Role of peroxynitrite in the vasoactive and cytotoxic effects of alzheimer's β-amyloid1-40 peptide

Experimental Neurology

Volumn 152, Issue 1, 1998, Pages 116-122

  Paris, Daniel ^a   Parker, Timothy A ^a   Town, Terrence ^a   Suo, Zhiming ^a   Fang, Chunhong ^a   Humphrey, James ^a   Crawford, Fiona ^a   Mullan, Michael ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Guanylyl cyclase; MnTBAP; Oxidative stress; Peroxynitrite; Vasoactivity

Indexed keywords

AMYLOID BETA PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; GUANYLATE CYCLASE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; ANIMAL CELL; AORTA; ARTICLE; CYTOTOXICITY; ENDOTHELIUM CELL; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VASCULAR AMYLOIDOSIS;

EID: 0031869301     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6828     Document Type: Article

References (36)

1. Beckman, J. S., T. W. Becman, J. Chen, P. A. Marshall, and B. A. Freeman. 1990. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87: 1620-1624.
2. Behl, C., J. B. Davis, R. Lesley, and D. Schubert. 1994. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77: 817-827.
3. Busse, R., and A. Mulsch. 1990. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS. Lett. 275: 87-90.
4. Chabot, F., J. A. Mitchell, G. J. Quinlan, and T. W. Evans. 1997. Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: Role of poly(adenosine 5′-diphosphoribose) synthase. Br. J. Pharm. 121: 485-490.
5. Crawford, F., Z. Suo, C. Fang, A. Sawar, G. Su, G. Arendash, and M. Mullan. 1997. The vasoactivity of Aβ peptides. Ann. N.Y. Acad. Sci. 826: 35-46.
6. Day, B. J., S. Shawen, S. I. Liochev, and J. D. Crapo. 1995. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury, in vitro. J. Pharmacol. Exp. Ther. 275: 1227-1232.
7. Day, B. J., and J. D. Crapo. 1996. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury in vivo. Toxicol. Appl. Pharmacol. 140: 94-100.
8. Douglas, S. A., and E. H. Ohlstein. 1997. Signal transduction mechanisms mediating the vascular actions of endothelin. J. Vasc. Res. 34: 152-164.
9. Ehrenreich, H., and L. Schilling. New developments in the understanding of cerebral vasoregulation and vasospasm: The endothelin-nitric oxide network. Cleve. Clin. J. Med. 62: 105-116.
10. Ellis, R. J., J. M. Olichney, L. J. Thal, S. S. Mirra, J. C. Morris, D. Beekly, and A. Heyman. 1996. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV. Neurology 46: 1592-1596.
11. Famulari, A. L., E. R. Marschoff, S. F. Llesuy, S. Kohan, J. A. Serra, R. O. Dominguez, M. Repetto, C. Reides, and E. Sacerdote de Lustig. 1996. The antioxidant enzymatic blood profile in Alzheimer's and vascular diseases. Their association and a possible assay to differentiate demented subjects and controls. J. Neurol. Sci. 141: 69-78.
12. Freeman, B. A., C. R. White, H. Gutierrez, A. Parler-Martinez, M. M. Tarpey, and H. Rubbo. 1995. Oxygen radical-nitric oxide reactions in vascular diseases. Adv. Pharmacol. 34: 45-69.
13. Good, P. F., P. Werner, A. Hsu, C. W. Olanow, and D. P. Perl. 1996. Evidence of neuronal oxidative damage in Alzheimer's disease. Am. J. Pathol. 149: 21-28.
14. Gsell, W., R. Conrad, M. Hickethier, E. Sofic, L. Frolich, I. Wichart, K. Jellinger, G. Moll, G. Ransmayr, and H. Beckmann. 1995. Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type. J. Neurochem. 64: 1216-1223.
15. Guo, Z., M. Viitanen, L. Fratiglioni, and B. Winblad. 1997. Blood pressure and dementia in the elderly: Epidemiologic perspectives. Biomed. Pharmacother. 51: 68-73.
16. Hubel, C. A., S. T. Davidge, and M. K. McLaughlin. 1993. Lipid hydroperoxides potentiate mesenteric artery vasoconstrictor responses. Free. Rad. Biol. Med. 14: 397-407.
17. Kooy, N. W., J. A. Royall, Y. Z. Ye, D. R. Kelly, and J. S. Bekman. 1995. Evidence for in vivo peroxynitrite in human acute lung injury. Am. J. Respir. Crit. Care. Med. 151: 1250-1254.
18. Lis, C. G., and M. Gaviria. 1997. Vascular dementia, hypertension, and the brain. Neurol. Res. 19: 471-480.
19. Liu, S., J. S. Bekman, and D. D. Ku. 1994. Peroxynitrite, a product of superoxide and nitric oxide, produces coronary vasorelaxation in dogs. J. Pharmacol. Exp. Ther. 268: 1114-1121.
20. Lovell, M. A., W. D. Ehmann, S. M. Butler, and W. R. Markesbery. 1995. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology Aug. 45: 1594-1601.
21. Markesbery, W. R. 1997. Oxidative stress hypothesis in Alzheimer's disease. Free. Rad. Biol. Med. 23: 134-147.
22. Mattson, M. P., Y. Goodman, H. Luo, W. Fu, and K Furukawa. 1997. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 15: 681-697.
23. Moncada, S., R. M. J. Palmer, and E. A. Higgs. 1991. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-141.
24. Radi, R., M. Rodriguez, L. Castro, and R. Telleri. 1994. Inhibition of mitochondrial electron transport by peroxynitrite. Arch. Biochem. Biophys. 308: 89-95.
25. Shearman, M. S., C. I. Ragan, and L. L. Iversen. 1994. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proc. Natl. Acad. Sci. USA 91: 1470-1474.
26. Smith, M. A., P. L. Richey, Harris, L. M. Sayre, J. S. Beckman, and G. Perry. 1997. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17: 2653-2657.
27. Sparks, D. L. 1997. Coronary artery disease, hypertension, ApoE, and cholesterol: A link to Alzheimer's disease? Ann. N.Y. Acad. Sci. 826: 128-146.
28. Suo, Z., C. Fang, F. Crawford, and M. Mullan. 1997. Superoxide free radical and intracellular calcium mediate Abeta(1-42) induced endothelial toxicity. Brain Res. 762: 144-152.
29. Suo, Z., F. Crawford, C. Fang, D. Paris, T. Parker, A. Gauntlett, J. Humphrey, and M. Mullan. A spin trapping agent Phenyl N-Tert-Butyl Nitrone blocks both Aβ cytotoxicity and vasoactivity. (Submitted).
30. Szabo, C., B. J. Day, and A. L. Salzman. 1996. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett. 381: 82-86.
31. Thomas, T., G. Thomas, C. McLendon, T. Sutton, and M. Mullan. 1996. B-amyloid mediated vasoactivity and vascular endothelial damage. Nature. 380: 168-171.
32. Thomas, T., C. McLendon, A. Tugertimur, and K. Thomas. 1998. Amyloid β-peptides Aβ 1-40 and Aβ 1-42 induce cerebrovascular endothelial dysfunction. Alzheimer's Reports 1: 17-24.
33. Thome, J., W. Gsell, M. Rosler, J. Kornhuber, L. Frolich, E. Hashimoto, B. Zielke, G. A. Wiesbeck, and P. Riederer. 1997. Oxydative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease. Life Sci. 60: 13-19.
34. Villa, L. M., E. Salas, V. M. Darley-Usmar, M. Radomski, and S. Moncada. 1994. Peroxynitrite induces both vasodilatation and impaired relaxation in the isolated perfused heart. Proc. Natl. Acad. Sci. USA 91: 12383-12387.
35. Wu, M., K. A. J. Pritchard, P. M. Kaminski, R. J. Fayngersh, T. H. Hintze, and M. S. Wolin. 1994. Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries by peroxynitrite. Am. J. Physiol. 266: H2108-2113.
36. Zingarelli, B., B. J. Day, J. D. Crapo, A. L. Salzman, and C. Szabo. 1997. The potential role of peroxynitrite in the vascular contractile and energetic failure in endotoxic shock. Br. J. Pharmacol. 120: 259-267.