Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth

Cancer Research

Volumn 61, Issue 5, 2001, Pages 1786-1790

  Karpanen, Terhi ^a   Egeblad, Mikala ^b   Karkkainen, Marika J ^a,b   Kubo, Hajime ^a   Ylä Herttuala, Seppo ^c   Alitalo, Kari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 3;

ANGIOGENESIS; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL PROLIFERATION; GENETIC TRANSFECTION; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; RECEPTOR BINDING; TUMOR GROWTH;

ANIMALS; BREAST NEOPLASMS; CELL DIVISION; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMANS; IMMUNOGLOBULINS; LYMPHATIC SYSTEM; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 0035266283     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Proteolytic processing regulates receptor specificity and activity of VEGF-C
2. Structure, expression, and receptor-binding properties of novel vascular endothelial growth factors
3. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
4. VEGF and VEGF-C: Specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane
5. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
6. Vascular endothelial growth factor C induces angiogenesis in vivo
7. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia
8. Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors
9. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
10. Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis
11. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
12. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
13. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
14. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors
15. Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors
16. Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells
17. High-frequency transformation of human repair-deficient cell lines by an Epstein-Barr virus-based cDNA expression vector
18. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
19. Cell death induced by TNF or serum starvation is independent of ErbB receptor signaling in MCF-7 breast carcinoma cells
20. Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu
21. Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis
22. Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium
23. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
24. Identification of the sentinel node in patients with breast cancer
25. Absence of functional lymphatics within a murine sarcoma: A molecular and functional evaluation
26. Oncotic pressure in solid tumors is elevated
27. The prognostic value of lymphatic and blood vessel invasion in operable breast cancer
28. Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes