Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

EMBO Journal

Volumn 16, Issue 6, 1997, Pages 1391-1400

  Komarova, Elena A ^a   Chernov, Mikhail V ^b   Franks, Roberta ^a   Wang, Kaihua ^a   Armin, Gabriella ^a   Zelnick, Carolyn R ^c   Chin, Dot M ^c   Bacus, Sarah S ^c   Stark, George R ^b   Gudkov, Andrei V ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c Advanced Cellular Diagnostics Inc   (United States)

Author keywords

galactosidase; Apoptosis; Development; Radiation; Transgene

Indexed keywords

DOXORUBICIN; MESSENGER RNA; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DRUG SENSITIVITY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GAMMA RADIATION; GENE EXPRESSION; MALE; MOUSE; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; RADIOSENSITIVITY; REPORTER GENE; SMALL INTESTINE; SPLEEN; THYMUS; TRANSGENE;

3T3 CELLS; ANIMALS; APOPTOSIS; BASE SEQUENCE; DNA DAMAGE; DNA PRIMERS; DOXORUBICIN; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, P53; GENES, REPORTER; LAC OPERON; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PREGNANCY; RADIATION TOLERANCE; RNA, MESSENGER; TISSUE DISTRIBUTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS;

EID: 0031003552     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.6.1391     Document Type: Article

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