Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair

Cancer Research

Volumn 61, Issue 20, 2001, Pages 7603-7607

  Kondo, Akira ^a   Safaei, Roohangiz ^a   Mishima, Misako ^a   Niedner, Hannes ^a   Lin, Xinjian ^a   Howell, Stephen B ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; MICROSATELLITE DNA; TIOGUANINE;

ARTICLE; BASE MISPAIRING; CELL SURVIVAL; CELL TYPE; COLON CARCINOMA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA SEQUENCE; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; HYPERSENSITIVITY; HYPOXIA; MICROSATELLITE INSTABILITY; MOLECULAR CLONING; MUTAGENESIS; PH; PRIORITY JOURNAL; TUMOR GROWTH;

ADENOCARCINOMA; BASE PAIR MISMATCH; CELL HYPOXIA; COLORECTAL NEOPLASMS; DNA REPAIR; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSATELLITE REPEATS; MUTAGENESIS; TUMOR CELLS, CULTURED;

EID: 0035886807     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Tumor hypoxia: Its impact on cancer therapy
2. Use of hypoxia-directed drugs in the therapy of solid tumors
3. Microenvironment-induced cancer metastasis
4. Hypoxia and drug resistance
5. Genetic instability induced by the tumor microenvironment
6. Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro
7. Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (Adriamycin) resistance
8. Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
9. Glucose starvation and acidosis: Effect on experimental metastatic potential. DNA content and MTX resistance of murine tumour cells
10. Mutagenesis induced by the tumor microenvironment
11. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
12. Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil
13. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
14. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
15. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
16. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
17. Mutation of a mutL homolog in hereditary colon cancer
18. Identification of mismatch repair genes and their role in the development of cancer
19. Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells
20. Cisplatin and Adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line
21. The role of DNA mismatch repair in platinum drug resistance
22. Effect of loss of DNA mismatch repair on development of topotecan-, gemcitabine-, and paclitaxel-resistant variants after exposure to cisplatin
23. p53 interacts with the DNA mismatch repair system to modulate the cytotoxicity and mutagenicity of hydrogen peroxide
24. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitroguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
25. A simplified model of hypoxic injury in primary cultured rat hepatocytes
26. In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair
27. A novel plasmid shuttle vector for the detection and analysis of microsatellite instability in cell lines
28. The role of mismatch repair in DNA damage-induced apoptosis
29. Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
30. Oxygen-derived free radicals in reperfusion injury
31. Reperfusion injury
32. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G - T and A - C substitutions
33. Induction of mutations in mouse FM3A cells by treatment with riboflavin plus visible light and its possible relation with formation of 8-hydroxyguanine (7, 8-dihydro-8-oxoguanine) in DNA
34. Repair of oxidative damage to DNA: Enzymology and biology
35. Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation
36. Induction of microsatellite instability by oxidative DNA damage
37. Reduction of GC→TA transversion mutation by overexpression of MutS in Escherichia coli K-12
38. Mechanism of translesion DNA synthesis by DNA polymerase II. Comparison to DNA polymerases I and III core
39. DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions
40. Error-prone lesion bypass by human DNA polymerase ε
41. Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro
42. The role of hMLHI, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: Correlation with replicative bypass of platinum-DNA adducts
43. DNA repair, DNA replication, and UV mutagenesis
44. Fidelity of DNA synthesis catalyzed by human DNA polymerase α and HIV-1 reverse transcriptase: Effect of reaction pH
45. Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase
46. Regulation of intracellular pH in tumor cell lines: Influence of microenvironmental conditions
47. Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: Potential implications for cell death in tumors
48. Regulation of proliferation-survival decisions during tumor cell hypoxia
49. 2-M cell cycle checkpoint arrest following ionizing radiation
50. Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells
51. p53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin