • (1994) Cell , vol.79 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 2
    • 0021320865 scopus 로고
    • Antimetastatic drugs: Laboratory to clinic
    • Hellmann K. Antimetastatic drugs: Laboratory to clinic. Clin Exp Metastasis 1984; 2: 1-4.
    • (1984) Clin Exp Metastasis , vol.2 , pp. 1-4
    • Hellmann, K.1
  • 3
    • 0022595793 scopus 로고
    • Clinical applications of anti-invasion and anti-metastatic agents
    • Liotta LA. Clinical applications of anti-invasion and anti-metastatic agents. Prog Clin Biol Res 1986. 212; 183-95.
    • (1986) Prog Clin Biol Res , vol.212 , pp. 183-195
    • Liotta, L.A.1
  • 4
    • 0025083071 scopus 로고
    • Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes memorial award lecture
    • Fidler IJ. Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 1990; 50: 6130-8.
    • (1990) Cancer Res , vol.50 , pp. 6130-6138
    • Fidler, I.J.1
  • 6
    • 12644317846 scopus 로고    scopus 로고
    • Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways
    • Arbiser JL, Moses MA, Fernandez CA et al. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci USA 1997; 94: 861-6.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 861-866
    • Arbiser, J.L.1    Moses, M.A.2    Fernandez, C.A.3
  • 7
    • 0034860222 scopus 로고    scopus 로고
    • Solitary cancer cells as a possible source of tumor dormancy?
    • Naumov GN, MacDonald IC, Chambers AF et al. Solitary cancer cells as a possible source of tumor dormancy? Semin Cancer Biol 2001; 11: 271-6.
    • (2001) Semin Cancer Biol , vol.11 , pp. 271-276
    • Naumov, G.N.1    MacDonald, I.C.2    Chambers, A.F.3
  • 8
    • 84975525035 scopus 로고
    • Clinical applications of research on angiogenesis
    • Folkman J. Clinical applications of research on angiogenesis. N Engl J Med 1995; 333: 1757-63.
    • (1995) N Engl J Med , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 9
    • 0000629930 scopus 로고
    • Selection of successive cell lines for metastasis
    • Fidler IJ. Selection of successive cell lines for metastasis. Nature. 1973. 242: 148-9.
    • (1973) Nature , vol.242 , pp. 148-149
    • Fidler, I.J.1
  • 10
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler IJ, Kripke ML. Metastasis results from preexisting variant cells within a malignant tumor. Science 1977; 197: 893-5.
    • (1977) Science , vol.197 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 11
    • 0024272364 scopus 로고
    • Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice
    • Morikawa K, Walker SM, Nakajima M et al. Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res 1988; 48: 6863-71.
    • (1988) Cancer Res , vol.48 , pp. 6863-6871
    • Morikawa, K.1    Walker, S.M.2    Nakajima, M.3
  • 12
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1889, 1: 571-3.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 13
    • 0025170899 scopus 로고
    • Growth dominance of the metastatic cancer cell: Cellular and molecular aspects
    • Kerbel RS. Growth dominance of the metastatic cancer cell: Cellular and molecular aspects. Adv Cancer Res 1990; 55: 87-132.
    • (1990) Adv Cancer Res , vol.55 , pp. 87-132
    • Kerbel, R.S.1
  • 14
    • 0024227818 scopus 로고
    • Analysis of growth, selection, and metastasis of tumor cell populations in vivo using random insertions of foreign DNA as genetic tags
    • Prodi G (ed). New York: Plenum Press
    • Waghorne C, Korczak B, Breitman ML et al. Analysis of growth, selection, and metastasis of tumor cell populations in vivo using random insertions of foreign DNA as genetic tags. In Prodi G (ed): Cancer Metastasis, Biological and Biochemical Mechanisms and Clinical Aspects. New York: Plenum Press 1988; 27-38.
    • (1988) Cancer Metastasis, Biological and Biochemical Mechanisms and Clinical Aspects , pp. 27-38
    • Waghorne, C.1    Korczak, B.2    Breitman, M.L.3
  • 15
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B/A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-67.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 16
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194: 23-8.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 17
    • 0026059693 scopus 로고
    • Identification of genes controlling metastatic behaviour
    • Hart IR, Easty D. Identification of genes controlling metastatic behaviour. Br J Cancer 1991; 63: 9-12.
    • (1991) Br J Cancer , vol.63 , pp. 9-12
    • Hart, I.R.1    Easty, D.2
  • 18
    • 0034468125 scopus 로고    scopus 로고
    • Molecular biology of breast cancer metastasis. 'Has it spread?': Disarming one of the most terrifying questions
    • Steeg PS. Molecular biology of breast cancer metastasis. 'Has it spread?': Disarming one of the most terrifying questions. Breast Cancer Res 2000; 2: 396-9.
    • (2000) Breast Cancer Res , vol.2 , pp. 396-399
    • Steeg, P.S.1
  • 19
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
    • Lopez T, Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2002; 1: 339-53.
    • (2002) Cancer Cell , vol.1 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 20
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • Clark EA, Golub TR, Lander ES et al. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000; 406: 532-5.
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3
  • 21
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002; 4: 487-94.
    • (2002) Nat Cell Biol , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 22
    • 0034468235 scopus 로고    scopus 로고
    • Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency
    • Chambers AF, Naumov GN, Vantyghem SA et al. Molecular biology of breast cancer metastasis. Clinical implications of experimental studies on metastatic inefficiency. Breast Cancer Res 2000; 2: 400-7.
    • (2000) Breast Cancer Res , vol.2 , pp. 400-407
    • Chambers, A.F.1    Naumov, G.N.2    Vantyghem, S.A.3
  • 23
    • 0015603212 scopus 로고
    • The relationship of embolic homogeneity, number, size, and viability to the incidence of experimental metastasis
    • Fidler IJ. The relationship of embolic homogeneity, number, size, and viability to the incidence of experimental metastasis. Eur J Cancer 1973; 9: 223-7.
    • (1973) Eur J Cancer , vol.9 , pp. 223-227
    • Fidler, I.J.1
  • 25
    • 0024360794 scopus 로고
    • Therapeutic implications of tumor heterogeneity
    • Heppner GH, Miller BE. Therapeutic implications of tumor heterogeneity. Semin Oncol 1989; 16: 91-105.
    • (1989) Semin Oncol , vol.16 , pp. 91-105
    • Heppner, G.H.1    Miller, B.E.2
  • 26
    • 0024592699 scopus 로고
    • Tumor cell societies
    • Heppner GH. Tumor cell societies. J Natl Canc Inst 1989; 81: 648-9.
    • (1989) J Natl Canc Inst , vol.81 , pp. 648-649
    • Heppner, G.H.1
  • 27
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta LA, Kohn EC. The microenvironment of the tumour-host interface. Nature 2001; 411: 375-9.
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 28
    • 0024559239 scopus 로고
    • Possible role of tumour stem-end cell interaction in metastasis
    • Rak J. Possible role of tumour stem-end cell interaction in metastasis. Med Hypoth 1989; 29: 17-9.
    • (1989) Med Hypoth , vol.29 , pp. 17-19
    • Rak, J.1
  • 29
    • 0034770081 scopus 로고    scopus 로고
    • The hemostatic system and angiogenesis in malignancy
    • Wojtukiewicz MZ, Sierko E, Klement P et al. The hemostatic system and angiogenesis in malignancy. Neoplasia 2001; 3: 371-84.
    • (2001) Neoplasia , vol.3 , pp. 371-384
    • Wojtukiewicz, M.Z.1    Sierko, E.2    Klement, P.3
  • 30
    • 0035320245 scopus 로고    scopus 로고
    • It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment
    • Barcellos-Hoff M-H. It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment. J Mamm Gland Biol Neoplasia 2001; 6: 213-21.
    • (2001) J Mamm Gland Biol Neoplasia , vol.6 , pp. 213-221
    • Barcellos-Hoff, M.-H.1
  • 31
    • 0034763554 scopus 로고    scopus 로고
    • Extracellular signaling through microenvironment: A hypothesis relating carcinogenesis, bystander effects, and genomic instability
    • Barcellos-Hoff M-H, Brooks AL. Extracellular signaling through microenvironment: A hypothesis relating carcinogenesis, bystander effects, and genomic instability. Radiation Research 2001; 156: 618-27.
    • (2001) Radiation Research , vol.156 , pp. 618-627
    • Barcellos-Hoff, M.-H.1    Brooks, A.L.2
  • 32
    • 0032189662 scopus 로고    scopus 로고
    • Multiple changes in gene expression are associated with normal cell-induced modulation of the neoplastic phenotype
    • Chang GW, Terzaghi-Howe M. Multiple changes in gene expression are associated with normal cell-induced modulation of the neoplastic phenotype. Cancer Res 1998; 58: 4445-52.
    • (1998) Cancer Res , vol.58 , pp. 4445-4452
    • Chang, G.W.1    Terzaghi-Howe, M.2
  • 33
    • 0030031959 scopus 로고    scopus 로고
    • Elimination of transformed cells by normal cells: A novel concept for the control of carcinogenesis
    • Bauer G. Elimination of transformed cells by normal cells: A novel concept for the control of carcinogenesis. Histol Histopathol 1996; 11: 237-55.
    • (1996) Histol Histopathol , vol.11 , pp. 237-255
    • Bauer, G.1
  • 34
    • 0034471876 scopus 로고    scopus 로고
    • Genes that regulate metastasis and angiogenesis
    • Webb CP, Vande WG. Genes that regulate metastasis and angiogenesis. J Neurooncol 2000; 50: 71-87.
    • (2000) J Neurooncol , vol.50 , pp. 71-87
    • Webb, C.P.1    Vande, W.G.2
  • 35
    • 0035802109 scopus 로고    scopus 로고
    • Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
    • Xu J, Rodriguez D, Petitclerc E. Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J Cell Biol 2001; 154: 1069-79.
    • (2001) J Cell Biol , vol.154 , pp. 1069-1079
    • Xu, J.1    Rodriguez, D.2    Petitclerc, E.3
  • 36
    • 0034695685 scopus 로고    scopus 로고
    • The hemostatic system as a regulator of angiogenesis
    • Browder T, Folkman J, Pirie-Shepherd S. The hemostatic system as a regulator of angiogenesis. J Biol Chem 2000; 275: 1521-4.
    • (2000) J Biol Chem , vol.275 , pp. 1521-1524
    • Browder, T.1    Folkman, J.2    Pirie-Shepherd, S.3
  • 37
    • 0033578910 scopus 로고    scopus 로고
    • Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
    • O'Reilly MS, Pirie-Shepherd S, Lane WS et al. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science 1999; 285: 1926-8.
    • (1999) Science , vol.285 , pp. 1926-1928
    • O'Reilly, M.S.1    Pirie-Shepherd, S.2    Lane, W.S.3
  • 38
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 1991; 64: 327-36.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 39
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249-57.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 40
    • 0036527585 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphangiogenesis in health and disease
    • Alitalo K, Carmeliet P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 2002; 1: 219-27.
    • (2002) Cancer Cell , vol.1 , pp. 219-227
    • Alitalo, K.1    Carmeliet, P.2
  • 41
    • 0028910567 scopus 로고
    • Consequences of angiogenesis for tumor progression, metastasis and cancer therapy
    • Rak J, St. Croix B, Kerbel RS. Consequences of angiogenesis for tumor progression, metastasis and cancer therapy. Anti-Cancer Drugs 1995; 6: 3-18.
    • (1995) Anti-Cancer Drugs , vol.6 , pp. 3-18
    • Rak, J.1    St. Croix, B.2    Kerbel, R.S.3
  • 42
    • 0041996839 scopus 로고    scopus 로고
    • Oncogenes and tumor angiogenesis
    • Rak J (ed). Totowa, New Jersey: Humana Press
    • Rak J, Kerbel RS. Oncogenes and tumor angiogenesis. In Rak J (ed): Oncogene-Directed Therapies. Totowa, New Jersey: Humana Press 2002.
    • (2002) Oncogene-Directed Therapies
    • Rak, J.1    Kerbel, R.S.2
  • 43
    • 0030484797 scopus 로고    scopus 로고
    • Reciprocal paracrine interactions between tumor cells and endothelial cells. The 'angiogenesis progression' hypothesis
    • Rak J, Filmus J, Kerbel RS. Reciprocal paracrine interactions between tumor cells and endothelial cells. The 'angiogenesis progression' hypothesis. Eur J Cancer 1996; 32A: 2438-50.
    • (1996) Eur J Cancer , vol.32 A , pp. 2438-2450
    • Rak, J.1    Filmus, J.2    Kerbel, R.S.3
  • 44
    • 0030701960 scopus 로고    scopus 로고
    • Halting angiogenesis suppresses carcinoma cell invasion
    • Skobe M, Rockwell P, Goldstein N et al. Halting angiogenesis suppresses carcinoma cell invasion. Nature Med 1997; 3: 1222-7.
    • (1997) Nature Med , vol.3 , pp. 1222-1227
    • Skobe, M.1    Rockwell, P.2    Goldstein, N.3
  • 45
    • 0028972105 scopus 로고
    • Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin
    • Brooks PC, Stromblad S, Klemke R et al. Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest 1995; 96: 1815-22.
    • (1995) J Clin Invest , vol.96 , pp. 1815-1822
    • Brooks, P.C.1    Stromblad, S.2    Klemke, R.3
  • 46
    • 0037036097 scopus 로고    scopus 로고
    • Targeting lymphatic metastasis
    • Gershenwald JE, Fidler IJ. Targeting lymphatic metastasis. Science 2002; 296: 1811-2.
    • (2002) Science , vol.296 , pp. 1811-1812
    • Gershenwald, J.E.1    Fidler, I.J.2
  • 47
    • 0027818475 scopus 로고
    • A paracrine migration-stimulating factor for metastatic tumor cells secreted by mouse hepatic sinusoidal endothelial cells: Identification as complement component C3b
    • Hamada J, Cavanaugh PG, Miki K et al. A paracrine migration-stimulating factor for metastatic tumor cells secreted by mouse hepatic sinusoidal endothelial cells: Identification as complement component C3b. Cancer Res 1993; 53: 4418-23.
    • (1993) Cancer Res , vol.53 , pp. 4418-4423
    • Hamada, J.1    Cavanaugh, P.G.2    Miki, K.3
  • 48
    • 0020621330 scopus 로고
    • Angiogenesis-dependent tumor spread in reinforced fibrin clot culture
    • Nicosia RF, Tchao R, Leighton J. Angiogenesis-dependent tumor spread in reinforced fibrin clot culture. Cancer Res 1983; 43: 2159-66.
    • (1983) Cancer Res , vol.43 , pp. 2159-2166
    • Nicosia, R.F.1    Tchao, R.2    Leighton, J.3
  • 49
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly MS, Holmgren L, Shing Y et al. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994; 79: 315-28.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3
  • 50
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med 1995; 1: 149-53.
    • (1995) Nature Med , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 51
    • 0024394546 scopus 로고
    • Unknown primary tumors: Establishment of cell lines, identification of chromosomal abnormalities, and implications for a second type of tumor progression
    • Bell CW, Pathak S, Frost P. Unknown primary tumors: Establishment of cell lines, identification of chromosomal abnormalities, and implications for a second type of tumor progression. Cancer Res 1989; 49: 4311-5.
    • (1989) Cancer Res , vol.49 , pp. 4311-4315
    • Bell, C.W.1    Pathak, S.2    Frost, P.3
  • 52
    • 0035211504 scopus 로고    scopus 로고
    • Angiogenesis-dependent diseases
    • Folkman J. Angiogenesis-dependent diseases. Semin Oncol 2001; 28: 536-42.
    • (2001) Semin Oncol , vol.28 , pp. 536-542
    • Folkman, J.1
  • 53
    • 0028214655 scopus 로고
    • Progressive loss of sensitivity to endothelium-derived growth inhibitors expressed by human melanoma cells during disease progression
    • Rak JW, Hegmann EJ, Lu C et al. Progressive loss of sensitivity to endothelium-derived growth inhibitors expressed by human melanoma cells during disease progression. J Cell Physiol 1994; 159: 245-55.
    • (1994) J Cell Physiol , vol.159 , pp. 245-255
    • Rak, J.W.1    Hegmann, E.J.2    Lu, C.3
  • 54
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 55
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J, Maisonpierre PC, Compton D et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999; 284: 1994-8.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3
  • 56
    • 0034648793 scopus 로고    scopus 로고
    • Vascular-specific growth factors and blood vessel formation
    • Yancopoulos GD, Davis S, Gale NW et al. Vascular-specific growth factors and blood vessel formation. Nature 2000; 407: 242-8.
    • (2000) Nature , vol.407 , pp. 242-248
    • Yancopoulos, G.D.1    Davis, S.2    Gale, N.W.3
  • 57
    • 17344390961 scopus 로고    scopus 로고
    • Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor
    • Pettersson A, Nagy JA, Brown LF et al. Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest 2000; 80: 99-115.
    • (2000) Lab Invest , vol.80 , pp. 99-115
    • Pettersson, A.1    Nagy, J.A.2    Brown, L.F.3
  • 58
    • 0032887340 scopus 로고    scopus 로고
    • Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry
    • Maniotis AJ, Folberg R, Hess A et al. Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry. Am J Pathol 1999; 155: 739-52.
    • (1999) Am J Pathol , vol.155 , pp. 739-752
    • Maniotis, A.J.1    Folberg, R.2    Hess, A.3
  • 59
    • 0002496634 scopus 로고    scopus 로고
    • Prospects and progress in the development of anti-angiogenic agents
    • Rosenberg SA (ed). New York: Lippincott, Williams & Wilkins
    • Rak J, Kerbel RS. Prospects and progress in the development of anti-angiogenic agents. In Rosenberg SA (ed): Principles and Practice of Biologic Therapy of Cancer - Updates. New York: Lippincott, Williams & Wilkins 2002; 3: 1-13.
    • (2002) Principles and Practice of Biologic Therapy of Cancer - Updates , vol.3 , pp. 1-13
    • Rak, J.1    Kerbel, R.S.2
  • 60
    • 0034502557 scopus 로고    scopus 로고
    • Oncogenes and angiogenesis: Signaling three-dimensional tumor growth
    • Rak J, Yu JL, Klement G et al. Oncogenes and angiogenesis: Signaling three-dimensional tumor growth. J Invest Dermatol Symp Proc 2000; 5: 24-33.
    • (2000) J Invest Dermatol Symp Proc , vol.5 , pp. 24-33
    • Rak, J.1    Yu, J.L.2    Klement, G.3
  • 62
    • 0033554723 scopus 로고    scopus 로고
    • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
    • Lyden D, Young AZ, Zagzag D et al. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 1999; 401: 670-7.
    • (1999) Nature , vol.401 , pp. 670-677
    • Lyden, D.1    Young, A.Z.2    Zagzag, D.3
  • 63
    • 0034057282 scopus 로고    scopus 로고
    • Genetic heterogeneity of angiogenesis in mice
    • Rohan RM, Fernandez A, Udagawa T et al. Genetic heterogeneity of angiogenesis in mice. FASEB J 2000; 14: 871-6.
    • (2000) FASEB J , vol.14 , pp. 871-876
    • Rohan, R.M.1    Fernandez, A.2    Udagawa, T.3
  • 64
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in turnout growth
    • Harris AL. Hypoxia - a key regulatory factor in turnout growth. Nat Rev Cancer 2002; 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 65
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza GL. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 2000; 35: 71-103.
    • (2000) Crit Rev Biochem Mol Biol , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 66
    • 0032169018 scopus 로고    scopus 로고
    • Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
    • Jain RK, Safabakhsh N, Sckell A et al. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proc Natl Acad Sci USA 1998; 95: 10820-5.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10820-10825
    • Jain, R.K.1    Safabakhsh, N.2    Sckell, A.3
  • 67
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • Dameron KM, Volpert OV, Tainsky MA et al. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994; 265: 1582-4.
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3
  • 68
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • Rak J, Mitsuhashi Y, Bayko L et al. Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995; 55: 4575-80.
    • (1995) Cancer Res , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3
  • 69
    • 0028834638 scopus 로고
    • Both v-Ha-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel S, Finkenzeller G, Weindel K et al. Both v-Ha-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J Biol Chem 1995; 270: 25915-9.
    • (1995) J Biol Chem , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3
  • 70
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
    • Mazure NM, Chen EY, Yeh P et al. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res 1996; 56: 3436-40.
    • (1996) Cancer Res , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3
  • 71
    • 0033924882 scopus 로고    scopus 로고
    • Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor
    • Laderoute KR, Alarcon RM, Brody MD et al. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin Cancer Res 2000; 6: 2941-50.
    • (2000) Clin Cancer Res , vol.6 , pp. 2941-2950
    • Laderoute, K.R.1    Alarcon, R.M.2    Brody, M.D.3
  • 72
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen T, Nahari D, Cerem LW et al. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 1996; 271: 736-41.
    • (1996) J Biol Chem , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3
  • 73
    • 0029846376 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density
    • Koura AN, Liu W, Kitadai Y et al. Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density. Cancer Res 1996; 56: 3891-4.
    • (1996) Cancer Res , vol.56 , pp. 3891-3894
    • Koura, A.N.1    Liu, W.2    Kitadai, Y.3
  • 74
    • 0034650744 scopus 로고    scopus 로고
    • Oncogenes and tumor anglogenesis: Differential modes of vascular endothelial growth factor upregulation in ras-transformed epithelial cells and fibroblasts
    • Rak J, Mitsuhashi Y, Sheehan C et al. Oncogenes and tumor anglogenesis: differential modes of vascular endothelial growth factor upregulation in ras-transformed epithelial cells and fibroblasts. Cancer Res 2000; 60: 490-8.
    • (2000) Cancer Res , vol.60 , pp. 490-498
    • Rak, J.1    Mitsuhashi, Y.2    Sheehan, C.3
  • 75
    • 0034608787 scopus 로고    scopus 로고
    • Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor
    • Sheta EA, Harding MA, Conaway MR et al. Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor. J Natl Cancer Inst 2000; 92: 1065-73.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1065-1073
    • Sheta, E.A.1    Harding, M.A.2    Conaway, M.R.3
  • 76
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR et al. Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8.
    • (1991) N Engl J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3
  • 77
    • 0031032073 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma
    • Gasparini G, Toi M, Gion M et al. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst 1997; 89: 139-47.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 139-147
    • Gasparini, G.1    Toi, M.2    Gion, M.3
  • 78
    • 0029128360 scopus 로고
    • Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer
    • Toi M, Inada K, Hoshima S et al. Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer. Clin Cancer Res 1995; 1: 961-4.
    • (1995) Clin Cancer Res , vol.1 , pp. 961-964
    • Toi, M.1    Inada, K.2    Hoshima, S.3
  • 79
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PA et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997; 57: 963-9.
    • (1997) Cancer Res , vol.57 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.3
  • 80
    • 0030823968 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells
    • Yoshiji H, Harris SR, Thorgeirsson UP. Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells. Cancer Res 1997; 57: 3924-8.
    • (1997) Cancer Res , vol.57 , pp. 3924-3928
    • Yoshiji, H.1    Harris, S.R.2    Thorgeirsson, U.P.3
  • 81
    • 0034993498 scopus 로고    scopus 로고
    • In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects
    • Filleur S, Volpert OV, Degeorges A et al. In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects. Genes Dev 2001; 15: 1373-82.
    • (2001) Genes Dev , vol.15 , pp. 1373-1382
    • Filleur, S.1    Volpert, O.V.2    Degeorges, A.3
  • 82
    • 0035908479 scopus 로고    scopus 로고
    • Angiogenic heterogeneity: Regulation of neoplastic angiogenesis by the organ microenvironment
    • Fidler IJ. Angiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment. J Natl Cancer Inst 2001; 93: 1040-1.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1040-1041
    • Fidler, I.J.1
  • 83
    • 0036161382 scopus 로고    scopus 로고
    • The seed and soil hypothesis: Vascularization and brain metastases
    • Fidler IJ, Yano S, Zhang RD et al. The seed and soil hypothesis: Vascularization and brain metastases. Lancet Oncol 2002; 3: 53-7.
    • (2002) Lancet Oncol , vol.3 , pp. 53-57
    • Fidler, I.J.1    Yano, S.2    Zhang, R.D.3
  • 84
    • 0035912621 scopus 로고    scopus 로고
    • Targeted drugs take center stage at US cancer meeting
    • McCarthy M. Targeted drugs take center stage at US cancer meeting. Lancet 2001; 357: 1593.
    • (2001) Lancet , vol.357 , pp. 1593
    • McCarthy, M.1
  • 85
    • 0033151608 scopus 로고    scopus 로고
    • Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
    • Coussens LM, Raymond WW, Bergers G et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 1999; 13: 1382-97.
    • (1999) Genes Dev , vol.13 , pp. 1382-1397
    • Coussens, L.M.1    Raymond, W.W.2    Bergers, G.3
  • 86
    • 0033107533 scopus 로고    scopus 로고
    • Collateral expression of proangiogenic and tumorigenic properties in intestinal epithelial cell variants selected for resistance to anoikis
    • Rak J, Mitsuhashi Y, Sheehan C et al. Collateral expression of proangiogenic and tumorigenic properties in intestinal epithelial cell variants selected for resistance to anoikis. Neoplasia 1999; 1: 23-30.
    • (1999) Neoplasia , vol.1 , pp. 23-30
    • Rak, J.1    Mitsuhashi, Y.2    Sheehan, C.3
  • 88
    • 0029562231 scopus 로고
    • Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: Suppression by expression of a mutant c-H-ras oncogene
    • Rak J, Mitsuhashi Y, Erdos V et al. Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: Suppression by expression of a mutant c-H-ras oncogene. J Cell Biol 1995; 131: 1587-98.
    • (1995) J Cell Biol , vol.131 , pp. 1587-1598
    • Rak, J.1    Mitsuhashi, Y.2    Erdos, V.3
  • 89
    • 0034678411 scopus 로고    scopus 로고
    • Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells
    • Rosen K, Rak J, Leung T et al. Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells. J Cell Biol 2000; 149: 447-56.
    • (2000) J Cell Biol , vol.149 , pp. 447-456
    • Rosen, K.1    Rak, J.2    Leung, T.3
  • 90
    • 0242547990 scopus 로고    scopus 로고
    • Downregulation of Bak plays a critical role in the growth of the ras-induced malignant phenotype in intestinal epithelial cells
    • Rosen K, Rak J, Jin J et al. Downregulation of Bak plays a critical role in the growth of the ras-induced malignant phenotype in intestinal epithelial cells. Curr Biol 1998; 8: 13314.
    • (1998) Curr Biol , vol.8 , pp. 13314
    • Rosen, K.1    Rak, J.2    Jin, J.3
  • 91
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996; 379: 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 92
    • 0035069527 scopus 로고    scopus 로고
    • Heterogeneous vascular dependence of tumor cell populations
    • Yu JL, Rak JW, Carmeliet P et al. Heterogeneous vascular dependence of tumor cell populations. Am J Pathol 2001; 158: 1325-34.
    • (2001) Am J Pathol , vol.158 , pp. 1325-1334
    • Yu, J.L.1    Rak, J.W.2    Carmeliet, P.3
  • 93
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu JL, Rak JW, Coomber BL et al. Effect of p53 status on tumor response to antiangiogenic therapy. Science 2002; 295: 1526-8.
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3
  • 94
    • 0035886807 scopus 로고    scopus 로고
    • Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair
    • Kondo A, Safaei R, Mishima M et al. Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair. Cancer Res 2001; 61: 7603-7.
    • (2001) Cancer Res , vol.61 , pp. 7603-7607
    • Kondo, A.1    Safaei, R.2    Mishima, M.3
  • 95
    • 0035704913 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor in angiogenesis
    • Ferrara N, Gerber HP. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol 2001; 106: 148-56.
    • (2001) Acta Haematol , vol.106 , pp. 148-156
    • Ferrara, N.1    Gerber, H.P.2
  • 96
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Welch HA et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992; 359: 845-8.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Welch, H.A.3
  • 98
    • 0037144460 scopus 로고    scopus 로고
    • Oxygen-mediated regulation of tumour cell invasiveness: Involvement of a nitric oxide signalling pathway
    • Postovit LM, Adams MA, Lash GE et al. Oxygen-mediated regulation of tumour cell invasiveness: involvement of a nitric oxide signalling pathway. J Biol Chem 2002; 277: 35730-7.
    • (2002) J Biol Chem , vol.277 , pp. 35730-35737
    • Postovit, L.M.1    Adams, M.A.2    Lash, G.E.3
  • 99
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • Luzzi KJ, MacDonald IC, Schmidt EE et al. Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol 1998; 153: 865-73.
    • (1998) Am J Pathol , vol.153 , pp. 865-873
    • Luzzi, K.J.1    MacDonald, I.C.2    Schmidt, E.E.3
  • 100
    • 0034193321 scopus 로고    scopus 로고
    • Temporal progression of metastasis in lung: Cell survival, dormancy, and location dependence of metastatic inefficiency
    • Cameron MD, Schmidt EE, Kerkvliet N et al. Temporal progression of metastasis in lung: Cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res 2000; 60: 2541-6.
    • (2000) Cancer Res , vol.60 , pp. 2541-2546
    • Cameron, M.D.1    Schmidt, E.E.2    Kerkvliet, N.3
  • 101
    • 0036554830 scopus 로고    scopus 로고
    • Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: Mammary fat pad versus cranial tumors
    • Monsky WL, Carreira CM, Tsuzuki Y et al. Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: Mammary fat pad versus cranial tumors. Clin Cancer Res 2002; 8: 1008-13.
    • (2002) Clin Cancer Res , vol.8 , pp. 1008-1013
    • Monsky, W.L.1    Carreira, C.M.2    Tsuzuki, Y.3
  • 102
    • 0036531949 scopus 로고    scopus 로고
    • What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors
    • Rak JW, Yu JL, Kerbel RS et al. What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors. Cancer Res 2002; 62: 1931-4.
    • (2002) Cancer Res , vol.62 , pp. 1931-1934
    • Rak, J.W.1    Yu, J.L.2    Kerbel, R.S.3
  • 103
    • 0032508704 scopus 로고    scopus 로고
    • Differences in migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620)
    • Kubens BS, Zanker KS. Differences in migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620). Cancer Lett 1998; 131: 55-64.
    • (1998) Cancer Lett , vol.131 , pp. 55-64
    • Kubens, B.S.1    Zanker, K.S.2
  • 104
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Muller A, Homey B, Soto H et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410: 24-5.
    • (2001) Nature , vol.410 , pp. 24-25
    • Muller, A.1    Homey, B.2    Soto, H.3
  • 105
    • 0033962906 scopus 로고    scopus 로고
    • E-selectin can mediate the arrest type of adhesion of colon cancer cells under physiological shear flow
    • Kitayama J, Tsuno N, Sunami E et al. E-selectin can mediate the arrest type of adhesion of colon cancer cells under physiological shear flow. Eur J Cancer 2000; 36: 121-7.
    • (2000) Eur J Cancer , vol.36 , pp. 121-127
    • Kitayama, J.1    Tsuno, N.2    Sunami, E.3
  • 106
    • 0024815584 scopus 로고
    • An inducible endothelial cell surface glycoprotein mediates melanoma adhesion
    • Rice GE, Bevilacqua MP. An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science 1989; 246: 1303-6.
    • (1989) Science , vol.246 , pp. 1303-1306
    • Rice, G.E.1    Bevilacqua, M.P.2
  • 107
    • 0032482987 scopus 로고    scopus 로고
    • P-selectin deficiency attenuates tumor growth and metastasis
    • Kim YJ, Borsig L, Varki NM et al. P-selectin deficiency attenuates tumor growth and metastasis. Proc Natl Acad Sci USA 1998; 95: 9325-30.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9325-9330
    • Kim, Y.J.1    Borsig, L.2    Varki, N.M.3
  • 108
    • 0025753662 scopus 로고
    • Structure, function and biological properties of integrin alpha v beta 3 on human melanoma cells
    • Cheresh DA. Structure, function and biological properties of integrin alpha v beta 3 on human melanoma cells. Cancer Metastasis Rev 1991; 10: 3-10.
    • (1991) Cancer Metastasis Rev , vol.10 , pp. 3-10
    • Cheresh, D.A.1
  • 109
    • 0027652426 scopus 로고
    • Adhesion molecules and their role in cancer metastasis
    • Lafernie RM, Buchanan MR, Orr FW. Adhesion molecules and their role in cancer metastasis. Cell Biophys 1993; 23: 3-89.
    • (1993) Cell Biophys , vol.23 , pp. 3-89
    • Lafernie, R.M.1    Buchanan, M.R.2    Orr, F.W.3
  • 110
    • 0033376770 scopus 로고    scopus 로고
    • Cell adhesion molecules in the development and progression of malignant melanoma
    • Johnson JP. Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev 1999; 18: 345-57.
    • (1999) Cancer Metastasis Rev , vol.18 , pp. 345-357
    • Johnson, J.P.1
  • 111
    • 0036158116 scopus 로고    scopus 로고
    • Hematogenous spread as a mechanism for the generation of abdominal wound metastases following laparoscopy
    • Brundell S, Ellis T, Dodd T et al. Hematogenous spread as a mechanism for the generation of abdominal wound metastases following laparoscopy. Surg Endosc 2002; 16: 292-5.
    • (2002) Surg Endosc , vol.16 , pp. 292-295
    • Brundell, S.1    Ellis, T.2    Dodd, T.3
  • 112
    • 0021242388 scopus 로고
    • Tumor heterogeneity
    • Heppner GH. Tumor heterogeneity. Cancer Res 1989; 44: 2259-65.
    • (1989) Cancer Res , vol.44 , pp. 2259-2265
    • Heppner, G.H.1
  • 113
    • 0037086083 scopus 로고    scopus 로고
    • Hypoxia promotes lymph node metastasis in human melanoma xenografts by upregulating the urokinase-type plasminogen activator receptor
    • Rofstad EK, Rasmussen H, Galappathi K et al. Hypoxia promotes lymph node metastasis in human melanoma xenografts by upregulating the urokinase-type plasminogen activator receptor. Cancer Res 2002; 62: 1847-53.
    • (2002) Cancer Res , vol.62 , pp. 1847-1853
    • Rofstad, E.K.1    Rasmussen, H.2    Galappathi, K.3
  • 114
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene expression to hypoxic tumor cells
    • Dachs GU, Patterson AV, Firth JD et al. Targeting gene expression to hypoxic tumor cells. Nat Med 1997; 3: 515-20.
    • (1997) Nat Med , vol.3 , pp. 515-520
    • Dachs, G.U.1    Patterson, A.V.2    Firth, J.D.3
  • 115
    • 0033867776 scopus 로고    scopus 로고
    • Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation
    • Dachs GU, Tozer GM. Hypoxia modulated gene expression: Angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer 2000; 36: 1649-60.
    • (2000) Eur J Cancer , vol.36 , pp. 1649-1660
    • Dachs, G.U.1    Tozer, G.M.2
  • 116
    • 0033970086 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment
    • Denko N, Schindler C, Koong A et al. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin Cancer Res 2000; 6: 480-7.
    • (2000) Clin Cancer Res , vol.6 , pp. 480-487
    • Denko, N.1    Schindler, C.2    Koong, A.3
  • 117
    • 0034652596 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in tumors and serum of head and neck cancer patients
    • Sanchez-Cespedes M, Esteller M, Wu L et al. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res 2000; 60: 892-5.
    • (2000) Cancer Res , vol.60 , pp. 892-895
    • Sanchez-Cespedes, M.1    Esteller, M.2    Wu, L.3
  • 118
    • 0034692447 scopus 로고    scopus 로고
    • Hypermethylation of the death associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer
    • Tang X, Khuri FR, Lee JJ et al. Hypermethylation of the death associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. J Natl Cancer Inst 2000; 92: 1511-16.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1511-1516
    • Tang, X.1    Khuri, F.R.2    Lee, J.J.3
  • 119
    • 0031830664 scopus 로고    scopus 로고
    • Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
    • Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 1998; 153: 333-9.
    • (1998) Am J Pathol , vol.153 , pp. 333-339
    • Hirohashi, S.1
  • 120
    • 0034567741 scopus 로고    scopus 로고
    • Molecular aspects of adhesion-epigenetic mechanism for inactivation of the E-cadherin-mediated cell adhesion system in cancer
    • Hirohashi S. Molecular aspects of adhesion-epigenetic mechanism for inactivation of the E-cadherin-mediated cell adhesion system in cancer. Verh Dtsch Ges Pathol 2000; 84: 28-32.
    • (2000) Verh Dtsch Ges Pathol , vol.84 , pp. 28-32
    • Hirohashi, S.1
  • 121
    • 0035575781 scopus 로고    scopus 로고
    • Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma
    • Park TJ, Han SU, Cho YK et al. Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma. Cancer 2001; 92: 2760-8.
    • (2001) Cancer , vol.92 , pp. 2760-2768
    • Park, T.J.1    Han, S.U.2    Cho, Y.K.3
  • 122
    • 0034723255 scopus 로고    scopus 로고
    • Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression
    • Graff JR, Gabrielson E, Fuji H et al. Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 2000; 275: 2727-32.
    • (2000) J Biol Chem , vol.275 , pp. 2727-2732
    • Graff, J.R.1    Gabrielson, E.2    Fuji, H.3
  • 123
    • 0035887043 scopus 로고    scopus 로고
    • Lymphatic function, lymphangiogenesis, and cancer metastasis
    • Swartz MA, Skobe M. Lymphatic function, lymphangiogenesis, and cancer metastasis. Microsc Res Tech 2001; 55: 92-9.
    • (2001) Microsc Res Tech , vol.55 , pp. 92-99
    • Swartz, M.A.1    Skobe, M.2
  • 124
    • 0037036136 scopus 로고    scopus 로고
    • Lymphatic metastasis in the absence of functional intratumor lymphatics
    • Padera TP, Kadambi A, di Tomaso E et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002; 296: 1883-6.
    • (2002) Science , vol.296 , pp. 1883-1886
    • Padera, T.P.1    Kadambi, A.2    Di Tomaso, E.3
  • 125
    • 0035126049 scopus 로고    scopus 로고
    • VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    • Stacker SA, Caesar C, Baldwin ME et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001; 7: 186-91.
    • (2001) Nat Med , vol.7 , pp. 186-191
    • Stacker, S.A.1    Caesar, C.2    Baldwin, M.E.3
  • 126
    • 0034899437 scopus 로고    scopus 로고
    • Lymphangiogenesis and tumor metastasis: Myth or reality?
    • Pepper MS. Lymphangiogenesis and tumor metastasis: Myth or reality? Clin Cancer Res 2001; 7: 462-8.
    • (2001) Clin Cancer Res , vol.7 , pp. 462-468
    • Pepper, M.S.1
  • 127
    • 0035122537 scopus 로고    scopus 로고
    • Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    • Skobe M, Hawighorst T, Jackson DG et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001; 7: 192-8.
    • (2001) Nat Med , vol.7 , pp. 192-198
    • Skobe, M.1    Hawighorst, T.2    Jackson, D.G.3
  • 128
    • 0034693879 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
    • Karkkainen MJ, Petrova TV. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Oncogene 2000; 19: 5598-605.
    • (2000) Oncogene , vol.19 , pp. 5598-5605
    • Karkkainen, M.J.1    Petrova, T.V.2
  • 129
    • 17744390184 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
    • Mandriota SJ, Jussila L, Jeltsch M et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 2001; 20: 672-68.
    • (2001) EMBO J , vol.20 , pp. 672-668
    • Mandriota, S.J.1    Jussila, L.2    Jeltsch, M.3
  • 130
    • 0036288934 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa
    • Amioka T, Kitadai Y, Tanaka S et al. Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa. Eur J Cancer 2002; 38: 1413-9.
    • (2002) Eur J Cancer , vol.38 , pp. 1413-1419
    • Amioka, T.1    Kitadai, Y.2    Tanaka, S.3
  • 131
    • 0032564411 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C induces angiogenesis in vivo
    • Cao Y, Linden P, Farnebo J et al. Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci USA 1998; 95: 14389-94.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14389-14394
    • Cao, Y.1    Linden, P.2    Farnebo, J.3
  • 132
    • 0034842967 scopus 로고    scopus 로고
    • Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma
    • Skobe M, Hamberg LM, Hawighorst T et al. Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am J Pathol 2001; 159: 893-903.
    • (2001) Am J Pathol , vol.159 , pp. 893-903
    • Skobe, M.1    Hamberg, L.M.2    Hawighorst, T.3
  • 134
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel RS. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. BioEssays 1991; 13: 31-6.
    • (1991) BioEssays , vol.13 , pp. 31-36
    • Kerbel, R.S.1
  • 135
    • 0031443206 scopus 로고    scopus 로고
    • A cancer therapy resistant to resistance
    • Kerbel RS. A cancer therapy resistant to resistance. Nature 1997; 390: 335-6.
    • (1997) Nature , vol.390 , pp. 335-336
    • Kerbel, R.S.1
  • 136
    • 0024994008 scopus 로고
    • Vascular and interstitial barriers to delivery of therapeutic agents in tumors
    • Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev 1990; 9: 253-66.
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 253-266
    • Jain, R.K.1
  • 137
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahau D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 138
    • 0030005902 scopus 로고    scopus 로고
    • Antiangiogenic therapy of transgenic mice impairs de novo tumor growth
    • Parangi S, O'Reilly MS, Christofori G et al. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci USA 1996; 93: 2002-7.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2002-2007
    • Parangi, S.1    O'Reilly, M.S.2    Christofori, G.3
  • 139
    • 0023938431 scopus 로고
    • Antiangiogenesis as a strategy for antimetastasis
    • D'Amore P. Antiangiogenesis as a strategy for antimetastasis. Seminars Thromb Hemostasis 1988; 14: 73-8.
    • (1988) Seminars Thromb Hemostasis , vol.14 , pp. 73-78
    • D'Amore, P.1
  • 140
    • 0037087585 scopus 로고    scopus 로고
    • Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors
    • Kuenen BC, Rosen L, Smit EF et al. Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J Clin Oncol 2002; 20: 1657-67.
    • (2002) J Clin Oncol , vol.20 , pp. 1657-1667
    • Kuenen, B.C.1    Rosen, L.2    Smit, E.F.3
  • 141
    • 0037007037 scopus 로고    scopus 로고
    • Induction of endothelial cell resistance to chemotherapy by VEGF mediated up-regulation of survivin
    • Tran J, Master Z, Yu JL et al. Induction of endothelial cell resistance to chemotherapy by VEGF mediated up-regulation of survivin. Proc Natl Acad Sci USA 2002; 99: 4349-54.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 4349-4354
    • Tran, J.1    Master, Z.2    Yu, J.L.3
  • 142
    • 0035692285 scopus 로고    scopus 로고
    • Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches
    • Kerbel RS, Yu J. Tran J et al. Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches. Cancer Metastasis Rev 2001; 20: 79-86.
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 79-86
    • Kerbel, R.S.1    Yu, J.2    Tran, J.3
  • 143
    • 0028342711 scopus 로고
    • Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells
    • Dong Z, Radinsky R, Fan D et al. Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. J Natl Cancer Inst 1994; 86: 913-20.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 913-920
    • Dong, Z.1    Radinsky, R.2    Fan, D.3
  • 144
    • 0035266283 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • Karpanen T, Egeblad M, Karkkainen MJ et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res 2001; 61: 1786-90.
    • (2001) Cancer Res , vol.61 , pp. 1786-1790
    • Karpanen, T.1    Egeblad, M.2    Karkkainen, M.J.3
  • 145
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 2002; 94: 785-7.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 785-787
    • He, Y.1    Kozaki, K.2    Karpanen, T.3
  • 146
    • 0035575012 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and vascular targeting of solid tumors
    • Brekken RA, Thorpe PE. Vascular endothelial growth factor and vascular targeting of solid tumors. Anticancer Res 2001; 21: 4221-9.
    • (2001) Anticancer Res , vol.21 , pp. 4221-4229
    • Brekken, R.A.1    Thorpe, P.E.2
  • 147
    • 13144254247 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2
    • Lin P, Buxton JA, Acheson A. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. Proc Natl Acad Sci USA 1998; 95: 8829-34.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8829-8834
    • Lin, P.1    Buxton, J.A.2    Acheson, A.3
  • 148
    • 0034924216 scopus 로고    scopus 로고
    • Angiogenesis research: Guidelines for translation to clinical application
    • Folkman J, Browder T, Palmblad J. Angiogenesis research: Guidelines for translation to clinical application. Thromb Haemost 2001; 86: 23-33.
    • (2001) Thromb Haemost , vol.86 , pp. 23-33
    • Folkman, J.1    Browder, T.2    Palmblad, J.3
  • 149
    • 0028672529 scopus 로고
    • The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin
    • Dameron KM, Volpert OV, Tainsky MA et al. The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin. Cold Spring Harb Symp Quant Biol 1994; 59: 483-9.
    • (1994) Cold Spring Harb Symp Quant Biol , vol.59 , pp. 483-489
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3
  • 150
    • 0242717098 scopus 로고    scopus 로고
    • Genetic basis of altered responsiveness of cancer cells to their microenvironment
    • Rak J (ed). Totowa, New Jersey: Humana Press
    • Giaccia A. Genetic basis of altered responsiveness of cancer cells to their microenvironment. In Rak J (ed): Oncogene-Directed Therapies. Totowa, New Jersey: Humana Press 2002; 1-34.
    • (2002) Oncogene-Directed Therapies , pp. 1-34
    • Giaccia, A.1
  • 151
    • 0032733837 scopus 로고    scopus 로고
    • Characterization of p53 mutations in colorectal liver metastases and correlation with clinical parameters
    • Tullo A, D'Erchia AM, Honda K et al. Characterization of p53 mutations in colorectal liver metastases and correlation with clinical parameters. Clin Cancer Res 1999; 5: 3523-8.
    • (1999) Clin Cancer Res , vol.5 , pp. 3523-3528
    • Tullo, A.1    D'Erchia, A.M.2    Honda, K.3
  • 152
    • 0036317838 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3 beta1 integrin
    • Giannelli G, Fransvea E, Marinosci F et al. Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3 beta1 integrin. Am J Pathol 2002; 161: 183-93.
    • (2002) Am J Pathol , vol.161 , pp. 183-193
    • Giannelli, G.1    Fransvea, E.2    Marinosci, F.3
  • 153
    • 0035983872 scopus 로고    scopus 로고
    • TNF alpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells
    • Barshishat M, Ariel A, Cahalon L et al. TNF alpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells. Clin Exp Metastasis 2002; 19: 327-37.
    • (2002) Clin Exp Metastasis , vol.19 , pp. 327-337
    • Barshishat, M.1    Ariel, A.2    Cahalon, L.3
  • 154
    • 0036173548 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    • Wu Y, Dakar S, Sao L et al. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 2002; 62: 1030-5.
    • (2002) Cancer Res , vol.62 , pp. 1030-1035
    • Wu, Y.1    Dakar, S.2    Sao, L.3
  • 155
    • 18244390016 scopus 로고    scopus 로고
    • Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: Involvement of microvascular hot spots induced in hypoxic foci by Interleukin 8
    • Rofstad EK, Halsor EF. Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: Involvement of microvascular hot spots induced in hypoxic foci by Interleukin 8. Br J Cancer 2002; 86: 301-8.
    • (2002) Br J Cancer , vol.86 , pp. 301-308
    • Rofstad, E.K.1    Halsor, E.F.2
  • 156
    • 0037086083 scopus 로고    scopus 로고
    • Hypoxia promotes lymph node metastasis in human melanoma xenografts by upregulating the urokinase-type plasminogen activator receptor
    • Rofstad EK, Rasmussen H, Galappathi K et al. Hypoxia promotes lymph node metastasis in human melanoma xenografts by upregulating the urokinase-type plasminogen activator receptor. Cancer Res 2002; 62: 1847-53.
    • (2002) Cancer Res , vol.62 , pp. 1847-1853
    • Rofstad, E.K.1    Rasmussen, H.2    Galappathi, K.3
  • 157
    • 0035849792 scopus 로고    scopus 로고
    • Multi-faceted analyses of a highly metastatic human lung cancer cell line NC1-H460-LNM35 suggest mimicry of inflammatory cells in metastasis
    • Kozaki K, Koshikawa K, Tatematsu Y et al. Multi-faceted analyses of a highly metastatic human lung cancer cell line NC1-H460-LNM35 suggest mimicry of inflammatory cells in metastasis. Oncogene 2001; 20: 4228-34.
    • (2001) Oncogene , vol.20 , pp. 4228-4234
    • Kozaki, K.1    Koshikawa, K.2    Tatematsu, Y.3
  • 158
    • 0037077225 scopus 로고    scopus 로고
    • Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions
    • Pilch J, Habermann R, Felding-Habermann B. Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions. J Biol Chem 2002; 277: 21930-8.
    • (2002) J Biol Chem , vol.277 , pp. 21930-21938
    • Pilch, J.1    Habermann, R.2    Felding-Habermann, B.3
  • 159
    • 0032793097 scopus 로고    scopus 로고
    • Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow
    • Kitayama J, Nagawa H, Tsuno N et al. Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow. Br J Cancer 1999; 80: 1927-34.
    • (1999) Br J Cancer , vol.80 , pp. 1927-1934
    • Kitayama, J.1    Nagawa, H.2    Tsuno, N.3
  • 160
    • 0036644895 scopus 로고    scopus 로고
    • Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma
    • Schagdarsurengin U, Gimm O, Hoang-Vu C et al. Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma. Cancer Res 2002; 62: 3698-701.
    • (2002) Cancer Res , vol.62 , pp. 3698-3701
    • Schagdarsurengin, U.1    Gimm, O.2    Hoang-Vu, C.3
  • 161
    • 0034946061 scopus 로고    scopus 로고
    • Methylation of the E-cadherin gene promoter correlates with progression of prostate cancer
    • Li LC, Zhao H, Nakajima K et al. Methylation of the E-cadherin gene promoter correlates with progression of prostate cancer. J Urol 2001; 166: 705-9.
    • (2001) J Urol , vol.166 , pp. 705-709
    • Li, L.C.1    Zhao, H.2    Nakajima, K.3
  • 162
    • 0034109902 scopus 로고    scopus 로고
    • Epigenetic silencing of maspin gene expression in human breast cancers
    • Domann FE, Rice JC, Hendrix MJ et al. Epigenetic silencing of maspin gene expression in human breast cancers. Int J Cancer 2000; 85: 805-10.
    • (2000) Int J Cancer , vol.85 , pp. 805-810
    • Domann, F.E.1    Rice, J.C.2    Hendrix, M.J.3
  • 163
    • 0033558192 scopus 로고    scopus 로고
    • Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers
    • Bachman KE, Herman JG, Corn PG et al. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res 1999; 59: 798-802.
    • (1999) Cancer Res , vol.59 , pp. 798-802
    • Bachman, K.E.1    Herman, J.G.2    Corn, P.G.3
  • 164
    • 0028916485 scopus 로고
    • Transcriptional regulation of the mts1 gene in human lymphoma cells: The role of DNA-methylation
    • Tulchinsky E, Grigorian M, Tkatch T et al. Transcriptional regulation of the mts1 gene in human lymphoma cells: the role of DNA-methylation. Biochim Biophys Acta 1995; 1261: 243-8.
    • (1995) Biochim Biophys Acta , vol.1261 , pp. 243-248
    • Tulchinsky, E.1    Grigorian, M.2    Tkatch, T.3
  • 165
    • 0035167659 scopus 로고    scopus 로고
    • Molecular cloning of a functional promoter of the human plakoglobin gene
    • Potter E, Braun S, Lehmann U et al. Molecular cloning of a functional promoter of the human plakoglobin gene. Eur J Endocrinol 2001: 145: 625-33.
    • (2001) Eur J Endocrinol , vol.145 , pp. 625-633
    • Potter, E.1    Braun, S.2    Lehmann, U.3
  • 166
    • 0037137899 scopus 로고    scopus 로고
    • Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation
    • Chen LM, Chai KX. Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation. Int J Cancer 2002; 97: 323-9.
    • (2002) Int J Cancer , vol.97 , pp. 323-329
    • Chen, L.M.1    Chai, K.X.2
  • 167
    • 0035108784 scopus 로고    scopus 로고
    • Epigenetic regulation of human bone morphogenetic protein 6 gene expression in prostate cancer
    • Tamada H, Kitazawa R, Gohji K et al. Epigenetic regulation of human bone morphogenetic protein 6 gene expression in prostate cancer. J Bone Miner Res 2001; 16: 487-96.
    • (2001) J Bone Miner Res , vol.16 , pp. 487-496
    • Tamada, H.1    Kitazawa, R.2    Gohji, K.3
  • 168
    • 0035939841 scopus 로고    scopus 로고
    • Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: Control of transcription by DNA methylation and intronic sequences
    • Lu A, Gupta A, Li C et al. Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: Control of transcription by DNA methylation and intronic sequences. Oncogene 2001; 20: 5173-5185.
    • (2001) Oncogene , vol.20 , pp. 5173-5185
    • Lu, A.1    Gupta, A.2    Li, C.3


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