Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases

American Journal of Pathology

Volumn 153, Issue 3, 1998, Pages 865-873

  Luzzi, Keith J ^a   MacDonald, Ian C ^a   Schmidt, Eric E ^a   Kerkvliet, Nancy ^b   Morris, Vincent L ^a   Chambers, Ann F ^a,b,c   Groom, Alan C ^a  

^a Department of Medical Biophysics ^*  (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c LONDON REGIONAL CANCER PROGRAM   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; EXTRAVASATION; FEMALE; IMMUNOHISTOCHEMISTRY; LIVER CIRCULATION; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 0031655802     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65628-3     Document Type: Article

References (38)

1. Weinstat-Saslow D, Steeg PS: Angiogenesis and colonization in the tumor metastatic process: basic and applied advances. FASEB J 1994, 8:401-407
2. Fidler IJ, Ellis LM: The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994, 79:185-188
3. Liotta LA, Stetler-Stevenson WG: Principles of molecular cell biology of cancer: cancer metastasis. Cancer: Principles and Practice of Oncology. Edited by DeVita VT Jr, Hellman S, Rosenberg SA, Philadelphia, Lippincott, 1993, pp 134-149
4. Weiss L: Metastatic inefficiency. Adv Cancer Res 1990, 54:159-211
5. 125l-5-iodo-2′-deoxyuridine. J Natl Cancer Inst 1970, 45:773-782
6. Hanna N: Role of natural killer cells in control of cancer metastasis. Cancer Metastasis Rev 1982, 1:45-64
7. Key M: Macrophages in cancer metastasis and their relevance to metastatic growth. Cancer Metastasis Rev 1983, 2:75-88
8. Weiss L: The biomechanics of cancer cell traffic, arrest, and intravascular destruction. Microcirculation in Cancer Metastasis. Edited by Orr FW, Buchanan MR, Weiss L, Boca Raton, FL, CRC Press, 1991, pp 131-144
9. Liotta LA, Steeg PS, Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991, 64:327-336
10. Koop S, MacDonald IC, Luzzi K, Schmidt, EE, Morris VL, Grattan M, Khokha R, Chambers AF, Groom AC: Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res 1995, 55:2520-2523
11. Koop S, Schmidt EE, MacDonald IC, Morris VL, Khokha R, Grattan M, Leone J, Chambers AF, Groom AC: Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well. Proc Natl Acad Sci USA 1996, 93:11080-11084
12. Chambers AF, MacDonald IC, Schmidt EE, Koop S, Morris VL, Khokha R, Groom AC: Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Rev 1995, 14:279-301
13. Morris VL, MacDonald IC, Koop S, Schmidt EE, Chambers AF, Groom AC: Early interactions of cancer cells with the microvasculature in mouse liver and muscle during hematogenous metastasis: videomicroscopic analysis. Clin Exp Metastasis 1993, 11:377-390
14. Fidler IJ: Selection of successive tumor lines for metastasis. Nature 1973, 242:148-149
15. Morris VL, Koop S, MacDonald IC, Schmidt EE, Grattan M, Percy D, Chambers AF, Groom AC: Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth. Clin Exp Metastasis 1994, 12:357-367
16. Weiss L, Nannmark U, Johansson BR, Bagge U: Lethal deformation of cancer cells in the microcirculation: a potential rate regulator of hematogenous metastasis. Int J Cancer 1992, 50:103-107
17. MacPhee PJ, Schmidt EE, Keown PA, Groom AC: Microcirculatory changes in livers of mice infected with murine hepatitis virus: evidence from microcorrosion casts and measurements of red cell velocity. Microvasc Res 1988, 36:140-149
18. Yasumura S, Lin W, Hirabayashi H, Vujanovic NL, Herberman RB, Whiteside TL: Immunotherapy of liver metastases of human gastric carcinoma with interleukin 2-activated natural killer cells. Cancer Res 1994, 54:3808-3816
19. Rudolph AM, Heymann MA: The circulation of the fetus in utero: methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 1967, 21:163-184
20. MacPhee PJ, Schmidt EE, Groom AC: Intermittence of blood flow in liver sinusoids, studied by high-resolution in vivo microscopy. Am J Physiol 1995, 269:G692-G698
21. R B16F1 murine melanoma cells to assess clonality of experimental metastases in the immune-deficient chick embryo. Clin Exp Metastasis 1988, 6:171-182
22. Talmadge JE, Wolman SR, Fidler IJ: Evidence for the clonal origin of spontaneous metastases. Science 1982, 217:361-363
23. Talmadge JE, Zbar B: Clonality of pulmonary metastases from the bladder 6 subline of the B16 melanoma studied by Southern hybridization. J Natl Cancer Inst 1987, 78:315-320
24. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992, 119:493-501
25. Gerdes J, Li L, Schlueter C, Duchrow M, Wohlenberg C, Gerlach C, Stahmer I, Kloth S, Brandt E, Flad HD: Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol 1991, 138:867-873
26. Kindblom LG, Lodding P, Rosengren L, Baudier J, Haglid K: S-100 protein in melanocytic tumors. Acta Pathol Microbiol Immunol Scand A 1984, 92:219-230
27. Stetler-Stevenson WG, Aznavoorian S, Liotta LA: Tumor cell interactions with extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993, 9:541-543
28. Nicolson GL: Molecular mechanisms of cancer metastasis: tumor and host properties and the role of oncogenes and suppressor genes. Curr Opin Oncol 1991, 3:75-92
29. Liotta LA, Stetler-Stevenson WG: Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 1991, 51:5054s-5059s
30. Fidler IJ, Gersten DM, Riggs CW: Relationship of host immune status to tumor cell arrest, distribution, and survival in experimental metastasis. Cancer 1977, 40:46-55
31. Wheelock EF, Weinhold KJ, Levich J: The tumor dormant state. Adv Cancer Res 1981, 34:107-140
32. Hadfield G: The dormant cancer cell. Br Med J 1954, 2:607-609
33. Folkman J: The role of angiogenesis in tumor growth. Semin Cancer Biol 1992, 3:65-71
34. Holmgren L, O'Reilly MS, Folkman J: Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med 1995, 1:149-153
35. Nicolson GL: Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis. Cancer Metastasis Rev 1993, 12:325-343
36. Bates RC, Lincz LF, Burns GF: Involvement of integrins in cell survival. Cancer Metastasis Rev 1995, 14:191-203
37. Radinsky R: Modulation of tumor cell gene expression and phenotype by the organ-specific metastatic environment. Cancer Metastasis Rev 1995, 14:323-338
38. Searle PF, Young LS: Immunotherapy. II. Antigens, receptors, and costimulation. Cancer Metastasis Rev 1996, 15:329-349