Brca1 required for T cell lineage development but not TCR loci rearrangement

Nature Immunology

Volumn 1, Issue 1, 2000, Pages 77-82

  Mak, Tak W ^a,b   Hakem, Anne ^a,b   McPherson, J Peter ^a,b   Shehabeldin, Amro ^a,b   Zablocki, Elzbieta ^a,b   Migon, Eva ^a,b   Duncan, Gordon S ^a,b   Bouchard, Denis ^a,b   Wakeham, Andrew ^a,b   Cheung, Alison ^a,b   Karaskova, Jana ^b   Sarosi, Ildiko ^c   Squire, Jeremy ^b   Marth, Jamey ^d   Hakem, Razqallah ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c AMGEN INC   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN;

ANIMAL; ARTICLE; CELL LINEAGE; CYTOLOGY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; MOUSE; MOUSE MUTANT; T LYMPHOCYTE;

ANIMALS; BRCA1 PROTEIN; CELL LINEAGE; GENE EXPRESSION REGULATION; GENE REARRANGEMENT, T-LYMPHOCYTE; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES;

EID: 7444231187     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/76950     Document Type: Article

References (37)

1. Fischer, A. and Malissen, B. Natural and engineered disorders of lymphocyte development. Science 5361, 237-243 (1998).
2. Sleckman, B.P. et al. Accessibility control of variable region gene assembly during T-cell development. Immunol. Rev. 165, 121-130 (1998).
3. Frank, K.M. et al. Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV. Nature 396, 173-177 (1998).
4. Gao, Y. et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404, 897-900 (2000).
5. Ford, D., Easton, D.F., Bishop, D.T., Narod, S.A. & Goldgar, D.E. Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Lancet 343, 692-695 (1994).
6. Miki, Y. et al. A strong candidate for the breast and ovarian-cancer susceptibility gene. Science 266, 66-71 (1994).
7. Gudas, J.M. et al. Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell. Growth Differ. 7, 717-723 (1996).
8. Chen, Y. et al. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res. 56, 3168-3172 (1996).
9. Scully, R. et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425-435 (1997).
10. Thomas, J.E., Smith, M.,Tonkinson, J.L., Rubinfeld, B. & Polakis, P. Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage. Cell Growth Differ. 8, 801-809 (1997).
11. Cortez, D., Wang, Y., Qin, J. & Elledge, S.J. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks. Science 286, 1162-1166 (1999).
12. Lee, J.S., Collins, K.M., Brown, A.L., Lee, C.H. & Chung, J.H. hCdsI-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000).
13. Scully, R. et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275 (1997).
14. Zhong, Q. et al. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 285, 747-750 (1999).
15. Shen, S.X. et al. A targeted disruption of the marine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 17, 3115-3124 (1998).
16. Gowen, L.C., Avrutskaya, A.V., Latour, A.M., Koller, B.H. & Leadon, S.A. BRCA1 is required for transcription-coupled repair of oxidative DNA damage. Science 281, 1009-1012 (1998).
17. Gowen, L.C., Johnson, B.L., Latour, A.M., Sulik, K.K. & Koller, B.H. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet 12, 191-194 (1996).
18. Hakem, R. et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023 (1996).
19. Liu, C.-Y., Flesken-Nikitin, A., Li, S., Zeng, Y. & Lee, W.H. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 10, 1835-1843 (1996).
20. Sauer, B. Inducible gene targeting in mice using the Cre/lox system. Methods. Ann. Companion Meth. Enzymol. 14, 381-392 (1998).
21. Hennet, T., Hagen, F.K., Tabak, L.A. & Marth, J.D. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl- transferase gene by site-directed recombination. Proc. Natl Acad. Sci. USA 92, 12070-12074 (1995).
22. Sebzda, E. et al. Selection of the T cell repertoire. Annu. Rev. Immunol. 17, 829-874 (1999).
23. Levine, A.J. p53, the cellular gatekeeper for growth and division. Cell 88, 323-331 (1997).
24. el-Deiry, W.S. Regulation of p53 downstream genes. Semin. Cancer Biol. 8, 345-357 (1998).
25. Oltvai, Z.N., Milliman, C.L. & Korsmeyer, S.J. Bcl2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619 (1993).
26. Ludwig, T., Chapman, D.L., Papaioannou, V.E. & Efstratiadis, A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11, 1226-1241 (1997).
27. Hakem, R., de la Pompa, J.L., Elia, A., Potter, J. & Mak, T.W. Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nature Genet. 16, 298-302 (1997).
28. + stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1, 197-205 (1994).
29. Strasser, A., Harris, A.W., Corcoran, L.M. & Cory, S. Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature 368, 457-460 (1994).
30. -/- mice. Cell 89, 1011-1019 (1997).
31. Haks, M.C., Krimpenfort, P., van den Brakel, J.H.& Kruisbeek, A.M., Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11, 91-101 (1999).
32. Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643-649 (1998).
33. Difilippantonio, M.J. et al. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404, 510-514 (2000).
34. Brugarolas, J. et al. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552-557 (1995).
35. Strasser, A., Harris, A.W. & Cory, S. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67, 889-899 (1991).
36. Hakem, R. et al. Differential requirement for caspase 9 in apoptotic patways in vivo. Cell 94, 339-352 (1998).
37. Dracopoli, N. C. Current Protocols in Human Genetics (John Wiley and Sons Inc, New York, 1999).