Aβ42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3β signaling-dependent mechanism

Neurobiology of Aging

Volumn 24, Issue 3, 2003, Pages 437-451

  Suhara, Toshimitsu ^a   Magrané, Jordi ^a,b   Rosen, Kenneth ^a   Christensen, Rial ^a,b   Kim, Hyo Soo ^a   Zheng, Bing ^c   McPhie, Donna L ^d   Walsh, Kenneth ^a,b   Querfurth, Henry ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD UNIVERSITY   (United States)

^d MCLEAN HOSPITAL   (United States)

Author keywords

Akt pathway; Apoptosis; Cerebral congophilic amyloid angiopathy; Endothelial NOS; Herpes simplex virus; PDK 1

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CASPASE 3; NITRIC OXIDE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; AGAMMAGLOBULINAEMIA TYROSINE KINASE; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CASP3 PROTEIN, HUMAN; CASPASE; GLYCOGEN SYNTHASE KINASE; NITRIC OXIDE SYNTHASE; PEPTIDE FRAGMENT; PROTEIN TYROSINE KINASE;

ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOLOGY; CYTOTOXICITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NERVE CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN; VASOCONSTRICTION; APOPTOSIS; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; INTRACELLULAR FLUID; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SECOND MESSENGER; SIGNAL TRANSDUCTION; TRANSGENE; VASCULAR ENDOTHELIUM;

AMYLOID BETA-PROTEIN; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GLYCOGEN SYNTHASE KINASES; HUMANS; INTRACELLULAR FLUID; NITRIC OXIDE SYNTHASE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSGENES; UMBILICAL VEINS;

EID: 0037404666     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(02)00135-5     Document Type: Article

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