SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 24, 2001, Pages 13681-13686

  Bennett, B L ^a   Sasaki, D T ^a   Murray, B W ^a   O'Leary, E C ^a   Sakata, S T ^a   Xu, W ^a   Leisten, J C ^a   Motiwala, A ^a   Pierce, S ^a   Satoh, Y ^a   Bhagwat, S S ^a   Manning, A M ^a   Anderson, D W ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTHRAPYRAZOLONE DERIVATIVE; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOOXYGENASE 2; CYTOKINE; ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 2; PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER; CELL ACTIVATION; CELL CULTURE; CELL DIFFERENTIATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; INFLAMMATORY DISEASE; OSMOTIC STRESS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THYMOCYTE; ULTRAVIOLET RADIATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTHRACENES; ANTHRAQUINONES; BINDING, COMPETITIVE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; MONOCYTES; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRAZOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0035923665     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.251194298     Document Type: Article

References (41)