The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 26, 1998, Pages 15587-15591

  Wu, Xinyi ^a   Senechal, Kristen ^a   Neshat, Mehran S ^a   Whang, Young E ^a,b   Sawyers, Charles L ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTATE SPECIFIC ANTIGEN; RNA;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN PHOSPHORYLATION; RAT; RNA TRANSLATION; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MICE; MICE, SCID; PHOSPHORIC MONOESTER HYDROLASES; POLYMERASE CHAIN REACTION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEINS;

EID: 0032431032     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.26.15587     Document Type: Article

References (53)

1. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) Science 275, 1943-1947.
2. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., et al. (1997) Nat. Genet. 15, 356-362.
3. Teng, D. H.-F., Hu, R., Lin, H., Davis, T., Iliev, D., Frye, C., Swedlund, B., Hansen, K. L., Vinson, V. L., Gumpper, K. L., et al. (1998) Cancer Res. 57, 5221-5225.
4. Whang, Y. E., Wu, X., Suzuki, H., Reiter, R., Tran, C., Vessella, R. L., Said, J. W., Isaacs, W. B. & Sawyers, C. L. (1998) Proc. Natl. Acad. Sci. USA 95, 5246-5250.
5. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., et al. (1997) Nat. Genet. 16, 64-67.
6. Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J. & Eng, C. (1997) Nat. Genet. 16, 333-334.
7. Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandoifi, P. P. (1998) Nat. Genet. 1998, 348-355.
8. Furnari, F. B., Lin, H., Huang, H. J. & Cavenee, W. K. (1997) Proc. Natl. Acad. Sci. USA 94, 12479-12484.
9. Tamura, M., Gu, J., Matsumoto, K., Aota, S.-I., Parsons, R. & Yamada, K. M. (1998) Science 280, 1614-1617.
10. Li, D. M. & Sun, H. (1997) Cancer Res. 57, 2124-2129.
11. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. & Tonks, N. K. (1997) Proc. Natl. Acad. Sci. USA 94, 9052-9057.
12. Maehama, T. & Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378.
13. Klingmuller, U., Lorenz, U., Cantley, L. C., Neel, B. G. & Lodish, H. F. (1995) Cell 80, 729-738.
14. Tonks, N. K. & Neel, B. G. (1996) Cell 87, 365-368.
15. Tonks, N. K. (1996) Adv. Pharmacol. 36, 91-119.
16. Zhou, S. & Cantley, L. C. (1995) Trends Biochem. Sci. 20, 470-475.
17. Weiss, A. & Schlessinger, J. (1998) Cell 94, 277-280.
18. Sun, H. & Tonks, N. K. (1994) Trends Biochem. Sci. 19, 480-485.
19. Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., et al. (1997) Curr. Biol. 7, 776-789.
20. Alessi, D. R., Kozlowski, M. T., Weng, Q.-P., Morrice, N. & Avruch, J. (1997) Curr. Biol. 8, 69-81.
21. Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A. & Thomas, G. (1998) Science 279, 707-710.
22. Downward, J. (1998) Science 279, 673-674.
23. Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S., Stokoe, D., McCormick, F., Feng, J. & Tsichlis, P. (1998) Oncogene 17, 313-325.
24. Datta, K., Bellacosa, A., Chan, T. O. & Tsichlis, P. N. (1996) J. Biol. Chem. 271, 30835-30839.
25. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R. & Tsichlis, P. N. (1995) Cell 81, 727-736.
26. Datta, K., Franke, T. F., Chan, T. O., Makris, A., Yang, S. I., Kaplan, D. R., Morrison, D. K., Golemis, E. A. & Tsichlis, P. N. (1995) Mol. Cell. Biol. 15, 2304-2310.
27. Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N. & Hay, N. (1997) Genes Dev. 11, 701-713.
28. Ahmed, N. N., Grimes, H. L., Bellacosa, A., Chan, T. O. & Tsichlis, P. N. (1997) Proc. Natl. Acad. Sci. USA 94, 3627-3632.
29. Marte, B. M. & Downward, J. (1997) Trends Biochem. Sci. 22, 355-358.
30. Vanhaesebroeck, B., Stein, R. C. & Waterfield, M. D. (1996) Cancer Surv. 27, 249-270.
31. Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D. R. & Franke, T. F. (1997) Proc. Natl. Acad. Sci. USA 94, 11345-11350.
32. Downward, J. (1998) Curr. Opin. Cell. Biol. 10, 262-267.
33. Muller, A. J., Pendergast, A. M., Havlik, M. H., Puil, L., Pawson, T. & Witte, O. N. (1992) Mol. Cell. Biol. 12, 5087-5093.
34. Gingras, A. C., Kennedy, S. G., O'Leary, M. A., Sonenberg, N. & Hay, N. (1998) Genes Dev. 12, 502-513.
35. Pang, S., Taneja, S., Dardashti, K., Cohan, P., Kaboo, R., Sokoloff, M., Tso, C. L., Dekernion, J. B. & Belldegrun, A. S. (1995) Hum. Gene Ther. 6, 1417-1426.
36. Matthews, R. J., Bowne, D. B., Flores, E. & Thomas, M. L. (1992) Mol. Cell. Biol. 12, 2396-2405.
37. Rodriguez-Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A. & Downward, J. (1997) Cell 89, 457-467.
38. del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R. & Nunez, G. (1997) Science 278, 687-689.
39. Horoszewicz, J. S., Eeong, S. S., Kawinski, E., Karr, J. P., Rosenthal, H., Chu, T. M., Mirand, E. A. & Murphy, G. P. (1983) Cancer Res. 43, 1809-1818.
40. Senechal, K., Heany, C., Druker, B. & Sawyers, C. L. (1998) Mol. Cell. Biol. 18, 5082-5090.
41. Raitano, A. B., Halpern, J. R., Hambuch, T. M. & Sawyers, C. L. (1995) Proc. Natl. Acad. Sci. USA 92, 11746-11750.
42. Marshall, C. J. (1995) Cell 80, 179-185.
43. Rousseau, D., Kaspar, R., Rosenwald, I., Gehrke, L. & Sonenberg, N. (1996) Proc. Natl. Acad. Sci. USA 93, 1065-1070.
44. Sonenberg, N. (1996) in Translational Control (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 245-269.
45. Peterson, R. T. & Schreiber, S. L. (1998) Curr. Biol. 8, R248-R250.
46. Cichy, S. B., Uddin, S., Danilkovich, A., Guo, S., Klippel, A. & Unterman, T. G. (1998) J. Biol. Chem. 273, 6482-6487.
47. Mazure, N. M., Chen, E. Y., Laderoute, K. R. & Giaccia, A. J. (1997) Blood 90, 3322-3331.
48. Skorski, T., Bellacosa, A., Nieborowska-Skorska, N., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., et al. (1997) EMBO J. 16, 6151-6161.
49. Paradis, S. & Ruvkun, G. (1998) Genes Dev. 12, 2488-2498.
50. Staal, S. P. (1987) Proc. Natl. Acad. Sci. USA 84, 5034-5037.
51. Jimenez, C., Jones, D. R., Rodriguez-Viciana, P., Gonzalez-Garcia, A., Leonardo, E., Wennstrom, S., von Kobbe, C., Toran, J. L., R-Borlado, L., Calvo, V., et al. (1998) EMBO J. 17, 743-753.
52. Bellacosa, A., Testa, J. R., Staal, S. P. & Tsichlis, P. N. (1991) Science 254, 274-277.
53. Chang, H. W., Aoki, M., Fruman, D., Auger, K. R., Bellacosa, A., Tsichlis, P. N., Cantley, L. C., Roberts, T. M. & Vogt, P. K. (1997) Science 276, 1848-1850.