Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma

American Journal of Pathology

Volumn 159, Issue 3, 2001, Pages 893-903

  Skobe, Mihaela ^a   Hamberg, Leena M ^a   Hawighorst, Thomas ^a   Schirner, Michael ^b   Wolf, Gerald L ^a   Alitalo, Kari ^c   Detmar, Michael ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BAYER PHARMA AG   (Germany)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN C;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPH VESSEL; MACROPHAGE; MELANOMA; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0034842967     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61765-8     Document Type: Article

References (66)

1. Lymphangiogenesis: Mechanisms, significance and clinical implications
2. The prognostic value of lymphatic and blood vessel invasion in operable breast cancer
3. Attenuated cells in breast stroma: The missing lymphatic system of the breast
4. Role of lymphagenesis in neovascularisation
5. Ultrastructural studies on the invasion of melanomas in initial lymphatics of human skin
6. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3
7. Angiogenesis and tumor growth
8. Absence of functional lymphatics within a murine sarcoma: A molecular and functional evaluation
9. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
10. Vascular endothelial growth factor-related protein: A ligand and specific activator of the tyrosine kinase receptor Flt4
11. VEGF and VEGF-C: Specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane
12. Hyperplasia of lymphatic vessels in VEGF-C trarsgenic mice
13. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
14. Vascular endothelial growth factor (VEGF) and its receptors
15. Proteolytic processing regulates receptor specificity and activity of VEGF-C
16. Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and fit-4 are expressed in AIDS-associated Kaposi's sarcoma
17. Vascular endothelial growth factor C induces angiogenesis in vivo
18. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia
19. Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors
20. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
21. Expression of vascular endothelial growth factor (VEGF) family members in breast cancer
22. Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa
23. Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues
24. Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma
25. Increased vascular endothelial growth factor and vascular endothelial growth factor-c and decreased nm23 expression associated with microdissemination in the lymph nodes in stage I non-small cell lung cancer
26. VEGF-C and VEGFR3 expression in human thyroid pathologies
27. Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features
28. Vascular endothelial growth factor-C gene expression in papillary and follicular thyroid carcinomas
29. Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer
30. VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours
31. High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas
32. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
33. A model of human cancer metastasis: Extensive spontaneous and artificial metastasis of a human pigmented melanoma and derived variant sublines in nude mice
34. Organ-specific metastases in immunodeficient mice injected with human melanoma cells: A quantitative pathological analysis
35. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors
36. Halting angiogenesis suppresses carcinoma cell invasion
37. Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium
38. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
39. Lymph node extraction of radiopaque nanoparticulates in the rabbit as measured in vivo with CT
40. A method to quantitatively measure transcapillary transport of iodinated compounds in canine brain tumors with computed tomography
41. 3 integrin, osteopontin, and thrombin
42. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymphspecific receptor for hyaluronan
43. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (FLT-4)
44. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D
45. Endothelial cell-to-cell junctions
46. Organization of the monocyte/macrophage system of normal human skin
47. F4/80, a monoclonal antibody directed specifically against the mouse macrophage
48. Angiogenesis in cancer and other diseases
49. Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies
50. The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors
51. Transport of molecules in the tumor interstitium: A review
52. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics
53. Structure, function and molecular control of the skin lymphatic system. Review
54. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume
55. Mechanisms causing initial lymphatics to expand and compress to promote lymph flow
56. Structure and function of lymphatics
57. The interaction between intracapillary and tissue forces in the overall regulation of interstitial fluid volume
58. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity
59. FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter
60. Expression of FLT4 and its ligand VEGF-C in acute myeloid leukemia
61. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
62. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
63. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth