The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans

Oncogene

Volumn 21, Issue 58 REV. ISS. 8, 2002, Pages 8994-9007

  Moynahan, Mary Ellen ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

BRCA1; BRCA2; Genetic instability; Tumor suppression

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; HORMONE RECEPTOR; PROTEIN P53;

ALLELE; ANIMAL MODEL; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GRADING; CANCER INHIBITION; FAMILIAL CANCER; FEMALE; GENE DELETION; GENE MUTATION; GENETIC STABILITY; HUMAN; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; ONCOGENE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW;

ANIMALS; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; DISEASE MODELS, ANIMAL; FETAL DEATH; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MUTATION; NEOPLASMS, EXPERIMENTAL; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0037115915     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206177     Document Type: Review

References (77)

1. Baer R and Ludwig T. (2002). Curr. Opin. Genet. Dev., 12, 86 - 91.
2. Basham VM, Lipscombe JM, Ward JM, Gayther SA, Ponder BA, Easton DF and Pharoah PD. (2002). Breast Cancer Res., 4, R2.
3. Breast Cancer Linkage Consortium. (1999). J. Natl. Cancer Inst., 91, 1310 - 1316.
4. Begg CB. (2002). J. Natl. Cancer Inst., 94, 1221 - 1226.
5. Bennett LM, McAllister KA, Blackshear PE, Malphurs J, Goulding G, Collins NK, Ward T, Bunch DO, Eddy EM, Davis BJ and Wiseman RW. (2000a). Mol. Carcinog., 28, 174 - 183.
6. Bennett LM, McAllister KA, Malphurs J, Ward T, Collins NK, Seely JC, Gowen LC, Koller BH, Davis BJ and Wiseman RW. (2000b). Cancer Res., 60, 3461 - 3469.
7. Bennett LM, McAllister KA, Ward T, Malphurs J, Collins NK, Seely JC, Davis BJ and Wiseman RW. (2001). Toxicol. Pathol., 29, 117 - 125.
8. Brodie SG, Xu X, Qiao W, Li WM, Cao L and Deng CX. (2001). Oncogene, 20, 7514 - 7523.
9. Brose MS, Rebbeck TR, Calzone KA, Stopfer JE, Nathanson KL and Weber BL. (2002). J. Natl. Cancer Inst., 94, 1365 - 1372.
10. Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM and Scully R. (1998). Mol. Cell, 2, 317 - 328.
11. Connor F, Bertwistle D, Mee PJ, Ross GM, Swift S, Grigorieva E, Tybulewicz VL and Ashworth A. (1997). Nat. Genet., 17, 423 - 430.
12. Cortez D, Wang Y, Qin J and Elledge SJ. (1999). Science, 286, 1162 - 1166.
13. Cressman VL, Backlund DC, Avrutskaya AV, Leadon SA, Godfrey V and Koller BH. (1999a). Mol. Cell. Biol., 19, 7061 - 7075.
14. Cressman VL, Backlund DC, Hicks EM, Gowen LC, Godfrey V and Koller BH. (1999b). Cell Growth Differ., 10, 1 - 10.
15. Crook T, Brooks LA, Crossland S, Osin P, Barker KT, Waller J, Philp E, Smith PD, Yulug I, Peto J, Parker G, Allday MJ, Crompton MR and Gusterson BA. (1998). Oncogene, 17, 1681 - 1689.
16. Davies AA, Masson JY, McIlwraith MJ, Stasiak AZ, Stasiak A, Venkitaraman AR and West SC. (2001). Mol. Cell, 7, 273 - 282.
17. Deng CX. (2002). Oncogene, 21, 6222 - 6227.
18. Deng CX and Brodie SG. (2001). Semin. Cancer Biol., 11, 387 - 394.
19. Easton DF, Bishop DT, Ford D and Crockford GP. (1993). Am. J. Hum. Genet., 52, 678 - 701.
20. Frank TS, Deffenbaugh AM, Reid JE, Hulick M, Ward BE, Lingenfelter B, Gumpper KL, Scholl T, Tavtigian SV, Pruss DR and Critchfield GC. (2002). J. Clin. Oncol., 20, 1480 - 1490.
21. Friedman LS, Thistlethwaite FC, Patel KJ, Yu VP, Lee H, Venkitaraman AR, Abel KJ, Carlton MB, Hunter SM, Colledge WH, Evans MJ and Ponder BA. (1998). Cancer Res., 58, 1338 - 1343.
22. Gowen LC, Johnson BL, Latour AM, Sulik KK and Koller BH. (1996). Nat. Genet., 12, 191 - 194.
23. Greenblatt MS, Chappuis PO, Bond JP, Hamel N and Foulkes WD. (2001). Cancer Res., 61, 4092 - 4097.
24. Gruber SB and Petersen GM. (2002). J. Natl. Cancer Inst., 94, 1344 - 1345.
25. Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J and Mak TW. (1996). Cell, 85, 1009 - 1023.
26. Hakem R and Mak TW. (2001). Annu. Rev. Genet., 35, 209 - 241.
27. Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B and King MC. (1990). Science, 250, 1684 - 1689.
28. Hedenfalk I, Duggan D, Chen Y, Radmacher M, Bittner M, Simon R, Meltzer P, Gusterson B, Esteller M, Kallioniemi OP, Wilfond B, Borg A and Trent J. (2001). N. Engl. J. Med., 344, 539 - 548.
29. Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P and Fodde R. (2001). Oncogene, 20, 2544 - 2550.
30. Janocko LE, Brown KA, Smith CA, Gu LP, Pollice AA, Singh SG, Julian T, Wolmark N, Sweeney L, Silverman JF and Shackney SE. (2001). Cytometry, 46, 136 - 149.
31. Jazaeri AA, Yee CJ, Sotiriou C, Brantley KR, Boyd J and Liu ET. (2002). J. Natl. Cancer Inst., 94, 990 - 1000.
32. Jones C, Nonni AV, Fulford L, Merrett S, Chaggar R, Eusebi V and Lakhani SR. (2001). Br. J. Cancer, 85, 422 - 427.
33. Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M and Berns A. (2001). Nat. Genet., 29, 418 - 425.
34. Karabinis ME, Larson D, Barlow C, Wynshaw-Boris A and Moser AR. (2001). Carcinogenesis, 22, 343 - 346.
35. Kuperwasser C, Hurlbut GD, Kittrell FS, Dickinson ES, Laucirica R, Medina D, Naber SP and Jerry DJ. (2000). Am. J. Pathol., 157, 2151 - 2159.
36. Lakhani SR, Van De Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, McGuffog L and Easton DF. (2002). J. Clin. Oncol., 20, 2310 - 2318.
37. Lee JS, Collins KM, Brown AL, Lee CH and Chung JH. (2000). Nature, 404, 201 - 204.
38. Levy-Lahad E, Lahad A, Eisenberg S, Dagan E, Paperna T, Kasinetz L, Catane R, Kaufman B, Beller U, Renbaum P and Gershoni-Baruch R. (2001). Proc. Natl. Acad. Sci. USA, 98, 3232 - 3236.
39. Liu CY, Flesken-Nikitin A, Li S, Zeng Y and Lee WH. (1996). Genes Dev., 10, 1835 - 1843.
40. Ludwig T, Chapman DL, Papaioannou VE and Efstratiadis A. (1997). Genes Dev., 11, 1226 - 1241.
41. Ludwig T, Fisher P, Ganesan S and Efstratiadis A. (2001a). Genes Dev., 15, 1188 - 1193.
42. Ludwig T, Fisher P, Murty V and Efstratiadis A. (2001b). Oncogene, 20, 3937 - 3948.
43. MacLachlan TK, Takimoto R and El-Deiry WS. (2002). Mol. Cell. Biol., 22, 4280 - 4292.
44. Mak TW, Hakem A, McPherson JP, Shehabeldin A, Zablocki E, Migon E, Duncan GS, Bouchard D, Wakeham A, Cheung A, Karaskova J, Sarosi I, Squire J, Marth J and Hakem R. (2000). Nat. Immunol., 1, 77 - 82.
45. McAllister KA, Bennett LM, Houle CD, Ward T, Malphurs J, Collins NK, Cachafeiro C, Haseman J, Goulding EH, Bunch D, Eddy EM, Davis BJ and Wiseman RW. (2002). Cancer Res., 62, 990 - 994.
46. Medina D, Ullrich R, Meyn R, Wiseman R and Donehower L. (2002). Environ. Mol. Mutagen., 39, 178 - 183.
47. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM and Ding W et al. (1994). Science, 266, 66 - 71.
48. Monteiro AN. (2002). Cancer Biol. Ther., 1, 187 - 188.
49. Moynahan ME, Chiu JW, Koller BH and Jasin M. (1999). Mol. Cell, 4, 511 - 518.
50. Moynahan ME, Cui TY and Jasin M. (2001a). Cancer Res., 61, 4842 - 4850.
51. Moynahan ME, Pierce AJ and Jasin M. (2001b). Mol. Cell, 7, 263 - 272.
52. Phillips KA. (2000). J. Clin. Oncol., 18, 107S - 112S.
53. Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, Jack E, Vesprini DJ, Kuperstein G, Abrahamson JL, Fan I, Wong B and Narod SA. (2001). Am. J. Hum. Genet., 68, 700 - 710.
54. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T and Livingston DM. (1997). Cell, 88, 265 - 275.
55. Seidman AD, Fornier MN, Esteva FJ, Tan L, Kaptain S, Bach A, Panageas KS, Arroyo C, Valero V, Currie V, Gilewski T, Theodoulou M, Moynahan ME, Moasser M, Sklarin N, Dickler M, D'Andrea G, Cristofanilli M, Rivera E, Hortobagyi GN, Norton L and Hudis CA. (2001). J. Clin. Oncol., 19, 2587 - 2595.
56. Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C, Sands A, Eichele G, Hasty P and Bradley A. (1997). Nature, 386, 804 - 810.
57. Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T and Deng CX. (1998). Oncogene, 17, 3115 - 3124.
58. Shin SJ and Rosen PP. (2002). Am. J. Surg. Pathol., 26, 413 - 420.
59. Smith PD, Crossland S, Parker G, Osin P, Brooks L, Waller J, Philp E, Crompton MR, Gusterson BA, Allday MJ and Crook T. (1999). Oncogene, 18, 2451 - 2459.
60. Thompson D and Easton DF. (2002). J. Natl. Cancer Inst., 94, 1358 - 1365.
61. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ and Abraham RT. (2000). Genes Dev., 14, 2989 - 3002.
62. Turner BC, Ottey M, Zimonjic DB, Potoczek M, Hauck WW, Pequignot E, Keck-Waggoner CL, Sevignani C, Aldaz CM, McCue PA, Palazzo J, Huebner K and Popescu NC. (2002). Cancer Res., 62, 4054 - 4060.
63. Tutt A, Gabriel A, Bertwistle D, Connor F, Paterson H, Peacock J, Ross G and Ashworth A. (1999). Curr. Biol., 9, 1107 - 1110.
64. Tutt AN, van Oostrom CT, Ross GM, van Steeg H and Ashworth A. (2002). EMBO Rep., 3, 255 - 260.
65. van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R and Friend SH. (2002). Nature, 415, 530 - 536.
66. Wang WW, Spurdle AB, Kolachana P, Bove B, Modan B, Ebbers SM, Suthers G, Tucker MA, Kaufman DJ, Doody MM, Tarone RE, Daly M, Levavi H, Pierce H, Chetrit A, Yechezkel GH, Chenevix-Trench G, Offit K, Godwin AK and Struewing JP. (2001). Cancer Epidemiol. Biomarkers Prev., 10, 955 - 960.
67. Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG, Deng CX and Ried T. (2002). Oncogene, 21, 5097 - 5107.
68. Welcsh PL and King MC. (2001). Hum. Mol. Genet., 10, 705 - 713.
69. Welcsh PL, Lee MK, Gonzalez-Hernandez RM, Black DJ, Mahadevappa M, Swisher EM, Warrington JA and King MC. (2002). Proc. Natl. Acad. Sci. USA, 99, 7560 - 7565.
70. Wooster R, Neuhausen SL, Mangion J, Quirk Y, Ford D, Collins N, Nguyen K, Seal S, Tran T and Averill D et al. (1994). Science, 265, 2088 - 2090.
71. Xu B, Kim S and Kastan MB. (2001a). Mol. Cell. Biol., 21, 3445 - 3450.
72. Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC and Deng CX. (2001b). Nat. Genet., 28, 266 - 271.
73. Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A and Deng CX. (1999a). Nat. Genet., 22, 37 - 43.
74. Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T and Deng CX. (1999b). Mol. Cell, 3, 389 - 395.
75. Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH and Pavletich NP. (2002). Science, 297, 1837 - 1848.
76. Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH and Brody LC. (2002). Nat. Genet., 30, 285 - 289.
77. Yu VP, Koehler M, Steinlein C, Schmid M, Hanakahi LA, van Gool AJ, West SC and Venkitaraman AR. (2000). Genes Dev., 14, 1400 - 1406.