p53 regulation of DNA excision repair pathways

Mutagenesis

Volumn 17, Issue 2, 2002, Pages 149-156

  Smith, Martin L ^a,b   Seo, Young R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; PROTEIN P53;

APOPTOSIS; CANCER; CANCER CHEMOTHERAPY; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DRUG TARGETING; EMBRYO; EXCISION REPAIR; GENE MUTATION; HUMAN; MOUSE; MUTAGENESIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; ULTRAVIOLET RADIATION;

EID: 0036121363     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/17.2.149     Document Type: Review

References (77)

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8. Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest
9. Characterization of defective nucleotide excision repair in XPC mutant mice
10. The tumor suppressor candidate p33(Ing1) mediates repair of UV-damaged DNA
11. p53-dependent signalling sustains DNA replication and enhances clonogenic survival in 254 nm ultraviolet-irradiated human fibroblasts
12. The presence of wild-type p53 is necessary for the radioprotective effect of the Bowman Birk proteinase inhibitor in normal fibroblasts
13. The radioprotective effect of BBI is associated with the activation of DNA repair-relevant genes
14. P63alpha and deltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
15. Definition of a consensus binding site for p53
16. P53 degradation by HPV16-E6 preferentially affects the removal of cyclobutane pyrimidine dimers from non-transcribed strand and sensitizes mammary epithelial cells to UV-irradiation
17. Modulation of cisplatinum cytotoxicity by p53: Effect of p53-mediated apoptosis and DNA repair
18. Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard
19. Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV-resistance
20. Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts
21. Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to UV-irradiation
22. DNA Repair and Mutagenesis
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27. P53 inactivation by HPV16-E6 results in increased mutagenesis in human cells
28. Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents
29. XPD exon 10 and 23 polymorphisms and DNA repair in human skin in situ
30. P53 affects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells
31. DMBA carcinogenesis in gadd45-null mice is associated with decreased DNA repair and increased mutation frequency
32. Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity
33. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromotosis: Oxyradical overload disease
34. Expression of the p48xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair
35. DNA repair activity of 8-oxoguanine DNA glycosylase (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser(326)/Cys(326)
36. BRCA1 activation of the GADD45 promoter
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38. A mammalian cell cycle checkpoint pathway utilizing p53 and Gadd45 is defective in ataxia telangiectasia
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41. Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations
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43. P53-dependent DNA repair and apoptosis respond differently to high and low-dose ultraviolet radiation
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45. P53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells
46. A common polymorphism acts as an intragenic modifier of mutant p53 behavior
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50. Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light
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63. P21(waf1/cip1)-null human fibroblasts are deficient in nucleotide excision repair downstream of the recruitment of PCNA to repair sites
64. Mammalian base excision repair by DNA polymerases delta and epsilon
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66. P53 tagged sites from human genomic DNA
67. P73a overexpression is associated with resistance to treatment with DNA-damaging agents in a human ovarian cancer cell line
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71. Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N′-bis(2-chloroethyl)-N-nitrosourea and mafosfamide using the DNA Implications for protective gene therapy applications
72. P53 contains a DNA break-binding motif similar to the functional part of BRCT-related region of Rb
73. Induction of p53 in mouse cells decreases mutagenesis by UV-radiation
74. Induction of cellular p53 activity by DNA-damaging agents and growth arrest
75. Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation
76. A role for p53 in base excision repair
77. Decreased DNA repair efficiency by loss or disruption of p53 function preferentially affects removal of cyclobutane pyrimidine dimers from the non-transcribed strand and slow repair sites in transcribed strand