Brca2-null embryonic survival is prolonged on the balb/c genetics background

Molecular Carcinogenesis

Volumn 28, Issue 3, 2000, Pages 174-183

  Bennett, L Michelle ^a   McAllister, Kimberly A ^a   Blackshear, Pamela E ^a,b   Malphurs, Jason ^a   Goulding, Gina ^a   Collins, N Keith ^a   Ward, Toni ^a   Bunch, Donna O ^a   Eddy, Edward M ^a   Davis, Barbara J ^a   Wiseman, Roger W ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

BALB c; Brca2; Embryonic lethality; Gene targeting

Indexed keywords

RNA DIRECTED DNA POLYMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER INHIBITION; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; HYBRIDIZATION; MALE; MOUSE; NONHUMAN; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BRCA1 PROTEIN; BRCA2 PROTEIN; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, BRCA1; GENES, LETHAL; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0033861439     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2744(200007)28:3<174::AID-MC6>3.0.CO;2-C     Document Type: Article

References (39)

1. Rahman N, Stratton M. The genetics of breast cancer susceptibility. Annu Rev Genet 1998;32:95-120.
2. Ford D, Easton D, Stratton M, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 1998;62:676-689.
3. The Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 1999;91:1310-1316.
4. Thorlacius, S Olafsdottir, G Tryggvadottir L, et al. A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nat Genet 1996;13:117-119.
5. Ramus SJ, Friedman LS, Gayther SA, et al. A breast/ovarian cancer patient with germline mutations in both BRCA1 and BRCA2. Nat Genet 1997;15:14-15.
6. Randall TC, Bell KA, Rebane BA, Rubin SC, Boyd J. Germline mutations of the BRCA1 and BRCA2 genes in a breast and ovarian cancer patient. Gynecol Oncol 1998;70:432-434.
7. Scully R, Chen J, Plug A, et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997;88:265-275.
8. Patel KJ, Yu VPC, Lee HS, et al. Involvement of Brca2 in DNA repair. Mol Cell 1998;1:347-357.
9. Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 1998;281:1009-1012.
10. Chen JJ, Silver D, Cantor S, Livingston DM, Scully R. BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res 1999;59:1752s-1756s.
11. Morimatsu M, Donoho G, Hasty P. Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to γ-radiation and premature senescence. Cancer Res 1998;58:3441-3447.
12. Zhong Q, Chen CF, Li S, et al. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 1999;285:747-750.
13. Chen J, Silver DP, Walpita D, et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 1998;2:317-328.
14. Blackshear PE, Goldsworthy SM, Foley JF, et al. Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene 1998;16:61-68.
15. Rajan JV, Marquis ST, Garder HP, Chodosh LA. Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol 1997;184:385-401.
16. Hakem R, de la Pompa JL, Mak TW. Developmental studies of Brca1 and Brca2 knock-out mice. J Mammary Gland Biol Neoplasia 1998;3:431-445.
17. Bronson SK, Smithies O. Altering mice by homologous recombination using embryonic stem cells. J Biol Chem 1994;269:27155-27158.
18. Liu C-Y, Flesken-Nikitin A, Li S, Zeng Y, Lee W-H. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev 1996;10:1835-1843.
19. Hakem R, de la Pompa JL, Sirard C, et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 1996;85:1009-1023.
20. Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet 1996;12:191-194.
21. Sharan SK, Morimatsu M, Albrecht U, et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 1997;386:804-810.
22. Suzuki A, de la Pompa JL, Hakem R, et al. Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev 1997;11:1242-1252.
23. Ludwig T, Chapman DL, Papaiouannou VE, Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53 and Brca2/p53 nullizygous embryos. Genes Dev 1997;11:1226-1241.
24. Connor F, Bertwistle D, Mee PJ, et al. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet 1997;17:423-430.
25. Friedman LS, Thislethwaite FC, Patel KJ, et al. Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res 1998;58:1338-1343.
26. McAllister KA, Haugen-Strano A, Hagevik S, et al. Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene. Cancer Res 1997;57:3121-3125.
27. Dix DJ, Allen JW, Collins BW, et al. Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci USA 1996;93: 3264-3268.
28. Hogan B, Beddington R, Costantini F, Lacy E. Manipulating the mouse embryo: A laboratory manual. Cold Spring Harbor: Cold Spring Harbor Press; 1994.
29. Wilkinson DG. Whole in situ hybridization of vertebrate embryos. In: Wilkinson DG, editor. In situ hybridization: A practical approach. New York: Oxford University Press; 1992. p 75-83.
30. Doetschman, T. Interpretation of phenotype in genetically engineered mice. Lab Animal Sci 1999;49:137-143.
31. LeCouter JE, Kablar B, Whyte PFM, Ying C, Rudnicki MA. Strain-related embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development 1998; 125:4669-4679.
32. Suzuki A, Luis de la Pompa J, Stambolic V, et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 1998;8:1169-1178.
33. Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumor suppression. Nat Genet 1998;19:348-355.
34. Sibilia M, Wagner E. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 1995;269: 234-238.
35. Threadgill D, Dlugosz A, Hansen L, et al. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 1995;269:230-234.
36. Gayther, SA, Pharoah PDP, Ponder BAJ. The genetics of inherited breast cancer. J Mammary Gland Biol Neoplasia 1998;3:365-376.
37. Rebbeck TR, Couch FJ, Kant, J, et al. Genetic heterogeneity in hereditary breast cancer: Role of BRCA1 and BRCA2. Am J Hum Genet 1996;59:547-553.
38. Easton, DF. How many more breast cancer predisposition genes are there? Breast Cancer Res 1999;1:1-4.
39. Ponnaiya B, Cornforth MN, Ullrich RL. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white. Radiat Res 1997; 147:121-125.