Polycystin-1, the PKD1 gene product, is in a complex containing E- cadherin and the catenins

Journal of Clinical Investigation

Volumn 104, Issue 10, 1999, Pages 1459-1468

  Huan, Yonghong ^a   Van Adelsberg, Janet ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; CELL ADHESION MOLECULE; GENE PRODUCT; POLYCYSTIN; UVOMORULIN;

ARTICLE; CELL POLARITY; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0032744937     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5111     Document Type: Article

References (70)

1. Gabow, P.A. 1993. Autosomal dominant polycystic kidney disease. N. Engl. J. Med. 329:332-342.
2. European Polycystic Kidney Disease Consortium. 1994. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. Cell. 77:881-894.
3. American PKD1 Consortium. 1995. Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease gene predicts the presence of a leucine-rich repeat. Hum. Mol. Genet. 4:575-582.
4. International Polycystic Kidney Disease Consortium. 1995. Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. Cell. 81:289-298.
5. Hughes, J., et al. 1995. The polycystic kidney disease 1 gene encodes a novel protein with multiple cell recognition domains. Nat. Genet. 10:151-159.
6. Ariza, M., et al. 1997. A family with a milder form of adult dominant polycystic kidney disease not linked to the PKD1 (16p) or PKD2 (4q) genes. J. Med. Genet. 14:587-589.
7. Daoust, M.C., Reynolds, D.M., Bichet, D.G., and Somlo, S. 1995. Evidence for a third genetic locus for autosomal dominant polycystic kidney disease. Genomics, 25:733-736.
8. de Almeida, S., et al. 1995. Autosomal dominant polycystic kidney disease: evidence for the existence of a third locus in a Portuguese family. Hum. Genet. 96:83-88.
9. Turco, A.E., Clementi, M., Rossetti, S., Tenconi, R., and Pignatti, P.F. 1996. An Italian family with autosomal dominant polycystic kidney disease unlinked to either the PKD1 or PKD2 gene. Am. J. Kidney Dis. 28:759-761.
10. Qian, F., et al. 1997. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat. Genet. 16:179-183.
11. Tsiokas, L., Kim, E., Arnould, T., Sukhatme, V.P., and Walz, G. 1997. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc. Natl. Acad. Sci. USA. 94:6965-6970.
12. van Adelsberg, J.S., Chamberlain, S., and D'Agati, V. 1997. Polycystin expression is temporally and spatially regulated during renal development. Am. J. Physiol. 272:F602-F609.
13. Palsson, R., et al. 1996. Immunolocalization of PKD1 in normal kidneys. Mol. Med. 2:702-711.
14. Ibraghimov-Beskrovnaya, O., et al. 1997. Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein. Proc. Natl. Acad. Sci. USA. 94:6397-6402.
15. Ong, A.C., Ward, C.J., Biddolph, S., Migone, N., and Harris, P.C. 1997. Polycystin expression in PKD1, infantile PKD1, and TSC-2/PKD1 cystic kidney: evidence against a two-hit disease mechanism in cyst initiation. J. Am. Soc. Nephrol. 8:378A. (Abstr.)
16. Griffin, M.D., et al. 1997. Expression of polycystin in mouse metanephros and extra-metanephric tissues. Kidney Int. 52:1196-1205.
17. Geng, L., et al. 1996. Identification and localization of polycystin, the PKD1 gene product. J. Clin. Invest. 98:2674-2682.
18. Nelson, W.J. 1993. Regulation of cell surface polarity in renal epithelia. Pediatr. Nephrol. 7:599-604.
19. Gumbiner, B.M., and McCrea, P.D. 1993. Catenins as mediators of the cytoplasmic functions of cadherins. J. Cell Sci. Suppl. 17:155-158.
20. Aberle, H., Schwartz, H., and Kemler, R. 1996. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell Biochem. 61:514-523.
21. Gumbiner, B. 1995. Signal transduction by β-catenin. Curr. Opin. Cell Biol. 7:634-640.
22. Barth, A.I., Nathke, I.S., and Nelson, W.J. 1997. Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr. Opin. Cell Biol. 9:683-690.
23. Grantham, J.J. 1990. Polycystic kidney disease: neoplasia in disguise. Am. J. Kidney Dis. 15:110-116.
24. Nelson, W.J., Shore, E.M., Wang, A.Z., and Hammerton, R.W. 1990. Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin (E-cadherin), ankyrin, and fodrin in MadinDarby canine kidney epithelial cells. J. Cell Biol. 110:349-357.
25. McNeill, H., Ozawa, M., Kemler, R., and Nelson, W.J. 1990. Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell. 62:309-316.
26. Graeve, L., Drickamer, K., and Rodriguez-Boulan, E. 1989. Polarized endocytosis by Madin-Darby canine kidney cells transfected with functional chicken liver glycoprotein receptor. J. Cell Biol. 109:2809-2816.
27. Devarajan, P., Scaramuzzino, D.A., and Morrow, J.S. 1994. Ankyrin binds to two distinct cytoplasmic domains of Na,K-ATPase alpha subunit. Proc. Natl. Acad. Sci. USA. 91:2965-2969.
28. Alejandro, V.S., et al. 1995. Postischemic injury, delayed function and Na+/K(+)-ATPase distribution in the transplanted kidney. Kidney Int. 48:1308-1315.
29. Molitoris, B.A., Geerdes, A.M., and McIntosh, J.R. 1991. Dissociation and redistribution of Na+,K(+)-ATPase from its surface membrane actin cytoskeletal complex during cellular ATP depletion. J Clin. Invest. 88:462-469.
30. Wilson, P.D., et al. 1991. Reversed polarity of Na(+)-K(+)-ATPase: mislocation to apical plasma membranes in polycystic kidney disease epithelia. Am J. Physiol. 260:F420-F430.
31. Brill, S.R., et al. 1996. Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney disease. Proc. Natl. Acad. Sci. USA. 93:10206-10211.
32. Carone, F.A., et al. 1994. Cell polarity in human renal cystic disease. Lab. Invest. 70:648-655.
33. Ozawa, M., and Kemler, R. 1992. Molecular organization of the uvomorulin-catenin complex. J. Cell Biol. 115:989-996.
34. Jou, T.S., Stewart, D.B., Stappert, J., Nelson, W.J., and Marrs, J.A. 1995. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc. Natl. Acad. Sci. USA. 92:5067-5071.
35. van Adelsberg, J.S. 1999. The role of the polycystins in kidney development. Pediatr. Nephrol. 13:454-459.
36. Lu, W., et al. 1997. Perinatal lethality with kidney and pancreas defects in mice with a targeted Pkd1 mutation. Nat. Genet. 17:179-181.
37. van Adelsberg, J.S. 1994. Murine polycystic kidney epithelial cell lines have increased integrin-mediated adhesion to collagen. Am. J. Physiol. 276:F1082-F1093.
38. Bullions, L.C., and Levine, A.J. 1998. The role of beta-catenin in cell adhesion, signal transduction, and cancer. Curr. Opin. Oncol. 10:81-87.
39. Marrs, J.A., et al. 1995. Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules. J. Cell Biol. 129:507-519.
40. Lewis, J.E., et al. 1997. Cross-talk between adherens junctions and desmosomes depends on plakoglobin. J. Cell Biol. 136:919-934.
41. Qian, F., Germino, J., Zhang, F., and Germino, G. 1997. Putative binding partners of polycystin. J. Am. Soc. Nephrol. 8:380A. (Abstr.)
42. Maeda, Y., et al. 1997. Identification of potential binding proteins for PKD2. J. Am. Soc. Nephrol. 8:376A. (Abstr.)
43. Kim, E., Arnould, T., and Walz, G. 1997. Isolation of polycystin-interacting proteins. J. Am. Soc. Nephrol. 8:375A. (Abstr.)
44. Kim, E., et al. 1999. Interaction between RGS7 and polycystin. Proc. Natl. Acad. Sci. USA. 96:6371-6376.
45. Kim, K., Sharma, C.P., and Arnaout, M.A. 1997. An interaction of 14-3-3 adapter proteins with polycystin. J. Am. Soc. Nephrol. 8:375A. (Abstr.)
46. Hinck, L., Näthke, I.S., Papkoff, J., and Nelson, W.J. 1994. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J. Cell Biol. 125:1327-1340.
47. Näthke, I.S., Hinck, L., Swedlow, J.R., Papkoff, J., and Nelson, W.J. 1994. Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells. J. Cell Biol. 125:1341-1352.
48. Larue, L., Ohsugi, M., Hirchenhain, J., and Kemler, R. 1994. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc. Natl. Acad. Sci. USA. 91:8263-8267.
49. Riethmacher, D., Brinkmann, V., and Birchmeier, C. 1995. A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc. Natl. Acad. Sci. USA. 92:855-859.
50. Levine, E., Lee, C.H., Kintner, C., and Gumbiner, B.M. 1994. Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant. Development. 120:901-909.
51. Haegel, H., et al. 1995. Lack of beta-catenin affects mouse development at gastrulation. Development. 121:3529-3537.
52. Kopito, R.R. 1999. Biosynthesis and degradation of CFTR. Physiol. Rev. 79:S167-S173.
53. +,K(+)-ATPase. J. Biol. Chem. 270:29971-29975.
54. McCrea, P.D., Turck, C.W., and Gumbiner, B.M. 1991. A homolog of the armadillo protein in Drosophila (plakoglobin) associated wich E-cadherin. Science. 254:1359-1361.
55. Hirano, S., Kimoto, N., Shimoyama, Y., Hirohashi, S., and Takechi, M. 1992. Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization. Cell. 70:293-301.
56. Kim, E., et al. 1999. The polycystic kidney disease 1 gene product modulates Wnt signaling. J. Biol. Chem. 274:4947-4953.
57. Cowley, B.D., Jr., Smardo, F.L., Jr., Grantham, J.J., and Calvet, J.P. 1987. Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease. Proc. Natl. Acad. Sci. USA. 84:8394-8398.
58. Klingel, et al. 1992. Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma. Am. J. Kidney Dis. 19:22-30.
59. Cowley, B.D., Jr., et al. 1993. Autosomal-dominant polycystic kidney disease in the rat. Kidney Int. 43:522-534.
60. Trudel, M., D'Agari, V.D., and Costantini, F. 1991. C-myc as an inducer of polycystic kidney disease in transgenic mice. Kidney Int. 39:665-671.
61. Sorenson, C.M. 1999. Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. Am. J. Physiol. 276:F210-F217.
62. Huber, O., et al. 1996. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1. Mech. Dev. 59:3-10.
63. Monier-Gavelle, F., and Duband, J.L. 1997. Cross talk between adhesion molecules: control of N-cadherin activity by intracellular signals elicited by beta 1 and beta3 integrins in migrating neural crest cells. J. Cell Biol. 137:1663-1681.
64. Novak, A., et al. 1998. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc. Natl. Acad. Sci. USA. 95:4374-4379.
65. Daikha-Dahmane, F., et al. 1997. Distribution of alpha-integrin subunits in fetal polycystic kidney diseases. Pediatr. Nephrol. 11:267-273.
66. Korhonen, M., Ylanne, J., Laitinen, L., and Virtanen, I. 1990. The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron. J. Cell Biol. 111:1245-1254.
67. Simon, E.E., and McDonald, J.A. 1990. Extracellular matrix receptors in the kidney cortex. Am. J. Physiol. 259:F783-F792.
68. Korhonen, M., Laitinen, L. Ylänne, J., Gould, V.E., and Virtanen, I. 1992. Integrins in developing, normal, and malignant human kidney. Kidney Int. 41:641-644.
69. Schwimmer, R., and Ojakian, G.K. 1995. The alpha 2 beta 1 integrin regulates collagen-mediated MDCK epithelial membrane remodeling and tubule formation. J. Cell Sci. 108:2487-2498.
70. Zuk, A., and Matlin, K.S. 1996. Apical beta 1 integrin in polarized MDCK cells mediates tubulocyst formation in response to type I collagen overlay. J. Cell Sci. 109:1875-1889.