Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls

Brain Research

Volumn 828, Issue 1-2, 1999, Pages 179-183

  Natté, Remco ^a   De Boer, Willem I ^a   Maat Schieman, Marion L C ^a   Baelde, Hans J ^a   Vinters, Harry V ^a,b   Roos, Raymund A C ^a   Van Duinen, Sjoerd G ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Cerebral amyloid angiopathy; HCHWA D; In situ hybridization

Indexed keywords

AMYLOID BETA PROTEIN; MESSENGER RNA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BLOOD VESSEL WALL; BRAIN BLOOD VESSEL; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; VASCULAR AMYLOIDOSIS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL ANGIOGRAPHY; CEREBRAL ARTERIES; CEREBRAL HEMORRHAGE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; MIDDLE AGED; RNA, MESSENGER;

EID: 0033562856     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01361-X     Document Type: Article

References (20)

1. Castillo G.M., Ngo C.T., Cummings J., Wight T.N., Snow A.D. Perlecan binds to the β-amyloid proteins (Aβ) of Alzheimer's disease, accelerates Aβ fibril formation, and maintains Aβ fibril stability. J. Neurochem. 69:1997;2452-2465.
2. Goedert M. Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease. EMBO J. 6:1987;3627-3632.
3. Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B., Selkoe D.J. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 359:1992;322-325.
4. Hamano T., Yoshimura M., Yamazaki T., Shinkai Y., Yanagisawa K., Kuriyama M., Ihara Y. Amyloid β-protein (Aβ) accumulation in the leptomeninges during aging and in Alzheimer disease. J. Neuropathol. Exp. Neurol. 56:1997;922-932.
5. Levy E., Carman M.D., Fernandez Madrid I.J., Power M.D., Lieberburg I., van Duinen S.G., Bots G.T.A.M., Luyendijk W., Frangione B. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science. 248:1990;1124-1126.
6. Maat-Schieman M.L.C., van Duinen S.G., Bornebroek M., Haan J., Roos R.A.C. Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): II. A review of histopathological aspects. Brain Pathol. 6:1996;115-120.
7. Maggio J.E., Stimson E.R., Ghilardi J.R., Ellen C.J., Dahl C.E., Whitcomb D.C., Vigna S.R., Vinters H.V., Labenski M.E., Mantyh P.W. Reversible in vitro growth of Alzheimer disease β-amyloid plaques by deposition of labeled amyloid peptide. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5462-5466.
8. Mita S., Schon E.A., Herbert J. Widespread expression of amyloid beta-protein precursor gene in rat brain. Am. J. Pathol. 134:1989;1253-1261.
9. Neve R.L., Finch E.A., Dawes L.R. Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron. 1:1988;669-677.
10. van Nostrand W.E., Rozemuller A.J.M., Chung R., Cotman C.W., Saporito-Irwin S.M. Amyloid β-protein precursor in cultured leptomeningeal smooth muscles. Amyloid Int. J. Clin. Exp. Invest. 1:1994;1-7.
11. Schmechel D.E., Goldgaber D., Burkhart D.S., Gilbert J.R., Gajdusek D.C., Roses A.D. Cellular localization of messenger RNA encoding amyloid-beta-protein in normal tissue and in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 2:1988;96-111.
12. Shoji M., Hirai S., Harigaya Y., Kawarabayashi T., Yamaguchi H. The amyloid beta-protein precursor is localized in smooth muscle cells of leptomeningeal vessels. Brain Res. 530:1990;113-116.
13. Takahashi R.H., Sawa H., Takada A., Kitabatake A., Nagashima K. Expression of amyloid precursor protein mRNA in vascular smooth muscle cells of the human brain. Neuropathology. 17:1997;11-14.
14. Tanzi R.E., Wenniger J.J., Hyman B.T. Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Res. Mol. Brain. Res. 18:1993;246-252.
15. Urmoneit B., Prikulis I., Wihl G., D'Urso D., Frank R., Heeren J., Beisiegel U., Prior R. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy. Lab. Invest. 77:1997;157-166.
16. Verbeek M.M., de Waal R.M.W., Schipper J.J., van Nostrand W.E. Rapid degeneration of cultured human brain pericytes by amyloid β protein. J. Neurochem. 68:1997;1135-1141.
17. Vinters H.V., Wang Z.Z., Secor D.L. Brain parenchymal and microvascular amyloid in Alzheimer's disease. Brain Pathol. 6:1996;179-195.
18. Vinters H.V. Cerebral amyloid angiopathy. A critical review. Stroke. 18:1987;311-324.
19. Weller R.O., Massey A., Newman T.A., Hutchings M., Kuo Y.-M., Roher A.E. Cerebral amyloid angiopathy Amyloid β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am. J. Pathol. 153:1998;725-733.
20. Zlokovic B.V., Ghiso J., Mackic J.B., McComb J.G., Weiss M.H., Frangione B. Blood-brain barrier transport of circulating Alzheimer's amyloid β Biochem. Biophys. Res. Comm. 197:1993;1034-1040.